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Tips & Tricks 
for CTO intervention 
Fuminobu Yoshimachi MD, PhD 
Tokai University School of Medicine
Problems of Treating CTO 
bending 
calcification 
long lesion 
bifurcation 
entry 
exit 
CTO is has various 
pathological characters, 
therefor sometimes it is 
difficult to get success.
Problems of Treating CTO 
bending 
long lesion 
bifurcation 
entry 
calcification 
exit 
CTO is complex lesion 
II 
Combination of device selection is needed
antegrade approach 
Our devices on antegrade approach for CTO are 
GuidWires and support catheters. 
Sometimes, we need IVUS Guided PCI to check 
entry point of occlusion or to control the 
GuideWire to insert true lumen. 
We have to change the devices according to the 
lesion.
Guide Wire for treating CTO 
XTR 
Wizard 78 
GAIA series 
Miracle 
Wizard 3 
confianza 
1. eel type: soft & floppy 
The GW can pass through “Micro 
channel” or “ loose tissue” 
2. Knife type: good torque performance 
The GW can be controlled intentionally, 
but making space & modification to 
the tissue . 
3. spear type: stiff & taper 
penetration to straight way
Coronary CT 
Coronary CT is good for checking not only 
occlusion but character of the lesion including 
eccentrically-located calcification.
Micro Channel in CTO 
160~230 μm = 0.16~0.23 mm 
60~70% in CTO lesion 
tapered > abrupt type 
Short > long lesion 
Sakuda H et al 
Am J Pathol 1992:141(6):1507-16 
Katsuragawa M et al. 
J Am Coll Cardiol. 1993 Mar 1;21(3):604-11 
Kumamoto M et al 
Hum Pathol. 1995 Apr;26(4):450-6 
Srivatsa SS et al. 
Am Coll Cardiol. 1997 Apr;29(5):955-63 
Carlino M et al 
Catheter Cardiovasc Interv. 2008 Jan 1;71(1):20-6
Treating Micro Channel / Loose Tissue 
- Soft and tapered GuideWire - 
Micro Channel 
loose tissue tracking
Treating bending & calcified lesion 
- controllable GuideWire - 
Making space and modifying the tissue by 
the GW, sometimes it makes big dissection 
lumen.
Treating hard lesion 
- penetration GuideWire - 
Hard and stiff tapered GW makes small 
space. 
But it goes straight , and it is difficult to 
control the direction.
high & anterior take-off orifice of RCA
Wizard 78
tornus
Sapphire 1.0mm
TREK 2.0x15mm
Eagle Eye Platinum
Xience Prime 2.5x38mm
TREK 3.0x15mm
It is easy to engage to abnormal orifice of RCA 
with Slender Catheter, and getting successful 
for CTO lesion with some GWs & devices.
Wizard 78
LAXA 3.0x15mm
iBP 3.5x10mm
Resolute Integrity 3.5x38mm
corsair & Wizard78
conquest 8-20
Gaia 2nd
corsair
not cross! 
Safire 1.0x6mm 
& 
rapture
Rotablator 1.5mm
KAMUI 3.0x15mm
Opticross
LAXA 4.0x10mm
Resolute Integrity 3.5x34mm
Ikazuchi Rev.1.25x10mm
retrograde approach 
1. channel selection 
septal channel 
apex channel 
epicald channel 
2. device selection 
GW 
support catheter 
3. how to make the ante-retro connection 
same as TFI
retrograde approach 
The most important essence for retrograde 
approach is to confirm and select retrograde 
channel, and to select effective device to pass the 
channel. 
main branch 
small channel 
same as TFI
Wizard3 
rt. radial approach, SL 4.0 5Fr
XTR & Corsair
Retrograde approach with single GC is possible.
SL4.0 5Fr
Corsair & Wizard 78
Corsair & conquest 8-20
bilateral TRI
bilateral TRI
bilateral TRI
Retrograde approach via lt. & rt. radial 
artery is possible !
Retrograde approach via lt. & rt. radial 
artery is possible !
Take Home Massage 
CTO is complex lesion with calcification, long diffuse 
bending ....and so on. 
To treat CTO, we have to select GuideWire ,support 
catheter and other devices, and adjust the PCI style to 
the situation. 
The essence of treating CTO including retro grade 
approach is the same as the TFI with big diameter GC. 
There is no limitation on TRI to treat CTO even if using 
a 5Fr GC.
Take Home Massage 
Why don’t you hesitate TRI for CTO ? 
Limitation is just in your mind !

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