why don\'t most other types of bacteria produce ulcers ( like helicobacter pylori bacteria) Solution helicobacter is a chronic inhabitant usually persists for lifelong(unless treated) in gastric mucosa. Helicobacter can capable of staying for longer in host so it can able to modulate the localized host tissue by producing cytokinines. these cytokinines are plays important role in ulcer pathogenesis. bacterial virulence factors cytotoxin-associated gene pathogenecity island encoded protein CagA and cytotoxin Vac A are could be responsible of ulcer pathogenesis. unlike other bacteria helicobacter can able to produce cytotoxins which can cause immune mediated tissue damage leads to ulcer formation.