1. Guillermo Umpierrez, M.D. Professor of Medicine Division of Endocrinology Emory University School of Medicine How do you write a scientific manuscript?

2. Consultants Number of consultants 8 Years in practice 26 (11 - 50) Clinical/basic research Clinical: 7, basic: 1, both: 2 Number of publications 316 (41 – 1300) Number of peer-review papers 104 (41 – 250)

13. The “Fundamental” Question “ Few clinical trials have focused on the optimal management of inpatient hyperglycemia in the non-critical setting. Accordingly, we conducted this prospective, randomized study to compare the efficacy and safety of a basal/bolus insulin regimen to SSI in patients with T2DM admitted to general medicine wards.” Umpierrez et al, Diabetes Care 30:2181–2186, 2007

17. 68 subjects with DKA IV Glulisine insulin therapy until resolution of DKA Transition to SC glargine once daily and glulisine before meals Insulin Analogs (n= 34) Human Insulin (n= 34) IV regular insulin therapy until resolution of DKA Transition to SC NPH and regular insulin twice daily Insulin Analogs versus Human Insulin in the Treatment of Patients with DKA

18. Umpierrez et at, Diabetes Care 30:1699-1703, 2003 Study Protocol

21. Umpierrez et al, Diabetes Care 27:1873-1878, 2004 Tables

22. Figures should stand alone for comprehension Umpierrez et al, Diabetes Care 30:2181–2186, 2007

29. Review Process Paper Submitted Initial Decision by Editor Confirmation of Receipt Rejection Decide to Review Assign Reviewers Reviews Completed Reject Accept Notification to Author Revise Accept Revise

35. Additional Tips! What additional recommendation(s) would you give to a busy clinician on how to write manuscripts? Do not procrastinate – just do it

36. Acknowledgement Faculty: Nadine Kaslow, Ph.D. Bobby Khan, M.D., Ph.D. Jeff Lennox, M.D. Jeff Sands, M.D. Peter Wilson, M.D. Nanette Wenger, M.D. Thomas Ziegler, M.D.