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Concentrating Asacol for the improved treatment of Crohn’s disease<br />Gustavo Perez Caballero<br />
What is Crohn’s disease?<br />It’s a form of inflammatory bowel disease.<br />It usually affects the intestines, but may o...
What is the cause of Crohn’s?<br />The exact cause is unknown. <br />It’s linked to a problem with the body's immune syste...
What is Asacol?<br />Asacol is an anti-inflammatory drug used to treat inflammation of the digestive tract ulcerative coli...
Asacol side-effects<br />Commonly:<br />	Diarrhea, Nausea, Cramping, Flatulence.<br />Uncommonly:<br />	Headache, Exacerba...
Hypothesis<br />That one of the concentrated Asacol pills will be enough to repress Crohn’s disease for the whole day.<br />
Objectives<br />To improve the Asacol pill so that it can be taken once daily or even once every 2 or 3 days. <br />Curren...
Objectives (cont.)<br />The thing is most health insurance companies don’t cover the pill.<br />For example a person whose...
Methodology<br />I will have my control group and my experimental group, control being 5 sets of 5 mice taking the normal ...
Expected Results<br />After numerous observations I expect that the mice in the concentrated Asacol group show more improv...
References<br />1. http://www.drugs.com/asacol.html<br />	Asacom,07/27/2010, Cerner Multum, Inc. ('Multum’)<br />2. http:/...
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Concentrating Asacol for the improved treatment of Crohn's Disease

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Concentrating Asacol for the improved treatment of Crohn's Disease

  1. 1. Concentrating Asacol for the improved treatment of Crohn’s disease<br />Gustavo Perez Caballero<br />
  2. 2. What is Crohn’s disease?<br />It’s a form of inflammatory bowel disease.<br />It usually affects the intestines, but may occur anywhere from the mouth to the end of the rectum.<br />
  3. 3. What is the cause of Crohn’s?<br />The exact cause is unknown. <br />It’s linked to a problem with the body's immune system response.<br />The result is an overactive immune response that leads to chronic inflammation. <br />
  4. 4. What is Asacol?<br />Asacol is an anti-inflammatory drug used to treat inflammation of the digestive tract ulcerative colitis and mild-to-moderate Crohn's disease. <br />Asacolis a bowel-specific aminosalicylatedrug that acts locally in the gut and has its predominant actions there, thereby having few systemic side effects.<br />
  5. 5. Asacol side-effects<br />Commonly:<br /> Diarrhea, Nausea, Cramping, Flatulence.<br />Uncommonly:<br /> Headache, Exacerbation of the colitis, Hypersensitivity reactions, Hair Loss, Interstitial nephritis.<br />Rarely:<br /> Acute pancreatitis, Hepatitis, Nephrotic syndrome, Blood disorders.<br />
  6. 6. Hypothesis<br />That one of the concentrated Asacol pills will be enough to repress Crohn’s disease for the whole day.<br />
  7. 7. Objectives<br />To improve the Asacol pill so that it can be taken once daily or even once every 2 or 3 days. <br />Currently a normal person has to take 6 pills of Asacol per day to allow it to be effective. <br />
  8. 8. Objectives (cont.)<br />The thing is most health insurance companies don’t cover the pill.<br />For example a person whose insurance wont cover the treatment and has to take six pills a day must pay the hefty amount of 700 to 800 dollars every 4 to for 5 weeks.<br />So this proposal will save people both time and money.<br />
  9. 9. Methodology<br />I will have my control group and my experimental group, control being 5 sets of 5 mice taking the normal Asacol treatment and my experimental being 5 sets of 5 mice taking the more concentrated type of Asacol.<br />I will observe them over a period of time to watch for any side-effects and see if there are any effects on offspring.<br />After which if there is no change in genes and presents no danger to humans I will test it on willing humans with the disease.<br />
  10. 10. Expected Results<br />After numerous observations I expect that the mice in the concentrated Asacol group show more improvement in rectal bleeding and stool frequency than in the normal treatment.<br />I also expect that it wont damage the offspring in anyway so that I can test it on willing humans with the disease.<br />
  11. 11. References<br />1. http://www.drugs.com/asacol.html<br /> Asacom,07/27/2010, Cerner Multum, Inc. ('Multum’)<br />2. http://www.medicinenet.com/crohns_disease/article.htm<br /> Jay W. Marks, MD,Crohn'sDisease, 12 Jul 1996<br />3. http://www.webmd.com/ibd-crohns-disease/crohns-disease/tc/crohns-disease-treatment-overview<br /> 2005-2011, WebMD,Healthwise<br />4. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001295/<br /> George F Longstreth, MD, Department of Gastroenterology, 12/13/2010, A.D.A.M., Inc.<br />

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