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immunodeficiency diseases
- 1. MICROBIOLOGY PAGE 1 IMMUNODEFICIENCY DISEASES DR.TARUNIKAA G
- 2. STORY TIME
- 3. The story of David Vetter
- 5. MICROBIOLOGY CLASS Dr.TARUNIKAA G PAGE 2 What is immunodeficiency Impaired host defence
- 6. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 3 CLASSIFICATION • PRIMARY • SECONDARY
- 7. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 4 Causes of immunodefeciency • Humoral immunity • Cell mediated immunity • Combined Specific Non-specific • Complements • Phagocytosis
- 8. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 5 PRIMARY IMMUNO- DEFICIENCY X linked Agammaglobulinaemia Transient hypoglobulinaemia of infancy Common variable immunodeficiency Selective immunoglobulin deficiency Immunodeficiencies with hyper IgM Transcobalamin II deficiency
- 9. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 6 X linked Agammaglobulinaemia Burton disease BOYS (X linked) Bcell maturation defect BTK gene Depletion of cells-Bursa dependant areas B 6 months virus
- 10. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 7 Late onset hypogammaglobulinaemia • 15-35years • Pyogenicinfections • Autoimmunedisorders • IncreasedsuppresorT cells • DecreasedhelperT cells Transient hypoglobulinaemia of infancy C o m m o n v a r i a b l e i m m u n o d e f i c i e n c y Selective immunoglobulin deficiency • Delay in synthesis • Spontaneous recovery 18 and 30 mo. • Rec. Otitis media • Respiratory infections Isolated IgA- Most common - Respiratory infection Selective IgM- Septicemia
- 11. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 8 I m m u n o d e f i c i e n c i e s w i t h h y p e r I g M T r a n s c o b a l a m i n I I d e f i c i e n c y X linked / Ar Ar Vitamin B12 deficiency
- 12. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 9 Thymic hypoplasia Chronic mucocutaneous candidiasis Purine nucleoside phosphorylase deficiency T cell defect • Associated endocrinopathies • Delayed hypersensitivity • Intracellular killing • Transfer factor therapy with amphotericin B C – Cardiac abnormalities A - Abnormal face T – T cell defect. Thymus abnormality C – Cleft palate H – Hypocalcemia 22 – Chr 22 Purines Hydroxanthine Uric acid
- 13. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 10 Combined immunodeficiency Wiskott Aldrich syndrome • Defective CI • Abnormal immunoglobulin • Bone marrow transplant • transfer factor • Thymus transplantation AR • Cerebellar ataxia • Telengectasia • Ovarian dysgenesis • Chr abnormality Ataxia telengectasia Nezelof's disease AR ECZEMA T P INFECTION
- 14. Reticular dysgenesis of De Vaal MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 11 Precursors of immunocompetent cells in fetal liver and bone marrow Multipotent hematopoietic stem cell SCID Swiss type agammaglobulinemial Lymphoid stem cell
- 15. SLE C3- Recurrent pyogenic infection C6 C7 C8- Neisserial infection. 01 Component deficiency Disorders of complement C1 inhibitor - Angioneurotic edema C3b inactivator - Pyogenic infeection. 02 Inhibitor deficiency
- 16. • Enzyme deficiency • Deficiency of opsonic antibody • Drugs • Antineutrohil autoantibodies Disorders of phagocytosis Shwachman disease Actin binding protein deficiency syndrome Hyper IgE syndrome Lazy leucocyte syndrome Tuftsin deficiency Job syndrome Myeloperoxidase deficiency Leucocyte G6PD deficiency
- 17. CHronic granulomatous infections • Catalase positive pyogenic pathogens - staphylococcus and coliforms • Diminished H2O2 • Defective release of myeloperoxidase • NBT test
- 18. CHEDIAK HIGASHI SYNDROME • Decreased pigmentation • Photophobia • Nystagmus • Peroxidase positive inclusion bodies
- 19. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 16 Secondary immunodeficiency
- 20. Can live vaccines be given in immune deficiency patients?
- 21. Enzyme that is deficient in SCID?
- 22. What are the 5 B's in X linked agammaglobulinemia?
- 23. MICROBIOLOGY CLASS Dr.Tarunikaa G PAGE 17 for listening !
Editor's Notes
- 23.01.2023
- 23.01.2023
- 23.01.2023