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Management Of Female
Infertility
Mohammed Majeed Alwaily
Treatment
Treatment of Cervical Factors:
Chronic cervicitis may be treated with antibiotics.
The easiest and most successful treatment is intrauterine
insemination (IUI).
Treatment of Uterine Factors:
The treatment of uterine malformations depends on the
severity of the problem.
Chronic cervical factor of absence of mucus - Intrauterine
insemination
Cervical incompetence - Cerclage
Damage/absence of fallopian tubes (ectopic) - In vitro
fertilization
Uterine anomalies can be corrected through operative
hysteroscopy under general anesthesia or conscious
sedation
Endometrial polyps are removed through operative
hysteroscopy
Fibroids should be treated if they are associated with
abnormal uterine bleeding or if they are thought to be the
cause of infertility. Three modalities are used to treat
myomas: medical treatment, surgical treatment, and
embolization.
Treatment of Ovarian Factors:
Clomiphene citrate (Clomid)
Human menopausal gonadotropins
Ovulation Inducers
Drug Name Rate of Ovulation Pregnancy
Clomiphene 80% 40%
HMG 90% 70-80%
Bromocriptine 90% 70-80%
GnRH 80% 50-80%
Ovarian drilling 70-80% 45-60%
Assisted reproductive technology
Therapy
Requires
Controlled ovarian hyperstimulation
Retrieval of oocytes
In vitro fertilization and embryo transfer
Procedures
IVF-ET (In Vitro fertilization-embryo transfer)
GIFT (Gamete intra-fallopian transfer)
ZIFT (Zygote intra-fallopian transfer)
ICSI (Intracytoplasmic sperm injection)
In Vitro Fertilization(IVF)
 Fresh-non-donor eggs, frozen-nondonor,
frozen-donor
 Ovulation Induction & Monitoring
 Oocyte Retrieval
 Fertilization
 Embryo Transfer
Oocyte Retrieval
B. GIFT & ZIFT:
 Gamete intrafallopian transfer – use of a laparoscope to
guide the transfer of unfertilized eggs and sperm into
the fallopian tubes
 Zygote intrafallopian transfer – fertilizing the eggs in
the laboratory and using a laparoscope to guide the
transfer of the zygotes into the fallopian tubes
C. Intracytoplasmic sperm injection (ICSI)
D. Surrogacy : a woman, other than the genetic mother
agrees to become pregnant and carry the fetus to full
term
E. Artificial insemination:
use of sperm from a donor or partner to fertilize an egg,
sperm collected and placed in vagina or uterus
IUI: intrauterine insemination, use a catheter to directly
place sperm into the uterine cavity
Thank you

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Infertility managment

  • 2. Treatment Treatment of Cervical Factors: Chronic cervicitis may be treated with antibiotics. The easiest and most successful treatment is intrauterine insemination (IUI). Treatment of Uterine Factors: The treatment of uterine malformations depends on the severity of the problem. Chronic cervical factor of absence of mucus - Intrauterine insemination Cervical incompetence - Cerclage
  • 3. Damage/absence of fallopian tubes (ectopic) - In vitro fertilization Uterine anomalies can be corrected through operative hysteroscopy under general anesthesia or conscious sedation Endometrial polyps are removed through operative hysteroscopy Fibroids should be treated if they are associated with abnormal uterine bleeding or if they are thought to be the cause of infertility. Three modalities are used to treat myomas: medical treatment, surgical treatment, and embolization. Treatment of Ovarian Factors: Clomiphene citrate (Clomid) Human menopausal gonadotropins
  • 4.
  • 5. Ovulation Inducers Drug Name Rate of Ovulation Pregnancy Clomiphene 80% 40% HMG 90% 70-80% Bromocriptine 90% 70-80% GnRH 80% 50-80% Ovarian drilling 70-80% 45-60%
  • 6. Assisted reproductive technology Therapy Requires Controlled ovarian hyperstimulation Retrieval of oocytes In vitro fertilization and embryo transfer Procedures IVF-ET (In Vitro fertilization-embryo transfer) GIFT (Gamete intra-fallopian transfer) ZIFT (Zygote intra-fallopian transfer) ICSI (Intracytoplasmic sperm injection)
  • 7.
  • 8. In Vitro Fertilization(IVF)  Fresh-non-donor eggs, frozen-nondonor, frozen-donor  Ovulation Induction & Monitoring  Oocyte Retrieval  Fertilization  Embryo Transfer
  • 9.
  • 11.
  • 12. B. GIFT & ZIFT:  Gamete intrafallopian transfer – use of a laparoscope to guide the transfer of unfertilized eggs and sperm into the fallopian tubes  Zygote intrafallopian transfer – fertilizing the eggs in the laboratory and using a laparoscope to guide the transfer of the zygotes into the fallopian tubes C. Intracytoplasmic sperm injection (ICSI) D. Surrogacy : a woman, other than the genetic mother agrees to become pregnant and carry the fetus to full term
  • 13. E. Artificial insemination: use of sperm from a donor or partner to fertilize an egg, sperm collected and placed in vagina or uterus IUI: intrauterine insemination, use a catheter to directly place sperm into the uterine cavity
  • 14.