2. Table of contents
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Acute Musculoskeletal Pain
Low Back Pain
Neck Pain
Upper Extremity Disorders
Lower Extremity Disorders
3. Acute Musculoskeletal Pain
is caused by various soft tissue injuries,
strains (injury to a tendon or a muscle), and
sprains (injury to a ligament).
3
4. Acute Musculoskeletal Pain
4
are inaccurately
treated with
opioids
20%
Substantial potential harms
âž” Risk for longer-term use
âž” Addiction
âž” Overdose
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
acute pain
(<4 weeks duration)
Topical
NSAIDs
second line
improved pain and function
Oral
NSAIDs
not recommended
Opioids
6. Low Back Pain
6
Most common identifiable causes
âž” spinal stenosis
âž” disk herniation
âž” compression fractures
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Chronic Pain
(>12 weeks)
Subacute Pain
(4 - 12 weeks)
Acute Pain
(<4 weeks)
Less common identifiable causes
âž” vertebral metastases
âž” infection
Diagnosis and Evaluation
9. Low Back Pain
9
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
History and Physical Examination
fever and
neurological signs
strength, sensory and
reflex testing of the
legs
ipsilateral and
contralateral straight
raise leg test
10. Low Back Pain
10
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
History and Physical Examination
11. Low Back Pain
11
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Further Diagnostic Testing
Within the first 6 weeks of symptoms
âž” avoid performing images routinely
âž” imaging abnormalities are
common
âž” obtaining images is not associated
with improved outcomes
âž” their discovery may lead to
unhelpful and costly interventions
Imaging indications
âž” severe or progresive neurologic
compromise
âž” suspicion of a life/function
threatening cause
âž” MRI is the preferred test for most
suspicions
12. Low Back Pain
12
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Treatment
Nonpharmacologic treatment Pharmacologic treatment
Acute Low Back Pain
âž” Physical therapy
âž” Local heat
âž” Acupuncture
âž” Spinal manipulation therapy
Chronic Low Back Pain
âž” Exercise therapy
âž” Massage therapy
âž” Acupuncture
âž” Yoga
âž” Cognitive Behavioral therapy
Acute Low Back Pain
âž” NSAIDs
âž” Non-benzodiazepine muscle
relaxants
Chronic Low Back Pain
âž” NSAIDs
âž” Non-benzodiazepine muscle
relaxants
âž” SNRIs
14. Neck Pain
14
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
A priority in evaluating neck pain is differentiating musculoskeletal pain from
conditions that may cause serious complications.
The most common causes
are musculoskeletal
âž” cervical strains
âž” spondylosis
âž” cervical facet osteoarthritis
Pain and stiffness in the absence of
neurologic abnormalities
15. Neck Pain
15
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
Radiculopathy and myelopathy are the most common causes of neurological neck pain.
Cervical radiculopathy
Paresthesia in a dermatomal
distribution
Radiating arm pain
Neck pain
Decreased deep tendon reflexes
Diminished strength
16. Neck Pain
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MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
Compressive cervical myelopathy
âž” neck pain with leg weakness
âž” gait/coordination disturbances
âž” bladder and bowel dysfunction
On examination
âž” upper motor neuron signs in upper
extremities
âž” lower motor neuron signs near
compression level
17. Neck Pain
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MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Treatment
A multimodal approach that is tailored for each individual appears to work best
âž” range of motion exercise
âž” physical therapy
âž” ice / heat applications
âž” stretching / strengthening
exercises
Analgesic agents
âž” NSAIDs
âž” Non-benzodiazepine muscle
relaxants
âž” SNRIs
âž” Neuromodulators
19. Thoracic Outlet Syndrome
19
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
Arterial
(1-3%)
âž” subclavian artery
compression
âž” w/wo thrombosis
âž” abnormal cervical rib
âž” arm or hand pain
âž” weakness
âž” paresthesia
âž” coolness
âž” pallor
Neurogenic
(>90%)
âž” compression of the
brachial plexus
âž” arm paresthesia
âž” pain
âž” weakness
Venous
(3-5%)
âž” axillary vein
compression
âž” thrombosis
âž” arm pain/fatigue
âž” swelling
âž” cyanosis
Thoracic Outlet Syndrome (TOS), refers to signs and symptoms due to compression of the
upper extremity neurovascular bundle.
Neurogenic TOS is a clinical diagnosis (electro-diagnostic testing may be
useful). Vascular causes require US. Arterial TOS may be identified using
chest x-ray imaging.
20. Thoracic Outlet Syndrome
20
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Treatment
Venous/Arterial TOS
âž” Catheter directed
thrombolysis
âž” Prompt surgical
decompression of the
thoracic outlet
Neurogenic TOS
âž” Improving posture
âž” Strengthening
shoulder girdle
muscles
âž” Surgical treatment if
disabling symptoms
are present
22. Shoulder Pain
22
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
Shoulder examination should be performed with both shoulders fully exposed, including
inspection, palpation, range-of-motion assessment, and specialized maneuvers.
Anterolateral shoulder pain
âž” most common shoulder pain
âž” impingement syndrome
âž” rotator cuff tendinopathy
âž” adhesive capsulitis
âž” labral tear
âž” biceps tendinitis
Posterior shoulder pain
âž” rotator cuff tendinopathy
âž” referred back pain
âž” glenohumeral joint pathology
âž” acromioclavicular pathology
23. Shoulder Pain
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MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Rotator Cuff Disease
âž” most common cause of shoulder
pain
âž” encompases all rotator cuff
disorders
âž” pain is worsened with overhead
activities
Risk Factors
âž” increasing age
âž” activities that require repetitive
overhead arm use
Pharmacologic treatment
âž” Acetaminophen
âž” Oral or topical NSAIDs
âž” Glucocorticoid injections
Surgery
(if conservative therapy has failed)
24. Shoulder Pain
24
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Adhesive Capsulitis
âž” anterolateral pain associated
with stiffness
âž” worse at night and in cold
weathers
Associated with
âž” prolonged immobilization
âž” history of shoulder injury
âž” diabetes
âž” hypothyroidism
âž” autoimmune disorders
Pharmacologic treatment
âž” Oral or topical NSAIDs
âž” Physical therapy
âž” Glucocorticoid injections
Surgery
(if conservative therapy has failed)
25. Shoulder Pain
25
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Acromioclavicular Joint Degeneration
âž” poorly localized pain on the
superior shoulder
âž” pain usually elicited on palpation
of the acromioclavicular joint
âž” the crossed-arm adduction test
often reproduces the pain
Pharmacologic treatment
âž” Oral or topical NSAIDs
âž” Activity modifications
26. Shoulder Pain
26
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Labral Tears
âž” superior labrum anterior and posterior
(SLAP) tears are common in athletes
and laborers
âž” pain worsens with abduction and
external rotation
âž” catching sensation, crepitus and
instability of the joint
early referral to an orthopedic surgeon
with experience in treating shoulder
injuries is recommended
28. Elbow Problems
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MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
Elbow problems may be caused by pathology within the elbow joint, surrounding tissues, or
nerves. Evaluation focuses on the patient history and physical examination.
Epicondylitis
âž” caused by repetitive strain of extensor
tendons
âž” pain and tenderness are located over the
lateral epicondyle and increase with
resisted wrist extension
Management
âž” avoidance of pain inducing activities
âž” physical therapy
âž” NSAIDs
Radial or Ulnar Nerve Entrapment
âž” the radial nerve is susceptible to
compression
âž” prolonged unconsciousness
âž” wrist drop
âž” sensory loss on the dorsum of the first 3
fingers
Management
âž” avoidance of elbow trauma
âž” nocturnal splinting
âž” NSAIDs
29. Elbow Problems
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MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
Olecranon Bursitis and Synovitis
âž” most common cause of swelling of the
elbow
âž” secondary to trauma, crystal disease or
infection
âž” bursa or joint aspiration with culture and
fluid analysis (for severe pain), when there
is any suspicion of infection, or when crystal
disease is suspected.
Management
âž” joint rest
âž” elbow protection
âž” NSAIDs
30. Elbow Problems
30
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
Wrist and Hand Pain
may be caused by trauma or overuse leading to musculoskeletal abnormalities and nerve
compression.
âž” acute pain associated with trauma
suggests fracture - requires imaging
âž” ulnar nerve entrapment
↪ wrist pain
↪ interosseous muscle weakness
↪ diminished sensation
âž” ganglion cysts
herniated synovial tissue around tendon
sheaths Finkelstein test for de Quervain stenosing
tenosynovitis
31. Elbow Problems
31
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
Carpal Tunnel Syndrome
âž” median nerve compression
âž” wrist / hand pain
âž” paresthesia and weakness first 3
digits
âž” worse at night and with repetitive
wrist motion
Some findings include
âž” hipoalgesia
âž” thenar muscle atrophy
âž” weakened thumb abduction
Treatment
âž” activity modification
âž” wrist splinting
âž” short course of oral glucocorticoids
âž” surgery
33. Hip Pain
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MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
The location of the pain (anterior/groin, lateral, or posterior) is often helpful in focusing the
evaluation.
Anterior hip pain
âž” insidious pain that worsens standing
(suggests osteoarthritis) older patients
(labral tear) younger patients
(infectious) fever
âž” gradual onset
↪ avascular necrosis
↳ alcoholism
↳ glucocorticoid use
↳ sickle cell anemia
↳ SLE
34. Hip Pain
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MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
35. Hip Pain
35
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
Lateral Hip Pain
âž” commonly caused by greater
trochanteric pain syndrome (GTPS)
âž” pain that worsens with lying on the
affected side suggests GTPS
âž” distal anterolateral thigh paresthesia
associated with tight-fitting clothes or
obesity
Symptoms follow the distribution of the lateral
femoral cutaneous nerve
Posterior Hip Pain
âž” lumbar radiculopathy
âž” vascular claudication
âž” sacroiliac joint dysfunction
âž” gluteal tendinopathy
The presence of morning stiffness, fever, or
peripheral joint symptoms should prompt
consideration of sacroiliitis
36. Hip Pain
36
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
FABER (Flexion, ABduction, and External Rotation) Test
37. Hip Pain
37
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Treatment
Labral Tears
âž” muscle strengthening
âž” activity modification
âž” arthroscopic surgery if conservative
measures fail
âž” hip arthroplasty
(advanced avascular necrosis)
Greater Trochanteric Pain Syndrome
âž” activity modification
âž” NSAIDs
âž” glucocorticoid injection
Meralgia Paresthetica
âž” reassurance
âž” avoidance of tight-fitting clothes
âž” weight loss
39. Knee and Leg Pain
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MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Diagnosis and Evaluation
The history should focus on timing (acute, subacute, or chronic) and pain characteristics. History of
knee injury or surgery, osteoarthritis, and crystal arthropathies should also be elicited.
Knee examination
(with both full knees exposed)
âž” inspection
âž” palpation
âž” range of motion testing
âž” special maneuvers
Radiography
âž” suspicion of
↪ fracture
↪ bone pathology
↪ osteoarthritis
MRI
âž” internal derangements
âž” surgery considerations
Joint Aspiration
âž” palpable effusion
(exclude inflammatory
or infectious arthritis)
Ligament and Meniscal Tears
42. Knee and Leg Pain
42
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Patellofemoral Pain Syndrome
âž” caused by disordered patellar tracking
with knee movement
âž” poorly localized anterior knee pain
and/or stiffness with prolonged sitting,
climbing, or descending stairs, and with
running or squatting
âž” abrupt patellar deviation may be noted
during squatting and standing
Treatment
âž” NSAIDs
âž” ice
âž” physical therapy
âž” strengthening exercises
43. Knee and Leg Pain
43
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Other disorders
Disorder Manifestations Causes Treatment
Bursitis acute or chronic swelling anterior to
the patella, tenderness, warmth, and
erythema
infection, trauma and gout Septic bursitis
knee immobilization, systemic antibiotics, and
re-aspiration if needed
Gouty bursitis managed with appropriate gout
therapy
Traumatic bursitis managed with activity
modification (avoidance of kneeling) and NSAID
Tendinopathies
and Tears
knee pain with movement, such as
jumping, running, or squatting
tendon tear causes acute
knee pain with effusion after
low-impact trauma or
fluoroquinolone or
glucocorticoid use
strengthening and stretching exercises and
NSAIDs
Osteochondral
Injury
diffuse knee pain significant trauma to the
knee or as an overuse injury
surgical
44. Knee and Leg Pain
44
MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Other disorders
Disorder Manifestations Causes Treatment
Medial Tibial Stress
Syndrome
pain in the mid to distal shins,
usually after activity
structural stress avoidance of high-impact activities
(e.g., running) and using shock-
absorbing insoles
Chronic Exertional
Compartment
Syndrome
swelling of a specific muscle bed,
throbbing pain during exercise
exercise modification of the exercise regimen
and occasionally surgical fasciotomy
Iliotibial Band
Syndrome
poorly localized lateral knee and
distal thigh pain
exercise abstaining from the inciting activity
and using ice, followed by a gradual
return to activity, stretching,
strengthening, and local massage
Popliteal Cysts posterior knee pain and swelling knee trauma, osteoarthritis, or
inflammatory arthritis
joint aspiration and intra-articular
glucocorticoid injection. Ruptured
cysts can be treated with rest,
elevation, and NSAIDs, surgical
excision
46. Ankle and Foot Pain
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MKSAP 19. General Internal Medicine I. Common Musculoskeletal Problems
Disorder Manifestations Causes Treatment
Ankle Sprains ecchymosis and swelling with
tenderness of involved ankle
ligaments
excessive ankle inversion intermittent cryotherapy and a lace-up support or air
stirrup brace combined with elastic compression
wrapping, acetaminophen and NSAIDs can be used for
pain control
Stress
Fracture
bony tenderness, pain with
percussion, or pain with hopping
on a single leg
structural stress immobilization and serial imaging or surgical fixation;
specialist involvement should be considered
Hindfoot
Pain
activity-related posterior heel
pain and stiffness that improves
with rest, tenderness of the
Achilles tendon
strenuous activities, although it
may occur spontaneously in
the elderly or rarely with
fluoroquinolone useral stress
treatment includes activity modification, eccentric
exercises (muscle lengthening in response to external
resistance), and use of appropriate footwear. NSAIDs
can be used for pain control
Midfoot Pain posteromedial heel paresthesia
that radiates distally into the
plantar foot surface
posterior tibial nerve
compression as it passes
through the tarsal tunnel
First-line treatment consists of activity modification,
orthotics, NSAIDs, and neuromodulators
Forefoot Pain pain between the metatarsal
heads and the sensation of
walking on a pebble
Morton neuroma, Hammertoe
deformities and Hallux or
bunion deformity
Ffootwear modification and padding. Glucocorticoid
injections may provide temporary relief. Interdigital
nerve resection is reserved for those who do not
respond to conservative measures