Жинхэнэ полицитеми

1. PolycythemiaVera

2. What is PolycythemiaVera?
PolycythemiaVera is an idiopathic chronic and
myeloproliferative disorder which has a very
slow progression. It is characterized by an
overproduction of the red blood cells from the
bone marrow.

3. Red blood cells are responsible for carrying oxygen into blood cells to all body
parts. PolycythemiaVera may also result in an overproduction of other blood
cells, platelets and white blood cells as well. Due to an overproduction of
blood cells, the blood will get thicker leading to various complications.

4. Causes of PolycythemiaVera
• PolycythemiaVera results from an overproduction of red blood cells, as well as
other blood cells from the bone marrow due to a mutation in a bone marrow cell.
• In PolycythemiaVera the body’s mechanism which normally regulates the number
of the each three blood cells does not function normally, resulting in an
overproduction of one or more of the blood cells types.
• A mutation of the gene JAK2V617F has been identified as the one causing
PolycythemiaVera. However, other mutations have been identified as well in
patients diagnosed with PolycythemiaVera, even though the role of these
mutations is not yet known.
• The real reason of the JAK2 protein mutation is not known. Researchers believe
that the mutation occurs after conception, meaning that it is not an inherited
mutation, rather an acquired one.The JAK2 gene is responsible for the production
of a protein that helps make blood cells from the bone marrow.

9. PolycythemiaVera Complications
• Splenomegaly
• Blood clots
• Skin problems
• Other blood disorders
• Other health problems due to an increased number of red blood cells, etc.

13. Diagnosis
•PolycythemiaVera is diagnosed most frequently
from a blood test examination. In a complete
blood count (CBC) an increased number of red
blood cells, elevated hematocrit measures,
elevated levels of hemoglobin and very low levels
of erythropoietin are revealed-илрүүлэх.

16. Treatment of PolycythemiaVera
• There is no cure for PolycythemiaVera. As it is a chronic condition the treatment is
only focused on reducing the amount of blood cells, which will help reduce the risk
for various complications or eliminate and relief the signs and symptoms of
PolycythemiaVera.
• Treatment of PolycythemiaVera includes:
• Phlebotomy
• It is a medical procedure which consists in taking out blood from the veins
regularly. How often a phlebotomy will be necessary, depends from the severity of
the condition.
• Phlebotomy is used to reduce the circulating volume of red blood cells so that
blood can circulate normally and function properly. Initially, 300 to 500 ml of blood
is removed every other day. Once the hematocrit is below the targeted value,
additional phlebotomies are performed as needed. In elderly patients 200 to 300
ml of blood is removed.

17. • Гидроксиуреа: Антиметаболит(Рибонуклеатид редуктаз ферменийг
дарангуйлагч)Гематокрит багассан тохиолдолд 20мг/кг/хоног
тунгаар барих эмчилгээ хйинэ.

18. • Aspirin
• It is recommended to reduce the risk of blood clots. Low doses of Aspirin
will also help relieve the burning sensation on the hands and feet.
• Antihistamines – are recommended to reduce and relieve itchiness.
• Ultraviolet light treatments – are also recommended to reduce and relieve
itchiness and other skin problems.
• Medications to decrease blood cells such as hydroxyurea are recommended
as well to suppress the ability of the bone marrow to produce red blood
cells.
• Interferon alpha is also used to stimulate the immune system to fight the
overproduction of the blood cells from the bone marrow. 3-5 сая нэгжээр 7
хоногт 3 удаа

19. Thank you for attention
Sourse of PV
• https://healthhymn.com/polycythemia-vera/
• www.mpncanada.co