ZAFA Pharmaceutical faces several challenges in Pakistan's political, economic, social, and technological environment:
Politically, price pressures and supply issues due to strikes increase costs and hurt availability. Economically, high taxes, duties, and inflation make it difficult to determine pricing and introduce new drugs. Socially, diseases are growing rapidly but poverty prevents affordable access to needed medications. Technologically, innovation is restricted by regulations and litigation while infrastructure investment is hindered by the economic climate and power outages.