This study analyzed the relationship between D-dimer levels and the progression of COVID-19 in 279 patients over 10 days. The results showed that D-dimer levels were positively correlated with disease severity and progression. D-dimer levels were higher in patients whose condition worsened initially then improved compared to those whose condition remained mild or moderate. D-dimer levels remained elevated in patients whose condition deteriorated. The study suggests that monitoring D-dimer levels can help predict COVID-19 progression and that anticoagulant treatment may benefit severe patients, especially those without pre-existing cardiovascular disease.
A cohort study evaluated the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on older COVID-19 patients. 17 patients received DMB and 26 did not. Significantly fewer DMB patients required oxygen therapy (17.6% vs 61.5%). DMB exposure was associated with reduced odds of oxygen therapy need and intensive care support. The study supports larger trials to determine if DMB can ameliorate COVID-19 severity through immunomodulation.
Evaluation of Signs and Symptoms Post Recovery in COVID Patients: A Questionn...DrHeena tiwari
This document describes a questionnaire survey of 287 individuals who recovered from COVID-19. The survey found that only 10.8% reported no ongoing symptoms, while most reported fatigue (72.8%), anxiety (38%), joint pain (31.4%), or other symptoms. Symptom severity was related to severity of initial COVID-19 infection and presence of pre-existing conditions. The study aims to evaluate ongoing signs and symptoms in post-recovery COVID patients.
Childhood and later-onset vitiligo have diversetloanphan
1. The study compared the characteristics of 126 patients with childhood-onset vitiligo (before age 12) to 107 patients with later-onset vitiligo.
2. Childhood-onset vitiligo more often involved the eyelids and lower extremities initially and was more commonly segmental. It had a higher prevalence of allergic diseases and lower prevalence of thyroid disease.
3. In childhood-onset vitiligo, longer disease duration and a family history of thyroid disease were associated with thyroid disease, whereas female sex was the only predictor for later-onset vitiligo.
Clinical characteristics in 113 turkish vitiligo patientstloanphan
This study examined 113 Turkish patients with vitiligo over a 2-year period. The key findings were:
1) Slightly more female patients than male, with ages ranging from 2-76 years. 2) Most common sites of initial lesions were upper limbs, head/neck, and trunk. 3) Majority of cases were generalized vitiligo. 4) Psychiatric comorbidities like depression and anxiety were common. 5) Some patients also had autoimmune disorders like thyroiditis or diabetes.
Stigmatisation, avoidance behaviour and difficulties in coping are common amo...tloanphan
This study explored quality of life, coping, depression, and experiences of stigmatization among 96 patients with vitiligo compared to 23 controls. Key findings include:
1) Stigmatization was common among patients, with 90% reporting questions/approaches about their skin and 24% experiencing nasty comments. 66.7% avoided social situations or concealed white spots due to vitiligo.
2) Patients scored higher than controls on all quality of life and coping questionnaires, indicating more impairment and difficulties. However, depression scores were similar.
3) Treatment with pro-pseudocatalase reduced social anxiety/avoidance, depressed mood, and depression scores.
4) Patients who
A cohort study evaluated the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on older COVID-19 patients. 17 patients received DMB and 26 did not. Significantly fewer DMB patients required oxygen therapy (17.6% vs 61.5%). DMB exposure was associated with reduced odds of oxygen therapy need and intensive care support. The study supports larger trials to determine if DMB can ameliorate COVID-19 severity through immunomodulation.
Evaluation of Signs and Symptoms Post Recovery in COVID Patients: A Questionn...DrHeena tiwari
This document describes a questionnaire survey of 287 individuals who recovered from COVID-19. The survey found that only 10.8% reported no ongoing symptoms, while most reported fatigue (72.8%), anxiety (38%), joint pain (31.4%), or other symptoms. Symptom severity was related to severity of initial COVID-19 infection and presence of pre-existing conditions. The study aims to evaluate ongoing signs and symptoms in post-recovery COVID patients.
Childhood and later-onset vitiligo have diversetloanphan
1. The study compared the characteristics of 126 patients with childhood-onset vitiligo (before age 12) to 107 patients with later-onset vitiligo.
2. Childhood-onset vitiligo more often involved the eyelids and lower extremities initially and was more commonly segmental. It had a higher prevalence of allergic diseases and lower prevalence of thyroid disease.
3. In childhood-onset vitiligo, longer disease duration and a family history of thyroid disease were associated with thyroid disease, whereas female sex was the only predictor for later-onset vitiligo.
Clinical characteristics in 113 turkish vitiligo patientstloanphan
This study examined 113 Turkish patients with vitiligo over a 2-year period. The key findings were:
1) Slightly more female patients than male, with ages ranging from 2-76 years. 2) Most common sites of initial lesions were upper limbs, head/neck, and trunk. 3) Majority of cases were generalized vitiligo. 4) Psychiatric comorbidities like depression and anxiety were common. 5) Some patients also had autoimmune disorders like thyroiditis or diabetes.
Stigmatisation, avoidance behaviour and difficulties in coping are common amo...tloanphan
This study explored quality of life, coping, depression, and experiences of stigmatization among 96 patients with vitiligo compared to 23 controls. Key findings include:
1) Stigmatization was common among patients, with 90% reporting questions/approaches about their skin and 24% experiencing nasty comments. 66.7% avoided social situations or concealed white spots due to vitiligo.
2) Patients scored higher than controls on all quality of life and coping questionnaires, indicating more impairment and difficulties. However, depression scores were similar.
3) Treatment with pro-pseudocatalase reduced social anxiety/avoidance, depressed mood, and depression scores.
4) Patients who
Oral Health & Its Effect on COVID 19: Systematic Review & Meta Analysis.DrHeena tiwari
This document summarizes a systematic review and meta-analysis on the relationship between oral health and COVID-19. The review included 13 studies. Key findings included:
1) Infection control measures like telephone screening, social distancing and PPE were discussed across many studies as important for dental practices during the pandemic.
2) Pre-procedural mouthwashes and use of rubber dams and high-volume evacuation were recommended to reduce aerosol transmission during dental procedures.
3) Guidelines varied on types of masks to use, but N95 or equivalent masks were suggested for aerosol-generating procedures by many studies.
4) Psychological impacts of COVID-19 on dental workers and appropriate waste
CLINICAL FEATURES, DIFFERENCES IN COVID FIRST, SECOND, THIRD WAVES- A DATA BA...DrHeena tiwari
This study compared the clinical features of COVID-19 in children and youth across the first three waves in multiple countries. A total of 397 patients aged 18 or younger were included. More patients were asymptomatic in the second and third waves compared to the first wave. Most illnesses were mild in all waves. A few patients presented with unusual manifestations like chilblains or multisystem inflammatory syndrome. The study found differences in symptoms and hospital length of stay across the three waves.
Factors associated with development of vitiligo in patients with halo nevustloanphan
This study aimed to identify factors associated with the development of vitiligo in patients with halo nevus (HN). The researchers performed a retrospective study of 212 patients with HN, 101 of whom also had vitiligo (HNV group). Univariate analysis found that a personal history of thyroid disease and younger age of HN onset were associated with vitiligo. Multivariate analysis identified the Koebner phenomenon (skin depigmentation in areas of friction or trauma), multiple HN lesions, and a familial history of vitiligo as independent risk factors for vitiligo in HN patients. The study suggests HN patients with these risk factors should be monitored more closely for signs of vitiligo.
Vitiligo clinical findings in 1436 patientstloanphan
This study analyzed clinical findings from 1436 patients with vitiligo seen between 1989-1993. The key findings were:
1) Vitiligo vulgaris was the most common type (69.8% of patients), followed by focal (14.9%) and segmental (5.0%) vitiligo.
2) The most common sites of onset were the face (22.9%), trunk (22.3%), and legs (18.6%). Less than 20% body area was involved in 94.4% of patients.
3) Associated conditions included atopic/nummular eczema (1.4%), bronchial asthma (0.7%), diabetes (0.
This document summarizes the challenges encountered during a West Nile virus outbreak at a hospital in 2012. It found 55 cases of West Nile infection, including 12 cases of West Nile fever and 43 cases of West Nile neuroinvasive disease. Many patients presented without a documented fever, which challenged the application of diagnostic criteria. Neurological symptoms like altered mental status, headache and seizures were common in neuroinvasive disease cases. The outbreak resulted in a high mortality rate of 21% among neuroinvasive disease patients. Diagnosing and classifying West Nile virus infections proved difficult, highlighting challenges in outbreak response.
This document summarizes a study on mortality trends among type 2 diabetes patients in two hospitals in Nigeria. The study found that diabetic foot ulcer had the highest percentage of deaths at 42.8% of cases. Other leading causes of death were diabetic ketoacidosis, hypertension, and hyperglycemia. Married patients accounted for the majority of diabetes-related deaths at both hospitals. The study aimed to identify causes of premature death in diabetes patients to help reduce complications and mortality.
Background: The COVID-19 pandemic and control measures taken by countries around the worldcause stress and anxiety. The outbreak of corona virus not onlyhas a major impact on the physical health of the community, but also has a foremosteffect on thementalhealth of the public.Investigating the coping strategies to deal with this unique crisis is essential. Objective: The aim of this study was to assess the impact of covid-19 on stress and coping responses among general population. Methods: A descriptive cross-sectional study is adapted among 100 general populations. A convenient sampling technique was applied. The demographic data were collected using a structured questionnaire via interview method. The level of stress was measured by the perceived stress scale (PSS) and coping responses was evaluated by the brief cope scale. Result: The study outcomesdisplaysthat 53 (53%) had moderate stress, 28 (28%) had mild stress and 19 (19%) had severe stress during Covid-19. In respect to level of coping strategies among general population, 96% of the participants used planning coping strategy, 93% of them used religion coping strategy followed by 92% used self-distraction coping strategy. Conclusion: In our study, general population presented a moderate level of stress, in addition avoidance coping strategies was mostly used.Aiding the mental health care needs of public during these difficult times (pandemic) should be the top priority soadequate measures must be taken to promote the mental health of general public.
Assessing the effects of prognostic factors in recovery of tuberculosis patie...Alexander Decker
- The study assessed prognostic factors affecting recovery of tuberculosis patients in Ghana's Upper West Region. 400 patients were analyzed.
- Key factors found to significantly contribute to recovery were age, type of patient (pulmonary vs extra-pulmonary), duration of treatment, and HIV status.
- The median recovery time was 25.43 weeks. Older age was found to decrease the risk of relapse. Patients co-infected with HIV had a higher risk of treatment failure.
A STUDY ON PREVALENCE OF MICRO AND MACRO VASCULAR COMPLICATIONS IN TYPE 2 DI...IJSIT Editor
This study examined the prevalence of microvascular and macrovascular complications in 1200 patients with type 2 diabetes in India. Retinopathy was found in 13.5% of patients, nephropathy in 26%, neuropathy in 31.5%, cardiovascular disease in 19.1%, and peripheral vascular disease in 9.75%. Logistic regression revealed that older age, longer diabetes duration, and hypertension were significantly associated with all complications. Poor glycemic control was associated with higher rates of nephropathy and retinopathy. The study highlights the high prevalence of complications, especially nephropathy and neuropathy, in this population.
Clinical and epidemiological characteristics of childhoodtloanphan
This study analyzed clinical and epidemiological data from 701 children with vitiligo who were seen at a dermatology clinic in Brazil between 2006-2014. The main findings were:
1) Most patients were female (62%) and the average age of onset was 5.9 years. The most common subtype was generalized vitiligo (53.8%).
2) The most affected initial site was the head/neck region (44.2%). Emotional stressors were reported as triggering factors in 67% of patients.
3) Segmental and nonsegmental vitiligo differed significantly in characteristics like age of onset, presence of the Koebner phenomenon, associations with autoimmune diseases, and family
Vitiligo is a common autoimmune disease that causes loss of skin pigmentation. It has a significant psychological impact on patients' quality of life. There are different clinical presentations of vitiligo that provide clues about disease activity and prognosis. Segmental vitiligo presents as rapidly progressive patches but often stabilizes, whereas inflammatory, trichrome, and confetti-like lesions indicate more active disease. Recognizing vitiligo as treatable and initiating early treatment can help patients physically and psychologically.
Clinical and epidemiological characteristics of childhood vitiligo a study of...tloanphan
This study analyzed clinical and epidemiological data from 701 children with vitiligo who were seen at a dermatology clinic in Brazil between 2006-2014. The main findings were:
1) Vitiligo was more common in females (62% of cases) and the average age of onset was 5.9 years.
2) The most common subtype was generalized vitiligo (53.8% of cases) and the most common initial site was the head/neck region (44.2% of cases).
3) Associated autoimmune diseases, family history of vitiligo, and the Koebner phenomenon were present in 6.5%, 16.9%, and 38.2% of
This document discusses biomarkers in scleroderma and their potential uses. It defines biomarkers as measurable indicators of biological processes related to health and disease. Biomarkers could help predict disease progression and treatment response. The document reviews potential biomarkers related to skin involvement, lung fibrosis, renal disease, and pulmonary arterial hypertension in scleroderma. It highlights how biomarkers may help identify patients at high risk of organ complications who could benefit from early treatment or clinical trial enrollment.
Dexamethasone is a corticosteroid that has shown promise in improving outcomes for patients with bacterial meningitis. However, previous studies have found conflicting results on whether it benefits all patients or only certain subgroups. This study conducted a meta-analysis of individual patient data from 5 randomized controlled trials involving 2029 patients to identify which patients are most likely to benefit from dexamethasone treatment. The analysis found that dexamethasone did not significantly reduce death rates or neurological disability overall. It also did not provide significant benefits within any prespecified subgroups based on factors like causative organism, pre-treatment with antibiotics, HIV status, or age. The only benefit seen was a reduction in hearing loss among survivors.
This document summarizes a study examining causes of death among HIV-infected patients treated with antiretroviral therapy (ART) between 1996-2006. The study analyzed data from 13 cohorts including 39,272 patients. The main causes of death were AIDS-related (49.5% of deaths), non-AIDS malignancies (11.8%), non-AIDS infections (8.2%), and liver disease (7%). Rates of AIDS-related death were higher with lower CD4 count or higher viral load. Rates of several non-AIDS causes, like liver and respiratory disease, were higher in injection drug users. The proportion of AIDS-related deaths decreased with longer duration of ART, suggesting ART improves survival from
1. This study examined outcomes of 2541 hospitalized COVID-19 patients treated with hydroxychloroquine alone, hydroxychloroquine plus azithromycin, azithromycin alone, or neither drug.
2. Overall in-hospital mortality was 18.1%. Mortality was lowest in the hydroxychloroquine alone group (13.5%) and highest in the neither drug group (26.4%).
3. After controlling for risk factors, treatment with hydroxychloroquine alone or with azithromycin was associated with reduced COVID-19 mortality compared to no treatment. Prospective randomized trials are still needed.
To Assess the Severity and Mortality among Covid 19 Patients after Having Vac...YogeshIJTSRD
The severity and mortality of COVID 19 cases has been associated with the Three category such as vaccination status, severity of disease and outcome. Objective presently study was aimed to assess the severity and mortality among covid 19 patients. Methods Using simple lottery random method 100 samples were selected. From these 100 patients, 50 patients were randomly assigned to case group and 50 patients in control group after informed consents of relative obtained. Patients in the case group who being died after got COVID 19 whereas 50 patients in the control group participated who were survive after got infected from COVID 19 patients. Result It has three categories such as a Vaccination status For the vaccination status we have seen 59 patients were not vaccinated and 41 patients was vaccinated out of 100. b Incidence There were 41 patients were vaccinated whereas 59 patients were not vaccinated. c Severity In the case of mortality we selected 50 patients who were died from the Corona and I got to know that out of 50 patients there were 12 24 patients were vaccinated whereas 38 76 patients were non vaccinated. Although for the 50 control survival group total 29 58 patients were vaccinated and 21 42 patients was not vaccinated all graph start. Conclusion we have find out that those people who got vaccinated were less infected and mortality rate very low. Prof. (Dr) Binod Kumar Singh | Dr. Saroj Kumar | Ms. Anuradha Sharma "To Assess the Severity and Mortality among Covid-19 Patients after Having Vaccinated: A Retrospective Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45065.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/45065/to-assess-the-severity-and-mortality-among-covid19-patients-after-having-vaccinated-a-retrospective-study/prof-dr-binod-kumar-singh
Who 2019-n cov-corticosteroids-2020.1-engCIkumparan
This document provides recommendations from the WHO on the use of corticosteroids for the treatment of COVID-19. It recommends the use of systemic corticosteroids for patients with severe or critical COVID-19 based on moderate certainty evidence showing benefits. It conditionally recommends against the use of corticosteroids for non-severe COVID-19 based on low certainty evidence. The document was developed in collaboration with experts and reviews evidence on corticosteroid use from multiple clinical trials. It provides the background, methods, evidence and practical considerations regarding the recommendations.
Assessment of cardiovascular disease risk among qatari patients with type 2 p...Dr. Anees Alyafei
Original Research Paper on the Assessment of Cardiovascular Disease Risk on Qatari Diabetics. The behavior of two risk prediction tools categorized patients differently.
https://www.researchgate.net/publication/340895704_Assessment_of_Cardiovascular_Disease_Risk_among_Qatari_Patients_with_Type_2_Diabetes_Mellitus_Attending_Primary_Health_Care_Centers_2014
Guidance isth _management_of_coagulopathy_in_covid-19 Dr. Freddy Flores Malpa...Freddy Flores Malpartida
1) This document provides interim guidance from the International Society on Thrombosis and Haemostasis (ISTH) on recognizing and managing coagulopathy in COVID-19.
2) It recommends measuring D-dimers, prothrombin time, and platelet count in all COVID-19 patients to help stratify risk, with increased D-dimers indicating a higher risk of severe illness.
3) For hospitalized COVID-19 patients, the guidance suggests regular monitoring of D-dimers, prothrombin time, platelet count, and fibrinogen to identify worsening coagulopathy, which correlates with poorer outcomes. More aggressive care may be warranted for patients with worsening markers.
article 4.pdf about CAP pneumonia communitysakirhrkrj
This document analyzes factors influencing the development of deep venous thrombosis (DVT) in elderly patients with community-acquired pneumonia (CAP). The study examined 505 elderly CAP patients, of which 133 were diagnosed with DVT. Severe pneumonia and septic shock were associated with higher rates of DVT. Central venous catheterization, higher D-dimer levels, and higher Padua scores (indicating higher risk of thrombosis) were significantly correlated with the development of DVT. Logistic regression identified central venous catheterization, D-dimer level, and Padua score as significant risk factors for DVT in elderly CAP patients.
Oral Health & Its Effect on COVID 19: Systematic Review & Meta Analysis.DrHeena tiwari
This document summarizes a systematic review and meta-analysis on the relationship between oral health and COVID-19. The review included 13 studies. Key findings included:
1) Infection control measures like telephone screening, social distancing and PPE were discussed across many studies as important for dental practices during the pandemic.
2) Pre-procedural mouthwashes and use of rubber dams and high-volume evacuation were recommended to reduce aerosol transmission during dental procedures.
3) Guidelines varied on types of masks to use, but N95 or equivalent masks were suggested for aerosol-generating procedures by many studies.
4) Psychological impacts of COVID-19 on dental workers and appropriate waste
CLINICAL FEATURES, DIFFERENCES IN COVID FIRST, SECOND, THIRD WAVES- A DATA BA...DrHeena tiwari
This study compared the clinical features of COVID-19 in children and youth across the first three waves in multiple countries. A total of 397 patients aged 18 or younger were included. More patients were asymptomatic in the second and third waves compared to the first wave. Most illnesses were mild in all waves. A few patients presented with unusual manifestations like chilblains or multisystem inflammatory syndrome. The study found differences in symptoms and hospital length of stay across the three waves.
Factors associated with development of vitiligo in patients with halo nevustloanphan
This study aimed to identify factors associated with the development of vitiligo in patients with halo nevus (HN). The researchers performed a retrospective study of 212 patients with HN, 101 of whom also had vitiligo (HNV group). Univariate analysis found that a personal history of thyroid disease and younger age of HN onset were associated with vitiligo. Multivariate analysis identified the Koebner phenomenon (skin depigmentation in areas of friction or trauma), multiple HN lesions, and a familial history of vitiligo as independent risk factors for vitiligo in HN patients. The study suggests HN patients with these risk factors should be monitored more closely for signs of vitiligo.
Vitiligo clinical findings in 1436 patientstloanphan
This study analyzed clinical findings from 1436 patients with vitiligo seen between 1989-1993. The key findings were:
1) Vitiligo vulgaris was the most common type (69.8% of patients), followed by focal (14.9%) and segmental (5.0%) vitiligo.
2) The most common sites of onset were the face (22.9%), trunk (22.3%), and legs (18.6%). Less than 20% body area was involved in 94.4% of patients.
3) Associated conditions included atopic/nummular eczema (1.4%), bronchial asthma (0.7%), diabetes (0.
This document summarizes the challenges encountered during a West Nile virus outbreak at a hospital in 2012. It found 55 cases of West Nile infection, including 12 cases of West Nile fever and 43 cases of West Nile neuroinvasive disease. Many patients presented without a documented fever, which challenged the application of diagnostic criteria. Neurological symptoms like altered mental status, headache and seizures were common in neuroinvasive disease cases. The outbreak resulted in a high mortality rate of 21% among neuroinvasive disease patients. Diagnosing and classifying West Nile virus infections proved difficult, highlighting challenges in outbreak response.
This document summarizes a study on mortality trends among type 2 diabetes patients in two hospitals in Nigeria. The study found that diabetic foot ulcer had the highest percentage of deaths at 42.8% of cases. Other leading causes of death were diabetic ketoacidosis, hypertension, and hyperglycemia. Married patients accounted for the majority of diabetes-related deaths at both hospitals. The study aimed to identify causes of premature death in diabetes patients to help reduce complications and mortality.
Background: The COVID-19 pandemic and control measures taken by countries around the worldcause stress and anxiety. The outbreak of corona virus not onlyhas a major impact on the physical health of the community, but also has a foremosteffect on thementalhealth of the public.Investigating the coping strategies to deal with this unique crisis is essential. Objective: The aim of this study was to assess the impact of covid-19 on stress and coping responses among general population. Methods: A descriptive cross-sectional study is adapted among 100 general populations. A convenient sampling technique was applied. The demographic data were collected using a structured questionnaire via interview method. The level of stress was measured by the perceived stress scale (PSS) and coping responses was evaluated by the brief cope scale. Result: The study outcomesdisplaysthat 53 (53%) had moderate stress, 28 (28%) had mild stress and 19 (19%) had severe stress during Covid-19. In respect to level of coping strategies among general population, 96% of the participants used planning coping strategy, 93% of them used religion coping strategy followed by 92% used self-distraction coping strategy. Conclusion: In our study, general population presented a moderate level of stress, in addition avoidance coping strategies was mostly used.Aiding the mental health care needs of public during these difficult times (pandemic) should be the top priority soadequate measures must be taken to promote the mental health of general public.
Assessing the effects of prognostic factors in recovery of tuberculosis patie...Alexander Decker
- The study assessed prognostic factors affecting recovery of tuberculosis patients in Ghana's Upper West Region. 400 patients were analyzed.
- Key factors found to significantly contribute to recovery were age, type of patient (pulmonary vs extra-pulmonary), duration of treatment, and HIV status.
- The median recovery time was 25.43 weeks. Older age was found to decrease the risk of relapse. Patients co-infected with HIV had a higher risk of treatment failure.
A STUDY ON PREVALENCE OF MICRO AND MACRO VASCULAR COMPLICATIONS IN TYPE 2 DI...IJSIT Editor
This study examined the prevalence of microvascular and macrovascular complications in 1200 patients with type 2 diabetes in India. Retinopathy was found in 13.5% of patients, nephropathy in 26%, neuropathy in 31.5%, cardiovascular disease in 19.1%, and peripheral vascular disease in 9.75%. Logistic regression revealed that older age, longer diabetes duration, and hypertension were significantly associated with all complications. Poor glycemic control was associated with higher rates of nephropathy and retinopathy. The study highlights the high prevalence of complications, especially nephropathy and neuropathy, in this population.
Clinical and epidemiological characteristics of childhoodtloanphan
This study analyzed clinical and epidemiological data from 701 children with vitiligo who were seen at a dermatology clinic in Brazil between 2006-2014. The main findings were:
1) Most patients were female (62%) and the average age of onset was 5.9 years. The most common subtype was generalized vitiligo (53.8%).
2) The most affected initial site was the head/neck region (44.2%). Emotional stressors were reported as triggering factors in 67% of patients.
3) Segmental and nonsegmental vitiligo differed significantly in characteristics like age of onset, presence of the Koebner phenomenon, associations with autoimmune diseases, and family
Vitiligo is a common autoimmune disease that causes loss of skin pigmentation. It has a significant psychological impact on patients' quality of life. There are different clinical presentations of vitiligo that provide clues about disease activity and prognosis. Segmental vitiligo presents as rapidly progressive patches but often stabilizes, whereas inflammatory, trichrome, and confetti-like lesions indicate more active disease. Recognizing vitiligo as treatable and initiating early treatment can help patients physically and psychologically.
Clinical and epidemiological characteristics of childhood vitiligo a study of...tloanphan
This study analyzed clinical and epidemiological data from 701 children with vitiligo who were seen at a dermatology clinic in Brazil between 2006-2014. The main findings were:
1) Vitiligo was more common in females (62% of cases) and the average age of onset was 5.9 years.
2) The most common subtype was generalized vitiligo (53.8% of cases) and the most common initial site was the head/neck region (44.2% of cases).
3) Associated autoimmune diseases, family history of vitiligo, and the Koebner phenomenon were present in 6.5%, 16.9%, and 38.2% of
This document discusses biomarkers in scleroderma and their potential uses. It defines biomarkers as measurable indicators of biological processes related to health and disease. Biomarkers could help predict disease progression and treatment response. The document reviews potential biomarkers related to skin involvement, lung fibrosis, renal disease, and pulmonary arterial hypertension in scleroderma. It highlights how biomarkers may help identify patients at high risk of organ complications who could benefit from early treatment or clinical trial enrollment.
Dexamethasone is a corticosteroid that has shown promise in improving outcomes for patients with bacterial meningitis. However, previous studies have found conflicting results on whether it benefits all patients or only certain subgroups. This study conducted a meta-analysis of individual patient data from 5 randomized controlled trials involving 2029 patients to identify which patients are most likely to benefit from dexamethasone treatment. The analysis found that dexamethasone did not significantly reduce death rates or neurological disability overall. It also did not provide significant benefits within any prespecified subgroups based on factors like causative organism, pre-treatment with antibiotics, HIV status, or age. The only benefit seen was a reduction in hearing loss among survivors.
This document summarizes a study examining causes of death among HIV-infected patients treated with antiretroviral therapy (ART) between 1996-2006. The study analyzed data from 13 cohorts including 39,272 patients. The main causes of death were AIDS-related (49.5% of deaths), non-AIDS malignancies (11.8%), non-AIDS infections (8.2%), and liver disease (7%). Rates of AIDS-related death were higher with lower CD4 count or higher viral load. Rates of several non-AIDS causes, like liver and respiratory disease, were higher in injection drug users. The proportion of AIDS-related deaths decreased with longer duration of ART, suggesting ART improves survival from
1. This study examined outcomes of 2541 hospitalized COVID-19 patients treated with hydroxychloroquine alone, hydroxychloroquine plus azithromycin, azithromycin alone, or neither drug.
2. Overall in-hospital mortality was 18.1%. Mortality was lowest in the hydroxychloroquine alone group (13.5%) and highest in the neither drug group (26.4%).
3. After controlling for risk factors, treatment with hydroxychloroquine alone or with azithromycin was associated with reduced COVID-19 mortality compared to no treatment. Prospective randomized trials are still needed.
To Assess the Severity and Mortality among Covid 19 Patients after Having Vac...YogeshIJTSRD
The severity and mortality of COVID 19 cases has been associated with the Three category such as vaccination status, severity of disease and outcome. Objective presently study was aimed to assess the severity and mortality among covid 19 patients. Methods Using simple lottery random method 100 samples were selected. From these 100 patients, 50 patients were randomly assigned to case group and 50 patients in control group after informed consents of relative obtained. Patients in the case group who being died after got COVID 19 whereas 50 patients in the control group participated who were survive after got infected from COVID 19 patients. Result It has three categories such as a Vaccination status For the vaccination status we have seen 59 patients were not vaccinated and 41 patients was vaccinated out of 100. b Incidence There were 41 patients were vaccinated whereas 59 patients were not vaccinated. c Severity In the case of mortality we selected 50 patients who were died from the Corona and I got to know that out of 50 patients there were 12 24 patients were vaccinated whereas 38 76 patients were non vaccinated. Although for the 50 control survival group total 29 58 patients were vaccinated and 21 42 patients was not vaccinated all graph start. Conclusion we have find out that those people who got vaccinated were less infected and mortality rate very low. Prof. (Dr) Binod Kumar Singh | Dr. Saroj Kumar | Ms. Anuradha Sharma "To Assess the Severity and Mortality among Covid-19 Patients after Having Vaccinated: A Retrospective Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45065.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/45065/to-assess-the-severity-and-mortality-among-covid19-patients-after-having-vaccinated-a-retrospective-study/prof-dr-binod-kumar-singh
Who 2019-n cov-corticosteroids-2020.1-engCIkumparan
This document provides recommendations from the WHO on the use of corticosteroids for the treatment of COVID-19. It recommends the use of systemic corticosteroids for patients with severe or critical COVID-19 based on moderate certainty evidence showing benefits. It conditionally recommends against the use of corticosteroids for non-severe COVID-19 based on low certainty evidence. The document was developed in collaboration with experts and reviews evidence on corticosteroid use from multiple clinical trials. It provides the background, methods, evidence and practical considerations regarding the recommendations.
Assessment of cardiovascular disease risk among qatari patients with type 2 p...Dr. Anees Alyafei
Original Research Paper on the Assessment of Cardiovascular Disease Risk on Qatari Diabetics. The behavior of two risk prediction tools categorized patients differently.
https://www.researchgate.net/publication/340895704_Assessment_of_Cardiovascular_Disease_Risk_among_Qatari_Patients_with_Type_2_Diabetes_Mellitus_Attending_Primary_Health_Care_Centers_2014
Guidance isth _management_of_coagulopathy_in_covid-19 Dr. Freddy Flores Malpa...Freddy Flores Malpartida
1) This document provides interim guidance from the International Society on Thrombosis and Haemostasis (ISTH) on recognizing and managing coagulopathy in COVID-19.
2) It recommends measuring D-dimers, prothrombin time, and platelet count in all COVID-19 patients to help stratify risk, with increased D-dimers indicating a higher risk of severe illness.
3) For hospitalized COVID-19 patients, the guidance suggests regular monitoring of D-dimers, prothrombin time, platelet count, and fibrinogen to identify worsening coagulopathy, which correlates with poorer outcomes. More aggressive care may be warranted for patients with worsening markers.
article 4.pdf about CAP pneumonia communitysakirhrkrj
This document analyzes factors influencing the development of deep venous thrombosis (DVT) in elderly patients with community-acquired pneumonia (CAP). The study examined 505 elderly CAP patients, of which 133 were diagnosed with DVT. Severe pneumonia and septic shock were associated with higher rates of DVT. Central venous catheterization, higher D-dimer levels, and higher Padua scores (indicating higher risk of thrombosis) were significantly correlated with the development of DVT. Logistic regression identified central venous catheterization, D-dimer level, and Padua score as significant risk factors for DVT in elderly CAP patients.
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Application of ordinal logistic=China.pdfHenokBuno
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Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
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Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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Thinking of getting a dog? Be aware that breeds like Pit Bulls, Rottweilers, and German Shepherds can be loyal and dangerous. Proper training and socialization are crucial to preventing aggressive behaviors. Ensure safety by understanding their needs and always supervising interactions. Stay safe, and enjoy your furry friends!
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This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
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Assessment and Planning in Educational technology.pptxKavitha Krishnan
In an education system, it is understood that assessment is only for the students, but on the other hand, the Assessment of teachers is also an important aspect of the education system that ensures teachers are providing high-quality instruction to students. The assessment process can be used to provide feedback and support for professional development, to inform decisions about teacher retention or promotion, or to evaluate teacher effectiveness for accountability purposes.
1. Accepted
Article
This article has been accepted for publication and undergone full peer review but has
not been through the copyediting, typesetting, pagination and proofreading process,
which may lead to differences between this version and the Version of Record. Please
cite this article as doi: 10.1111/bjh.16811
This article is protected by copyright. All rights reserved
MR. KUN ZHAO (Orcid ID : 0000-0002-0882-9388)
Article type : Letters
Title: Dynamic relationship between D-dimer and COVID-19 severity
Running Title: D-dimer level varies as COVID-19 progresses
Yong Li, MD PhD 1#
; Kun Zhao, PhD 1#
; Hongcheng Wei, PhD 2#
; Wensen Chen, MD 3#
; Wei
Wang, MD 4
; Ling Jia, MD 5
; Qiongfang Liu, MD 6
; Jinpeng Zhang, MD 7
; Tao Shan, MD 8
;
Zhihang Peng, MD 9
*; Yun Liu, MD 10
*; Xiaoxiang Yan, MD PhD 11
*
1 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University,
Nanjing, 210029, China
2 State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical
University, Nanjing, 210029, China
3 Department of Infection Management, The First Affiliated Hospital of Nanjing Medical
University, Nanjing, Jiangsu, 210029, China
4 Network Information Center, Wuhan No.1 Hospital, No. 215 Liji North Road, Qiaokou
District, Wuhan, 430030, China
5 Department of Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical University, 109
Longmian Aenue, Nanjing, Jiangsu 211166, China
6 Department of Infection Management, Wuhan hankou hospital, 2273 Jiefang Avenue,
Jiang'an District, Wuhan, 430010, China
7 Department of Critical Care Medicine, Huanggang Central Hospital, NO. 11 Kaopeng Road
of Huangzhou District, Huanggang City, Hubei Province, 438300, China
8 Information Department , The First Affiliated Hospital of Nanjing Medical University,
Nanjing, Jiangsu, 210029, China
9 Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical
University, Nanjing, Jiangsu, 211166, China
10 Department of Medical Informatics, School of Biomedical Engineering and Informatics,
Nanjing Medical University, Nanjing, Jiangsu, 211166, China
11 Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of
Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China
#
These authors contributed equally to this work.
2. Accepted
Article
This article is protected by copyright. All rights reserved
* To whom correspondence should be addressed:
Dr. Xiaoxiang Yan, MD PhD
Department of Cardiology, Ruijin Hospital
Shanghai Jiao Tong University School of Medicine
197 Ruijin 2nd Road, Shanghai 200025, China
Tel: 86-21-6445-7177
Fax: 86-21-6445-7177
Email: cardexyanxx@hotmail.com
Or
Dr Zhihang Peng, MD
Department of Epidemiology and Biostatistics, School of Public Health
Nanjing Medical University
No.101 Longmian Road, Nanjing, Jiangsu 211166, China
Email: zhihangpeng@njmu.edu.cn
Or
Yun Liu, MD
Department of Medical Informatics, School of Biomedical Engineering and Informatics
Nanjing Medical University
No.101 Longmian Road, Nanjing, Jiangsu 211166, China
Email: liuyun@njmu.edu.cn
KEY POINTS:
1. The dynamic changes of D-dimer level were positively correlated with the severity of COVID-
19.
2. Anticoagulant treatment may reduce the motality of COVID-19 patients, especially those without
cardiovascular diseases.
Collectively, dynamic observation of D-dimer can help to predict the progression of COVID-
19. In addition, anticoagulant treatment may be benefical for critical COVID-19 patients, even those
without cardiovascular disease.
KEY WORDS:
coagulation parameter, D-dimer, COVID-19, anticoagulant treatment
3. Accepted
Article
This article is protected by copyright. All rights reserved
Letter to the editor:
Since December 2019, the seriousness of coronavirus disease 2019 (COVID-19) pandemic has
been on escalation (Lu, et al 2020). Coagulopathy is common in critically ill patients with COVID-
19 (Tang, et al 2020b). Systemic microvascular thrombosismay occur in most deaths, which was
further identified by a recent autopsy (Luo 2020). However, less has been known about the
coagulation parameter D-dimer in the progression of COVID-19. In this study, we describe 279
COVID-19 patients recruited from three hospitals in Hubei Province, China, and then investigate
the dynamic relationship between D-dimer level and the progression of COVID-19.
According to COVID-19 Diagnosis and Treatment Scheme (Trial Version 7) (Commission
2020), all laboratory-confirmed COVID-19 patients were mild and moderate cases on admission in
our study. We further divided them into three groups according to their clinical courses: ordinary
group (disease was mild or subsided, n=136); improved group (disease worsened first and was then
improved gradually after treatment, n=23); poor group (disease deteriorated and deaths, n=120). On
admission, the epidemiological data, comorbidities, and clinical symptoms of patients were obtained
(Table 1). Then, we tested coagulation profile for ten consecutive days since admission.
As shown in Table 1, the median age of 279 enrolled patients was 55.0 (IQR 39.0–68.0),
highest in poor group, followed by improved group. Cardiovascular disease (n=77, [27.6%]),
respiratory disease (n=29, [10.4%]), and endocrine disease (n=35, [12.5%]) were the most common
comorbidities.
Infection-induced coagulopathy and secondary hyper-fibrinolysis has been identified in severe
cases of COVID-19 (Ji, et al 2020). As well, higher D-dimer level on admission was related to a
worse prognosis of COVID-19 (Zhou, et al 2020). Thus, we tracked the variations of D-dimer for
ten consecutive days. Based on random forests, Gini index at Day 1 was obviously higher than that
at the other days in three groups (Figure 1a). On admission, D-dimer level was higher in improved
and poor groups than that in ordinary group. Then, the level decreased gradually in improved group,
but remained high in poor group as the disease deteriorated (Figure 1b). The results were further
adjusted and examined by multinomial logistic regression model. As shown in Figure 1c, on
admission, compared with ordinary group, improved group and poor group demonstrated an odds
ratio (OR) of 1.42 (95%CI: 1.04, 1.96, p=0.03) and 1.35 (95%CI: 1.02, 1.80, p=0.04), respectively
(Table S1). 0.93 (0.78, 1.10)
Further, we separated the ten days into three stages: Stage 1, Day 1; Stage 2, Day 2-5; Stage 3,
Day 6-10. At Stage 1, OR of ordinary group (0.25 (95% CI: 0.16, 0.37, p<0.001)) was obviously
different from that of poor group (0.93 (95%CI: 0.78, 1.10, p=0.37)) (Figure 1d, e). From Stage 1
to Stage 2, D-dimer level increased with disease progression in poor group (1.60 (95%CI: 1.28, 2.00,
p<0.001)), but not in ordinary group (1.19 (95%CI: 0.97, 1.46, p=0.09)) (Figure 1d, e). The same
trend from Stage 2 to Stage 3 was also observed, and the OR of ordinary group and poor group
was1.25 (95%CI: 1.07, 1.47, p=0.07), and 1.71 (95%CI: 1.43, 2.05,p<0.001), respectively (Figure
1d, e). The detailed information was shown in Table S2.
4. Accepted
Article
This article is protected by copyright. All rights reserved
Pulmonary thrombosis is most responsible for the elevation of D-dimer in severe cases (Wang,
et al 2011). Altough more evidence is needed, our finding is meaningful for the establishment of
early diagnosis and dynamic intervention.
Moreover, it has been well documented that abonomal D-dimer is helpful in indicating deep
venous thrombosis in cardiovascular diseases (Giannitsis, et al 2017). Thus, we analysed the
correlation between D-dimer level with clinical prongnosis inpatients with/without cardiovasucular
disease. First, there was a difference in D-dimer levels of patients with and without cardiovascular
disease in the poor group (p=0.047) (Table S3). Then, among patients with cardiovascular disease
in the poor group, no difference was observed between non-survivors and survivors (p=0.83). Last,
among patients without cardiovascular disease in the poor group, non-survivors had higher D-dimer
levels than survivors (p=0.02).
As for the current therapeutic regimens for COVID-19, no effective antivirals and vaccines
have yet been recommended for patients with COVID-19. A previous report claimed that a D-dimer
level> 1μg/mL was associated with a lower mortality after heparin treatment (Tang, et al 2020a).
Thus, anticoagulant treatment appears to be beneficial in severe COVID-19 cases. Given that non-
survivors had higher D-dimer than survivors among the patients without cardiovascular diseases in
the poor group, timely and effective anticoagulant treatment may be workable.
When administrating anticoagulant treatment, enough attention should be paid to diffuse
alveolar hemorrhage (DAH), which is a life-threatening complication after warfarin use (Kiyota and
Shiota 2019). Thus, international normalized ratio (INR) should be used for early diagnosis and
rapid therapeutic intervention.
Overall, the dynamicly changes of D-dimer level is positively correlated with the prognosis of
COVID-19. Anticoagulant treatment may benefit severe COVID-19 patients, especially those
without cardiovascular diseases.
ACKNOWLEDGMENTS
We thank all patients involved in the study.
AUTHOR CONTRIBUTIONS
Drs Yong Li, Kun Zhao, Hongcheng Wei, Wensen Chen, Zhihang Peng, Yun Liu and Xiaoxiang
Yan had full access to all of the data in the study and take responsibility for the integrity of the data
and the accuracy of the data analysis.
Concept and design: Drs Yong Li, Zhihang Peng, Yun Liu and Xiaoxiang Yan. Acquisition,
analysis, or interpretation of data: All authors. Drafting of the manuscript: Drs Yong Li, Zhihang
Peng, Yun Liu and Xiaoxiang Yan. Critical revision of the manuscript for important intellectual
content: All authors. Statistical analysis: Drs Yong Li, Kun Zhao, Hongcheng Wei, Wensen Chen,
Zhihang Peng, Yun Liu and Xiaoxiang Yan. Supervision: Drs Yong Li and Xiaoxiang Yan.
5. Accepted
Article
This article is protected by copyright. All rights reserved
CONFLICTS OF INTEREST
The authors declare that they have no conflicts of interest.
FUNDING:
This work was supported by grants from the National key Research & Development plan of
the Ministry of Science and Technology of the People’s Republic of China (Grant no.
2018YFC1314900, 2018YFC1314901).
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Virus Pneumonia Diagnosis and Treatment Plan (Trial Version 7).
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Peacock, W.F., Plebani, M., Thygesen, K., Mockel, M., Mueller, C. & Lindahl,
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common risk factor for COVID-19 susceptibility. Physiol Rev.
Kiyota, T. & Shiota, S. (2019) Diffuse Alveolar Hemorrhage Caused by Warfarin after
Rifampicin Discontinuation. 2019, 4917856.
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in Wuhan, China: The mystery and the miracle. 92, 401-402.
Luo, W.Y., H.; Gou, J.; Li, X.; Sun, Y.; Li, J.; Liu, L (2020) Clinical Pathology of
Critical Patient with Novel Coronavirus Pneumonia (COVID-19). Preprints,
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6. Accepted
Article
This article is protected by copyright. All rights reserved
Figure 1: Association between D-dimer and COVID-19 Progression
Figure 1a: Feature importance based on random forest (left, ordinary group and improved group;
right, ordinary group and poor group).
Figure 1b: Variations of D-dimer for ten consecutive days from disease onset.
Figure 1c: Odds ratio of prognosis associated with 1 μg/mL increment in D-dimer level on
admission.
Figure 1d: Variations of D-dimer from Stage 1 to Stage 3.
Figure 1e: Odds ratio of prognosis associated with 1 μg/mL increment in D-dimer level at Stage 1,
from Stage 1 to Stage 2 (Δd1) and from Stage 2 to Stage 3 (Δd2), respectively.