This document discusses communicating evidence reviews through graphical summaries. It describes two graphics created by the author: Pharma Transport Town and GOfER (Graphical Overview for Evidence Reviews). Future plans are outlined to create policy, health professional, and general public versions of these graphics to help disseminate findings from evidence reviews. An example evidence review on donepezil trials for Alzheimer's disease is provided as a demonstration.
The document summarizes retail market conditions in Dublin, California for the 4th quarter of 2010. It finds that the retail vacancy rate dropped significantly from over 19% to just over 14% this quarter due to several large leasing deals. Total retail space absorption over the past year exceeded 131,000 square feet. Construction has begun on a new 370,000 square foot retail center anchored by Target, and the new West Dublin BART station is on track to open in February 2011. The report concludes that continued leasing momentum is expected through the first half of 2011.
This document summarizes retail market conditions in Dublin, California for the third quarter of 2010. It reports that vacancy rates decreased for grocery-anchored centers and power/lifestyle centers but remained high for free-standing retail and strip centers. Several large vacancies were filled, including spaces being taken by Grocery Outlet, Joanne's, and Sprouts Farmers Market. Absorption of available space increased over the previous quarter. The author expects continued improvement but slower growth heading into the holidays and until the completion of the West Dublin BART station in 2011.
The document summarizes the long service of four employees at the Debenhams department store in Bolton town centre, UK. Margaret Sharrocks, Linda Carey and Debra Moyle have worked there since it opened 24 years ago. Linda Carey estimates she has sold over 70,000 pairs of men's socks during her career. Margaret Moon says she has sold over 135,000 tea cups and mugs during her time there. The store manager praised the passion and expertise of the long-serving staff.
Vritti i-Media is expanding its audio outdoor advertising services across Maharashtra, Karnataka, and Punjab. It currently operates audio advertising at public bus stations in rural Maharashtra and will soon roll out services in Punjab and Northeast Karnataka through partnerships with local transportation authorities. The summary lists the key USPs and effectiveness of Vritti i-Media's audio advertising medium, and provides tables of specific locations where the service is currently available in each state.
The document presents information on using information graphics to explain the effects of climate change on health compared to textual presentation. It investigates using graphics to visualize how climate change can increase air pollution and flooding, and the related health impacts. Examples of graphics are provided on topics like air quality and disease, and floods and storms. The graphics show causes, trends, and how vulnerability may increase in the future.
This document summarizes a dissertation investigating the interaction between donepezil and rosiglitazone on cognition and neurochemistry in young and middle-aged rats. Donepezil is an acetylcholinesterase inhibitor used to treat Alzheimer's disease, while rosiglitazone is a PPARγ agonist with cognitive enhancing effects. Rats underwent object recognition testing after treatment with donepezil, rosiglitazone, or their combination. Molecular analyses included ELISAs of insulin, corticosterone, adiponectin, and ACh levels, as well as RT-PCR of genes related to cognition. Results found the drug combination did not enhance memory as expected, suggesting they may inhibit each other's
The document reports results from assays testing compounds 15a, 15b, tacrine, 6-chlorotacrine, and donepezil against human BChE, human AChE, and bovine AChE. It provides IC50 values in nM for each compound and enzyme combination. It also reports reduction of fluorescence percentages from a thioflavin T competition assay for tacrine, 6-chlorotacrine, donepezil, 15a, and 15b. Structures are provided for compounds 15a and 15b, which are donepezil-tacrine hybrids.
The document summarizes retail market conditions in Dublin, California for the 4th quarter of 2010. It finds that the retail vacancy rate dropped significantly from over 19% to just over 14% this quarter due to several large leasing deals. Total retail space absorption over the past year exceeded 131,000 square feet. Construction has begun on a new 370,000 square foot retail center anchored by Target, and the new West Dublin BART station is on track to open in February 2011. The report concludes that continued leasing momentum is expected through the first half of 2011.
This document summarizes retail market conditions in Dublin, California for the third quarter of 2010. It reports that vacancy rates decreased for grocery-anchored centers and power/lifestyle centers but remained high for free-standing retail and strip centers. Several large vacancies were filled, including spaces being taken by Grocery Outlet, Joanne's, and Sprouts Farmers Market. Absorption of available space increased over the previous quarter. The author expects continued improvement but slower growth heading into the holidays and until the completion of the West Dublin BART station in 2011.
The document summarizes the long service of four employees at the Debenhams department store in Bolton town centre, UK. Margaret Sharrocks, Linda Carey and Debra Moyle have worked there since it opened 24 years ago. Linda Carey estimates she has sold over 70,000 pairs of men's socks during her career. Margaret Moon says she has sold over 135,000 tea cups and mugs during her time there. The store manager praised the passion and expertise of the long-serving staff.
Vritti i-Media is expanding its audio outdoor advertising services across Maharashtra, Karnataka, and Punjab. It currently operates audio advertising at public bus stations in rural Maharashtra and will soon roll out services in Punjab and Northeast Karnataka through partnerships with local transportation authorities. The summary lists the key USPs and effectiveness of Vritti i-Media's audio advertising medium, and provides tables of specific locations where the service is currently available in each state.
The document presents information on using information graphics to explain the effects of climate change on health compared to textual presentation. It investigates using graphics to visualize how climate change can increase air pollution and flooding, and the related health impacts. Examples of graphics are provided on topics like air quality and disease, and floods and storms. The graphics show causes, trends, and how vulnerability may increase in the future.
This document summarizes a dissertation investigating the interaction between donepezil and rosiglitazone on cognition and neurochemistry in young and middle-aged rats. Donepezil is an acetylcholinesterase inhibitor used to treat Alzheimer's disease, while rosiglitazone is a PPARγ agonist with cognitive enhancing effects. Rats underwent object recognition testing after treatment with donepezil, rosiglitazone, or their combination. Molecular analyses included ELISAs of insulin, corticosterone, adiponectin, and ACh levels, as well as RT-PCR of genes related to cognition. Results found the drug combination did not enhance memory as expected, suggesting they may inhibit each other's
The document reports results from assays testing compounds 15a, 15b, tacrine, 6-chlorotacrine, and donepezil against human BChE, human AChE, and bovine AChE. It provides IC50 values in nM for each compound and enzyme combination. It also reports reduction of fluorescence percentages from a thioflavin T competition assay for tacrine, 6-chlorotacrine, donepezil, 15a, and 15b. Structures are provided for compounds 15a and 15b, which are donepezil-tacrine hybrids.
This document summarizes a study that tested the effectiveness of ZT-1, a precursor of the alkaloid huperzine A, and donepezil in reversing cognitive impairment induced by scopolamine in elderly volunteers. ZT-1 and donepezil were both able to significantly reduce impairments in attention, working memory, and episodic secondary memory caused by scopolamine administration. ZT-1 showed effects comparable to donepezil and indicated potential for further clinical research of huperzine A and related compounds in treating cognitive deficits. The study demonstrated the sensitivity of the CDR cognitive assessment system for detecting effects in the scopolamine model of cognitive impairment.
This document summarizes a study that investigated the effects of different doses of the acetylcholinesterase inhibitor donepezil on motor and cognitive outcomes in male rats after a controlled cortical impact traumatic brain injury. The study found that none of the five doses of donepezil tested improved motor or cognitive function compared to vehicle-treated controls. Furthermore, the two highest doses of donepezil significantly impaired beam balance, beam walking, and cognitive performance compared to vehicle controls. The results indicate that chronic donepezil administration is not effective and may be detrimental to recovery after moderate traumatic brain injury in rats.
Integrity está disponível para os usuários do Portal de Periódicos da Capes que integra dados biológicos, químicos e farmacêuticos de mais de 420.000 compostos com atividade biológica demonstrada, explorando seus parâmetros farmacológicos, dados de farmacocinética, estudos clínicos, alvos e genes relacionados, bem como mais de 235.000 registros de famílias de patentes, permite aprimorar atividades de descoberta e desenvolvimento de fármacos.
The document discusses the Memory Guard program and Alzheimer's disease. It describes how Alzheimer's disease affects areas of the brain responsible for memory, including the hippocampus and temporal lobes. Damage to these areas causes memory loss and inability to form new memories. The document also lists some FDA-approved medications used to treat Alzheimer's, including Donepezil, Rivastigmine, Galantamine, and Memantine. These drugs aim to boost neurotransmitters and may help with memory, speech, and behavioral issues, but their effectiveness is limited.
Fast Dissolving Oral Film Of Donepezil HCl By Swapnil Patil Swapnil Patil
The document discusses the formulation and evaluation of oral fast dissolving films of Donepezil Hydrochloride for the treatment of Alzheimer's disease. Various polymers like HPMC, Pullulan, and PVA are screened for their film forming properties. The optimized formulation will be developed using a factorial design to study the effect of polymer concentration and plasticizer on the drug release.
The document discusses various drug treatments for older adults with dementia. It describes cholinesterase inhibitors like donepezil and rivastigmine which increase acetylcholine levels in the brain. Anti-inflammatory agents like NSAIDs and antioxidants like vitamin C and E are also discussed as are cholesterol lowering drugs. The document provides recommendations on antipsychotics for psychotic symptoms and notes to avoid conventional antipsychotics. It also discusses using anticonvulsants like divalproex sodium for agitation and sedative options.
This document provides a summary of updated guidance from the National Institute for Health and Care Excellence (NICE) on the recognition and referral of suspected cancers from primary care. It includes:
1) A poster with recommendations for assessing and referring children, young adults, and adults with suspected cancers across different symptoms and lesion sites.
2) Information that the poster visually summarizes the full NICE guidance in two parts, one for children/young adults and one for adults.
3) Details on organizations and individuals that supported the development and distribution of the poster.
This document discusses information graphics and data visualization. It provides examples of different types of charts, graphs, maps, and diagrams that have been used throughout history to visualize data. These include charts created by William Playfair in the late 18th century, ISOTYPE diagrams developed by Otto and Marie Neurath, and Sankey diagrams. The document also discusses different tools that can be used to create visualizations, including standard programs like Excel, specialized tools like Tableau and Raw, or developing custom visualizations using programming languages. Finally, it provides some examples of visualizations and discusses reasons for visualizing data like efficient communication or enabling comparisons.
Dr Will Stahl-Timmins gave a talk in October 2014 about visualizing medical research data and the potential links between conservation activities and health. The document outlines several potential mechanisms and outcomes of participating in environmental activities, including physical activity, social contact, sense of achievement, and being in nature. It also discusses various moderators of these mechanisms and outcomes, such as the type of environmental engagement, characteristics of the individual, and type of conservation program.
The document is an information graphic that summarizes the causes and health impacts of floods and how their frequency and severity may increase in the future due to climate change. It discusses how rising sea levels and temperatures can lead to heavier rainfall and more extreme weather events. It also outlines the populations and areas most vulnerable to flooding, and the infectious diseases, toxic contamination, and mental health impacts that may result.
Visualising Climate Change - Data Visualisation Workshop IntroWill Stahl-Timmins
A brief introduction to data visualisation principles which was presented at the Visualising Climate Change event, May 2014, Bedruthan Steps Hotel, Cornwall, UK.
1. The document outlines an introductory presentation and workshop on data visualization hosted by Dr. Will Stahl-Timmins. The workshop will cover different types of visualizations including charts, maps, diagrams, and interactive graphics.
2. The Environment Agency uses data visualization and infographics to communicate complex environmental information to engage audiences. Staff are developing in-house skills to create non-standard graphics and support incident response.
3. The Climate Change and Resource Efficiency team works to help England and Wales meet emissions targets and adapt to climate change impacts through projects like the Catchment Visualization Tool and providing information on issues like sea level rise, habitat impacts
The document discusses the impacts of flooding on human health in the context of climate change. It notes that climate change is increasing global temperatures and sea levels, resulting in more extreme rainfall, storms, and floods. Flooding causes death and injury from drowning or trauma and spreads infectious diseases. Coastal and low-lying urban areas with high population densities are most at risk. Poorer communities and vulnerable groups like children and elderly are disproportionately affected. Future increases in global temperature are projected to significantly worsen flooding and health impacts in vulnerable regions like Bangladesh and coastal cities.
This document investigates the use of information graphics to explain the effects of climate change on health compared to textual presentation. It examines floods and storms as low-probability, high-impact events that can overwhelm infrastructure and communities. Major flood disasters in recent decades have affected hundreds of millions of people globally. Floods have various health impacts, including deaths, injuries, and increased infectious diseases. Vulnerable groups are most at risk. Future vulnerability may increase with continued climate change.
This document discusses communicating climate change through science, risk attitudes, and behavior. It covers:
1) Presenting climate change science and impacts clearly to engage the public, either through facts or values.
2) Knowledge of climate science does not necessarily drive views, which are influenced more by demographics, political ideology, and prior beliefs.
3) Specific challenges include reframing uncertainty as risk, addressing psychological distance from climate impacts, and communicating about extreme weather events.
Slides from Bernd Eggen, Health Protection agency. Presented at the third meeting of the Communicating Climate Change group, European Centre for Environment and Human Health, Truro, UK
Seeing is Believing - Information Design Conference 2012Will Stahl-Timmins
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
1. The document discusses using information graphics in health technology assessment to visually present scientific evidence that informs health policy decisions.
2. The author conducted a review of 98 health technology assessment reports from 2003-2007 which found that graphics were used in every report except one, with an average of 0.20 graphics per page compared to 0.58 tables per page.
3. The author also interviewed 5 advisors from NICE who noted that graphics are particularly useful for presenting complex data with multiple outcomes, subgroups, or variables, and when there are time limitations or a need to focus or compare results.
The document discusses the presenter's PhD research journey, including their Masters degree work, current PhD work examining the visual presentation of health data, and future opportunities. It provides details on their analysis of 50 health technology assessment reports and the types of graphics used. Overall, the presentation outlines the presenter's academic and research path.
This document summarizes a study that tested the effectiveness of ZT-1, a precursor of the alkaloid huperzine A, and donepezil in reversing cognitive impairment induced by scopolamine in elderly volunteers. ZT-1 and donepezil were both able to significantly reduce impairments in attention, working memory, and episodic secondary memory caused by scopolamine administration. ZT-1 showed effects comparable to donepezil and indicated potential for further clinical research of huperzine A and related compounds in treating cognitive deficits. The study demonstrated the sensitivity of the CDR cognitive assessment system for detecting effects in the scopolamine model of cognitive impairment.
This document summarizes a study that investigated the effects of different doses of the acetylcholinesterase inhibitor donepezil on motor and cognitive outcomes in male rats after a controlled cortical impact traumatic brain injury. The study found that none of the five doses of donepezil tested improved motor or cognitive function compared to vehicle-treated controls. Furthermore, the two highest doses of donepezil significantly impaired beam balance, beam walking, and cognitive performance compared to vehicle controls. The results indicate that chronic donepezil administration is not effective and may be detrimental to recovery after moderate traumatic brain injury in rats.
Integrity está disponível para os usuários do Portal de Periódicos da Capes que integra dados biológicos, químicos e farmacêuticos de mais de 420.000 compostos com atividade biológica demonstrada, explorando seus parâmetros farmacológicos, dados de farmacocinética, estudos clínicos, alvos e genes relacionados, bem como mais de 235.000 registros de famílias de patentes, permite aprimorar atividades de descoberta e desenvolvimento de fármacos.
The document discusses the Memory Guard program and Alzheimer's disease. It describes how Alzheimer's disease affects areas of the brain responsible for memory, including the hippocampus and temporal lobes. Damage to these areas causes memory loss and inability to form new memories. The document also lists some FDA-approved medications used to treat Alzheimer's, including Donepezil, Rivastigmine, Galantamine, and Memantine. These drugs aim to boost neurotransmitters and may help with memory, speech, and behavioral issues, but their effectiveness is limited.
Fast Dissolving Oral Film Of Donepezil HCl By Swapnil Patil Swapnil Patil
The document discusses the formulation and evaluation of oral fast dissolving films of Donepezil Hydrochloride for the treatment of Alzheimer's disease. Various polymers like HPMC, Pullulan, and PVA are screened for their film forming properties. The optimized formulation will be developed using a factorial design to study the effect of polymer concentration and plasticizer on the drug release.
The document discusses various drug treatments for older adults with dementia. It describes cholinesterase inhibitors like donepezil and rivastigmine which increase acetylcholine levels in the brain. Anti-inflammatory agents like NSAIDs and antioxidants like vitamin C and E are also discussed as are cholesterol lowering drugs. The document provides recommendations on antipsychotics for psychotic symptoms and notes to avoid conventional antipsychotics. It also discusses using anticonvulsants like divalproex sodium for agitation and sedative options.
This document provides a summary of updated guidance from the National Institute for Health and Care Excellence (NICE) on the recognition and referral of suspected cancers from primary care. It includes:
1) A poster with recommendations for assessing and referring children, young adults, and adults with suspected cancers across different symptoms and lesion sites.
2) Information that the poster visually summarizes the full NICE guidance in two parts, one for children/young adults and one for adults.
3) Details on organizations and individuals that supported the development and distribution of the poster.
This document discusses information graphics and data visualization. It provides examples of different types of charts, graphs, maps, and diagrams that have been used throughout history to visualize data. These include charts created by William Playfair in the late 18th century, ISOTYPE diagrams developed by Otto and Marie Neurath, and Sankey diagrams. The document also discusses different tools that can be used to create visualizations, including standard programs like Excel, specialized tools like Tableau and Raw, or developing custom visualizations using programming languages. Finally, it provides some examples of visualizations and discusses reasons for visualizing data like efficient communication or enabling comparisons.
Dr Will Stahl-Timmins gave a talk in October 2014 about visualizing medical research data and the potential links between conservation activities and health. The document outlines several potential mechanisms and outcomes of participating in environmental activities, including physical activity, social contact, sense of achievement, and being in nature. It also discusses various moderators of these mechanisms and outcomes, such as the type of environmental engagement, characteristics of the individual, and type of conservation program.
The document is an information graphic that summarizes the causes and health impacts of floods and how their frequency and severity may increase in the future due to climate change. It discusses how rising sea levels and temperatures can lead to heavier rainfall and more extreme weather events. It also outlines the populations and areas most vulnerable to flooding, and the infectious diseases, toxic contamination, and mental health impacts that may result.
Visualising Climate Change - Data Visualisation Workshop IntroWill Stahl-Timmins
A brief introduction to data visualisation principles which was presented at the Visualising Climate Change event, May 2014, Bedruthan Steps Hotel, Cornwall, UK.
1. The document outlines an introductory presentation and workshop on data visualization hosted by Dr. Will Stahl-Timmins. The workshop will cover different types of visualizations including charts, maps, diagrams, and interactive graphics.
2. The Environment Agency uses data visualization and infographics to communicate complex environmental information to engage audiences. Staff are developing in-house skills to create non-standard graphics and support incident response.
3. The Climate Change and Resource Efficiency team works to help England and Wales meet emissions targets and adapt to climate change impacts through projects like the Catchment Visualization Tool and providing information on issues like sea level rise, habitat impacts
The document discusses the impacts of flooding on human health in the context of climate change. It notes that climate change is increasing global temperatures and sea levels, resulting in more extreme rainfall, storms, and floods. Flooding causes death and injury from drowning or trauma and spreads infectious diseases. Coastal and low-lying urban areas with high population densities are most at risk. Poorer communities and vulnerable groups like children and elderly are disproportionately affected. Future increases in global temperature are projected to significantly worsen flooding and health impacts in vulnerable regions like Bangladesh and coastal cities.
This document investigates the use of information graphics to explain the effects of climate change on health compared to textual presentation. It examines floods and storms as low-probability, high-impact events that can overwhelm infrastructure and communities. Major flood disasters in recent decades have affected hundreds of millions of people globally. Floods have various health impacts, including deaths, injuries, and increased infectious diseases. Vulnerable groups are most at risk. Future vulnerability may increase with continued climate change.
This document discusses communicating climate change through science, risk attitudes, and behavior. It covers:
1) Presenting climate change science and impacts clearly to engage the public, either through facts or values.
2) Knowledge of climate science does not necessarily drive views, which are influenced more by demographics, political ideology, and prior beliefs.
3) Specific challenges include reframing uncertainty as risk, addressing psychological distance from climate impacts, and communicating about extreme weather events.
Slides from Bernd Eggen, Health Protection agency. Presented at the third meeting of the Communicating Climate Change group, European Centre for Environment and Human Health, Truro, UK
Seeing is Believing - Information Design Conference 2012Will Stahl-Timmins
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
1. The document discusses using information graphics in health technology assessment to visually present scientific evidence that informs health policy decisions.
2. The author conducted a review of 98 health technology assessment reports from 2003-2007 which found that graphics were used in every report except one, with an average of 0.20 graphics per page compared to 0.58 tables per page.
3. The author also interviewed 5 advisors from NICE who noted that graphics are particularly useful for presenting complex data with multiple outcomes, subgroups, or variables, and when there are time limitations or a need to focus or compare results.
The document discusses the presenter's PhD research journey, including their Masters degree work, current PhD work examining the visual presentation of health data, and future opportunities. It provides details on their analysis of 50 health technology assessment reports and the types of graphics used. Overall, the presentation outlines the presenter's academic and research path.
17. outcome measures used
no. of design, size baseline study cog func be glo
author location centres & follow-up MMSE sex ages quality
ADCS-ADL
ADCS-CGIC
ADAS-cog
other
other
other
CIBIC
MMSE
DAD
PDS
CDR
QoL
SIB
NPI
GDS
0yr 1 2 0 10 20 30 55 75 95
Donepezil 1mg N = 42 M F
Rogers & Rand
Donepezil 3mg N = 40 M F
? N = 161 Donepezil 5mg N = 39 M F
Char
Blind
Analy
1mg
3mg
1996 F
Placebo N = 40 M 5mg
Donepezil 5mg N = 154
M F 5mg
Rogers et al. Rand
M F Char 10
Donepezil 10mg N = 157 Blind mg
1998 (A) N = 473 Analy
M F
Placebo N = 162
Donepezil 5mg N = 157
M F 5mg
Rogers et al. Rand
M F Char 10
Donepezil 10mg N = 158 mg
Blind
1998 (B) N = 468 Analy
M F
Placebo N = 153
Donepezil 5mg N = 271
M F 5mg
Burns et al. Rand
M F Char 10mg
Donepezil 10mg N = 273 Blind
1999 Analy
N = 818 M F
Placebo N = 274
Greenberg Donepezil 5mg (D)
Rand
et al. group 1 (p-D-p-p) N=30 M F Char
group 2 (p-p-D-p) N=30 M F Blind
N = 60 Analy
2000 Placebo (p)
Donepezil 5mg N = 134
Homma et al. M F Rand
Char
Blind
2000 N = 268 M F Analy
Placebo N = 129
Donepezil 10mg N = 214
Mohs et al. M F Rand
Char
ADCS-CGIC
ADCS-ADL
Blind
ADAS-cog
2001 N = 431 M F Analy
MMSE
CIBIC
Placebo N = 217
DAD
other
other
other
CDR
GDS
PDS
QoL
NPI
SIB
0yr 1 2 0 10 20 30 55 75 95 cog func be glo
18. Mean task time
(% of total task time) Error Bars: 95% CI
20%
15%
two-sample t(69) = 4.4
p < 0.001
10%
5%
0%
Report GOfER
COGS
19. task accuracy
GOfER: 74.3%
report: 46.4%
c2 (1, N = 63) = 5.12, p = 0.024
20. outcome measures used
no. of design, size baseline study cog func be glo
author location centres & follow-up MMSE sex ages quality
ADCS-ADL
ADCS-CGIC
ADAS-cog
other
other
other
CIBIC
MMSE
DAD
PDS
CDR
QoL
SIB
NPI
GDS
0yr 1 2 0 10 20 30 55 75 95
Donepezil 1mg N = 42 M F
Rogers & Rand
Donepezil 3mg N = 40 M F
? N = 161 Donepezil 5mg N = 39 M F
Char
Blind
Analy
1mg
3mg
1996 F
Placebo N = 40 M 5mg
Donepezil 5mg N = 154
M F 5mg
Rogers et al. Rand
M F Char 10
Donepezil 10mg N = 157 Blind mg
1998 (A) N = 473 Analy
M F
Placebo N = 162
Donepezil 5mg N = 157
M F 5mg
Rogers et al. Rand
M F Char 10
Donepezil 10mg N = 158 mg
Blind
1998 (B) N = 468 Analy
M F
Placebo N = 153
Donepezil 5mg N = 271
M F 5mg
Burns et al. Rand
M F Char 10mg
Donepezil 10mg N = 273 Blind
1999 Analy
N = 818 M F
Placebo N = 274
Greenberg Donepezil 5mg (D)
Rand
et al. group 1 (p-D-p-p) N=30 M F Char
group 2 (p-p-D-p) N=30 M F Blind
N = 60 Analy
2000 Placebo (p)
Donepezil 5mg N = 134
Homma et al. M F Rand
Char
Blind
2000 N = 268 M F Analy
Placebo N = 129
Donepezil 10mg N = 214
Mohs et al. M F Rand
Char
ADCS-CGIC
ADCS-ADL
Blind
ADAS-cog
2001 N = 431 M F Analy
MMSE
CIBIC
Placebo N = 217
DAD
other
other
other
CDR
GDS
PDS
QoL
NPI
SIB
0yr 1 2 0 10 20 30 55 75 95 cog func be glo
21. ECEHH - European Centre for Environment and Human Health
Graphic 1 - Pharma Transport Town
Graphic 2 - GOfER