The document appears to be a medical exam containing multiple choice questions about various medical cases and diagnoses. Question 1 describes a patient found unconscious after resuscitation from drowning and asks for the diagnosis based on symptoms of unconsciousness, dilated pupils, and convulsions. Question 2 describes a welder complaining of weakness and fever with symptoms of anemia and asks for the cause of anemia.
This document contains a series of multiple choice questions related to medicine. The questions cover topics such as diagnosing a patient found unconscious after resuscitation, identifying the cause of anemia in a patient based on lab results, determining the appropriate secondary prevention measures for cardiovascular disease, and selecting the most likely diagnosis for various patient presentations and case histories.
This document provides an outline for a presentation on the management of acute wounds. It begins with introducing acute wounds as recent injuries that have yet to progress through wound healing stages. It then covers definitions, classifications including by etiology and depth, and complications if not properly managed. The main content discusses the assessment, investigations, debridement, cleaning, closure or dressing options for acute wounds based on factors like contamination level and wound characteristics. It emphasizes thorough surgical debridement to remove dead tissue and prevent chronic wounds or infection.
This case presentation discusses a 64-year-old man with gradual swelling of his left arm and chest. He has a history of pacemaker implantation and thickening of the skin on his hands and feet. Examination found wooly hair, thickened skin on his palms and soles, and dilated cardiomyopathy. Testing showed keratoderma on skin biopsy and severe left ventricular dysfunction on echocardiogram. The provisional diagnosis is Carvajal Syndrome, a rare cardiocutaneous syndrome caused by a gene mutation leading to wooly hair, palmoplantar keratoderma, and dilated cardiomyopathy predominantly affecting the left ventricle.
This document discusses parasitic infections of the skin, soft tissue, and musculoskeletal system. It begins by outlining the learning objectives of understanding the life cycle, pathogenesis, clinical features, diagnosis, treatment and prevention of certain parasitic infections including cutaneous leishmaniasis, cutaneous filariasis, dracunculiasis, trichinellosis, and cutaneous larva migrans. It then provides detailed sections on cutaneous leishmaniasis caused by Leishmania species, describing the life cycle, clinical features, laboratory diagnosis, and treatment recommendations for Old World and New World varieties. It also includes a section on cutaneous filariasis caused by the nematodes Loa loa and Onchoc
1) The document discusses current trends in wound management, outlining the phases of wound healing and factors that affect it.
2) Key aspects of wound management covered include wound bed preparation through debridement and dressing, as well as various closure methods and the use of negative pressure wound therapy.
3) Emerging treatments like hyperbaric oxygen therapy and various wound covers including skin substitutes are also summarized.
1) A 48-year-old woman presented with widespread cutaneous necrosis on her right leg as the initial manifestation of antiphospholipid syndrome (APS).
2) Biopsy showed thrombi in dermal vessels without vasculitis. She was treated with steroids and heparin, which stopped further lesions and led to healing.
3) Widespread cutaneous necrosis is a rare initial presentation of APS but should be considered a major thrombotic event. Early diagnosis and treatment may lead to a better prognosis.
The document appears to be a medical exam containing multiple choice questions about various medical cases and diagnoses. Question 1 describes a patient found unconscious after resuscitation from drowning and asks for the diagnosis based on symptoms of unconsciousness, dilated pupils, and convulsions. Question 2 describes a welder complaining of weakness and fever with symptoms of anemia and asks for the cause of anemia.
This document contains a series of multiple choice questions related to medicine. The questions cover topics such as diagnosing a patient found unconscious after resuscitation, identifying the cause of anemia in a patient based on lab results, determining the appropriate secondary prevention measures for cardiovascular disease, and selecting the most likely diagnosis for various patient presentations and case histories.
This document provides an outline for a presentation on the management of acute wounds. It begins with introducing acute wounds as recent injuries that have yet to progress through wound healing stages. It then covers definitions, classifications including by etiology and depth, and complications if not properly managed. The main content discusses the assessment, investigations, debridement, cleaning, closure or dressing options for acute wounds based on factors like contamination level and wound characteristics. It emphasizes thorough surgical debridement to remove dead tissue and prevent chronic wounds or infection.
This case presentation discusses a 64-year-old man with gradual swelling of his left arm and chest. He has a history of pacemaker implantation and thickening of the skin on his hands and feet. Examination found wooly hair, thickened skin on his palms and soles, and dilated cardiomyopathy. Testing showed keratoderma on skin biopsy and severe left ventricular dysfunction on echocardiogram. The provisional diagnosis is Carvajal Syndrome, a rare cardiocutaneous syndrome caused by a gene mutation leading to wooly hair, palmoplantar keratoderma, and dilated cardiomyopathy predominantly affecting the left ventricle.
This document discusses parasitic infections of the skin, soft tissue, and musculoskeletal system. It begins by outlining the learning objectives of understanding the life cycle, pathogenesis, clinical features, diagnosis, treatment and prevention of certain parasitic infections including cutaneous leishmaniasis, cutaneous filariasis, dracunculiasis, trichinellosis, and cutaneous larva migrans. It then provides detailed sections on cutaneous leishmaniasis caused by Leishmania species, describing the life cycle, clinical features, laboratory diagnosis, and treatment recommendations for Old World and New World varieties. It also includes a section on cutaneous filariasis caused by the nematodes Loa loa and Onchoc
1) The document discusses current trends in wound management, outlining the phases of wound healing and factors that affect it.
2) Key aspects of wound management covered include wound bed preparation through debridement and dressing, as well as various closure methods and the use of negative pressure wound therapy.
3) Emerging treatments like hyperbaric oxygen therapy and various wound covers including skin substitutes are also summarized.
1) A 48-year-old woman presented with widespread cutaneous necrosis on her right leg as the initial manifestation of antiphospholipid syndrome (APS).
2) Biopsy showed thrombi in dermal vessels without vasculitis. She was treated with steroids and heparin, which stopped further lesions and led to healing.
3) Widespread cutaneous necrosis is a rare initial presentation of APS but should be considered a major thrombotic event. Early diagnosis and treatment may lead to a better prognosis.
This document provides an overview of wound care including wound healing processes, types of wounds, evaluation and documentation of wounds, and wound management. It discusses the stages of wound healing including hemostasis, inflammation, proliferation, and remodeling. Different types of wounds such as incisions, lacerations, abrasions, and puncture wounds are described along with factors to evaluate like location, size, exudate, signs of infection, and surrounding tissue condition. Methods of documentation including photography and standardized descriptions are covered. The management section addresses wound care plans, cleaning, debridement, exudate management using various dressing materials, and treatment of infections.
Linda Cendales Composite Tissue Graft Summary Banff 2013 Meeting in BrazilKim Solez ,
Composite tissue graft summary from 12th Banff Conference on Transplant Pathology from the meeting in Comandatuba-Bahia, Brazil on August 23rd, 2013 http://cybernephrology.ualberta.ca/banff/2013
Raynaud’s Phenomenon used to describe episodic events which represent vasoconstriction of digital arteries, precapillary arterioles and arteriovenous shunts.
This document summarizes key points from a lecture on open fracture wound care. The lecture discusses principles of timing, antibiotic coverage, debridement techniques, irrigation methods, and wound closure/coverage. Some of the main topics covered include:
- The "6 hour rule" for treatment is not supported by evidence and timing is not a major factor in preventing infection.
- Initial debridement is most important to remove all foreign material and nonviable tissue.
- Irrigation with soap or saline is effective, and antibiotics provide no proven benefit for irrigation.
- Negative pressure wound therapy reduces bacteria and edema compared to wet-to-dry dressings.
- Primary closure can be considered
case presentation on post kala azar dermal leishmaniasis (PKDL)ChristyThomas37
This document presents a case study of post-kala azar dermal leishmaniasis (PKDL) in a 13-year old female patient who was previously treated for kala azar at age 6. Examinations found papular and nodular lesions on her face and macular lesions on her body. Diagnostic tests confirmed Leishmania parasites. She was diagnosed with PKDL and treated with liposomal amphotericin B and miltefosine. PKDL is usually a sequel of visceral leishmaniasis occurring months to years after treatment, characterized by skin lesions, and requires treatment to prevent further spread.
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by the bacterium Mycobacterium leprae. It primarily affects the skin and peripheral nerves. Leprosy has been recognized throughout history in many ancient civilizations. It is transmitted via droplets from the nose and mouth during close contact with untreated cases. While not highly infectious, untreated leprosy can cause permanent damage to skin, nerves, limbs, and eyes. Diagnosis is based on clinical signs and symptoms, and confirmation is through skin smears or biopsy. Treatment involves multidrug therapy with dapsone, rifampicin, and clofazimine.
Blood culture role in sepsis and it's managementDr Nisha Singh
This document discusses blood culture as the gold standard for sepsis diagnosis. It begins with definitions of sepsis, sepsis diagnosis, and sepsis burden. It then discusses sources of sepsis and outlines the sepsis six protocol. The document emphasizes that blood culture identifies the organism and enables antibiotic sensitivity testing to guide therapy. It also discusses newer rapid diagnostic methods but notes blood culture remains the gold standard.
This document presents 3 dermatology cases seen by Dr. Maha Assem Fahmy. Case 1 involves a 4-year-old male child with perianal lesions diagnosed as Langerhans cell histiocytosis through biopsy. Case 2 is a 42-year-old man with a skin-colored nodule on his cheek diagnosed as diffuse large B-cell lymphoma. Case 3 describes a 30-year-old woman with nodules on her face and eyebrows diagnosed as tumid lupus erythematosus through serological tests and direct immunofluorescence. Each case discusses treatment and provides literature to support diagnoses and management approaches.
This document discusses skin aging and wound care. It describes normal skin changes with aging like decreased thickness and moisture that impact wound healing. Risk factors for skin damage are reviewed like immobility and moisture. A wound staging system from I-IV is presented. The 7 principles of wound care are identified like keeping wounds clean and moist. Different wound care products are described like dressings, creams, and support surfaces. A case study is presented on a patient with diabetic foot ulcers and sacral wound, and their treatment plan is outlined.
This document discusses skin aging and wound care. It describes changes in aging skin that impact wound healing. Risk factors for skin damage and pressure ulcers are identified. A wound staging system is presented. The 7 basic principles of wound care are outlined, including accurately measuring wounds, preventing further tissue damage with saline, and supporting nutrition. A case study of a patient with wounds is provided along with treatment recommendations. Different wound care products and their uses are reviewed.
This case report describes a 15-year-old boy who presented with axillary swelling and fever after being scratched by a cat six weeks prior. Examination found swelling and tenderness in his left axilla and at the scratch site. Tests showed elevated white blood cell count and erythrocyte sedimentation rate. Fine needle aspiration of the lymph node showed granulomatous inflammation resembling tuberculosis. He was diagnosed with cat scratch disease and prescribed antibiotics, with complete resolution of symptoms after two months. Cat scratch disease is caused by Bartonella bacteria transmitted via cat scratches or bites, and typically presents as regional lymphadenopathy that resolves spontaneously within months.
This document discusses several mnemonics for dermatological conditions and diseases. It provides 3-sentence summaries for each mnemonic that include:
1) The mnemonic letters and their meaning as it relates to key aspects of the condition.
2) A brief 1-2 sentence description of the condition.
3) Information about the person/people associated with discovering or describing the condition.
This document summarizes the objectives and content of a winter school on tropical diseases taught by Dr. Alexandre Naime Barbosa at Botucatu School of Medicine in Brazil. The objectives are education of health students and professionals, community outreach to share scientific concepts, and scientific discussion. The course covers arboviruses including yellow fever, dengue, chikungunya, Zika and their transmission, symptoms, diagnosis and prevention. It provides an overview of each disease and the current epidemiological situation in Brazil.
This document provides information about severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP). It defines each condition, discusses their epidemiology, etiology, clinical features, investigations, treatment and prognosis. SJS/TEN is characterized by blistering and sloughing of the skin and mucous membranes. DRESS presents with rash and systemic involvement of organs. AGEP features non-follicular sterile pustules localized to flexural areas. Management involves identifying and stopping the culprit drug,
This document summarizes the objectives and content of a winter school on tropical diseases taught by Dr. Alexandre Naime Barbosa at Botucatu School of Medicine in Brazil. The objectives are education of health students and professionals, community outreach to share scientific concepts, and scientific discussion. The course covers arboviruses including yellow fever, dengue, chikungunya, Zika, their transmission cycles, symptoms, pathogenesis, diagnosis and prevention methods. It provides an overview of each disease and the current epidemics in Brazil.
This document provides an overview of oropharyngeal candidiasis including its etiology, epidemiology, clinical manifestations, diagnosis, and treatment. Key points include: Candida albicans is the most common cause, infecting 45-65% of children and 52% of adults. Risk factors include diabetes, immunosuppression, antibiotics, and xerostomia. Clinical presentations include pseudomembranous, erythematous, and hyperplastic lesions. Diagnosis involves microscopy, culture, and histology. Treatment involves topical or systemic antifungals like nystatin, fluconazole, or echinocandins depending on severity. Prevention emphasizes managing predisposing factors and good oral
2015: Wounds in the Geriatric Population-SalasSDGWEP
This document discusses wound care in the geriatric population. It outlines risk factors for wounds in older adults and describes assessing and managing different wound types like pressure ulcers, venous stasis ulcers, and diabetic foot ulcers. Standard wound treatments involve addressing underlying causes, cleaning the wound bed, and dressing changes. If wounds do not improve with standard care after 4 weeks, advanced therapies may be considered, such as skin substitutes, growth factors, and negative pressure wound therapy to aid healing. The goal is to diagnose and correct risk factors while managing the wound to assess progress and determine if specialized treatments could help non-healing or chronic wounds.
This document discusses different types of acute and chronic wounds, as well as the normal process of wound healing. It describes primary intention healing, secondary intention healing, and tertiary intention healing. Signs and symptoms of wound infection are listed. Recommendations are provided for wound care and management, including maintaining sterility during dressing changes, using sterile water if the wound is infected with MRSA, ensuring proper wound swabbing for culture and sensitivity testing, practicing hand hygiene, and observing wound progression. References on wound dressing, management of surgical wounds, and prevention of hospital-acquired infections are also included.
MICROBIAL AND PARASITIC INFECTIONS OF THE EYE.pptxBARNABASMUGABI
This document discusses various microbial and parasitic infections that can affect the eye. It covers lid infections like styes, hordeolums, and chalazions caused by staphylococcal or meibomian gland infections. It also discusses blepharitis, demodex, and parasitic infections like phthiriasis palpebrum. Orbital cellulitis and its complications are described. Infections of the lacrimal system like dacryocystitis and dacryoadenitis are covered. The document concludes with details on various types of conjunctivitis including bacterial, viral like adenovirus, and parasitic forms such as trachoma.
RADIOTHERAPY describes the various indicationsBARNABASMUGABI
Radiotherapy is the use of ionizing radiation to treat cancer and tumors. It can be classified as electromagnetic radiation like x-rays and gamma rays, or particulate radiation like protons, neutrons, and electrons. Radiotherapy is commonly used to treat retinoblastoma, uveal melanoma, and conjunctival tumors. For retinoblastoma, chemotherapy is the main treatment but radiotherapy techniques like plaque brachytherapy, proton beam therapy, and stereotactic radiotherapy may also be used. Uveal melanoma can be treated with plaque brachytherapy, proton beam therapy, or stereotactic radiotherapy. Conjunctival tumors are often treated with plaque brachytherapy or external beam
This document provides an overview of wound care including wound healing processes, types of wounds, evaluation and documentation of wounds, and wound management. It discusses the stages of wound healing including hemostasis, inflammation, proliferation, and remodeling. Different types of wounds such as incisions, lacerations, abrasions, and puncture wounds are described along with factors to evaluate like location, size, exudate, signs of infection, and surrounding tissue condition. Methods of documentation including photography and standardized descriptions are covered. The management section addresses wound care plans, cleaning, debridement, exudate management using various dressing materials, and treatment of infections.
Linda Cendales Composite Tissue Graft Summary Banff 2013 Meeting in BrazilKim Solez ,
Composite tissue graft summary from 12th Banff Conference on Transplant Pathology from the meeting in Comandatuba-Bahia, Brazil on August 23rd, 2013 http://cybernephrology.ualberta.ca/banff/2013
Raynaud’s Phenomenon used to describe episodic events which represent vasoconstriction of digital arteries, precapillary arterioles and arteriovenous shunts.
This document summarizes key points from a lecture on open fracture wound care. The lecture discusses principles of timing, antibiotic coverage, debridement techniques, irrigation methods, and wound closure/coverage. Some of the main topics covered include:
- The "6 hour rule" for treatment is not supported by evidence and timing is not a major factor in preventing infection.
- Initial debridement is most important to remove all foreign material and nonviable tissue.
- Irrigation with soap or saline is effective, and antibiotics provide no proven benefit for irrigation.
- Negative pressure wound therapy reduces bacteria and edema compared to wet-to-dry dressings.
- Primary closure can be considered
case presentation on post kala azar dermal leishmaniasis (PKDL)ChristyThomas37
This document presents a case study of post-kala azar dermal leishmaniasis (PKDL) in a 13-year old female patient who was previously treated for kala azar at age 6. Examinations found papular and nodular lesions on her face and macular lesions on her body. Diagnostic tests confirmed Leishmania parasites. She was diagnosed with PKDL and treated with liposomal amphotericin B and miltefosine. PKDL is usually a sequel of visceral leishmaniasis occurring months to years after treatment, characterized by skin lesions, and requires treatment to prevent further spread.
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by the bacterium Mycobacterium leprae. It primarily affects the skin and peripheral nerves. Leprosy has been recognized throughout history in many ancient civilizations. It is transmitted via droplets from the nose and mouth during close contact with untreated cases. While not highly infectious, untreated leprosy can cause permanent damage to skin, nerves, limbs, and eyes. Diagnosis is based on clinical signs and symptoms, and confirmation is through skin smears or biopsy. Treatment involves multidrug therapy with dapsone, rifampicin, and clofazimine.
Blood culture role in sepsis and it's managementDr Nisha Singh
This document discusses blood culture as the gold standard for sepsis diagnosis. It begins with definitions of sepsis, sepsis diagnosis, and sepsis burden. It then discusses sources of sepsis and outlines the sepsis six protocol. The document emphasizes that blood culture identifies the organism and enables antibiotic sensitivity testing to guide therapy. It also discusses newer rapid diagnostic methods but notes blood culture remains the gold standard.
This document presents 3 dermatology cases seen by Dr. Maha Assem Fahmy. Case 1 involves a 4-year-old male child with perianal lesions diagnosed as Langerhans cell histiocytosis through biopsy. Case 2 is a 42-year-old man with a skin-colored nodule on his cheek diagnosed as diffuse large B-cell lymphoma. Case 3 describes a 30-year-old woman with nodules on her face and eyebrows diagnosed as tumid lupus erythematosus through serological tests and direct immunofluorescence. Each case discusses treatment and provides literature to support diagnoses and management approaches.
This document discusses skin aging and wound care. It describes normal skin changes with aging like decreased thickness and moisture that impact wound healing. Risk factors for skin damage are reviewed like immobility and moisture. A wound staging system from I-IV is presented. The 7 principles of wound care are identified like keeping wounds clean and moist. Different wound care products are described like dressings, creams, and support surfaces. A case study is presented on a patient with diabetic foot ulcers and sacral wound, and their treatment plan is outlined.
This document discusses skin aging and wound care. It describes changes in aging skin that impact wound healing. Risk factors for skin damage and pressure ulcers are identified. A wound staging system is presented. The 7 basic principles of wound care are outlined, including accurately measuring wounds, preventing further tissue damage with saline, and supporting nutrition. A case study of a patient with wounds is provided along with treatment recommendations. Different wound care products and their uses are reviewed.
This case report describes a 15-year-old boy who presented with axillary swelling and fever after being scratched by a cat six weeks prior. Examination found swelling and tenderness in his left axilla and at the scratch site. Tests showed elevated white blood cell count and erythrocyte sedimentation rate. Fine needle aspiration of the lymph node showed granulomatous inflammation resembling tuberculosis. He was diagnosed with cat scratch disease and prescribed antibiotics, with complete resolution of symptoms after two months. Cat scratch disease is caused by Bartonella bacteria transmitted via cat scratches or bites, and typically presents as regional lymphadenopathy that resolves spontaneously within months.
This document discusses several mnemonics for dermatological conditions and diseases. It provides 3-sentence summaries for each mnemonic that include:
1) The mnemonic letters and their meaning as it relates to key aspects of the condition.
2) A brief 1-2 sentence description of the condition.
3) Information about the person/people associated with discovering or describing the condition.
This document summarizes the objectives and content of a winter school on tropical diseases taught by Dr. Alexandre Naime Barbosa at Botucatu School of Medicine in Brazil. The objectives are education of health students and professionals, community outreach to share scientific concepts, and scientific discussion. The course covers arboviruses including yellow fever, dengue, chikungunya, Zika and their transmission, symptoms, diagnosis and prevention. It provides an overview of each disease and the current epidemiological situation in Brazil.
This document provides information about severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP). It defines each condition, discusses their epidemiology, etiology, clinical features, investigations, treatment and prognosis. SJS/TEN is characterized by blistering and sloughing of the skin and mucous membranes. DRESS presents with rash and systemic involvement of organs. AGEP features non-follicular sterile pustules localized to flexural areas. Management involves identifying and stopping the culprit drug,
This document summarizes the objectives and content of a winter school on tropical diseases taught by Dr. Alexandre Naime Barbosa at Botucatu School of Medicine in Brazil. The objectives are education of health students and professionals, community outreach to share scientific concepts, and scientific discussion. The course covers arboviruses including yellow fever, dengue, chikungunya, Zika, their transmission cycles, symptoms, pathogenesis, diagnosis and prevention methods. It provides an overview of each disease and the current epidemics in Brazil.
This document provides an overview of oropharyngeal candidiasis including its etiology, epidemiology, clinical manifestations, diagnosis, and treatment. Key points include: Candida albicans is the most common cause, infecting 45-65% of children and 52% of adults. Risk factors include diabetes, immunosuppression, antibiotics, and xerostomia. Clinical presentations include pseudomembranous, erythematous, and hyperplastic lesions. Diagnosis involves microscopy, culture, and histology. Treatment involves topical or systemic antifungals like nystatin, fluconazole, or echinocandins depending on severity. Prevention emphasizes managing predisposing factors and good oral
2015: Wounds in the Geriatric Population-SalasSDGWEP
This document discusses wound care in the geriatric population. It outlines risk factors for wounds in older adults and describes assessing and managing different wound types like pressure ulcers, venous stasis ulcers, and diabetic foot ulcers. Standard wound treatments involve addressing underlying causes, cleaning the wound bed, and dressing changes. If wounds do not improve with standard care after 4 weeks, advanced therapies may be considered, such as skin substitutes, growth factors, and negative pressure wound therapy to aid healing. The goal is to diagnose and correct risk factors while managing the wound to assess progress and determine if specialized treatments could help non-healing or chronic wounds.
This document discusses different types of acute and chronic wounds, as well as the normal process of wound healing. It describes primary intention healing, secondary intention healing, and tertiary intention healing. Signs and symptoms of wound infection are listed. Recommendations are provided for wound care and management, including maintaining sterility during dressing changes, using sterile water if the wound is infected with MRSA, ensuring proper wound swabbing for culture and sensitivity testing, practicing hand hygiene, and observing wound progression. References on wound dressing, management of surgical wounds, and prevention of hospital-acquired infections are also included.
MICROBIAL AND PARASITIC INFECTIONS OF THE EYE.pptxBARNABASMUGABI
This document discusses various microbial and parasitic infections that can affect the eye. It covers lid infections like styes, hordeolums, and chalazions caused by staphylococcal or meibomian gland infections. It also discusses blepharitis, demodex, and parasitic infections like phthiriasis palpebrum. Orbital cellulitis and its complications are described. Infections of the lacrimal system like dacryocystitis and dacryoadenitis are covered. The document concludes with details on various types of conjunctivitis including bacterial, viral like adenovirus, and parasitic forms such as trachoma.
RADIOTHERAPY describes the various indicationsBARNABASMUGABI
Radiotherapy is the use of ionizing radiation to treat cancer and tumors. It can be classified as electromagnetic radiation like x-rays and gamma rays, or particulate radiation like protons, neutrons, and electrons. Radiotherapy is commonly used to treat retinoblastoma, uveal melanoma, and conjunctival tumors. For retinoblastoma, chemotherapy is the main treatment but radiotherapy techniques like plaque brachytherapy, proton beam therapy, and stereotactic radiotherapy may also be used. Uveal melanoma can be treated with plaque brachytherapy, proton beam therapy, or stereotactic radiotherapy. Conjunctival tumors are often treated with plaque brachytherapy or external beam
Optic Disc Abnormalities and their presentationsBARNABASMUGABI
This document discusses various optic disc abnormalities including optic nerve hypoplasia, optic pits, and morning glory disc anomaly. Optic nerve hypoplasia is characterized by a decreased number of optic nerve fibers and can cause visual impairment. It has known risk factors such as young maternal age. Optic pits appear as depressions of the optic disc and can sometimes cause macular serous detachments. Morning glory disc anomaly is a funnel-shaped excavation of the optic disc that is typically unilateral and sometimes associated with retinal detachments or brain abnormalities.
OCULAR TOXOPLASMOSIS the blinding disease and is classified among the torch i...BARNABASMUGABI
the disease spreads from the cats and causes retinochoroiditis and its a blinding disease aswell.its managed with spiromyscin,folinic acid and incase of retinal detachment,vitrectomy is done
OCULAR VIRAL ILLNESSES with different ocular manifestationsBARNABASMUGABI
it entails a description of the ocular manifestations of various viral infections and their management aswell as their complications and how to go about the complications
LEUKEMIC DISEASES AND THE EYE.pptx. This talks about the ocular manifestation...BARNABASMUGABI
This document provides an overview of leukemic diseases and their ocular manifestations. It discusses the different types of leukemia including acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, and chronic lymphocytic leukemia. It covers the pathogenesis, classification, signs and symptoms, diagnostic testing including blood counts, bone marrow examination, and cytochemical staining. It also describes the various ocular changes that can occur due to anemia, thrombocytopenia, hyperviscosity, thrombosis, infiltration of tissues, and metabolic abnormalities associated with leukemias.
HYPERTENSIVE RETINOPATHY. The effects of hypertension on the eyeBARNABASMUGABI
Hypertension can cause narrowing of retinal arterioles and pre-existing arteriosclerosis. Hypertensive retinopathy is characterized by vasoconstriction of retinal arterioles, leakage from these vessels, and progression of arteriosclerosis in the retina.
1.Ocular headache and the causes of raised ocular pressureBARNABASMUGABI
This document provides an overview of headache evaluation and management for ophthalmologists. It begins by classifying headaches as either primary or secondary, with the primary types including migraine, tension-type headache, and trigeminal autonomic cephalgias. For evaluation, it recommends taking a thorough history and performing ocular, neurological, and laboratory exams. It describes features that warrant neuroimaging using the "SNOOP" mnemonic. Treatment approaches for migraine and tension-type headaches include acute symptomatic relief as well as prophylactic management. Specific headache syndromes like cluster headache and SUNCT are also outlined. Secondary headaches can result from ocular, orbital, vascular, or intracranial pathology.
This document provides an overview of diabetic retinopathy. It discusses the etiology, anatomy, epidemiology, pathophysiology, risk factors, classification, imaging, and treatment of diabetic retinopathy. Some key points include:
- Diabetic retinopathy is caused by prolonged hyperglycemia and is a leading cause of blindness. It affects the retinal microvasculature.
- Risk factors include duration of diabetes, glycemic control, hypertension, and pregnancy.
- Stages include mild, moderate, and severe non-proliferative diabetic retinopathy and proliferative diabetic retinopathy.
- Diabetic macular edema can occur at any stage and is a major cause of
This document provides an overview of several retinal vascular diseases including sickle cell disease, vasculitis, cystoid macular edema, Coats disease, macular telangiectasia, phakomatoses, radiation retinopathy, Valsalva retinopathy, and Purtscher retinopathy. Key details are provided on the pathogenesis, clinical presentation, diagnosis, and management of each condition. The document is intended as an educational guide for retinal specialists and contains technical terminology related to retinal anatomy and diseases.
A 36-year-old man presented with complaints of blurry vision when reading or doing near tasks. Examination found compound hyperopic astigmatism. Refraction found +2.00/-1.00X100° in the right eye and +2.25/-1.00X100° in the left eye. Astigmatism is caused by an irregular curvature of the cornea or lens that results in unequal refractive power in different meridians. It is typically treated with spectacles containing cylindrical lenses.
This document presents a case of orbital Burkitt lymphoma in a 14-year-old male from Uganda who initially presented with abdominal symptoms and was diagnosed with Burkitt lymphoma. He received chemotherapy but later developed right eye swelling and proptosis. Examination found a large orbital mass and biopsy confirmed recurrent Burkitt lymphoma. The key points discussed include the clinical features of Burkitt lymphoma, the diagnostic approach involving imaging and biopsy, the characteristic pathology findings, and management with chemotherapy and possible radiation therapy.
This document provides information on evaluating patients for refractive surgery. It discusses examining the patient's medical, ocular, and refractive history. Important tests include visual acuity, refraction, corneal topography and tomography to check for ectasia risk, wavefront analysis, and evaluating dry eye and ocular surface disease. Key considerations are patient expectations, corneal health, stability of refractive error, and identifying contraindications.
This document presents a case of orbital Burkitt lymphoma in a 14-year-old male from Uganda who originally presented with abdominal symptoms and was diagnosed with Burkitt lymphoma. He received chemotherapy but later developed right eye swelling and proptosis. Examination found a large orbital mass and biopsy confirmed recurrent Burkitt lymphoma. The key points discussed include the clinical features of Burkitt lymphoma, the diagnostic approach involving imaging and biopsy, the characteristic pathology findings, and management with chemotherapy and possible radiation therapy.
The document discusses the anatomy, development and physiology of the lacrimal secretory and drainage systems. It describes the embryological development of the lacrimal system from ectodermal tissue. It details the anatomy of the lacrimal gland, puncta, canaliculi, sac, duct and nasolacrimal drainage system. It explains the physiology of tear secretion, composition of the tear film layers, and the role of nerves, blood vessels and muscles in lacrimal secretion and drainage.
PERIOCULAR MALPOSITIONS AND INVOLUTIONAL CHANGES.pptxBARNABASMUGABI
This document summarizes various periorbital malpositions and involutional changes including ectropion, entropion, and symblepharon. Ectropion is outward turning of the eyelid and has several types including involutional, cicatricial, and paralytic. Entropion is inward turning and can be involutional, acute spastic, or cicatricial. Symblepharon is an adhesion between conjunctival surfaces caused by inflammation, infection, or trauma. The document discusses examination, risk factors, pathophysiology, and management options for each condition including surgical procedures and medical treatment.
Clinical refraction involves determining the eye's best corrected vision and refractive error using objective and subjective techniques. Retinoscopy is an objective technique that uses the characteristics of the retinal reflex seen through a retinoscope to neutralize the reflex and determine the refractive error. The power of the correcting lens at neutrality minus the working distance provides the actual refractive error. Subjective techniques refine the result by having the patient respond to lenses placed before their eyes.
A 24-year-old male presented with blunt trauma to the right eye after being punched 1 week prior without eye protection. On examination, he had a hyphema, traumatic cataract, corneal edema, and uveitis in the right eye. He was managed conservatively with medications, close monitoring, and later referred to a vitreoretinal surgeon. Over subsequent follow ups his condition improved, though he was still advised to limit activity and continue regular monitoring. Blunt ocular trauma can cause various injuries like hyphema, cataract, uveitis, retinal tears or detachment depending on the force and location of impact. Evaluation involves examination to identify injuries and rule out perforating injuries, with
Primary health care is a vital component of eye care that includes promotion of eye health, prevention and treatment of conditions that may lead to visual loss. Primary eye care aims to make eye care services universally accessible through community-based programs. A primary eye care worker is trained to manage some eye conditions, diagnose others, and refer patients appropriately. Essential components of primary eye care include health promotion, disease prevention, treatment of common diseases, and rehabilitation. Regular training, supervision, and interaction between full-time eye care workers and volunteer community workers is important for a successful primary eye care program.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Debunking Nutrition Myths: Separating Fact from Fiction"AlexandraDiaz101
In a world overflowing with diet trends and conflicting nutrition advice, it’s easy to get lost in misinformation. This article cuts through the noise to debunk common nutrition myths that may be sabotaging your health goals. From the truth about carbohydrates and fats to the real effects of sugar and artificial sweeteners, we break down what science actually says. Equip yourself with knowledge to make informed decisions about your diet, and learn how to navigate the complexities of modern nutrition with confidence. Say goodbye to food confusion and hello to a healthier you!
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
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3. CASE PRESENTATION
Namyalo Aidah,68 years.
A two weeks history.
Remembered to have been pierced by a thorn in her left
foot that she left in for 3 days.
PMHx:Diabetic and hypertensive.
PDHx:Glibenclamide, metformin,lasix and nifedipine.
Vitals:Temp-37.8C. Pulse-135b/m. B.P-144/85mmHg.
Investigations:CBC. RBS-23.7mmol. U/S scan and X-ray.
4. DEFINITION
A wound is a type of injury which happens
relatively quickly in which skin is torn,cut ,or
punctured(an open wound),or where blunt force
trauma causes a contusion(a closed wound).
7. CLASSIFICATION
Open,according to the object that caused the wound:
Incisions or incised wounds
Lacerations-regular or irregular.
Abrasions(grazes)
Avulsions
Puncture
Penetration wounds
Gunshot
10. PATHOPHYSIOLOGY
When the epidermis or dermis is broken,an
orchestrated cascade of biochemical events is
set into motion to repair the damage:
1. Haemostasis
2. Inflammation
3. Proliferation
4. Maturation
12. MANAGEMENT
Depends on the type,cause and depth of the wound
and whether other structures beyond the skin(dermis)
are involved.
o Recent lacerations.
o Minor wouds like bruises.
o Abrasions
o Punctures
13. MANAGEMENT
Cleaning:
Also known as wound toilet,evidence to support
cleaning of a wound before closure is scant:
Tap water
Sterile saline solution
Betadine
Hydrogen peroxide.
Savron
17. WORK UP
A. Evaluating the wound,its extent and severity.
B. Cultures
C. X-rays
D. Tetanus shot.
18. CHRONIC
Diabetic foot:
o 25% of diabetic patients will develop foot ulcers
o Associated with inadequate circulation,poorly functioning
veins,and immobility
o Amputation every 30 seconds somewhere in the world
o Interdisciplinary approach to treatment.
19.
20.
21.
22.
23.
24. HISTORY
The body and the soul were believed to be intimately connected.
Wounds on the body were believed to correlate with wounds to the soul and vise
versa
Wounds were also seen as a writing on the ‘’tablet’’ of the body.
25. REFERENCES
Fernandez R., Griffiiths R.(15th February 2012). « Water for wound
dressing ».
Eliya-Masamba, Martha C.;Banda,GraceW.(2013-10-22). »Primary closure
versus delayed closure for non bite traumatic wounds within 24 hours post
injury ».
“The Clinical Case for Use of Hyperbaric Oxygen The therapy in the
Treatment of Diabetic Wounds,” Diversified Clinical Services,copyright 2009.
Reichardt,Paul F.(1984). “Gawain and the image of the wound”.
Sheth,V.M.;Weitzul,S. (2008). “Postoperative topical antimicrobial
use”.Dermatitis: contact,atopic,occupational,drug.