Nutritional Practices & Habits of Boomer Consumers: Why Active Snacking is the Most Effective Method of Nutritional Supplementation. Nutritional tools to minimize age accelerators and enhance an active and healthy functional lifestyle. View more at http://www.GoBeneVia.com/blog

1. Nutritional Practices & Habits of Boomer Consumers: Why Active Snacking is the Most Effective Method of Nutritional Supplementation Nutritional tools to minimize age accelerators and enhance an active and healthy functional lifestyle

3. 18 25 35 50 65 75 85 AGE 100 75 50 Normal Life Function Response Curve Effect of Heart Disease & Diabetes on Life Function Cognitive Decline Effect BeneVia Nutrition Advantage BeneVia & Exercise Effect Healthy Life Function Response Curve & The Influence of Chronic Diseases, Nutrition and Exercise on Overall Functional Activity with Aging. Strong & Active Health Management (Adapted from Am.Fam.Phys, 56:1815-1822,1997;NatlHealthStatistics 2009; NEJM 343:530-540, 2000) Percent of Full Function

4. 18 25 35 50 65 75 85 AGE 50 40 30 20 10 Normal Life Function Response Curve Cascade of Age Accelerators Effecting Healthy Life Function. An illustration of the impact of nutrition, physiology and chronic disease risk on active life stages. Increasing Risk Results in Loss of Healthy Life Function (Adapted with NEJM 343:530-540,2000; NHANES 2000; NIA 2010) Percent Increase Risk 100 75 50 Percent Of Normal Healthy Life Function Decreasing Quality Protein Intake Results in Loss of Lean Muscle Body Weight, Reduces Strength & Energy and compromises healthy life function over time Increasing Fat Mass Leads to Increased Rates of Obesity; Inactivity Causes further Decline High Incidence of Heart & Cardiovascular Disease Increases risk of co-morbidities Increased Prevalence of Diabetes accelerated due to below issues Increased Risk & Incidence of Loss of Cognitive Performance Poor Protein, low AntiOx, No Active Nutrients Accelerates Aging Faster Initial Threshold of Age Acceleration Chronic Disease Threshold of Age Acceleration Therapeutic Nutrition Health Management Threshold Life Function Responses (% of Peak) (lines right /below are scaled to far right axis) Healthy, Active Age Accelerated Normal Age Decline

5. The aging shift to more Fat Mass vs Muscle can be controlled with intake of quality protein sources and fewer calories. This helps avoid build up of fat in the blood and muscle, reduces inflammation and minimizes the age resistance of muscle and thus the acceleration of the aging process (ABC Study 2007, Am J.Clin Nutrition) Inadequate Protein Intake Is the Primary Cause of Healthy Functional Decline in Aging. Lean Body (Muscle) Mass is a Critical Need in Aging while Caloric Controls can help Avoid the Age Accelerators of Excess Fat Mass and Body Weight (USDA RDA’s 2009; NHANES 2006;J.Am.Ger.Soc.54:991-1001,2007) (Controllable Nutrient Accelerators of Aging) Key Nutritional Variable Optimal Intake Level for Normal, Healthy Aging (age 50 – 75 yrs) Threshold Intake Level at or below which Aging is Accelerated Typical & Average Intake Levels for 50 to 75 yr Consumers Calories 1600 kcal/day 1300 kcal/day 1800kcal/day Protein 1.2g/kg-bw/day (avg 85g/day) 0.8g/kg-bw/day (avg 56g/day) 65g/day Carbohydrate 206 g/day 175 g/day 200g/day Essential Amino Acids + Leucine 40g/day on avg 25.2g/day on avg 26g/day Calcium Vitamin D Omega3/DHA Lutein B Vitamins 1200 mg/d 600 IU >250 mg/d 4mg/d 1.8 mg/d 800 mg/d 400 IU 50 mg/d 2mg/d 1.3mg/d 700 mg/d 500 IU 30 mg/d < 2mg/d 1.6mg/d

6. Soy Casein Whey Hi Leu/EAA Effective Nutritional Supplementation that Slows the Accelerators of Aging Must address Three Critical issues – 1) Effectively Increase Protein Intake, 2) Use a High Leucine Essential Amino Acid Protein Blend that overcomes Aging Muscles Resistance to Building More Muscle and 3) Time Nutritional Supplementation Intake that Optimizes the Effects of Active Nutrients on the Muscle & Body Systems (Layman. Nutrition and Metabolism 2009; 6: 12 Volpi E, Kobayashi H, Sheffield-Moore M, et al: Am J Clin Nutr 2003;78:250-258) ) Muscle Building Muscle Breakdown Percent Muscle Building Percent Muscle Activity Supplementation with Protein Blends of High Leucine/Essential Amino Acids Improves the Muscle Building Balance to More Muscle Building and Less Breakdown. In subjects 50 to 75 yrs this improvement overcomes the resistance of aging muscles to build stronger muscle mass. (Clin. Nutrition,2008) Optimal & Maximal Protein Synthesis is Achieved when 7–15grams of Essential Amino Acids/Leucine Blends are used or when intact/total protein sources of 25 – 35grams is available . (Exp Geront. 2006; 41:215-219; Am.J.Physiol 2006; 291:381; Biolo et al. Am J Physiol 1997; 273: E122-E129) Use of High Leucine/Essential Amino Acid Protein Blends by subjects 50 to 75 yrs is a More Effective Source of Protein at Building and Improving Muscle Mass than other protein forms of Supplementation Paddon Jones et al. Am J Physiol 286: E321-E325, 2004; Am J Physiol 288: E761-E767, 2005 Optimal Muscle Building Range 15g Intact Protein Source Effect 30g intake levels 7 & 15g intake of amino acid blend with Leucine Concentrated, lower volume Leucine/EAA blends are More Effective than Intact Protein

7. Percent Muscle Building Effectiveness 100 75 50 25 0 Optimal Muscle Building Range Per Intake Average Per Meal Protein Intake Pattern for 50 to 75 yr Consumers 13g protein 36g protein 20g protein Breakfast Lunch Dinner Exercise Breakfast Lunch Dinner Snack 14g protein Average Daily Muscle Bu ilding Effect Typical Per Meal Daily Protein Intake Levels and Source of Protein is Inadequate to Optimally Stimulate Muscle Building Capacity. This is in spite of Consumption of Adequate Caloric Intake Above the Age Accelerator Threshold Caloric Intake 600 400 200 Average Per Meal Caloric Intake Pattern for 50 to 75 yr Consumers 405 479 767 356 2007 total calories consumed daily Adapted from: Paddon Jones et al. Am J Physiol 286: E321-E325, 2004; Am J Physiol 288: E761-E767, 2005; NHANES 2006 Summary reports Data represents nutriitonal intake of 50-75yr old consumers as reported from NHANES 2006 and NFSII 2004)

8. Percent Muscle Building Effectiveness 100 75 50 25 0 Optimal Muscle Building Range Per Intake Average Per Meal Protein Intake Pattern for 50 to 75 yr Consumers 13g protein 36g protein 20g protein Breakfast Lunch Dinner Exercise Breakfast Lunch Dinner Snack 14g protein Average Daily Muscle Bu ilding Effect Supplementation with Typical Nutritional Beverages will Have Little to No effect on Increasing Muscle Building Capacity and will Result in only an Excess of 250 to 350 Calories Caloric Intake 600 400 200 Average Per Meal Caloric Intake Pattern for 50 to 75 yr Consumers 405 479 767 356 2007 total calories consumed daily 10g protein 250 cal Supplementation Effect Adapted by: Paddon-Jones D and Rasmussen BB. Curr Opin Clin Nutr Metab Care 2009;12:86-90

9. Percent Muscle Building Effectiveness 100 75 50 25 0 Optimal Muscle Building Range Per Intake Average Per Meal Protein Intake Pattern for 50 to 75 yr Consumers 13g protein 36g protein 20g protein Breakfast Lunch Dinner Exercise Breakfast Lunch Dinner Snack 14g protein Average Daily Muscle Bu ilding Effect Meal Replacement with Typical Nutritional Beverages will Result in even Less Effective Muscle Building Capacity and a Net Zero to Plus 25 Caloric Increase Adpated from Fiatarone et al. J Am Ger Soc 41: 333-7, 1993, NEJM, 1994 ; AmJPhysiol. 286:E32, 2004) Caloric Intake 600 400 200 Average Per Meal Caloric Intake Pattern for 50 to 75 yr Consumers 405 479 767 356 1950 total calories consumed daily 14g protein 354 cal Meal Replacers Don’t Work @ Stopping Age Accelerators

10. Percent Muscle Building Effectiveness 100 75 50 25 0 Optimal Muscle Building Range Per Intake 13g protein 36g protein 20g protein Breakfast Lunch Dinner Exercise 15g protein Average Daily Muscle Building Effect Before Optimal Supplementation Supplementation with Low Volume Highly Concentrated Protein Blends with High Leucine/Essential Amino Acids Will Provide a Convenient and 4X More Effective Method of Optimizing Muscle Building Capacity without a Significant Caloric Load Supplementation with 8g High Leucine/Essential Amino Acids at Meal time will Improve Muscle Building Capacity by 4X and in a Low Volume Non-Satiating Manner. 100 Calories will be manageable Improvement in Muscle Building Capacity Active Snacking (Supplement between Meals) with low volume concentrated Protein Blends of High Leucine/Essential Amino Acids is the Most Effect Means of overcoming Age Accelerators of Inadequate Nutritient & Protein Intake Plus 4X Protein Power and 100 cal Plus 4X Protein Power and 100 cal Adapted with Paddon-Jones D and Rasmussen BB. Curr Opin Clin Nutr Metab Care 2009;12:86-90; Paddon Jones et al. Am J Physiol 286: E321-E325, 2004; Am J Physiol 288: E761-E767, 2005

12. Active Nutrients Play a Significant Role in Targeting Specific Health Benefits and are Not Readily Available at Therapeutic Levels in the Typical Diet 2) Increase active Nutrients to therapeutic levels for targeted health benefits 3) Avoid adding age accelerators to the diet when adding active nutrients Selection of food items should avoid those that add high levels of fat and saturated fat and that would result in 20% or more calories to the typical intake level of around 1800 calories/day unless food items are substituted. Saturated fats are key age accelerators and should be minimized. Smaller convenient portion sizes are also important to improve compliance and to avoid satiation such that a net decrease in caloric intake is unnecessarily achieved Therapeutic Nutrient Required Amount for Therapeutic Benefit Percent 50 – 75 yr olds not Meeting the required daily levels Average Daily Intake on Typical Dietary Practices Percent Gap between therapeutic benefit and intake level Omega -3/DHA 450mg/day+ 80% <150mg 67% Lutein 4mg 90%+ < 1mg 75% Vitamin D Calcium 1200IU 75% <600IU 50% B-Vitamins 1.9mg/d 40% 1.4mg/d 26% Leucine Amino Acid 14g 100% 6.0g 57%

13. Active Snacking Active Snacking provides a convenient and effective manner of nutritional supplementation for therapeutic benefit, Between meal supplementation helps to maximize the body’s net muscle building capacity by using specialized protein sources with high leucine/essential amino acid protein sources, Active snacking with nutritional beverages provides a convenient approach to supplementation while managing caloric intake (less than 100 calories/serving), maximizing delivery of active nutrients and keeping age accelerators such as additional fat out of the diet Recognizing the current dietary practices and habits of 50 to 75 yr old consumers, active snacking provides effective means of improving nutritional and health profiles needed for active lifestyles Active snacking avoids the issue of satiation which may not only decrease total food consumption but increase the likelihood that further loss of key nutrients might take place.

14. Summary Highlights on the Need & Effectiveness of Active Snacking The nutritional practices and habits of boomer consumers reveal that while caloric intake levels are adequate, insufficient protein and protein source intake levels contribute to an accelerated loss of muscle mass during the aging process Active nutrients that enhance healthy lifestyles also appear to be consumed at lower levels and as many of these have therapeutic health benefits, lack of availability in the diet may contribute to the risk of compromised health in aging, Inadequate and ineffective nutritional availability leads to an accelerated decline in aging and increased risk of chronic disease states, Inadequate protein intake couple with the age-resistance of muscle to building muscle requires not only higher protein levels to be consumed ( > 1.2g/kg bw/day) but also a quality source protein that includes a high leucine/essential amino acid protein blend that builds muscle more effectively. This superior protein source results in significantly higher muscle building capacity in a concentrated/smaller volume. This means that maximal muscle building capacity can be achieved with 7–15g of this blend vs the 30g required by intact protein sources (casein,whey) to achieve the same effect. Smaller volumes result in greater compliance, less satiation, more complete nutrient intake and superior outcomes Active Snacking between meals with high quality nutritional supplementation results in a greater net benefit in both protein and active nutrient therapeutic benefits

15. Contact BeneVia/HealthSpan Institute web: www.GoBeneVia.com facebook: http://www.facebook.com/GoBeneVia email: [email_address] phone: 1-888-855-4442 HealthSpan Solutions, LLC 2228 Cottondale Lane, Suite 100 Little Rock, AR 72205