Best for quality control and standardization of herbals, subject preparation for next month under me nikal gya tha isliye call nahi kar sakte hai na isliye bol raha hu ki kya karu mai ab mar gya to bol dena chahiye nazim bhai ne
The document discusses the evaluation of herbal drugs. It explains that evaluation is necessary to identify herbs, determine quality and purity, and detect adulteration. Various evaluation methods are described, including organoleptic, microscopic, physical, chemical, and biological methods. Standards and limits are set by organizations like WHO to ensure the safety of herbal medicines with regards to contaminants and residues. Proper identification, testing, and storage of herbal drugs is important for stability and quality.
WHO has established several guidelines for quality control and standardization of herbal medicines. This includes guidelines for crude plant materials, processed plant materials, and analytical procedures. Key aspects that must be standardized include authentication of plant identity and source, absence of contaminants, determination of marker compounds, and ensuring safety through tests for heavy metals, pesticides, and microbiological limits. Proper application of WHO guidelines can help ensure the quality, safety and efficacy of herbal medicines.
Dr.Lavanya.S.A - standardization of herbal drugsDr.Lavanya .S.A
The document discusses the standardization of herbal drugs. It begins by introducing the growth of herbal medicine and the need for standardization. It then defines herbs, herbal drugs, and what standardization of herbal drugs refers to. The document outlines some of the key procedures for standardizing herbal drugs, including authentication, physical and chemical analysis, and microbiological and residue testing. It also discusses identifying crude drugs through systematic study, microscopic identification of features like stomata and veins, and various quantitative studies that can be done on crude drugs. Overall, the document provides an overview of the importance and processes involved in standardizing herbal medicines.
The document discusses parameters for evaluating crude drugs and herbal formulations. It outlines physical, chemical, botanical, and biological/toxicological parameters to assess, including foreign matter, pesticides, and other contaminants. Methods are provided for determining pesticide residues using extraction, column chromatography, and thin-layer chromatography. Maximum residue limits for pesticides in herbal drugs are calculated based on acceptable daily intake limits.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This document summarizes the standardization and in vitro screening of selected plants for pharmacological properties. It describes the aims to standardize plants according to WHO guidelines and screen for anti-diabetic activity. The methodology involves standardizing the selected plant Daucus carota by evaluating various physicochemical parameters like organoleptic properties, foreign matter, moisture content, ash values, density and angle of repose. It also involves preliminary phytochemical analysis and in vitro assays for antioxidant and alpha amylase inhibition potential. The results show Daucus carota has properties like light yellow color, fruity odor, sweet taste. It reports values for parameters like tapped density, bulk density, Carr's index, Hausner's ratio
The document discusses standardization of herbal formulations, which is essential to ensure quality, safety, and efficacy. It outlines various techniques used for standardization, including authentication of raw materials, assessment of identity, purity, and content/assay. Key aspects of standardization addressed are quality control procedures, stability assessment and shelf-life determination, and safety and efficacy evaluation. The World Health Organization provides guidelines for quality control of herbal drugs and standardized herbal formulations.
This document outlines 8 parameters for quality control testing of herbal drugs:
1. Macroscopic examination including organoleptic evaluation of color, odor, shape, etc.
2. Microscopic evaluation to identify plant species and parts.
3. Determination of foreign matter through visual inspection or microscopy.
4. Determination of ash content through burning to measure total ash and acid-insoluble ash.
5. Determination of heavy metals using color reactions or instrumental analysis.
6. Determination of microbial contaminants and aflatoxins through standard procedures.
7. Determination of swelling index by measuring volume after shaking in water.
8. Determination of pesticide residues by extracting and
The document discusses the evaluation of herbal drugs. It explains that evaluation is necessary to identify herbs, determine quality and purity, and detect adulteration. Various evaluation methods are described, including organoleptic, microscopic, physical, chemical, and biological methods. Standards and limits are set by organizations like WHO to ensure the safety of herbal medicines with regards to contaminants and residues. Proper identification, testing, and storage of herbal drugs is important for stability and quality.
WHO has established several guidelines for quality control and standardization of herbal medicines. This includes guidelines for crude plant materials, processed plant materials, and analytical procedures. Key aspects that must be standardized include authentication of plant identity and source, absence of contaminants, determination of marker compounds, and ensuring safety through tests for heavy metals, pesticides, and microbiological limits. Proper application of WHO guidelines can help ensure the quality, safety and efficacy of herbal medicines.
Dr.Lavanya.S.A - standardization of herbal drugsDr.Lavanya .S.A
The document discusses the standardization of herbal drugs. It begins by introducing the growth of herbal medicine and the need for standardization. It then defines herbs, herbal drugs, and what standardization of herbal drugs refers to. The document outlines some of the key procedures for standardizing herbal drugs, including authentication, physical and chemical analysis, and microbiological and residue testing. It also discusses identifying crude drugs through systematic study, microscopic identification of features like stomata and veins, and various quantitative studies that can be done on crude drugs. Overall, the document provides an overview of the importance and processes involved in standardizing herbal medicines.
The document discusses parameters for evaluating crude drugs and herbal formulations. It outlines physical, chemical, botanical, and biological/toxicological parameters to assess, including foreign matter, pesticides, and other contaminants. Methods are provided for determining pesticide residues using extraction, column chromatography, and thin-layer chromatography. Maximum residue limits for pesticides in herbal drugs are calculated based on acceptable daily intake limits.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This document summarizes the standardization and in vitro screening of selected plants for pharmacological properties. It describes the aims to standardize plants according to WHO guidelines and screen for anti-diabetic activity. The methodology involves standardizing the selected plant Daucus carota by evaluating various physicochemical parameters like organoleptic properties, foreign matter, moisture content, ash values, density and angle of repose. It also involves preliminary phytochemical analysis and in vitro assays for antioxidant and alpha amylase inhibition potential. The results show Daucus carota has properties like light yellow color, fruity odor, sweet taste. It reports values for parameters like tapped density, bulk density, Carr's index, Hausner's ratio
The document discusses standardization of herbal formulations, which is essential to ensure quality, safety, and efficacy. It outlines various techniques used for standardization, including authentication of raw materials, assessment of identity, purity, and content/assay. Key aspects of standardization addressed are quality control procedures, stability assessment and shelf-life determination, and safety and efficacy evaluation. The World Health Organization provides guidelines for quality control of herbal drugs and standardized herbal formulations.
This document outlines 8 parameters for quality control testing of herbal drugs:
1. Macroscopic examination including organoleptic evaluation of color, odor, shape, etc.
2. Microscopic evaluation to identify plant species and parts.
3. Determination of foreign matter through visual inspection or microscopy.
4. Determination of ash content through burning to measure total ash and acid-insoluble ash.
5. Determination of heavy metals using color reactions or instrumental analysis.
6. Determination of microbial contaminants and aflatoxins through standard procedures.
7. Determination of swelling index by measuring volume after shaking in water.
8. Determination of pesticide residues by extracting and
This document discusses herbs and herbal drugs, including:
1) Herbs have been used for medicine since ancient times, and WHO reports 80% of people worldwide use herbal products. Quality control of herbal drugs and raw materials is important.
2) Various organizations have developed monographs and guidelines for evaluating herbal drugs. Producing new herbal remedies is a complex, defined process involving raw materials, formulation, production, quality control, and intellectual property protection.
3) Authentication of herbal drugs can involve taxonomic, macroscopic, microscopic, physicochemical, chromatographic, and molecular methods to verify identity. Quality of raw materials is crucial for ensuring quality of final herbal products.
The document discusses guidelines for quality control and standardization of herbal medicines provided by the World Health Organization (WHO). It defines key terms like quality, safety, purity and potency. It outlines the need for quality control to reduce adulteration and ensure proper authentication, validation of claims, and safety. The WHO guidelines provide standardization procedures for herbal drugs, including definitions, authentication, absence of contaminants, microscopic and chromatographic analysis. It also discusses analytical procedures like botanical, physicochemical, biological and toxicological parameters for testing herbal medicines.
This document provides a review of standardization techniques for herbal formulations. It discusses the importance of standardizing herbal drugs to ensure quality, safety, and efficacy. Various parameters for standardization are described, including authentication of raw materials, assessment of purity, content/assay, stability testing, safety evaluation, and efficacy assessment. Techniques used for standardization include pharmacognostic evaluation, physico-chemical analysis, chemical characterization, chromatographic methods, toxicity testing, and clinical trials. The World Health Organization guidelines for quality control of herbal drugs are summarized. Several examples of standardized Indian herbal formulations are also mentioned. Overall, the document outlines the key factors and analytical methods used in the standardization of herbal medicines.
The term “herbal drugs” denotes plants or plant parts that have been converted into phytopharmaceuticals by means of simple processes involving harvesting, drying, and storage.
Standardization of Unani Medicine -Parameters and Exigency Dr. NTR University
This document discusses the standardization of herbal medicines. It begins by defining standardization according to the World Health Organization and the American Herbal Product Association. Standardization is described as the process of prescribing a set of standards to ensure quality, efficacy, safety and reproducibility of herbal medicines.
The document then outlines the various parameters used for evaluating and standardizing unani medicines, including organoleptic, microscopic, physical, chemical and biological evaluations. Specific evaluation methods are described under each parameter such as morphological examination for organoleptic evaluation and determination of values like moisture content and ash for physical evaluation. Thin layer chromatography, high performance liquid chromatography and other spectroscopic techniques are discussed for chemical evaluation.
TLC for chlorinated pesticide determination Bapi Mondal Bapi Mondal
In this assignment file i will demonstrate the process involved in Thin layer chromatography for Chlorinated Pesticide
determination. if u like this work feel free to share this file. thank you.
Standardization of herbal drugs refers to “confirmation of its identity and determination of its quality, purity and detection of nature of adulterant by various parameters”.
The World Health Organization (WHO) Herbal Guideline is a comprehensive and authoritative document intended to provide standardized recommendations and principles for the safe and effective use of herbal medicines worldwide. This guideline is developed by a panel of experts in herbal medicine, pharmacology, and public health, amalgamating the most up-to-date research, traditional knowledge, and clinical evidence available.
In this pdf, you will get information about manufacturing , standardization , validation , processing , etc. for herbal drugs followed by the WHO guidelines.
This document discusses quality control testing methods for determining foreign matter, heavy metals, pesticide residues, phototoxins, and microbial contamination in herbal formulations.
Key tests include determining heavy metals using atomic absorption spectroscopy, pesticide residues using chromatography methods like gas chromatography, and phototoxins like furanocoumarins in celery seed using extraction and chromatography techniques. Acceptable limits for contaminants are set by organizations like WHO.
The document discusses methods for determining various contaminants in herbal formulations, including:
- Foreign matter, heavy metals, pesticide residues, phototoxins, and microbial contamination. Methods include inspection, atomic absorption spectroscopy, chromatography, and plate counting.
- Acceptable limits for contaminants are specified by organizations like WHO. Pesticide residues are determined by extracting samples and analyzing by gas chromatography.
- Phototoxins like furocoumarins are isolated from plants using solvent extraction and identified using thin layer chromatography or column chromatography.
In vitro evaluation techniques are important for screening potential drugs before clinical trials. There are two stages of biological screening - primary and secondary assays - to identify plants with therapeutic activity. Various in vitro assays can evaluate antioxidant and anticancer properties of herbal extracts, including DPPH radical scavenging, MTT, and SRB assays. In vitro methods have advantages over animal models for initial drug screening by reducing animal use and providing reproducible, economical screening of potential drug candidates. While in vitro models cannot fully replace in vivo studies, they provide an important first step in evaluating biological activity of natural products.
Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...Md. Mohabbot Hossen
Since ancient times humanity has depended on the diversity of plant resources for food, clothing, shelter, and traditional medicine to cure myriads of ailments. By using modern science now plant is greatly used in pharmaceutical industries and various test have involved here.
It's about the Standardization of herbal drugs.
It's includes
# Definition of herbs
# Herbal drugs definition
# Herbal technology
# Standardization definition
# Methods of Standardization of herbal drugs
Standardization of Poly Herbal Siddha Medicine Eladhi Chooranaminventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
This document discusses herbs and herbal drugs, including:
1) Herbs have been used for medicine since ancient times, and WHO reports 80% of people worldwide use herbal products. Quality control of herbal drugs and raw materials is important.
2) Various organizations have developed monographs and guidelines for evaluating herbal drugs. Producing new herbal remedies is a complex, defined process involving raw materials, formulation, production, quality control, and intellectual property protection.
3) Authentication of herbal drugs can involve taxonomic, macroscopic, microscopic, physicochemical, chromatographic, and molecular methods to verify identity. Quality of raw materials is crucial for ensuring quality of final herbal products.
The document discusses guidelines for quality control and standardization of herbal medicines provided by the World Health Organization (WHO). It defines key terms like quality, safety, purity and potency. It outlines the need for quality control to reduce adulteration and ensure proper authentication, validation of claims, and safety. The WHO guidelines provide standardization procedures for herbal drugs, including definitions, authentication, absence of contaminants, microscopic and chromatographic analysis. It also discusses analytical procedures like botanical, physicochemical, biological and toxicological parameters for testing herbal medicines.
This document provides a review of standardization techniques for herbal formulations. It discusses the importance of standardizing herbal drugs to ensure quality, safety, and efficacy. Various parameters for standardization are described, including authentication of raw materials, assessment of purity, content/assay, stability testing, safety evaluation, and efficacy assessment. Techniques used for standardization include pharmacognostic evaluation, physico-chemical analysis, chemical characterization, chromatographic methods, toxicity testing, and clinical trials. The World Health Organization guidelines for quality control of herbal drugs are summarized. Several examples of standardized Indian herbal formulations are also mentioned. Overall, the document outlines the key factors and analytical methods used in the standardization of herbal medicines.
The term “herbal drugs” denotes plants or plant parts that have been converted into phytopharmaceuticals by means of simple processes involving harvesting, drying, and storage.
Standardization of Unani Medicine -Parameters and Exigency Dr. NTR University
This document discusses the standardization of herbal medicines. It begins by defining standardization according to the World Health Organization and the American Herbal Product Association. Standardization is described as the process of prescribing a set of standards to ensure quality, efficacy, safety and reproducibility of herbal medicines.
The document then outlines the various parameters used for evaluating and standardizing unani medicines, including organoleptic, microscopic, physical, chemical and biological evaluations. Specific evaluation methods are described under each parameter such as morphological examination for organoleptic evaluation and determination of values like moisture content and ash for physical evaluation. Thin layer chromatography, high performance liquid chromatography and other spectroscopic techniques are discussed for chemical evaluation.
TLC for chlorinated pesticide determination Bapi Mondal Bapi Mondal
In this assignment file i will demonstrate the process involved in Thin layer chromatography for Chlorinated Pesticide
determination. if u like this work feel free to share this file. thank you.
Standardization of herbal drugs refers to “confirmation of its identity and determination of its quality, purity and detection of nature of adulterant by various parameters”.
The World Health Organization (WHO) Herbal Guideline is a comprehensive and authoritative document intended to provide standardized recommendations and principles for the safe and effective use of herbal medicines worldwide. This guideline is developed by a panel of experts in herbal medicine, pharmacology, and public health, amalgamating the most up-to-date research, traditional knowledge, and clinical evidence available.
In this pdf, you will get information about manufacturing , standardization , validation , processing , etc. for herbal drugs followed by the WHO guidelines.
This document discusses quality control testing methods for determining foreign matter, heavy metals, pesticide residues, phototoxins, and microbial contamination in herbal formulations.
Key tests include determining heavy metals using atomic absorption spectroscopy, pesticide residues using chromatography methods like gas chromatography, and phototoxins like furanocoumarins in celery seed using extraction and chromatography techniques. Acceptable limits for contaminants are set by organizations like WHO.
The document discusses methods for determining various contaminants in herbal formulations, including:
- Foreign matter, heavy metals, pesticide residues, phototoxins, and microbial contamination. Methods include inspection, atomic absorption spectroscopy, chromatography, and plate counting.
- Acceptable limits for contaminants are specified by organizations like WHO. Pesticide residues are determined by extracting samples and analyzing by gas chromatography.
- Phototoxins like furocoumarins are isolated from plants using solvent extraction and identified using thin layer chromatography or column chromatography.
In vitro evaluation techniques are important for screening potential drugs before clinical trials. There are two stages of biological screening - primary and secondary assays - to identify plants with therapeutic activity. Various in vitro assays can evaluate antioxidant and anticancer properties of herbal extracts, including DPPH radical scavenging, MTT, and SRB assays. In vitro methods have advantages over animal models for initial drug screening by reducing animal use and providing reproducible, economical screening of potential drug candidates. While in vitro models cannot fully replace in vivo studies, they provide an important first step in evaluating biological activity of natural products.
Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...Md. Mohabbot Hossen
Since ancient times humanity has depended on the diversity of plant resources for food, clothing, shelter, and traditional medicine to cure myriads of ailments. By using modern science now plant is greatly used in pharmaceutical industries and various test have involved here.
It's about the Standardization of herbal drugs.
It's includes
# Definition of herbs
# Herbal drugs definition
# Herbal technology
# Standardization definition
# Methods of Standardization of herbal drugs
Standardization of Poly Herbal Siddha Medicine Eladhi Chooranaminventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
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3. Quality control of herbal medicines aims
to ensure their consistency, safety and
efficacy.
Chemical fingerprinting has been
demonstrated to be a powerful technique
for the quality control of herbal medicines.
Introduction
4. For the purpose of quality control of herbal drugs, the World Health Organization (WHO)
has prepared the guidelines. The objective of the guidelines involves general test methods
and also the general limits for contaminants in herbal drugs. A typical monograph for herbal
drugs as per WHO Guidelines is as follows:
Monograph for Herbal Drugs as per WHO Guidelines
Introduction
Monograph Title Parameters Types
Botanical
Sensory Evaluation Visual/ Macroscopy/ Touch/
Taste/ Odour/ Size/ Colour
Foreign Matter Foreign plants, animals, minerals
(soil, stones, sand and dust)
Microscopy Histological observation,detection,
measurement of specimens, etc.
5. Introduction
Monograph Title Parameters Types
Physicochemical
TLC Ascending technique, horizontal
technique, etc.
Ash Total, acid insoluble, water-soluble
Microscopy Histological observation,detection,
measurement of specimens, etc.
Extractable matter Hot water, cold water and ethanol
Water content
and volatile
Matter
LOD, Azeotropic
Volatile oils By steam distillation
6. Monograph Title Parameters Types
Pharmacological
Bitterness value Units Ex- To the bitterness of
standard solution of Quinine
hydrochloride
Haemolytic Activity On Ox blood by comparison
with standard saponin
Astringency Fraction (Tannins) that binds to
standard hide powder
Swelling Index In water
Foaming Index Foam height produced by 1 gm
material under specified
conditions
Monograph
7. Monograph
Monograph Title Parameters Types
Toxicological
Pesticide residue Total organic chloride and total
organic
Phosphorus
Arsenic Stain produced on HgBr2
paper in comparison to
standard stain
Heavy metals Cadmium and Lead
Microbial Contamination
Aerobic count pathogen Enterobacteriaceae -
Escherichia coli, Salmonella,
Staphylococcus,
Pseudomonas
Aflatoxins TLC using standard Aflatoxins
(B;, Bz, G;, G2) mixture
8. Monograph
Monograph Title Parameters Types
Radioactive
contamination
Microbial growth in herbals can be avoided by irradiation.
Nature
and the intensity of irradiation depend on the source. The
radioactivity of the plant samples should be checked
according to
the guidelines of the International Atomic Energy Agency
(IAEA),
Vienna, Austria.
9. THANKS!
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