Dermo, caused by the protozoan Perkinsus marinus, is a disease that infects and kills oysters. It was first observed in Wellfleet Harbor in the 1970s. Temperature and salinity are key environmental factors influencing Dermo outbreaks, with warmer temperatures and higher salinities increasing infection rates. As climate change causes waters to warm, conditions are expected to become more suitable for Dermo, potentially leading to increased outbreaks in Wellfleet Harbor in the future. Monitoring programs could help track and manage potential future Dermo issues in the harbor.