Waldridge.aafp slc 2013
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Kentucky president Ron Waldridge hopes to have God and Kentucky on his side in advancing collaborative agreements (CAs) between physicians and other providers in the state. The document discusses the history of CAs in Kentucky, recent legislative successes in passing bills to curb pill mills and hiring a KAFP lobbyist. It outlines goals of making CAs optional, establishing a joint committee between medical associations, and requiring 5 years of experience under a physician for CAs.
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The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Pharmacology of Prostaglandins, Thromboxanes and Leukotrienes
This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
Can Traditional Chinese Medicine Treat Blocked Fallopian Tubes.pptx
There are many traditional Chinese medicine therapies to treat blocked fallopian tubes. And herbal medicine Fuyan Pill is one of the more effective choices.
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Fexofenadine is sold under the brand name Allegra.
It is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the blood–brain barrier and causes lesser sedation, as compared to first-generation antihistamines.
It is on the World Health Organization's List of Essential Medicines. Fexofenadine has been manufactured in generic form since 2011.
Breast cancer :hormonal discordance.pptx
Receptor Discordance in Breast Carcinoma During the Course of Life
Definition:
Receptor discordance refers to changes in the status of hormone receptors (estrogen receptor ERα, progesterone receptor PgR, and HER2) in breast cancer tumors over time or between primary and metastatic sites.
Causes:
Tumor Evolution:
Genetic and epigenetic changes during tumor progression can lead to alterations in receptor status.
Treatment Effects:
Therapies, especially endocrine and targeted therapies, can selectively pressure tumor cells, causing shifts in receptor expression.
Heterogeneity:
Inherent heterogeneity within the tumor can result in subpopulations of cells with different receptor statuses.
Impact on Treatment:
Therapeutic Resistance:
Loss of ERα or PgR can lead to resistance to endocrine therapies.
HER2 discordance affects the efficacy of HER2-targeted treatments.
Treatment Adjustment:
Regular reassessment of receptor status may be necessary to adjust treatment strategies appropriately.
Clinical Implications:
Prognosis:
Receptor discordance is often associated with a poorer prognosis.
Biopsies:
Obtaining biopsies from metastatic sites is crucial for accurate receptor status assessment and effective treatment planning.
Monitoring:
Continuous monitoring of receptor status throughout the disease course can guide personalized therapy adjustments.
Understanding and managing receptor discordance is essential for optimizing treatment outcomes and improving the prognosis for breast cancer patients.
Nutritional deficiency disorder in Child
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
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2nd-generation Antihistaminic Part I.pptx
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
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Helminthiasis or Worm infestation in Children for Nursing students
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All about shoulder joint , Anatomy ,Examination, Special tests and radiology.
Spontaneous Bacterial Peritonitis - Pathogenesis , Clinical Features & Manage...
In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
The reference for this presentation is Sleisenger and Fordtran's Gastrointestinal and Liver Disease Textbook ( 11th edition ).
mortality & morbidity indicators of health .pptx
Indicators for measurement of health including mortality, morbidity an d disability
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Waldridge.aafp slc 2013
- 1. Kentucky Staying in the Union Ron Waldridge, II, MD President Kentucky Academy of Family Physicians
- 2. “I hope to have God on my side, but I must have Kentucky.” Born: February 12, 1809, Hodgenville, KY Height: 6' 4" (1.93 m) Assassinated: April 15, 1865, Spouse: Mary Todd Lincoln of Lexington, KY
- 4. Where We Have Been • History of CA-NS & CA-CS • Deloitte Study – WAMI Study • Media – Courier Journal – Video
- 5. Where We Are • Pill Mill Bill – Governor’s – Senate President • Hiring KAFP Lobbyist – Opening Doors • Push for Being 18 • Freeze – Education/Training Difference – PCMH
- 6. Where We Hope To Be • Opt In • Joint Working Committee of KBML & KNA • 5 Years under a CA with a Physician
- 7. Where We Hope To Be • Opt In • Joint Working Committee of KBML & KNA • 5 Years under a CA with a Physician
Editor's Notes
- Skillman, Susan et. al. “Understanding Advanced Practice Registered Nurse Distribution in Urban and Rural Areas of the United States Using National Provider Identifier Data”. WWAMI Rural Health Research Center, February 2012. Stated, “… showed that ARNP will go into areas that physician will not." Bill Crump looked at study and concluded, “First, comparing ARNPs and CRNAs is much worse than apples and oranges, and should not be included in the same report. The data in Table 2 [WAMI Study] does not support the conclusion that is presented in the section on rural practice for ARNPs. In fact, the data show that more independent practice is NOT associated with more rural practice, so the conclusion is unfounded. With a study this large, the "crossing of 1" in the relative risk is fairly strong evidence AGAINST their conclusion. To their credit, they infer this but not clearly enough.” Deloitte – Recommendation 7.1 – Improve professional licensure data quality and reporting across all workforce groups 7.2 – Promote additional limited service clinics to expand access in rural/underserved areas 7.3 – Create support programs for small practices in rural and underserved areas 7.4 – Increase/Expand Medicaid reimbursement for rural areas and technology-driven care 7.5 – Expand programs to engage international medical graduates in rural and underserved areas 7.6 – Address scope of practice limitations for mid-level practitioners 7.7 – Evaluate medical malpractice caps 7.8 – Expand loan forgiveness programs to improve distribution in rural and underserved areas 7.9 – Enhance programs that support recruiting for retention 7.10 – Expand regional rural health tracks to improve rural pipeline and retention 7.11 – Increase health care degree and residency capacity across the Commonwealth