This document discusses homeopathic treatment for vitiligo. It summarizes a study of 80 vitiligo patients treated with homeopathic medicines. Key findings include:
1) The most commonly prescribed medicines were Natrum mur, Pulsatilla, Lycopodium, Arsenic album and Sulphur.
2) 23% of patients shifted from the active stage to the static stage, 42% shifted from static to recovery, and 12% remained static.
3) 52% of patients achieved remission with no new or spreading lesions for at least 6 months, and 8% achieved remission for over 2 years.
4) The study shows the efficacy of homeopathic medicines in achieving remission
Ppt for MD DERMATOLOGY Residency. includes basics of topical preparations in dermatology. made as a part of curriculum of MD dermatology. includes all definitions, classification, mechanism , uses and side effects. based on rooks, IADVL, and many articles.
Cysts with a lining of stratified squamous epithelium: Epidermoid cyst
Milium
Trichilemmal cyst
Vellus hair cyst
Steatocystoma
Dermoid cyst
Cysts lined with non-stratified squamous epithelium: Hidrocystoma, Eccrine or Apocrine
Cysts without an epithelial lining: Mucocele
Digital mucous cyst
Ganglion
Hereditary disorder of keratinization characterized by expanding atrophic anular patch(es) surrounded by prominent keratotic ridge called the cornoid lamella
This presentation includes -classification, biological in psoriasis,TNF alpha inbitors, T cell inhibitos, IL-12/23 inhibitors (indications,containdications,guidelines, adverse effects)
skin is an organ where internal disorders are manifested. some are early signs, some are late signs, some may be the only manifestation. they can result in diagnostic dilemma.
Vitiligo, a commonde pigmenting skin condition, has an estimated prevalence of 0.5–2 of the population worldwide. The disease is marked by the selective loss of melanocytes which results in typical nonscaly, chalky white macules. In recent years, tremendous progress has been made in our understanding of the aetiology of vitiligo which is now clearly characterised as an autoimmune disease. Vitiligo is typically overlooked as a cosmetic disease, although its effects can be mentally devastating, often with a major bur den on everyday living. In 2011, a worldwide consensus classified segmental vitiligo separately from all other forms of vitiligo, and the term vitiligo was defined to designate all kinds of nonsegmental vitiligo. This review highlights the existing knowledge on vitiligo and strives to give an overview of vitiligo. Miss. Pranjali D Thakare | Mr. Sharukh A Khan | Mr. Ram G. Kale | Mr. Sachin S. Pawar "Vitiligo: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd61317.pdf Paper Url: https://www.ijtsrd.com/pharmacy/pharmacology-/61317/vitiligo-a-review/miss-pranjali-d-thakare
Ppt for MD DERMATOLOGY Residency. includes basics of topical preparations in dermatology. made as a part of curriculum of MD dermatology. includes all definitions, classification, mechanism , uses and side effects. based on rooks, IADVL, and many articles.
Cysts with a lining of stratified squamous epithelium: Epidermoid cyst
Milium
Trichilemmal cyst
Vellus hair cyst
Steatocystoma
Dermoid cyst
Cysts lined with non-stratified squamous epithelium: Hidrocystoma, Eccrine or Apocrine
Cysts without an epithelial lining: Mucocele
Digital mucous cyst
Ganglion
Hereditary disorder of keratinization characterized by expanding atrophic anular patch(es) surrounded by prominent keratotic ridge called the cornoid lamella
This presentation includes -classification, biological in psoriasis,TNF alpha inbitors, T cell inhibitos, IL-12/23 inhibitors (indications,containdications,guidelines, adverse effects)
skin is an organ where internal disorders are manifested. some are early signs, some are late signs, some may be the only manifestation. they can result in diagnostic dilemma.
Vitiligo, a commonde pigmenting skin condition, has an estimated prevalence of 0.5–2 of the population worldwide. The disease is marked by the selective loss of melanocytes which results in typical nonscaly, chalky white macules. In recent years, tremendous progress has been made in our understanding of the aetiology of vitiligo which is now clearly characterised as an autoimmune disease. Vitiligo is typically overlooked as a cosmetic disease, although its effects can be mentally devastating, often with a major bur den on everyday living. In 2011, a worldwide consensus classified segmental vitiligo separately from all other forms of vitiligo, and the term vitiligo was defined to designate all kinds of nonsegmental vitiligo. This review highlights the existing knowledge on vitiligo and strives to give an overview of vitiligo. Miss. Pranjali D Thakare | Mr. Sharukh A Khan | Mr. Ram G. Kale | Mr. Sachin S. Pawar "Vitiligo: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd61317.pdf Paper Url: https://www.ijtsrd.com/pharmacy/pharmacology-/61317/vitiligo-a-review/miss-pranjali-d-thakare
vitiligo is the chronic skin disease . people get confusion about leprosy and vitiligo so in this slide describe about both the disease through the picture
Mucocutaneous Involvement in Behcets Diseasenavasreni
Behçet’s disease is a chronic inflammatory disease characterized by its clinical polymorphism associating mucocutaneous involvement to systemic manifestations. The mucocutaneous lesions are considered the hallmark of the disease, being the most common symptoms presenting at the onset of disease. Our objective was to determine the characteristics of this skin involvement during Behçet’s disease. We conducted a descriptive study over a period of 30 years, having collected all patients with Behçet’s disease.
Mucocutaneous Involvement in Behcets Diseasepateldrona
Behçet’s disease is a chronic inflammatory disease characterized by its clinical polymorphism associating mucocutaneous involvement to systemic manifestations. The mucocutaneous lesions are considered the hallmark of the disease, being the most common symptoms presenting at the onset of disease. Our objective was to determine the characteristics of this skin involvement during Behçet’s disease
Mucocutaneous Involvement in Behcets Diseasekomalicarol
Behçet's disease is a chronic inflammatory disease characterized by
its clinical polymorphism associating mucocutaneous involvement
to systemic manifestations. The mucocutaneous lesions are
considered the hallmark of the disease, being the most common
symptoms presenting at the onset of disease. Our objective was
to determine the characteristics of this skin involvement during
Behçet's disease. We conducted a descriptive study over a period
of 30 years, having collected all patients with Behçet's disease.
These were 98 patients. A male predominance was observed in
our studied population with a Sex Ratio of 2.5. The mean age at
diagnosis was 34 years. Mucocutaneous involvement was observed
in all patients. Oral aphthosis was constant and genital ulcers, were
observed in 81 cases. The other mucocutaneous manifestations
were: pseudofolliculitis (61 cases), erythema nodosum (7 cases),
skin ulcers (4 cases), acneiform lesions (2 cases), perianal ulcers (1
case), skin ulceration (1 case) and erythema multiforme. (1 case).
All of our patients were treated with colchicine. Corticosteroids
and non-steroidal anti-inflammatory drugs were each indicated in
one case for resistant forms
Mucocutaneous Involvement in Behcets Diseasesemualkaira
Behçet's disease is a chronic inflammatory disease characterized by
its clinical polymorphism associating mucocutaneous involvement
to systemic manifestations. The mucocutaneous lesions are
considered the hallmark of the disease, being the most common
symptoms presenting at the onset of disease. Our objective was
to determine the characteristics of this skin involvement during
Behçet's disease. We conducted a descriptive study over a period
of 30 years, having collected all patients with Behçet's disease.
These were 98 patients. A male predominance was observed in
our studied population with a Sex Ratio of 2.5. The mean age at
diagnosis was 34 years. Mucocutaneous involvement was observed
in all patients. Oral aphthosis was constant and genital ulcers, were
observed in 81 cases. The other mucocutaneous manifestations
were: pseudofolliculitis (61 cases), erythema nodosum (7 cases),
skin ulcers (4 cases), acneiform lesions (2 cases), perianal ulcers (1
case), skin ulceration (1 case) and erythema multiforme. (1 case).
All of our patients were treated with colchicine. Corticosteroids
and non-steroidal anti-inflammatory drugs were each indicated in
one case for resistant forms.
The Vitiligo Research Foundation Handbook
for answering the most common questions on Vitiligo
• Question
• Key points
• Answer
• Sources and essential
further reading
Get Rid Of White Patches On Skin - Vitilito Frequently Asked QuestionsBernardo Valdes
Get Rid Of White Patches On Skin - Vitiligo Frequently Asked Questions. In This Slide Presentation. We Answer Questions Like. What Causes Vitiligo. What Are The Treatment Options. We Give You A Treatment Solution For Vitiligo.
Trends in management of rheumatoid arthritis Dr.Neena Mehan
Rheumatoid Arthritis (RA) is an auto-immune disease in which body mistakenly considers some parts of its own system as pathogens and attacks them.
LESSER KNOWN PEARLS OF WISDOM OF MATERIA MEDICA found in WORKS OF BOENNINGHAU...homoeopathyenewsletter
LESSER KNOWN PEARLS OF WISDOM OF MATERIA MEDICA found in WORKS OF BOENNINGHAUSEN
FROM
DR. ANJU JETHANISENIOR MEDICAL OFFICER,
Medical center, high court of delhi, dte. of ayush, gnct of delhi
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
1. INTRODUCTION
VITILIGO - A HOMEOPATHIC PERSPECTIVE
BACKGROUND
Based on dermatological outpatient
records, the incidence of vitiligo is found to
be 0.25-2.5% in India.Vitiligo occurs world
wide with an overall prevalence of
1% The highest incidence of the
condition
has been recorded in Indians from the
Indian subcontinent, followed by Mexicans
and Japanese.There is a stigma attached
to vitiligo and affected persons
and family.This disorder does not result
in restriction of capacity to work or
expectancy of life, but it
causes cosmetic disfigurement leading
to psychological trauma to the
patients.The spread of the disease
can be arrested and substantial amount of
repigmentation can be achieved in majority
of patients who undergo appropriate
treatment.
This paper unearthes homeopathic
treatment as a most viable treatment
modality in vitiligo .
Vitiligo is an acquired autoimmune
depigmentary condition characterized by
appearance of chalky or milky white
macules with well defined margins of
varying sizes and shapes.It has familial
predisposition. It is the only skin disease
which does not itch, pain or give any kind
of physical discomfort.
AIMS AND OBJECTIVE
Study design and settings
80 self reporting vitiligo patients attending out patient
department of a hospital were selected for the study.
It was a observational, descriptive study done in OPD of
SHMC.for a period of three yrs (April 2010 to march 2013.)
INCLUSIVE CRITERIA
Well diagnosed cases of vitiligo were taken for study. The
patients reported in three different stages:
V1 – Active stage, lesion size increasing and borders ill-defined
and hypo pigmented.
V2 - No new lesion, lesions stationary in size. Static stage.
V3- Lesions decreasing in size, no new lesion, re-pigmentation
of margins which become well defined. It is a recovery stage.
EXCLUSIVE CRITERIA
Albinism
Nevus achromicus
Tenia versicolor
Leprosy
Pityriasis alba
Lichen scelerosis
Piebaldism
Data collection The demographic and clinical data of the
patients were collected using a data collection form and also
from the medical records of patients.
MATERIALS AND METHODS
1) To highlight the efficacy of homeopathic medicines in
achieving and maintaining the remission state in natural
course of vitiligo.
2) The objective of the present study was to assess the
prevalence, precipitating factors clinical features
and concomitant disease in vitiligo patients.
CASES
Sulphur 200
Natrum mur 200
Lachesis 200
Natrum mur 200
3. Associated systemic(autoimmune) and cutaneous diseases
were observed in 38.8% of the patients.Thyroid disease being
the most common(17.3%) followed by diabetes mellitus (15.8%).
Association of Koebner phenomenon was observed in 20%
of the patients which is a common feature of active stage
(progressive) .
The associated cutaneous diseases noted in this study were
Alopeciaareata (12.5%), leukotrichia (6.3%). Leukotrichia is
considered to be a poor prognostic,factor.,atopic dermatitis (3.8
%),pruritis in (2.3%).
The distribution pattern of lesions which denotes the clinical
types of vitiligo were.
Vitiligo vulgaris / generalized vitiligo(53.7%) the most
common morphological pattern. Other patterns seen were
focal vitiligo (18.8%)
acrofacial vitiligo (13.8%),
segmental vitiligo (8.8%),
mucosal vitiligo (3.8%)
The most common site of onset of vitiligo lesion was
lower limbs (42.5%), followed by face (27.5%), upper limbs
(13.8%), finger
tips (7.5%), trunk (3.8%), scalp (2.5%), and genital mucosa (2.5
%) in the descending order of frequency
Drug analysis:
Medicines found to be most effective
Nat Mur=42% cases Pulsatilla=28%
Lycopodium=8 % arsenic album=6%
Sulphur=17% Tuberculinum-6%
Sepia=4 Medorrhinum=4%
Lachesis=3% Natrum silicate=2%
Nux Vom=2% Baryta sulph=2%
23%of patients shifted fromV1 to V2, 42%from V2 to V3 and
12% remained static in V2stage.92%patients completed the
study.52%of patients went into remission and there was no
appearance of new lesion and spread of old lesion for a
minimum period of 6 months.8% of patients had remission
of as long as period of 2 yrs.
CONCLUSION
This study shows the efficacy of
Homoeopathic medicines in
achieving remission, preventing
recurrence and checking its
further progression.
Prospectus for future: To study the
role of homeopathic medicines as
immunomodulators in the natural
course of vitiligo.
Key words: depigmentation,
autoimmunity, leucotrichia, koebners
phenomenon, constitutional
treatment, repigmentation,
remission,concomitant disease
ACKNOWLEDGEMENT
I express my gratitute to Dr V.K
Chauhan,principal,SHMC for his
constant support and encouragement
throughout the project.
I am thankful to Dr S.N.Jana,(co
guide) ,Drs pavneet,arushi
,kalpna,meenakshi parvez,neha
richa,himanshuand manu interns
who have helped me in the OPD.
Dr Neena Mehan
Asst.professor
Department of medicine,SHMC
Project guide
Sepia 200
Natrum mur 200
Calcarea silicata
Staph 200