ICAO is working to establish a more seamless and global air traffic management (ATM) system through initiatives like the Global ATM Operational Concept and Global Air Navigation Plan. As the ATM system grows more complex, ICAO is also evolving its approach to safety to be more proactive and predictive through requirements for states to establish safety programs and for aviation organizations to implement safety management systems that identify hazards, ensure remedial actions, and continuously monitor safety performance. The presentation outlines ICAO's efforts to enhance both the efficiency and safety of the growing global ATM system.