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Vidalista 5 Mg contains 5mg of Tadalafil as its active ingredient. Tadalafil is a drug that relaxes smooth muscles in blood vessel walls thus improving blood flow to certain body parts.
Vidalista (Generic Tadalafil Tablets) is an oral medicine that is used for treating impotence (the inability to attain or maintain a penile erection). You can choose to take it on an as needed basis or take a low dose version everyday, so that you can be ready anytime.
Cialis 20mg for use as needed was shown to increase erectile function compared to placebo up to 36 hours following dosing. Therefore, when advising patients on optimal usage of Cialis, this should be taken into consideration.
Vidalista 60, powered by Tadalafil, is the maestro of intimacy. Taken 30 minutes before, it orchestrates extended passion for up to 36 hours. With a 60mg dose, it's a personalized crescendo, offering a weekend of heightened pleasure and satisfaction.
Vidalista 60, a marvel of intimacy, is fortified with Tadalafil, transforming moments of connection.
This 60mg dynamo, consumed 30 minutes prelude to passion, directs a symphony of increased blood flow, granting up to 36 hours of heightened pleasure. It's not just a pill; it's a tailored experience.
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Tadalafil is a prescription medication which is FDA-approved to treat the following in men: erectile dysfunction (ED), a condition in which you can’t get or keep an erection, symptoms of benign prostatic hyperplasia (BPH), a prostate condition that may cause problems with urination and ED and symptoms of BPH together.
Tadalafil's effect starts working in 30 minutes and lasts for upto 36 hours. Tadalafil can also be used daily by using the 5 mg dose, so you can be ready anytime. It’s available in three strengths: 5mg, 10 mg and 20 mg. It is also available as an Oral jelly in the strength of 20 mg.
Tadalafil tablets are also indicated to improve the ability to exercise in adults with Pulmonary Arterial Hypertension (PAH).
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Buy Tadalista 10 mg (PDE-5 inhibitor) is an active salt in Tadalista 10 Mg tablet which is increases the blood flow to the penis by relaxing the muscles in penile blood vessels hence, treating Erectile Dysfunctioning. It also treats pulmonary hypertension by relaxing the blood vessels in the lungs to allow blood to flow more smoothly.
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Generic Tadalafil Medications to Effectively Treat Erectile DysfunctionThe Swiss Pharmacy
Generic Tadalafil is a prescription medication which is FDA-approved to treat the following in men: erectile dysfunction (ED), a condition in which you can’t get or keep an erection, symptoms of benign prostatic hyperplasia (BPH), a prostate condition that may cause problems with urination and ED and symptoms of BPH together.
Tadalafil's effect starts working in 30 minutes and lasts for upto 36 hours. Tadalafil can also be used daily by using the 5 mg dose, so you can be ready anytime. It’s available in three strengths: 5mg, 10 mg and 20 mg. It is also available as an Oral jelly in the strength of 20 mg.
Tadalafil tablets are also indicated to improve the ability to exercise in adults with Pulmonary Arterial Hypertension (PAH).
Effectively Treat Erectile Dysfunction With Tadalafil MedicationsClearsky Pharmacy
Tadalafil is a prescription medication which is FDA-approved to treat the following in men: erectile dysfunction (ED), a condition in which you can’t get or keep an erection, symptoms of benign prostatic hyperplasia (BPH), a prostate condition that may cause problems with urination and ED and symptoms of BPH together.
Tadalafil's effect starts working in 30 minutes and lasts for upto 36 hours. Tadalafil can also be used daily by using the 5 mg dose, so you can be ready anytime. It’s available in three strengths: 5mg, 10 mg and 20 mg. It is also available as an Oral jelly in the strength of 20 mg.
Tadalafil tablets are also indicated to improve the ability to exercise in adults with Pulmonary Arterial Hypertension (PAH).
Buy Vidalista 10 mg (Tadalafil) relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Tadalafil out cold the declare of is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (augmented prostate). Different brand of tadalafil is Adcirca, which is handled to treat pulmonary arterial hypertension and postscript taking place exercise capacity in men and women.
Tadali (Generic Tadalafil Tablets) is a PDE5 inhibitor prescribed for the treatment of erectile dysfunction (ED), also known as impotence, in men 18 years and above. This is when a man cannot get, or maintain, a hard erect penis suitable for sexual activity.
It is also approved by the US FDA for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction when the conditions coincide. This medicine is also used for the treatment of pulmonary arterial hypertension.
Buy Tadalista 5mg Tadalafil (PDE-5 inhibitor) is an active salt in Tadalista 5Mg tablet which is increases the blood flow to the penis by relaxing the muscles in penile blood veins hence, treating Erectile Dysfunctioning. It also treats pulmonary hypertension by relaxing the blood vessels in the lungs to allow blood to flow more smoothly.
Buy Tadalista 5mg dose is 5 to 20 mg orally once a day, as needed, prior to sexual activity based on individual efficacy and tolerability. For daily use for Erectile Dysfunction and Benign Prostatic Hyperplasia (BPH): Use 5 mg orally once a day at the same time, without regard to timing of sexual activity. Adult Dose for Pulmonary Hypertension: Use 40 mg orally once a day.
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I-Introduction
II. Pharamacodynamics
III. Pharmacokinetics
IV. Therapeutic Indications
V. Precautions & Adverse Reactions
VI. Drug Interactions
VII. Summary
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Buy Tadalista 10 mg (PDE-5 inhibitor) is an active salt in Tadalista 10 Mg tablet which is increases the blood flow to the penis by relaxing the muscles in penile blood vessels hence, treating Erectile Dysfunctioning. It also treats pulmonary hypertension by relaxing the blood vessels in the lungs to allow blood to flow more smoothly.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
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