The Vanguard Initiative aims to advance economic growth and industrial renaissance in Europe through a new cluster policy and smart specialization strategies. A recent workshop emphasized the importance of cross-sector collaboration, innovative value chains, and result-oriented approaches to promote competitiveness, investment, and market access for SMEs. The initiative supports the development of interregional networks and public-private co-investments to enhance the EU's global competitiveness and integrate regional clusters into the broader European growth agenda.