The 1400s saw major global exploration as regions like Africa, North and South America, and Australia remained unknown. Christopher Columbus embarked on an expedition in 1492 with three ships and 50 men seeking new trade routes with Asia to acquire gold, spices, and fabrics. He also hoped to spread Christianity and gain land, wealth, and scientific knowledge. While arriving in Spain in 1493, Columbus made first contact with indigenous peoples in the Americas, unintentionally exposing them to diseases that devastated their populations.