Pharmacognosy & Phytochemistry -I Sem -IV

1. Welcome
Pharmacognosy
Introduction, History, Scope &
Development of Pharmacognosy
Presented By:
Dept. of Pharmacognosy,
Mr.Vishal H Thorat
Bharati Vidyapeeth College of Pharmacy,Kolhapur

2. Definition :
Pharmacy is the science of drug making / deals with their
procurement (bring about), testing, storage and conversion into
suitable forms ( tablets, capsules, emulsions etc)
Drug :
Any substance used in the treatment of disease or diagnosis is
known as drug . Diagnosis is the determination of nature of
disease.
Crude drug
It is the simple drug ,crude drugs are plant, animal and their
parts which after collection are subjected only to drying or
making them into transverse or longitudinal pieces or peeling
(stripping off skin or bark).They exist in natural forms.

3. Pharmacognosy:
• Pharmacognosy is the science of drugs of biological origin ( plant,
animal, mineral) or The word pharmacognosy was coined in 1815
by
a German Scientist SEYDLER has been derived from two Greek
words , Pharmacon ---- ‘ a drug, gignosco – ‘ acquire the
knowledge of
•Pharmacognosy is the subject of crude drugs obtained from the plants
(vegetable), animal and mineral origin. Or It can also defined as the
objective study of crude drugs of the natural sources processed
scientifically.
•Pharmacognosy is the study of medicinal use of various naturally
occurring drugs its history, sources, distributions, method of
cultivation, active constituents, medicinal uses, identification test,
preservation methods, substituents and adulterants.

4. HISTORICAL DEVELOPMENT OF PHARMACOGNOSY
History of pharmacognosy represents the history of pharmacy & medicine.
Pharmacognosy had its origin in the health-related activities of the most
primitive human race of the remote past.
They acquired knowledge of medicinal properties of plants in the following way
a)By guesswork or trial & error
b) While searching for food
c)By superficial resemblance between the plant parts & the affected organs,
that is, by examining the “Signature of Nature”
d)By observing other animals instinctive(natural) discrimination(taste) between
toxic & palatable(edible) plants.
e) By accidental discovery

5. The Babylonians were aware of the Medicinal effects of a number of
plants.
Ancient Egyptians possessed a sound knowledge of human anatomy as
well as a knowledge of the medicinal uses of many plants and animals.

6. •Papyrys Ebers- written in 1550 B.C. (16th century) & discovered in a
tomb of a mummy, much has been said about the- skill and knowledge
of those people in this field.
• it contain more than 800 formula & 700 different drug.
In India, the study of the drugs was started about 5000 years ago at the
time of the Vedas. Ayrurvedic system (1200 B.C. Ago list with 127
plants.)
Charaka, 50 grups of 10 herbs each for illness.(Charak Samhita)
Sushruta, 7 grps of 760 herbs based on properties of plants. (Sushruta
Samhita)

7. •Hippocrates (460 - 370 B.C.) deals with
anatomy and physiology in many of his
treatises.“Father of Medicine”
•Aristotle (384 - 322 B.C.), the great philosopher
wrote much about the animal kingdom and his
writings were placed on scientific footing free
from all superstitions.
•Theophrastus (370-287 B.C.) wrote about plants
and described medicinal uses of plants.

8. Dioscorides a Greek physician of the1st Century A.D. was the writer
of the first Materia Medica (40-80 A.D.) Here he described 600
medicinal plants, including Belladona, Colchicum, Opium,
Hyoscyamus, etc.
• C.A.Seydler, German scientist, amedical student at Halle,Germany
in 1815;wrote his doctoral thesis titled Analectica
Pharmacognostica
•Swede Linnaeus (1707 – 1778) the great systamtist classified the
plant & introdused system of naming the plant known as binomial
system.

9. •Galen (131 -200 A.D.) the first Pharmacist, who described the
method of preparing drugs of vegetable and animal origin and laid
down many formulas contained in a treatise(thesis) of 20 volumes.
•Pen Ts’ao Kang Moa 1000 B.C. (published only at 1597) contained an
incredible number of medicinal plants and drugs of animal origin. The
Chinese thought that for every disease, there must be a drug is only
provided by the nature.
•Plant Classification was developed by Benthan & Hooker (1862 –
1863), A.W. Eichler (1883), Engler & Prandtl (1887 – 1898)
•In 1865, G. Mendel’s important observation on plant hybrids

10. •Letter, Voehl, Tschirch & others, reported anatomica l cheracters of
several powdered drug.
• “An Anatomical Atlas of Powdered & Vegitable Drugs” was
complied by Greenish & Colin”
•In China, medicinal plants uses since 5000 B.C..
•The oldest document “Pentaso” written by Shen nung.

12. SCOPE OF PHARMACOGNOSY
• Pharmacognosy has broad scope in the field of pharmacy
such as :
1. ISOLATION OR ANALYSIS OF PHYTOCHEMICAL :
•
• Eg ;Strong acting substances such as glycosides from
digitalis leaves,
• Alkaloids from the plants of Belladonna, Hyocyamus,
Rauwlofia
• Morphine and other alkaloids from the plant opium were
isolated and clinical uses studied

13. 2. STRUCTURE ACTIVITYRELATIONSHIP :
Eg :Tubocurarine and Toxiferine from curare
plant have muscle relaxant properties because
of quaternary ammonium groups.
The hypotensive and tranquillizing actions of
reserpine are due to the trimethoxy benzoic
acid

14. 3. DRUGS OBTAIN:ED BYPARTIALSYNTHESIS OF NATURAL
PRODUCTS:
Eg : Preparation of Steroid hormones from diosgenin by
acetolysis and oxidation and further preparation of
cortisone by microbial reactions.
4. NATURALPRODUCTS AS MODELS FOR SYNTHESIS OF NEW
DRUGS :
Eg: Morphine is the model of a large group of potent drugs .
Cocaine for local anaesthetics
Atropine for certain spasmolytics

15. 5. DRUGS OF DIRECT THERAPEUTIC USES :
•
• Among the natural constituents which even now cannot be
replaced are important group of antibiotics, steroids, ergot
alkaloids, vincristine etc
6. BIOSYNTHETIC PATHWAYS INVESTIGATION :
•
• Biosynthetic pathways are of primary and secondary
metabolites.
• Some of the important pathways are Clavin ‘s cycle of
photosynthesis,
• Shikimic acid pathway of aromatic compounds.

16. •
•
Acetate hypothesis for antharacene glyco sides
Isoprenoid hypothesis for terpens
• 7.C ULTIVATION AND C OLLECTION OF MEDICINAL PLANTS :
• clove, cinchona ,cinnamo n, senna, opium, etc
• 8. PREPARATION OF HERBAL FORMULATIONS :
• churnas, asvas, aristas, leha, etc
• 9. DEVELOPMENT OF TISSUE CULTURED PL ANTS
• 10. Indigunious system of Medicine: WHO utilize system of medicine
based on the locally available raw material, like medicinal plant
• 11. Novel medicine: it is infrastructure of novel medicine which depends
on evaluation.

18. Development of Pharmacognosy
Modern Pharmacognosy occurred during 1934 - 1960.
This development was mainly due to some events like:
Discovery of Penicillin in 1928
Isolation of Resperine 1952
Anticancer properties of Vinca rosea
Discovery of Dioscorea was utilized to prepare semi-
synthetic steroidal hormones.

19. Development of Pharmacognosy
•Pharmacognosy as an applied science.
•It played a crucial role in the development of different disciplines of
science.
•Pharmacognosy is an imp link between Pharmacology and Medicinal
Chemistry

20. Development of Pharmacognosy
Natural products got more and more therapeutic importance with
developments like:
Isolation of therapeutically active constituents
Their identification and structure elucidation.
There is close link between structure and Pharmacological action.

21. Development of Pharmacognosy
Natural products served the purpose of precursor for synthesis
of several medicinally important compounds.
Some isolated components from plants were made into different
formulations and used as drugs.

22. Development of Pharmacognosy
Step by step processes in biosynthesis of Primary &
Secondary metabolites were presented before the world.
Invention of microscopy and different chemical test reagents.

23. Development of Pharmacognosy
Knowledge of
• Plant taxonomy
• Plant breeding (propogation
• Plant pathology
• Plant genetics
Is helpful in the development of cultivation technology
for medicinal and aromatic plants.

24. Alternative and Complementary systems
of medicine
(aka folk medicine, traditional medicine)
Ayurveda,
Unani,
Siddha,
Homeopathy,
Chinese medicine
Aromatherapy.

25. Ayurvedic system of medicine
The word ‘veda’ means knowledge. It evolved from 4 Vedas namely:
Rigveda, Samaveda, Yajurveda and Atharvaveda.
It deals with the diseases, injuries, fertility, sanity and health.
History of Ayurveda
Texts of Charaka and Sushruta
Charaka (1st century A.D.) wrote Charaka Samhita (samhita-
meaning collection of verses written in Sanskrit).
Sushruta (4th century A.D.) Sushruta Samhita.
2000 plants that were used in healing diseases and abating symptoms
were identified in these books.

26. Ayurvedic Dosage Forms
Various dosage forms according to its physical status of
product
1. Solid dosage form: Vati, Churna, bhasma, Kshara
2. Semisolid dosage form: Avleha, ghirta
3. Liquid dosage form: Taila, Asava-arista, Arka

27. Unani System of Medicine
System of medicine which was developed during Arabian
civilization.
In Europe it is known as Arab medicine.
It is based on well-established knowledge and practices
relating to the promotion of positive health and prevention
of diseases.
Traditional medicines in Egypt, Syria, Iraq, Persia, India,
China and other Middle East countries.

28. The system of medicine was documented in Al-Qanoon, a
medical Bible, by Sheikh Ali Sina (Avicena, 980-1037 AD),
and Razi (Rhazes, 850-923 AD) and in many other books
written by the Unani physicians. The literature of the Unani
system is mostly found in Arabic, Persian and Urdu
languages.
It is also based on use of herbs and minerals.
Basic principle is to treat root cause rather than symptoms.

29. Homoeopathic System of Medicine
Hahnemann (1790)
Homoeo (similar) pathos (suffering).
Based on law of Simular's,
“Similia Similibus Curantur”
Effect of antimalarial drug cinchona on his healthy body.
Surprisingly,he found symptoms of malaria developing in
him which disappeared after he discontinued the drug. He
continued his research in that direction by studying the
effect of different substances on this close friends and
relatives and ultimately published his discovery in 1796.

30. Theory and Basic Concept
The doctrine of Similia Similibus Curantur (Let like be treated by like)
is the basic foundation of it.
A tree cannot be destroyed by just cutting it’s branches or roots
because the branches may sprout again.
Uprooting is necessary if the tree is to be destroyed permanently.
In the same way, a disease will not recur if the root cause of the
disease is removed completely from the patient.

31. Potencies and Dilution
Sources of Homeopathic medicines
Plant kingdom: Various morphological parts of plants, fungi, etc.
Animal kingdom: Secretion, saliva, poisons and whole animal, etc.
Minerals and chemicals: Inorganic salts, non-metals, acids and
mixtures etc.
Important Homeopathic drugs and their uses
Allium cepa: Allergies and hay fever
Arnica spp:. Aches, pain
Atropa belladonna: Headache, fever
Borax: Ulcers
Calendula: Antiseptic
Rauwolfia: Hypertension
Urtica urens: Burn treatment

32. Siddha System of Medicine
One of the most ancient recorded herbal systems of medicine,
dating back to pre-Ayurvedic period.
It is believed to be developed with the ancient civilization of
Mohenjodaro hadappa in the Indus valley.
Bogar, a Chinese, who came to India and settled down on the
pazhani hills, is known for his extensive work on alchemy and
medicine.
Siddha Vaidyas have studied thousands of herbs, and have
arrived at tangible solutions for health problems, which are
relevant to modern age.

33. Theory and Basic Principles
3 principles vata, pitta, kapha (Triguna).
Treatment
Siddha Vaidya keeps the knowledge of thousands of herbs
and their effectiveness in specific composition and
formulation.
Kashayam (extracts); churnam (powders); tailams (medicated
oils); bhasmam (calx prepared by calcination); ghritam
(medicated ghee);
Kashayam for infants; jaundice; piles
Churnam Panchammruta; kadukai; ashwagandha
Lehyam Amla lehya; ginger lehya; coconut lehya

34. Traditional Chinese medicine (TCM)
•TCM as a healing system is thousands of years old.
•A principle of TCM is that the interaction of people
with their environment is most significant in creating
health
•The concept most central to TCM is Qi/chi, which is
translated as energy.
•Qi represents an invisible flow of energy that
circulates through plants, animals, and people as well
as the earth and sky.

35. Yin and Yang
•Qi is further viewed as either yin or yang energy.
•Opposites and complementary,
•Good Health is present when they are in balance
in a person and his/her total environment.
•Imbalance of yin and yang is considered to be the
cause of illness.

36. Aromatherapy
•Can be defined as the controlled use of
oils to maintain
psychological,
and promote
and spiritual
essential
physical,
wellbeing.
•Use of essential oils of plants to treat
symptoms
•Commonly used essential oils in a healthcare
setting are ginger or peppermint for nausea
and lavender or chamomile for insomnia

37. Aromatherapy uses pure essential oils to balance the body’s
equilibrium and to improve mental and physical health.
It involves more than fragrance. Plant essential oils have
therapeutic powers in addition to beneficial fragrance, and have
antiseptic action in different degrees.

38. The natural healing art of aromatherapy is an excellent way to
promote optimum health and vitality.
It can reduce stress, improve sleep and give you more energy.
It can improve your complexion, treat an annoying skin itch and
eliminate a stomachache.

39. Thank You