Ubiquitin
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Ubiquitination is a key regulatory mechanism attaching the small protein modifier ubiquitin to protein substrates, thereby modifying their structure, cellular location, function, or targeting them for destruction via proteolysis. https://www.creative-biogene.com/Services/Drug-Discovery-Services/Ubiquitin-Screening-Profiling-Services.html
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COTI-2 | Reactivating Mutant p53
COTI-2 is a small molecule discovered by Critical Outcome Technologies to reactivate mutant p53 through zinc chelation. It demonstrates strong efficacy against a wide range of p53 mutations in vitro and significant tumor growth inhibition in vivo without inducing resistance. Further studies confirmed COTI-2's p53-dependent mechanism of action and ability to modulate the PI3K/AKT pathway. An IND filing is planned in mid-2014 to study COTI-2 in gynecological cancers.
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The R&D team of Creative
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based on the proprietary
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which enable the precise
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100% accuracy.https://www.creative-biolabs.com/blog/index.php/a-series-of-antibody-sequencing-services-from-creative-biolabs/
De novo antibody seuqencing
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NE3107 is a small molecule in Phase 3 clinical trials for Alzheimer's disease and Parkinson's disease. It works by inhibiting neuroinflammation and insulin resistance, two key drivers of cognitive decline. A Phase 3 trial for Alzheimer's is underway testing NE3107's ability to slow cognitive decline compared to placebo. Preclinical studies show NE3107 reduces inflammation, enhances insulin sensitivity, and has neuroprotective effects, supporting its potential in neurodegenerative diseases. A Phase 2 trial will assess NE3107's activity and safety when combined with L-dopa for Parkinson's disease.
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COTI-2 | Reactivating Mutant p53
COTI-2 is a small molecule discovered by Critical Outcome Technologies to reactivate mutant p53 through zinc chelation. It demonstrates strong efficacy against a wide range of p53 mutations in vitro and significant tumor growth inhibition in vivo without inducing resistance. Further studies confirmed COTI-2's p53-dependent mechanism of action and ability to modulate the PI3K/AKT pathway. An IND filing is planned in mid-2014 to study COTI-2 in gynecological cancers.
Business and Scientific Update
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More than just a potential BREAKTHROUGH treatment for many cancers
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An overview of Critical Outcome Technologies' lead cancer drug candidate, COTI-2, which represents a potential breakthrough treatment for many types of cancer. Critical Outcome Technologies is listed on the TSX Venture Exchange under the symbol COT.De novo antibody seuqencing
The R&D team of Creative
Biolabs has achieved an
unparalleled breakthrough
based on the proprietary
Database Assisted Shotgun
Sequencing (DASS) technology,
which enable the precise
identification of leucine and
isoleucine, determining the
antibody sequences with
100% accuracy.https://www.creative-biolabs.com/blog/index.php/a-series-of-antibody-sequencing-services-from-creative-biolabs/
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https://www.creative-bioarray.com/filter/epithelial-cell-and-media-11.html
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Dna methyltransferase screening
A methyl group from S-adenosyl-methionine (SAM) is transferred to the C5 position of the pyrimidine ring of cytosine residues by DNMTs in genomic CpG dinucleotides.
https://www.creative-biogene.com/Services/Drug-Discovery-Services/DNA-Methyltransferase-Screening-and-Profiling.html
Epigenetic service
Creative Biogene offers epigenetic screening and profiling services to help with drug discovery. Their scientists provide expertise in epigenetics to advance drug programs targeting epigenetic mechanisms. They have high-throughput and customized assays to screen compound libraries against epigenetic targets or profile a drug's activity against multiple targets. Epigenetics involves heritable gene expression changes not from DNA alterations, and impacts many disease areas making it important for diagnostics and therapeutics.
Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer. Research contains mechanism study (including molecule mechanism), pathological research, surgical method, medical treatment therapy (chemotherapy, radiotherapy), management for an individual patient, new drug development, etc. Obviously, oncology is often managed through discussion on multi-disciplinary.
https://www.creative-bioarray.com/oncology.htm
Herg safety assay
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The problem is that we have a health industry that is not concerned with food…
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Andrew Haythorpe
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Mobile: +61407 737 973
Email: a@bettercells.com
Skype: andrewhaythorpe
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Join Dr. Danyi Wen as she describes a novel drug efficacy test using Patient Derived Xenograft (PDX) samples to measure drug efficacy and identify therapeutic candidates in personalized oncology treatments.
LIDE’s novel MiniPDX is a 7-day, in vivo drug efficacy test for oncology therapeutics. It is the in vivo version of a 3D organoid assay and correlates with traditional PDX by 92%, and with clinical end point at 82%. These high correlations make MiniPDX an effective option to test targeted drugs, chemotherapies, angiogenesis drugs, and more, while demonstrating superior testing times and cost-effectiveness versus traditional PDX. In a clinical setting, MiniPDX, together with next-generation sequencing (NGS), is playing an emerging role in personalized oncology.
The process starts with a freshly prepared cell suspension from either a clinical sample or PDX (Patient Derived Xenograft) model. This sample is sealed into a mini capsule with 500 KD cut-off pores. Capsules are implanted into SCID mice subcutaneously, and a test compound is given systemically for 7 days. The efficacy of the test compound is then evaluated by measuring ATP of the cancer cells in the capsule.
The MiniPDX mouse trial can also be coupled with “K-Cell Omic” analysis (DNA, RNA, and Protein), presenting a powerful tool for the identification of drug candidates and the discovery of companion diagnostic markers.
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Understand how MiniPDX + Omics analysis empowers precision medicine
Pros and cons of functional diagnosis assays (CR, Organoid, MiniPDX, PDX)
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ICTC
The document provides an overview of Integrated Counselling and Testing Centres (ICTCs) in India. ICTCs were established in 2006 by integrating Voluntary Counselling and Testing Centres (VCTCs) and facilities providing Prevention of Parent to Child Transmission of HIV/AIDS (PPTCT) services. ICTCs provide HIV counseling, testing, and linkage to care services. They play a key role in HIV prevention, diagnosis, and treatment initiatives like PPTCT. The document outlines the functions, infrastructure, staffing, testing strategies and protocols of ICTCs in India.
Global liquid biopsy market opportunity & technology outlook 2020
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https://www.creative-bioarray.com/filter/epithelial-cell-and-media-11.html
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Mouse Interleukin-13 (IL-13) is produced primarily by activated Th2 cells. IL-13 is a pleiotropic immune regulatory cytokine that promotes growth of human B cells; induces expression of germ line Ce transcripts, directs na?ve B cells to switch to the synthesis of IgE and IgG4, and induces expression of CD23 and Class II-MHC.
https://www.creative-bioarray.com/ActoFactor%E2%84%A2-Recombinant-Mouse-Interleukin-13-CSC-CTK0002-item-4204.htm
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https://www.creative-bioarray.com/Services/custom-cell-tissue-lysates-service.htm
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Fluorescence in situ hybridization (FISH), developed in 1980s, is a cytogenetic technique using fluorescent probes to bind the chromosome with a high degree of complementarity. It is a powerful and easy method to detect RNA or DNA sequences in cells, tissues and tumors.
https://www.creative-bioarray.com/services/Fluorescent-In-Situ-hybridization-FISH.htm
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https://www.creative-biogene.com/Services/Drug-Discovery-Services/ABC-transporters-Screening-and-Profilin-Assays.html
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https://www.creative-biogene.com/Services/Drug-Discovery-Services/DNA-Methyltransferase-Screening-and-Profiling.html
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Creative Biogene offers epigenetic screening and profiling services to help with drug discovery. Their scientists provide expertise in epigenetics to advance drug programs targeting epigenetic mechanisms. They have high-throughput and customized assays to screen compound libraries against epigenetic targets or profile a drug's activity against multiple targets. Epigenetics involves heritable gene expression changes not from DNA alterations, and impacts many disease areas making it important for diagnostics and therapeutics.
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https://www.creative-bioarray.com/filter/epithelial-cell-and-media-11.html
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Ion channels are pore-forming membrane proteins that create a gated, water-filled pore to help establish and control voltage potential across cell membranes through control of the active flow of ions between the intracellular and the extracellular environments.
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LAM PCR
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A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Best Ayurvedic medicine for Gas and Indigestion
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
The Electrocardiogram - Physiologic Principles
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ABDOMINAL TRAUMA in pediatrics part one.
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Role of Mukta Pishti in the Management of Hyperthyroidism
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Journal Article Review on Rasamanikya
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
STIs may cause PID. For the both disease, herbal medicine Fuyan Pill can be a solution.
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
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Adhd Medication Shortage Uk - trinexpharmacy.com
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
share - Lions, tigers, AI and health misinformation, oh my!.pptx
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
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• Equipping health professionals to address questions, concerns and health misinformation
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NVBDCP.pptx Nation vector borne disease control program
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
It includes regulation of combination products and medical devices. FDA and industry liaisons.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Ubiquitin
- 2. Ubiquitin Screening Ubiquitination is a key regulatory mechanism attaching the small protein modifier ubiquitin to protein substrates, thereby modifying their structure, cellular location, function, or targeting them for destruction via proteolysis. The process of protein ubiquitylation regulates many aspects of cell function and provides a wealth of drug target opportunities to many therapeutic areas including cancers, cardiovascular, metabolism, inflammation, diabetes, neurodegeneration and infectious diseases.
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