Taiwan Society for the Prevention of Cruelty to Animals (TSPCA), Be Cruelty-Free Taiwan, was launched in March 2014 and strives to enhance public awareness of the issue while pushing for a legislative ban.
The document discusses using neurite growth as an endpoint for assessing developmental neurotoxicity in vitro. It describes how neurite outgrowth is critical for proper brain wiring and is sensitive to toxicants. A human neuronal cell line called LUHMES can be used to measure neurite growth in automated high-content assays allowing efficient screening of chemicals. Several known neurotoxicants were found to reduce neurite growth in the LUHMES cells. The document proposes applying omics technologies like transcriptomics and metabolomics to the LUHMES model to identify pathways of toxicity and classify chemicals. A proof-of-principle study on MPP+ is described where multi-omics analysis revealed perturbed genes, metabolites and pathways in MPP+-treated
Humane Research Australia is a not for profit organisation that challenges the use of animals in research and promotes more humane and scientifically-valid non-animal methods of research.
The New Zealand Anti-Vivisection Society (NZAVS) is a campaign group that opposes all animal testing. It achieves this through research, education, public awareness and political lobbying.
Division of Toxicology/RIKILT Institute of Food Safety, Wageningen University and Research Centre, Netherlands.
In addition to method development and validation of tests, RIKILT also advises and participates in panels from the European Food Safety Authority (EFSA) and CODEX. The Division of Toxicology is part of the Agrotechnology and Food Sciences Group (AFSG) at Wageningen University. Areas of research vary from food toxicology to environmental toxicology.
The Laboratory of Mathematical Chemistry (LMC) was established 30 years ago, in Burgas, Bulgaria, within the University ‘Prof. Dr. Asen Zlatarov’.
Nowadays, the Laboratory is one of the most influential molecular modelling labs worldwide.
The Africa Network for Animal Welfare (ANAW) was established in 2006 as a Pan African Non-Governmental Organisation.
It is registered under the provisions of the Non-Governmental Organisations Co-ordination Act, of the Laws of Kenya and its mission is to work together with Communities, Governments and other animal welfare stakeholders in promoting humane treatment of all Animals across Africa.
Overview of 3D-human skin reconstructed models for irritation and corrosion t...An Van Rompay
Overview of 3D-human skin reconstructed models for irritation and corrosion testing
An Van Rompay
VITO NV & CARDAM, Belgium
from: Invitrom meeting, December 2011
Tips for Gaining Freedom from Nicotinenawsoutreach
This document provides tips for quitting nicotine use and maintaining nicotine abstinence. It discusses understanding nicotine addiction as a chemical dependency, preparing to quit by making an honest assessment of nicotine use and its effects, getting support from others, managing cravings and withdrawal symptoms, and maintaining abstinence over time through continued use of program tools and principles. The overall message is that quitting nicotine is possible through education, willingness, support, coping strategies, and an ongoing commitment to recovery.
The document discusses using neurite growth as an endpoint for assessing developmental neurotoxicity in vitro. It describes how neurite outgrowth is critical for proper brain wiring and is sensitive to toxicants. A human neuronal cell line called LUHMES can be used to measure neurite growth in automated high-content assays allowing efficient screening of chemicals. Several known neurotoxicants were found to reduce neurite growth in the LUHMES cells. The document proposes applying omics technologies like transcriptomics and metabolomics to the LUHMES model to identify pathways of toxicity and classify chemicals. A proof-of-principle study on MPP+ is described where multi-omics analysis revealed perturbed genes, metabolites and pathways in MPP+-treated
Humane Research Australia is a not for profit organisation that challenges the use of animals in research and promotes more humane and scientifically-valid non-animal methods of research.
The New Zealand Anti-Vivisection Society (NZAVS) is a campaign group that opposes all animal testing. It achieves this through research, education, public awareness and political lobbying.
Division of Toxicology/RIKILT Institute of Food Safety, Wageningen University and Research Centre, Netherlands.
In addition to method development and validation of tests, RIKILT also advises and participates in panels from the European Food Safety Authority (EFSA) and CODEX. The Division of Toxicology is part of the Agrotechnology and Food Sciences Group (AFSG) at Wageningen University. Areas of research vary from food toxicology to environmental toxicology.
The Laboratory of Mathematical Chemistry (LMC) was established 30 years ago, in Burgas, Bulgaria, within the University ‘Prof. Dr. Asen Zlatarov’.
Nowadays, the Laboratory is one of the most influential molecular modelling labs worldwide.
The Africa Network for Animal Welfare (ANAW) was established in 2006 as a Pan African Non-Governmental Organisation.
It is registered under the provisions of the Non-Governmental Organisations Co-ordination Act, of the Laws of Kenya and its mission is to work together with Communities, Governments and other animal welfare stakeholders in promoting humane treatment of all Animals across Africa.
Overview of 3D-human skin reconstructed models for irritation and corrosion t...An Van Rompay
Overview of 3D-human skin reconstructed models for irritation and corrosion testing
An Van Rompay
VITO NV & CARDAM, Belgium
from: Invitrom meeting, December 2011
Tips for Gaining Freedom from Nicotinenawsoutreach
This document provides tips for quitting nicotine use and maintaining nicotine abstinence. It discusses understanding nicotine addiction as a chemical dependency, preparing to quit by making an honest assessment of nicotine use and its effects, getting support from others, managing cravings and withdrawal symptoms, and maintaining abstinence over time through continued use of program tools and principles. The overall message is that quitting nicotine is possible through education, willingness, support, coping strategies, and an ongoing commitment to recovery.
Róber Bachinski is a biologist, master in public health and environment and PhD student of the Postgraduate Program on Science and Biotechnology in the Fluminense Federal University (PPBI/UFF), Brazil. In his PhD, Róber is developing research on 3D cell culture models, models for neuro-toxicology and neuro-pharmacology and alternatives for uses in the scientific education.
Thit Aarøe Mørck is a PhD student at the University of Copenhagen who studied human exposure to environmental chemicals. Her project involved collecting urine, hair, and blood samples from 145 mother-child pairs in Denmark to measure 64 biomarkers of exposure and early effects from chemicals like phthalates, PBDEs, PCBs, and metals. She plans to use the funding from the LUSH prize to analyze the data for associations between exposure measurements and early effects, and to identify patterns of chemical exposure.
Animal testing is used to study human diseases and test cosmetics and cleaners. The document discusses whether the reader agrees or disagrees with animal testing and includes three pictures related to testing on animals. The author is asking the reader their opinion on this issue.
This document summarizes Korea's growing interest in non-animal testing and efforts to end cosmetics testing on animals. It outlines Korea's regulations around animal testing from the 1990s to present and the government bodies involved. It also discusses Korea's increasing development of alternative test methods, including the establishment of KoCVAM in 2009 and CAMSEC in 2013. Finally, it describes efforts to revise laws to ban cosmetics animal testing and increase public awareness campaigns around companies' non-animal testing policies.
Animal testing involves experimenting on animals to test the safety of medicines and chemicals for human use. Over 1.4 million animals were used in the United States in 2002 for testing purposes, including rabbits, dogs, cats, and primates. While animal testing has helped develop vaccines and provide human health information, it causes suffering in animals and is not always predictive of human reactions due to physiological differences between species. Alternatives to animal testing are being explored.
- The hotel underwent a $15 million renovation in 2006 and an additional $9 million in renovations from 2009-2010. It has 503 guest rooms, 6 suites, and 25,000 square feet of meeting space.
- The hotel is located in downtown Portland within 10 miles of the Portland International Airport and close to many local attractions. It has received awards for its food and beverage program and environmental sustainability efforts.
- The hotel focuses on environmentally friendly operations through extensive recycling programs, energy efficient practices, and encouraging alternative transportation use among guests and staff.
The Karolinska Institute (KI) is the largest centre for medical education and research in Sweden and the home of the Nobel Prize in Physiology or Medicine.
KI consists of 22 departments and 600 research groups dedicated to improving human health through research and higher education.
The role of the Kohonen/Grafström team has been to guide the application, analysis, interpretation and storage of so called “omics” technology-derived data within the service-oriented subproject “ToxBank”.
This document discusses alternative in vitro test methods that can potentially replace animal tests for assessing eye and skin irritation. It provides background on the development of alternative methods and validation process. Two alternative eye irritation tests - Bovine Corneal Opacity and Permeability Assay and Isolated Chicken Eye Assay - have been validated and accepted by OECD for regulatory use. Reconstructed human epidermis models EpiDerm and EpiSkin have also been validated and accepted to classify chemicals for skin irritation hazard. The document outlines several alternative assay methods and their limitations but emphasizes the scientific push for non-animal tests due to ethical concerns and limitations of animal models.
Animal testing, also known as animal experimentation, involves using non-human animals like mice, monkeys, and dogs in medical experiments. While opponents argue it causes animal suffering, proponents contend it has led to major medical advances like the polio vaccine and discovery of insulin. The document concludes that animal testing has helped treat diseases and establish medication safety, and stopping it would make medical research more difficult.
This document summarizes Horst Spielmann's presentation on implementing alternative methods. It discusses his role as State Animal Welfare Officer in Berlin where he provides expert advice on animal welfare issues. The presentation covered topics like ending cosmetics testing in Europe, developing adverse outcome pathways, and alternative methods like embryonic stem cells, organ-on-chip technology, and using human cells for disease and infection models. It also discussed increasing collaboration between international regulatory agencies and researchers to advance alternative methods through information sharing and establishing performance standards.
The progress report summarizes research on the neuroprotective effects of antioxidants against endosulfan-induced neurotoxicity in mice. Experiments were conducted on mice to analyze the effects of endosulfan and antioxidants (resveratrol, alpha-lipoic acid, vitamin E) on levels of acetylcholinesterase, butyrylcholinesterase, and ATPase in the brain. Preliminary results found that endosulfan inhibited these enzyme activities, while antioxidant supplementation protected against this neurotoxicity. Further biochemical analysis and statistical evaluation are planned for the next year to complete the study.
This document discusses alternatives to animal testing in three areas:
1. It describes the establishment of the Danish 3R-Center, a collaboration between the government, pharmaceutical industry, and animal welfare organizations aimed at promoting alternatives to animal testing.
2. It discusses the researcher Lisbeth Knudsen's work studying biomarkers to assess human exposure to chemicals as an alternative to animal and cell studies. Her research involves biomonitoring chemicals in humans through samples like blood, urine, and hair.
3. It outlines a EU project that used biomonitoring to study levels of 64 chemicals and their effects in 145 mother-child pairs in Denmark, measuring samples like urine, hair, and blood to assess chemical exposure.
This document summarizes the work of Thomas Hartung and the CAAT (Center for Alternatives to Animal Testing) team over several decades to advance alternative methods to animal testing. It discusses their efforts to promote better science through alternative methods that are less reliant on animals, more relevant to humans, and faster and cheaper. It outlines CAAT's work developing new tools and methods as well as establishing think tanks, policy programs, and collaborations across Europe and the US to validate and implement alternative approaches.
The Center for Alternatives to Animal Testing (CAAT-Europe), housed at the University of Konstanz (Germany), brings together industry representatives, regulators, and academics to address the needs for human-relevant alternative methods to animal testing.
Troy Seidle is Director of Research & Toxicology for Humane Society International.
He manages the AXLR8 (pronounced “accelerate”) project, which aims to hasten the transition toward animal-free approaches to safety testing through internationally coordinated research and development.
This document summarizes the findings of EPA testing for PCBs in lighting fixtures in New York City schools. The EPA found that 113 out of 145 samples from 11 schools had PCB levels above health benchmarks, with some samples over 1 million ppm. NYC has committed to a 10-year, $149 million plan to retrofit lighting in 754 schools, though the EPA believes this timeline is too long. The retrofits will reduce exposure to PCBs and save energy costs.
Neurotoxicity, commonly caused by cytotoxic cancer therapy, can damage the central or peripheral nervous system. Ifosfamide chemotherapy can cause central neurotoxicity like encephalopathy or myelopathy. It is metabolized into neurotoxic compounds that damage mitochondria. Methylene blue may help restore mitochondrial function and prevent or treat ifosfamide neurotoxicity. Chemotherapy-induced peripheral neuropathy is a common side effect of neurotoxic drugs like platinum analogs, taxanes, and vinca alkaloids. It involves damage to dorsal root ganglia and axons, disrupting transport and causing length-dependent nerve damage. Symptoms include numbness, tingling and pain in hands and feet. Risk factors include
This document discusses polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), two common air pollutants. It provides background on PCBs and PAHs, including their chemical structures and properties. PCBs were widely used but are now banned globally due to their persistence in the environment and toxicity. Long-term exposure to PCBs and PAHs can lead to cancer and other health effects in animals and humans. The document also describes methods used to measure levels of PCBs and PAHs in ambient air samples.
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Róber Bachinski is a biologist, master in public health and environment and PhD student of the Postgraduate Program on Science and Biotechnology in the Fluminense Federal University (PPBI/UFF), Brazil. In his PhD, Róber is developing research on 3D cell culture models, models for neuro-toxicology and neuro-pharmacology and alternatives for uses in the scientific education.
Thit Aarøe Mørck is a PhD student at the University of Copenhagen who studied human exposure to environmental chemicals. Her project involved collecting urine, hair, and blood samples from 145 mother-child pairs in Denmark to measure 64 biomarkers of exposure and early effects from chemicals like phthalates, PBDEs, PCBs, and metals. She plans to use the funding from the LUSH prize to analyze the data for associations between exposure measurements and early effects, and to identify patterns of chemical exposure.
Animal testing is used to study human diseases and test cosmetics and cleaners. The document discusses whether the reader agrees or disagrees with animal testing and includes three pictures related to testing on animals. The author is asking the reader their opinion on this issue.
This document summarizes Korea's growing interest in non-animal testing and efforts to end cosmetics testing on animals. It outlines Korea's regulations around animal testing from the 1990s to present and the government bodies involved. It also discusses Korea's increasing development of alternative test methods, including the establishment of KoCVAM in 2009 and CAMSEC in 2013. Finally, it describes efforts to revise laws to ban cosmetics animal testing and increase public awareness campaigns around companies' non-animal testing policies.
Animal testing involves experimenting on animals to test the safety of medicines and chemicals for human use. Over 1.4 million animals were used in the United States in 2002 for testing purposes, including rabbits, dogs, cats, and primates. While animal testing has helped develop vaccines and provide human health information, it causes suffering in animals and is not always predictive of human reactions due to physiological differences between species. Alternatives to animal testing are being explored.
- The hotel underwent a $15 million renovation in 2006 and an additional $9 million in renovations from 2009-2010. It has 503 guest rooms, 6 suites, and 25,000 square feet of meeting space.
- The hotel is located in downtown Portland within 10 miles of the Portland International Airport and close to many local attractions. It has received awards for its food and beverage program and environmental sustainability efforts.
- The hotel focuses on environmentally friendly operations through extensive recycling programs, energy efficient practices, and encouraging alternative transportation use among guests and staff.
The Karolinska Institute (KI) is the largest centre for medical education and research in Sweden and the home of the Nobel Prize in Physiology or Medicine.
KI consists of 22 departments and 600 research groups dedicated to improving human health through research and higher education.
The role of the Kohonen/Grafström team has been to guide the application, analysis, interpretation and storage of so called “omics” technology-derived data within the service-oriented subproject “ToxBank”.
This document discusses alternative in vitro test methods that can potentially replace animal tests for assessing eye and skin irritation. It provides background on the development of alternative methods and validation process. Two alternative eye irritation tests - Bovine Corneal Opacity and Permeability Assay and Isolated Chicken Eye Assay - have been validated and accepted by OECD for regulatory use. Reconstructed human epidermis models EpiDerm and EpiSkin have also been validated and accepted to classify chemicals for skin irritation hazard. The document outlines several alternative assay methods and their limitations but emphasizes the scientific push for non-animal tests due to ethical concerns and limitations of animal models.
Animal testing, also known as animal experimentation, involves using non-human animals like mice, monkeys, and dogs in medical experiments. While opponents argue it causes animal suffering, proponents contend it has led to major medical advances like the polio vaccine and discovery of insulin. The document concludes that animal testing has helped treat diseases and establish medication safety, and stopping it would make medical research more difficult.
This document summarizes Horst Spielmann's presentation on implementing alternative methods. It discusses his role as State Animal Welfare Officer in Berlin where he provides expert advice on animal welfare issues. The presentation covered topics like ending cosmetics testing in Europe, developing adverse outcome pathways, and alternative methods like embryonic stem cells, organ-on-chip technology, and using human cells for disease and infection models. It also discussed increasing collaboration between international regulatory agencies and researchers to advance alternative methods through information sharing and establishing performance standards.
The progress report summarizes research on the neuroprotective effects of antioxidants against endosulfan-induced neurotoxicity in mice. Experiments were conducted on mice to analyze the effects of endosulfan and antioxidants (resveratrol, alpha-lipoic acid, vitamin E) on levels of acetylcholinesterase, butyrylcholinesterase, and ATPase in the brain. Preliminary results found that endosulfan inhibited these enzyme activities, while antioxidant supplementation protected against this neurotoxicity. Further biochemical analysis and statistical evaluation are planned for the next year to complete the study.
This document discusses alternatives to animal testing in three areas:
1. It describes the establishment of the Danish 3R-Center, a collaboration between the government, pharmaceutical industry, and animal welfare organizations aimed at promoting alternatives to animal testing.
2. It discusses the researcher Lisbeth Knudsen's work studying biomarkers to assess human exposure to chemicals as an alternative to animal and cell studies. Her research involves biomonitoring chemicals in humans through samples like blood, urine, and hair.
3. It outlines a EU project that used biomonitoring to study levels of 64 chemicals and their effects in 145 mother-child pairs in Denmark, measuring samples like urine, hair, and blood to assess chemical exposure.
This document summarizes the work of Thomas Hartung and the CAAT (Center for Alternatives to Animal Testing) team over several decades to advance alternative methods to animal testing. It discusses their efforts to promote better science through alternative methods that are less reliant on animals, more relevant to humans, and faster and cheaper. It outlines CAAT's work developing new tools and methods as well as establishing think tanks, policy programs, and collaborations across Europe and the US to validate and implement alternative approaches.
The Center for Alternatives to Animal Testing (CAAT-Europe), housed at the University of Konstanz (Germany), brings together industry representatives, regulators, and academics to address the needs for human-relevant alternative methods to animal testing.
Troy Seidle is Director of Research & Toxicology for Humane Society International.
He manages the AXLR8 (pronounced “accelerate”) project, which aims to hasten the transition toward animal-free approaches to safety testing through internationally coordinated research and development.
This document summarizes the findings of EPA testing for PCBs in lighting fixtures in New York City schools. The EPA found that 113 out of 145 samples from 11 schools had PCB levels above health benchmarks, with some samples over 1 million ppm. NYC has committed to a 10-year, $149 million plan to retrofit lighting in 754 schools, though the EPA believes this timeline is too long. The retrofits will reduce exposure to PCBs and save energy costs.
Neurotoxicity, commonly caused by cytotoxic cancer therapy, can damage the central or peripheral nervous system. Ifosfamide chemotherapy can cause central neurotoxicity like encephalopathy or myelopathy. It is metabolized into neurotoxic compounds that damage mitochondria. Methylene blue may help restore mitochondrial function and prevent or treat ifosfamide neurotoxicity. Chemotherapy-induced peripheral neuropathy is a common side effect of neurotoxic drugs like platinum analogs, taxanes, and vinca alkaloids. It involves damage to dorsal root ganglia and axons, disrupting transport and causing length-dependent nerve damage. Symptoms include numbness, tingling and pain in hands and feet. Risk factors include
This document discusses polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), two common air pollutants. It provides background on PCBs and PAHs, including their chemical structures and properties. PCBs were widely used but are now banned globally due to their persistence in the environment and toxicity. Long-term exposure to PCBs and PAHs can lead to cancer and other health effects in animals and humans. The document also describes methods used to measure levels of PCBs and PAHs in ambient air samples.
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Combined Illegal, Unregulated and Unreported (IUU) Vessel List.Christina Parmionova
The best available, up-to-date information on all fishing and related vessels that appear on the illegal, unregulated, and unreported (IUU) fishing vessel lists published by Regional Fisheries Management Organisations (RFMOs) and related organisations. The aim of the site is to improve the effectiveness of the original IUU lists as a tool for a wide variety of stakeholders to better understand and combat illegal fishing and broader fisheries crime.
To date, the following regional organisations maintain or share lists of vessels that have been found to carry out or support IUU fishing within their own or adjacent convention areas and/or species of competence:
Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR)
Commission for the Conservation of Southern Bluefin Tuna (CCSBT)
General Fisheries Commission for the Mediterranean (GFCM)
Inter-American Tropical Tuna Commission (IATTC)
International Commission for the Conservation of Atlantic Tunas (ICCAT)
Indian Ocean Tuna Commission (IOTC)
Northwest Atlantic Fisheries Organisation (NAFO)
North East Atlantic Fisheries Commission (NEAFC)
North Pacific Fisheries Commission (NPFC)
South East Atlantic Fisheries Organisation (SEAFO)
South Pacific Regional Fisheries Management Organisation (SPRFMO)
Southern Indian Ocean Fisheries Agreement (SIOFA)
Western and Central Pacific Fisheries Commission (WCPFC)
The Combined IUU Fishing Vessel List merges all these sources into one list that provides a single reference point to identify whether a vessel is currently IUU listed. Vessels that have been IUU listed in the past and subsequently delisted (for example because of a change in ownership, or because the vessel is no longer in service) are also retained on the site, so that the site contains a full historic record of IUU listed fishing vessels.
Unlike the IUU lists published on individual RFMO websites, which may update vessel details infrequently or not at all, the Combined IUU Fishing Vessel List is kept up to date with the best available information regarding changes to vessel identity, flag state, ownership, location, and operations.
Contributi dei parlamentari del PD - Contributi L. 3/2019Partito democratico
DI SEGUITO SONO PUBBLICATI, AI SENSI DELL'ART. 11 DELLA LEGGE N. 3/2019, GLI IMPORTI RICEVUTI DALL'ENTRATA IN VIGORE DELLA SUDDETTA NORMA (31/01/2019) E FINO AL MESE SOLARE ANTECEDENTE QUELLO DELLA PUBBLICAZIONE SUL PRESENTE SITO
AHMR is an interdisciplinary peer-reviewed online journal created to encourage and facilitate the study of all aspects (socio-economic, political, legislative and developmental) of Human Mobility in Africa. Through the publication of original research, policy discussions and evidence research papers AHMR provides a comprehensive forum devoted exclusively to the analysis of contemporaneous trends, migration patterns and some of the most important migration-related issues.
Preliminary findings _OECD field visits to ten regions in the TSI EU mining r...OECDregions
Preliminary findings from OECD field visits for the project: Enhancing EU Mining Regional Ecosystems to Support the Green Transition and Secure Mineral Raw Materials Supply.