Toxicity
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Toxicity occurs when too much of a drug accumulates in the bloodstream due to overdose or the inability of the kidneys or liver to break down the drug. The degree of harmful effects varies depending on the drug and dose but can be life-threatening. Acetaminophen toxicity specifically damages the liver between 72-96 hours after ingestion, causing hepatic necrosis and dysfunction which can lead to multi-organ failure if left untreated. It is important to always take drugs as directed and not exceed dosages in order to prevent toxicity, as acetaminophen is found in over 600 medications making it easy to inadvertently take too much.
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5 1 6 T o w a r d A l t e r n a t i v e s i n H e a l t h C a r e
S o l o t n o n , H . A . 1 9 8 4 . T h e E x a r c i s e M y t D . N e w Y o r k :
H a r c o u r t B r a c e J o v a n o v i c h .
S p i l m a n , M . A . , A . C i o e t z , J . S c h u l t z , R . B e l l i n g h a m ,
a n d D . J o h n s o n . 1 9 8 6 . E f f e c t s o f a H e a l t h P r o m o -
t i o n P r c r g r a n t . J o u r n a l o f O c c u p a t i o n a l M e d i c i n e
2 8 : 2 8 . 5 - 8 9 .
S t e i n , . f . 1 9 8 5 . I n d u s t r y ' s N e w B o t t o m L i n e o n H e a l t h
Ciare Costs: Is Less Better? Hastings Center Report
l - 5 ( . 5 ) : l 4 * 1 8 .
S t e r l i r r g , J . D . , a r . r c l f . . f . W e i n k a m . 1 9 8 6 . E x t e n t , P e r -
s i s t e n c c a n c l C l o n s t a n c y o f t h e l { c a l t h y W o r k e r o r
H c r l t l . r y P e r s o n F . f f e c t b v A l l a n d S e l e c t e d C l a u s e s o f
Death. Journal of Occupational Medicine 28:348-
5 3 .
S y m e , L . S . , a n d L . F . B e r k m a n . 1 9 7 6 . S o c i a l C l a s s ,
Susceptibility and Illness. American Jonrnal of Epr
demiologl' I 04: l-8. ,
U.S. Department of Health, E,ducation, and !ilelfare.
1,979. Healthy People: The Surgeon General's Re-
port on Health Promotion and Disease Preuention.'Washingtorr.
'Walsl.r, D.C. 1984. Corporate Smoking Policies: A
Revrew and an Analysis. Journal of Ocarpational
M e d i c i n e 2 6 : 1 7 - 2 2 .
A Cesn FoR RrpocussrNc Upsrnndtvt: THE Pouucet
EcoruouY oF lrrlurss
. l o h n B . M c K i n l a y
M y f r i c n c l , I r v i n g Z o l a , r e l a t e s t l - r e s t o r y o f a
p h y s i c i : r r r t r y i n g t o e x p l a i n t h e d i l c m r n a s o f t h e
r n o c l e r n p r a c t i c e < l f r r e d i c i n e :
" Y o u k n o r , " ' , " l r c s a i c l , " s o r l e t i r n e s i t f e e l s l i k e t l - r i s .
T h e r c I a m s f a n c l i n g b y t l r e s h o r e o f a s w i f t l y f l o w -
i n g r i v c r a n t l I h e e r t h c c r y o f l c l r o w n i n g m a n . S o I
j r r n r p i n t o t l i c r i v c r , p u t n 1 y r r r n s a r o u n c l h i m , p u l l
h i r n t o s h o r e a n c l a p p l y a r t i l i c i a l r c s p i r a t i o n . . f u s t
w l r c n h c b c g i n s t o b r c a t h c , t h e r c i s r r t o t h e r c r y f o r
h c l p . S o I j u m p i r r t o t l r c r i v e r , r c : r c h h i m , p u l l h i n r
t o s h o l c , a p p l v a r t i f i c i e l r c s p i r a t i o n , a r - r d t h e n j u s t
a s h e b c g i r r s t o b r e a t h e , r l n o t h e r c r y f o r h e l p . S o
b a c l < i n t l r c r i v e r r r g r r i n , r c r r c h i n g , p u l l i n g , a p p l y i n g ,
b r c a t h i n g a l i c l t h c n r u r o t h c r v e l l . A g a i n a n c l a g a i n ,
w i t h o u t e u .
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Holistic message
We are moving towards IT revolution in every sphere of life. In India we have started talking about Vedic Knowledge, the future of present Scientific evolution. We are talking about Holistic Development, instead of running after Dollar Culuture, which creates tension. Holistic Thinking creates peace and tranquility moving towards the Holistic Development of Whole Society. Through this approach we can create revolution in the following fields of Society:-
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Holistic Social Justice Holistic Development
A holistic approach to life incorporates things that nourish you other than food, including things like a career that inspires you, honest and open relationships, physical activity that invigorates you, and a spiritual or religious practice that connects you to something greater than yourself.
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5 1 6 T o w a r d A l t e r n a t i v e s i n H e a l t h .docx
5 1 6 T o w a r d A l t e r n a t i v e s i n H e a l t h C a r e
S o l o t n o n , H . A . 1 9 8 4 . T h e E x a r c i s e M y t D . N e w Y o r k :
H a r c o u r t B r a c e J o v a n o v i c h .
S p i l m a n , M . A . , A . C i o e t z , J . S c h u l t z , R . B e l l i n g h a m ,
a n d D . J o h n s o n . 1 9 8 6 . E f f e c t s o f a H e a l t h P r o m o -
t i o n P r c r g r a n t . J o u r n a l o f O c c u p a t i o n a l M e d i c i n e
2 8 : 2 8 . 5 - 8 9 .
S t e i n , . f . 1 9 8 5 . I n d u s t r y ' s N e w B o t t o m L i n e o n H e a l t h
Ciare Costs: Is Less Better? Hastings Center Report
l - 5 ( . 5 ) : l 4 * 1 8 .
S t e r l i r r g , J . D . , a r . r c l f . . f . W e i n k a m . 1 9 8 6 . E x t e n t , P e r -
s i s t e n c c a n c l C l o n s t a n c y o f t h e l { c a l t h y W o r k e r o r
H c r l t l . r y P e r s o n F . f f e c t b v A l l a n d S e l e c t e d C l a u s e s o f
Death. Journal of Occupational Medicine 28:348-
5 3 .
S y m e , L . S . , a n d L . F . B e r k m a n . 1 9 7 6 . S o c i a l C l a s s ,
Susceptibility and Illness. American Jonrnal of Epr
demiologl' I 04: l-8. ,
U.S. Department of Health, E,ducation, and !ilelfare.
1,979. Healthy People: The Surgeon General's Re-
port on Health Promotion and Disease Preuention.'Washingtorr.
'Walsl.r, D.C. 1984. Corporate Smoking Policies: A
Revrew and an Analysis. Journal of Ocarpational
M e d i c i n e 2 6 : 1 7 - 2 2 .
A Cesn FoR RrpocussrNc Upsrnndtvt: THE Pouucet
EcoruouY oF lrrlurss
. l o h n B . M c K i n l a y
M y f r i c n c l , I r v i n g Z o l a , r e l a t e s t l - r e s t o r y o f a
p h y s i c i : r r r t r y i n g t o e x p l a i n t h e d i l c m r n a s o f t h e
r n o c l e r n p r a c t i c e < l f r r e d i c i n e :
" Y o u k n o r , " ' , " l r c s a i c l , " s o r l e t i r n e s i t f e e l s l i k e t l - r i s .
T h e r c I a m s f a n c l i n g b y t l r e s h o r e o f a s w i f t l y f l o w -
i n g r i v c r a n t l I h e e r t h c c r y o f l c l r o w n i n g m a n . S o I
j r r n r p i n t o t l i c r i v c r , p u t n 1 y r r r n s a r o u n c l h i m , p u l l
h i r n t o s h o r e a n c l a p p l y a r t i l i c i a l r c s p i r a t i o n . . f u s t
w l r c n h c b c g i n s t o b r c a t h c , t h e r c i s r r t o t h e r c r y f o r
h c l p . S o I j u m p i r r t o t l r c r i v e r , r c : r c h h i m , p u l l h i n r
t o s h o l c , a p p l v a r t i f i c i e l r c s p i r a t i o n , a r - r d t h e n j u s t
a s h e b c g i r r s t o b r e a t h e , r l n o t h e r c r y f o r h e l p . S o
b a c l < i n t l r c r i v e r r r g r r i n , r c r r c h i n g , p u l l i n g , a p p l y i n g ,
b r c a t h i n g a l i c l t h c n r u r o t h c r v e l l . A g a i n a n c l a g a i n ,
w i t h o u t e u .
Acute stroke imaging and intervention-dr. n khandelwal
ACUTE STROKE: IMAGING AND INTERVENTIONS PERSPECTIVE
FP's and Telehealth, William Thornbury, MD - SLC 2015
William Thronbury, MD, Medical Associate Clinic, presented on Family Physicians and Telehealth at the State Legislative Conference on November 7, 2015.
Holistic message
We are moving towards IT revolution in every sphere of life. In India we have started talking about Vedic Knowledge, the future of present Scientific evolution. We are talking about Holistic Development, instead of running after Dollar Culuture, which creates tension. Holistic Thinking creates peace and tranquility moving towards the Holistic Development of Whole Society. Through this approach we can create revolution in the following fields of Society:-
Holistic Health Holistic Education
Holistic Agriculture Holistic Society
Holistic Social Justice Holistic Development
A holistic approach to life incorporates things that nourish you other than food, including things like a career that inspires you, honest and open relationships, physical activity that invigorates you, and a spiritual or religious practice that connects you to something greater than yourself.
Holistic philosophy of healing encompasses the physical, emotional, mental, psychological, social, spiritual and environmental dimensions of health. It is the paradigm of inter-connectedness and relationship in all things.” From the holistic standpoint, a healthcare practitioner cannot focus his or her attention solely upon a patient’s chief complaints, history of illness, or current stresses and disease states. The practitioner must also investigate the patient’s history of wellness. The practitioner must also find out about future circumstances under which the patient can imagine feeling truly well.
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Dr. Prakhar Garg, a renowned diabetologist in Noida, is highly regarded for his expertise in managing diabetes. With years of experience and a patient-centric approach, he offers comprehensive treatment plans, emphasizing lifestyle modifications and personalized care. Dr. Prakhar Garg is committed to improving the lives of his patients. https://swasthyamultispeciality.com
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A Diabetologist Prakhar Garg in Noida is a specialized medical professional who focuses on the diagnosis, treatment, and management of diabetes. They possess extensive knowledge in the field of endocrinology and employ a multidisciplinary approach to provide comprehensive care for patients with diabetes, ensuring optimal control of blood sugar levels and minimizing complications.
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If you want to get the best diabetes doctor in Noida? Then don't look further, visit swasthyamultispeciality.com and get the best treatment. For get an appointment, visit here: https://swasthyamultispeciality.com/dr-prakhar-garg/
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Supplemental oxygen can worsen the pulmonary to systemic blood flow ratio in single ventricle patients and cause them to have rising lactate levels and cardiac arrest from low systemic cardiac output. Intubation and positive pressure ventilation may impede pulmonary blood flow in patients with a Glenn shunt and the patient can become more desaturated. With increasing PEEP and higher respiratory rates, the patients will continue to deteriorate and desaturate. Regular dosing of adrenaline boluses in patients with single ventricle physiology who are nearly arrest, can worsen their systemic output by increasing systemic vascular resistance and promoting pulmonary overcirculation. Cardioversion of a previously healthy paediatric patient might be tempting when you see what looks like a stable ventricular tachycardia. This wide complex rhythm has fooled many people into shocking it. You might in fact be dealing with something else and can make the patient infinitely worse by shocking.
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Scanned by CamScannerl i a b l e p r e d i c t o r o f .docx
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l i a b l e p r e d i c t o r o f f u t u r e h e a l t h p r o b l e m s (K r a n t z , G r u n b e r g , & B a u m , 1 9 8 5 ;
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Birth Deformity PPT
If you want to help or donate please donate at my paypal:
dyokimura@gmail.com
https://www.buymeacoffee.com/dyokimura6
MORAL ISSUE ON BIRTH DEFORMITIES
Alexandra rothstein, former ct resident how to become a pharmaceutical resea...
Alexandra rothstein, former ct resident how to become a pharmaceutical resea...AlexandraRosensteinCT
Alexandra Rothstein, former CT resident, is an amateur poker player. Her father taught her how to play poker when she was a child. She loved watching him play games with his friends. Now that she is an adult, she loves to host poker nights. She has spent years developing her skills and has learned how to read her opponents. She always looks forward to a challenging game of poker with good friends. The Electrocardiogram - Physiologic Principles
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Supplemental oxygen can worsen the pulmonary to systemic blood flow ratio in single ventricle patients and cause them to have rising lactate levels and cardiac arrest from low systemic cardiac output. Intubation and positive pressure ventilation may impede pulmonary blood flow in patients with a Glenn shunt and the patient can become more desaturated. With increasing PEEP and higher respiratory rates, the patients will continue to deteriorate and desaturate. Regular dosing of adrenaline boluses in patients with single ventricle physiology who are nearly arrest, can worsen their systemic output by increasing systemic vascular resistance and promoting pulmonary overcirculation. Cardioversion of a previously healthy paediatric patient might be tempting when you see what looks like a stable ventricular tachycardia. This wide complex rhythm has fooled many people into shocking it. You might in fact be dealing with something else and can make the patient infinitely worse by shocking.
In her talk, Michele highlights the importance of understanding the physiology of your patients. This particularly applies to paediatric cardiac patients. In this population, the change from typical physiology means standard models of care are harmful. Tune in to hear what not to do!
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Scanned by CamScannerl i a b l e p r e d i c t o r o f .docx
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l i a b l e p r e d i c t o r o f f u t u r e h e a l t h p r o b l e m s (K r a n t z , G r u n b e r g , & B a u m , 1 9 8 5 ;
S o m e r e s e a r c h e r s h a v e q u e s t i o n e d w h e t h e r a h i
g
h s c o r e o n t h e S R R S i s a r
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Gaining The Knowledge Of Herbal Remedies NYC
New York College's Graduate School of Oriental Medicine offers a program in Oriental Medicine. This course includes the Acupuncture and Herbal Medicine to treat patients' illnesses.
Hospital administrators email list
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If you want to help or donate please donate at my paypal:
dyokimura@gmail.com
https://www.buymeacoffee.com/dyokimura6
MORAL ISSUE ON BIRTH DEFORMITIES
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Non-respiratory Functions of the Lungs.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
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3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
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Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Identification and nursing management of congenital malformations Physiology of Chemical Sensation of smell.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Toxicity
- 2. To x i c i t y i s t h e e f f e c t t h a t o c c u r s wh e n t o o mu c h o f a d r u g a c c umu l a t e s i n t h e b l o o d s t r e am. T h i s c o u l d b e d u e t o e i t h e r o v e r d o s e o r t h e i n a b i l i t y o f t h e k i d n e y o r l i v e r t o b r e a k d own t h e d r u g . T h e d e g r e e o f h a rmf u l e f f e c t s v a r i e s dependin g o n t h e d r u g a n d t h e d o s e , b u t t h e y c a n b e l i f e - t h r e a t e n i n g .
- 4. When the blood plasma level of the drug is below the minimum effective concentration, no therapeutic effect occurs. The therapeutic range falls between the MCE and the toxic concentration. This is where the blood plasma level of the drug is intended to be. The toxic concentration indicates the concentration of the drug that is not safe to be in the bloodstream.
- 10. WHAT DOES ACETAMINOPHEN TOXICITY DO TO THE LIVER? Damage to the liver occurs between 72-96 hours after acetaminophen ingestion. Hepatic necrosis occurs, along with hepatic dysfunction. If treatment is not received, multi-organ failure is possible. (Farrell, 2014)
- 11. HOW TO PREVENT TOXICITY… Always take drugs as directed. Do not exceed maximum dosage. Know the dosage of drug per tablet. Know how often to take the medication. Know what other medications to avoid while taking Tylenol. Acetaminophen is in over 600 medications, thus it is easy to exceed the therapeutic dose (Tylenol, 2014).
- 12. REFERENCES Farrell, S. E. (2014, June 24). Acetaminophen Toxicity . Retrieved September 1, 2014, from Medscape: http://emedicine.medscape.com/article/ 820200-overview Tylenol (2014). Frequently asked questions. Washington, PA: McNeil-PPC, Inc. Retrieved from Tylenol: http://www.tylenol.com/safety-dosing/faq#safety-dosing Tylenol (2014). Acetaminophen dosage for adults. Washington, PA: McNeil-PPC, Inc. Retrieved from http://www.getreliefresponsibly.com/acetaminophen-dosage/ adults?utm_source=google&utm_medium=cpc&utm_campaign=GRR+- +Unbranded&utm_term=acetaminophen%2520dosage&utm_content=Acetaminophen+- +Dosing|mkwid|s1RXEK6GM_dc|pcrid|27714131282|338ilu23432 Lehne, R. A. Parmacology for Nursing Care. St. Louis, Missouri, U.S.: Elsevier. Mehta, N. (2012, June 27). Drug-Induced Hepatotoxicity. Retrieved September 2, 2014, from Medscape: http://emedicine.medscape.com/article/169814-overview#aw2aab6b3