Vinod Varma has had a career in software engineering and consulting, working for both government and private companies in roles ranging from scientific assistant to general manager. He discusses keys to a successful career, including developing interpersonal skills like teamwork and understanding others, as well as continually improving technical skills and anticipating changes in technology. Varma emphasizes focusing on solutions rather than just problems, understanding market trends, and having ambitious goals of making a difference or changing the world through entrepreneurship.