4. MOA Cont.…
• Inositol phosphates are a group of mono- to
polyphosphorylated inositols. They play crucial roles in
diverse cellular functions, such as cell growth,
apoptosis, cell migration, endocytosis, and cell
differentiation.
• E.g Inositol trisphosphates act on the inositol
triphosphate receptor to release calcium into the
cytoplasm.
• Inositol, or more precisely myo-inositol, is a carbocyclic
sugar that is abundant in brain and other mammalian
tissues, mediates cell signal transduction in response
to a variety of hormones, neurotransmitters and
growth factors and participates in osmoregulation.
5.
6.
7.
8.
9.
10.
11.
12. Assignment 2
• Group 2
a. Define the term tocolytic as applied in
pharmacology.
b. List four (4) drugs that have tocolytic effects
c. Discuss the pharmacology of Ritodrine with
respect to class, Effect on uterus, therapeutic uses,
adverse effects and nursing implications.
13. Assignment 2
• Group 1
a. Define the term tocolytic as applied in
pharmacology.
b. List four (4) drugs that have tocolytic effects
c. Discuss the pharmacology of Terbutaline with
respect to class, Effect on uterus, therapeutic uses,
adverse effects and nursing implications.
Editor's Notes
CGMP : cyclic guanosine monophosphate (cGMP)
MYLK’s contain a catalytic core domain with an ATP binding domain. On either sides of the catalytic core sit calcium ion/calmodulin binding sites. Binding of calcium ion to this domain increases the affinity of MYLK binding to myosin light chain.
Calmodulin is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca²⁺, and the binding of Ca²⁺ is required for the activation of calmodulin.
Calmodulin is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca²⁺, and the binding of Ca²⁺ is required for the activation of calmodulin.
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway.
Myasthenia gravis is a chronic autoimmune neuromuscular disease that causes weakness in the skeletal muscles, which are responsible for breathing and moving parts of the body, including the arms and legs. The name myasthenia gravis, which is Latin and Greek in origin, means "grave, or serious, muscle weakness."
