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Chromatography: Optimize Helium Usage with the Thermo Scientific Helium Saver Module
The document discusses an innovative Helium Saver module designed for gas chromatography that can significantly extend the lifespan of helium cylinders, offering up to 14 years of usage without the need for frequent replacements. It highlights the advantages of maintaining existing methodologies while improving efficiency and budget savings in laboratories. Additionally, it provides insights into the limitations of current approaches to helium shortages and the potential financial benefits of implementing the new technology.
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Chromatography: Optimize Helium Usage with the Thermo Scientific Helium Saver Module
- 1. Maintain your Methods, Prolongyour Helium Supply, Supply and Save Your Budget with an Innovative Helium Solution The world leader in serving science 1
- 2. Existing Ways toTackle the Helium Supply Shortage • Migrate to H2 carrier gas • Switch over to nitrogen when the GC or GC-MS is not running g • Reduce the split ratio (and amount injected) during the split time of the split injection 2
- 3. Limitations of theExisting Approaches • Migrate to hydrogen carrier gas • • • • Safety concerns Method translation Reduced sensitivity QA/AC adjustments • Switch over to nitrogen when the GC or GC-MS is not running • Reduce the split ratio (and amount injected) during the split time of the split injection • • 3 Not applicable to splitless Accuracy may be affected with smaller-volume injections j
- 4. The Helium Saver The Threvolutionary Th l i Thermo Scientific™ I S i ifi ™ Instant C Connect H li Helium S Saver Module for chromatographers seeking freedom from the helium supply crisis, offers a GC & GC-MS instrument lifetime helium carrier gas solution while keeping existing methodology. Unlike others the Helium methodology others, Saver is a module that is always ready and works while your instrument is running, as well as when it is idle, providing up to 14 years of GC & GCMS operation from a single helium cylinder cylinder. • Maintain your Methods • Prolong your Supply • Save your Budget www.thermoscientific.com/heliumsaver 4
- 5. Instant Connect Modularity •Modularity makes the Thermo Scientific™ TRACE™ 1300 GC a futureproof GC platform • New modules are compatible with existing TRACE 1300 Series GCs • User-installable: no service engineer, special training/tools required • Swap modules for continuous operations • Tailor instrument configuration to workload • Quickly install injector/detector modules • Every module is self-sufficient • Reduce capital investments • Eliminate downtime 5
- 6. Helium Saver Enablesa Cylinder of Helium to Last… 3.5 years continuously used 24/7/365 for GC-MS analysis 5.4 years shutting Helium off or to N2 during weekends 10.5 years shutting Helium off or to N2 overnight (8 hr day) 14.6 14 6 years shutting Helium off or to N2 on weekends and overnight For a Thermo Scientific™ TRACE 1300 Series GC, ISQ ISQ™ Series GC-MS and TSQ™ 8000 GC-MS/MS TSQ with the Helium Saver Module, it means this could be the last and only helium cylinder that will b needed f th lif ti ill be d d for the lifetime of th i t f the instrument t 6
- 7. Helium Saver ModuleExample EPA 8270 EPA 8270 Standard GC Flow Conditions He carrier gas flow He split flow H li fl Gas saver flow Gas saver on Purge flow Run time He volume in cylinder Runs per Day He cylinder cost N2 cylinder cost mL/min mL/min L/ i mL/min min mL/min min L USD USD 1 60 20 3 5 25 7,300 57 $300 $60 • Example: U.S. EPA Method 8270 (semi-volatiles analysis with GC-MS) • Total Analysis Time: 25 minutes •A Around the Clock Analyses per Day: 57 d th Cl k A l D Helium cylinder life time was extended from 5 months to 3.5 years 35 of continous uninterrupted use Daily He Usage Helium Savings: 7 times g He Cylinder Life He Cylinder Life (continuous uninterrupted use) Daily N2 Usage N2 Cylinder Life Monetary Savings: 3 times 7 Total Annual Cost T t lA lC t Total Savings Standard He Consumption Liters Days Liters Days Helium Saver Consumption 46.56 157 0 0 5.76 1,267 1 267 40.8 179 $688 $205 $483
- 8. Helium Saver Modulevs. Conventional SSL Helium Saver Module Contains the SSL as a subsystem Industry standard injector Uses exactly th same methods U tl the th d Used for U d f > 80% methods th d Preserves your methods and saves helium 8 Conventional SSL Wastes most of the helium
- 9. Helium Saver vs.Conventional SSL: Rt Unchanged C10 C11 C12 C13 C14 C10 C11 C15 C16 C12 C13 C14 C15 C16 C19 C20 C17 C18 C19 C20 C17 C18 C21 C23 C24 C25 C22 C21 C23 C25 C22 C24 Helium Saver He column flow N2 split and septum purge SSL Only He supplied Splitless 1 uL 30 m, 0.25 mm ,0.25 µm Thermo Scientific™ TRACE TR5 Column 50 ˚ to 300 ˚C at 10 C/min CF 1 mL/min FID at 300 °C 9
- 10. Helium Saver: HighBoiling Compounds Transfer Complete recovery of high boiling compounds C14 C10 C12 C16 Component C18 C20 C22 Splitless 1 uL 7 m, 0.32 mm ID,0.25 µm TRACE TR5 Column 60 to 320 C at 10 C/min CF 2 mL/min Helium Saver SSL and FID at 340 C 10 C24 C26 C30 C34 C28 C32 C36 C38 C40 nC10 nC12 nC14 nC16 nC18 nC20 nC22 nC24 nC26 nC28 nC30 nC32 nC34 nC36 nC38 nC40 Absolute Peak Recovery Areas (%) * (%) * (counts) 2498258 100.3 2457224 98.7 2550661 102.4 2504229 100.6 2484007 99.8 2489876 100.0 2482628 99.7 2455417 98.6 2409871 96.8 2438442 97.9 2469831 99.2 2412554 96.9 2472760 99.3 2422105 97.3 2394975 96.2 2349780 94.4 * nC20 internal standard reference
- 11. EPA Method 8270Calibration Curves R2 Results SSL Helium Saver Average: 0.998 1.000 0.995 0 995 0.990 0.985 0.980 0.975 0.970 0.965 0.960 0.955 0.950 11 Compound Name N‐Nitrosodimethylamine y Pyridine Phenol Aniline Phenol, 2‐chloro‐ N‐nitrosodi‐n‐propylamine N nitrosodi n propylamine Phenol, 2‐nitro‐ Phenol, 2,4‐dichloro‐ p‐Chloroaniline Phenol, 4‐chloro‐3‐methyl‐ Hexachlorocyclopentadiene Phenol, 2,4,6‐trichloro‐ Phenol, 2,4,5‐trichloro‐ 2‐Nitroaniline Dimethyl phthalate Dimethyl phthalate 2,6‐dinitrotoluene SSL 0.99852 0.99831 0.99843 0.99846 0.99847 0.99811 0 99811 0.99838 0.99763 0.99901 0.99561 0.99541 0.99723 0.99609 0.99774 0.99820 0 99820 0.99702 Helium Saver 0.99871 0.99855 0.99722 0.99813 0.99743 0.99808 0 99808 0.99859 0.99937 0.99875 0.99660 0.99856 0.99948 0.99893 0.99915 0.99757 0 99757 0.99920
- 12. Helium Saver Technology:Revolutionary Approach Innovative and Unique Features and Benefits • Up to 14 years of one helium cylinder life time • Always saves – works during analytical run and idle time • Always ready – no switch-back equilibration time • Change septum and liner without GC or MS cooling down • Can maintain existing methods • Helium Saver Technology is covered by U.S. Patent 8,371,152 12
- 13. How Long CanOne Helium Cylinder Last in YOUR Lab? Use our calculator to find out how much the Helium Saver Module can help y p your lab. Enter your working parameters and discover the following: • How long one cylinder of helium can last in your lab y • How much budget you can save on helium supplies over the lifetime of your GC or GCy MS instrument www.thermoscientific.com/heliumsaver www thermoscientific com/heliumsaver 13
- 14. Interested in LearningMore? Visit the website address below for more information: • Determine your potential helium savings with our online calculator • Download a technical article that outlines the helium supply shortage and solution • Vi View a webinar that bi h discusses this information in detail www.thermoscientific.com/heliumsaver www thermoscientific com/heliumsaver 14
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