This document discusses University-Based Entrepreneurial Ecosystems (U-BEEs) and their role in accelerating regional development. It notes that universities are usually top job creators in regions when they have associated incubators, science parks, data centers, hospitals, schools and other facilities. These U-BEEs connect information flows between ecosystems in cities. The document also provides an outline of its discussion on trends of universities becoming more locally connected research centers and the evolution of cities becoming smarter.