Soft tissue sarcoma grading

1. FNCLCC Grading
Devita, Heron

2. FNCLCC Grading
• = Fédération Nationale des Centres de Lutte Contre le Cancer
• The most common grading system; defined by a combination of
tumor differentiation, mitotic count and necrosis
• For soft tissue sarcoma
• Purpose : to assign a level of differentiation
• Most important factor in prognosis, metastatic risk and management
of soft tissue tumors

3. FNCLCC Grading
• Three parameters are evaluated: tumour differentiation, mitotic
count and tumour necrosis.
• FNCLCC grading is less informative in RMS, Ewing sarcoma, ASPS,
epithelioid sarcoma and clear cell sarcoma; these are by definition
high grade.
• Sarcomas not graded in the FNCLCC system: embryonal and alveolar
rhabdomyosarcoma, angiosarcoma, extraskeletal myxoid
chondrosarcoma, alveolar soft part sarcoma, clear cell sarcoma and
epithelioid sarcoma

4. Husain, N., & Verma, N.
(2011). Curent Concepts in
Pathology of Soft Tissue
Sarcoma. Indian Journal of
Surgical Oncology, 2(4), 302–
308. doi:10.1007/s13193-012-
0134-6

5. Sources
• ESMO
• Husain, N., & Verma, N. (2011). Curent Concepts in Pathology of Soft
Tissue Sarcoma. Indian Journal of Surgical Oncology, 2(4), 302–308.
doi:10.1007/s13193-012-0134-6
• Obeidin F. Grading. PathologyOutlines.com website.
https://www.pathologyoutlines.com/topic/softtissuegrading.html.
Accessed March 31st, 2024.