This review describes the development of transcranial magnetic stimulation in 1985 and the research related to
this technique over the following 10 years. It not only focuses on work done at the National Institutes of Health
but provides a survey of other related research as well. Key topics are the calculation of the electric field produced
during magnetic stimulation, the interaction of this electric field with a long nerve axon, coil design, the time course
of the magnetic stimulation pulse, and the safety of magnetic stimulation.
Dr. V. Swarajya Lakshmi presented on electroconvulsive therapy (ECT) to treat severe mental illnesses. ECT involves inducing seizures in anesthetized patients using electric currents administered through electrodes placed on the head. It is effective for treating depression, mania, and schizophrenia. While its exact mechanisms are unclear, ECT is thought to impact neurotransmitter systems in the brain. It carries risks but is considered safe when properly administered. ECT remains an important treatment option for severe and treatment-resistant psychiatric conditions.
This document discusses the future of bioelectronics in medicine. It describes how the convergence of biology and electronics could allow for technologies like restoring vision or reversing spinal cord injuries using implanted devices. Key areas that could be impacted include healthcare, homeland security, and protecting the environment. The document outlines some of the materials being researched for bioelectronics like graphene and PEDOT, as well as devices like pacemakers and biosensors. Advances in bioelectronics hold promise for new medical treatments but also challenges in biocompatibility and sensor longevity that researchers are working to address.
A Historical Account of the Development of Deep Brain Stimulation:A SurveyIRJET Journal
This document provides a historical overview of the development of deep brain stimulation (DBS) as a therapeutic procedure over the last 200 years. It discusses how electrical stimulation of the brain has been used since ancient times for various medical purposes. In the 18th-19th centuries, scientists began systematically investigating the functions of the brain using electrical stimulation. In the 20th century, advances like electroencephalography, stereotactic surgery, and lesioning helped establish DBS. The first modern therapeutic application was electroconvulsive therapy in 1938. DBS is now used to treat various neurological and psychiatric conditions.
Do static magnetic or electric fields used for instance in medical imaging pose health risks?
Medical imaging devices (such as MRI scanners), trains, and television sets are examples of man-made equipment that can generate static magnetic or electric fields.
In some areas of research and medical imaging, stronger and stronger static magnetic fields are being used.
What is known so far about potential health consequences?
Cardiac Pacemakers: Function,
Troubleshooting, and Management
Part 1 of a 2-Part Series
Siva K. Mulpuru, MD, Malini Madhavan, MBBS, Christopher J. McLeod, MBCHB, PHD, Yong-Mei Cha, MD,
Paul A. Friedman, MD
The use of magnetism in medicine is recorded in the history of most civilizations. The first usage is noted in Chinese writings (approximately 2000 B.C.), referencing the use of magnetism in conjunction with acupuncture. Cleopatra is said to have worn a lodestone on her forehead to prevent aging.
This document provides a summary of the history and current status of electromagnetic field (EMF) therapy and its effects on the immune system and inflammation. It discusses how EMF therapy was used as early as 2750 BC to treat maladies. Modern research from the 1960s onward helped establish that tissues respond to biophysical inputs like electrical and electromagnetic fields. The document reviews how EMFs are generated and their effects on biosystems at the cellular level. It explains that EMF therapy may work by cells both generating and detecting EMFs to communicate. The anti-inflammatory effects of EMF therapy are also summarized, noting its potential to reduce inflammation through effects on calcium signaling and cell membrane processes.
A Review Article On The Roles Of Solid State Physics In The Modern Science De...Courtney Esco
This summarizes a review article on the importance of solid-state physics in modern science. Solid-state physics studies the structure and properties of rigid materials. It has contributed greatly to many fields such as electronics, materials science, and renewable energy. Some key developments include the semiconductor, which enabled modern electronics like transistors. Understanding nuclear fusion through a solid-state physics lens may help unlock cold fusion. Advances in solid-state biosensors allow for more compact medical devices. Manipulating a material's band gap through techniques like doping has expanded the functions of materials. Spectroscopy techniques relying on solid-state physics principles help determine molecular structures. Continued research in fields like spintronics may lead to improved energy storage solutions
Dr. V. Swarajya Lakshmi presented on electroconvulsive therapy (ECT) to treat severe mental illnesses. ECT involves inducing seizures in anesthetized patients using electric currents administered through electrodes placed on the head. It is effective for treating depression, mania, and schizophrenia. While its exact mechanisms are unclear, ECT is thought to impact neurotransmitter systems in the brain. It carries risks but is considered safe when properly administered. ECT remains an important treatment option for severe and treatment-resistant psychiatric conditions.
This document discusses the future of bioelectronics in medicine. It describes how the convergence of biology and electronics could allow for technologies like restoring vision or reversing spinal cord injuries using implanted devices. Key areas that could be impacted include healthcare, homeland security, and protecting the environment. The document outlines some of the materials being researched for bioelectronics like graphene and PEDOT, as well as devices like pacemakers and biosensors. Advances in bioelectronics hold promise for new medical treatments but also challenges in biocompatibility and sensor longevity that researchers are working to address.
A Historical Account of the Development of Deep Brain Stimulation:A SurveyIRJET Journal
This document provides a historical overview of the development of deep brain stimulation (DBS) as a therapeutic procedure over the last 200 years. It discusses how electrical stimulation of the brain has been used since ancient times for various medical purposes. In the 18th-19th centuries, scientists began systematically investigating the functions of the brain using electrical stimulation. In the 20th century, advances like electroencephalography, stereotactic surgery, and lesioning helped establish DBS. The first modern therapeutic application was electroconvulsive therapy in 1938. DBS is now used to treat various neurological and psychiatric conditions.
Do static magnetic or electric fields used for instance in medical imaging pose health risks?
Medical imaging devices (such as MRI scanners), trains, and television sets are examples of man-made equipment that can generate static magnetic or electric fields.
In some areas of research and medical imaging, stronger and stronger static magnetic fields are being used.
What is known so far about potential health consequences?
Cardiac Pacemakers: Function,
Troubleshooting, and Management
Part 1 of a 2-Part Series
Siva K. Mulpuru, MD, Malini Madhavan, MBBS, Christopher J. McLeod, MBCHB, PHD, Yong-Mei Cha, MD,
Paul A. Friedman, MD
The use of magnetism in medicine is recorded in the history of most civilizations. The first usage is noted in Chinese writings (approximately 2000 B.C.), referencing the use of magnetism in conjunction with acupuncture. Cleopatra is said to have worn a lodestone on her forehead to prevent aging.
This document provides a summary of the history and current status of electromagnetic field (EMF) therapy and its effects on the immune system and inflammation. It discusses how EMF therapy was used as early as 2750 BC to treat maladies. Modern research from the 1960s onward helped establish that tissues respond to biophysical inputs like electrical and electromagnetic fields. The document reviews how EMFs are generated and their effects on biosystems at the cellular level. It explains that EMF therapy may work by cells both generating and detecting EMFs to communicate. The anti-inflammatory effects of EMF therapy are also summarized, noting its potential to reduce inflammation through effects on calcium signaling and cell membrane processes.
A Review Article On The Roles Of Solid State Physics In The Modern Science De...Courtney Esco
This summarizes a review article on the importance of solid-state physics in modern science. Solid-state physics studies the structure and properties of rigid materials. It has contributed greatly to many fields such as electronics, materials science, and renewable energy. Some key developments include the semiconductor, which enabled modern electronics like transistors. Understanding nuclear fusion through a solid-state physics lens may help unlock cold fusion. Advances in solid-state biosensors allow for more compact medical devices. Manipulating a material's band gap through techniques like doping has expanded the functions of materials. Spectroscopy techniques relying on solid-state physics principles help determine molecular structures. Continued research in fields like spintronics may lead to improved energy storage solutions
This document summarizes scientific research on the mechanisms of acupuncture. It discusses that acupuncture stimulates the body's natural healing systems through neurological, biochemical and bioelectrical mechanisms. Extensive clinical research has found acupuncture effective for conditions like arthritis, dysmenorrhea, headache, and angina. Modern research has identified anatomical structures comprising acupuncture meridians and their distinct electrical properties. Studies show acupuncture enhances the body's natural healing responses by activating the nervous system and stimulating the release of chemicals and electric currents.
Effect of Combined Antenna Electromagnetic Power to Humandrboon
This paper investigates the effect of the combined signals from the nearby cellular towers that have toward population health in Thailand. We investigate the frequencies in the operating ranges of GSM 850/ 900/ 1800/ 1900/ and 2100 MHz. Both power and frequency of electromagnetic wave have influence to living cell. In theory, these combined signals strength can fluctuate the energy level of certain minerals that are key components of human internal organs. These minerals, such as K+, Ca++, and Na+, are crucial in maintaining the balance for healthy body. The damage to the living organ from the small amount of heat energy that caused by the vibration of polar dielectric, such as H2O is even less than the damage that is caused by displacement of electron in the these minerals. In theory the charged particle that originated from as such demonstrates property of electric vector (magnitude, phase and direction) which cause the living cell to be prone to oxidization and degenerated; it can deviate from its normality. Hence, this study is crucial to human and all livings.
The document summarizes research on how low electromagnetic fields interact with excitable cells. It discusses how the heart generates the largest electrical and magnetic fields in the body within the extremely low frequency range. It also describes how cardiac muscle cells are interconnected through intercalated discs and gap junctions to propagate electrical signals. Finally, it provides background on bioelectricity, biomagnetism, and how electrical and magnetic fields can induce currents in tissues.
This document describes an experiment to study how yeast cells move when subjected to non-uniform electric fields (dielectrophoresis). Yeast cells were placed in a suspension between two pointed platinum electrode tips and exposed to alternating electric fields of varying frequency. The motion and clustering of cells at the electrode tips, where the electric field was strongest, was observed under a microscope over time. The clustering behavior depended on factors like field strength, frequency, suspension conductivity, and biological characteristics of the yeast cells.
neurophysiological basis of therapeutic electricityRuchika Gupta
Neural control of muscles involves the transmission of nerve action potentials from the brain to muscles. Electrical stimulation of nerves and muscles works by altering the polarization of cell membranes. Cathodal stimulation causes depolarization by making the outside of cells more negative, while anodal stimulation causes hyperpolarization by making the outside more positive. The orientation of cells relative to the anode and cathode determines whether they are activated or deactivated during stimulation.
Digitally Modulated Higher Cervical Tetraplegic by facial Signaling Project |...CrimsonpublishersMedical
Digitally Modulated Higher Cervical Tetraplegic by facial Signaling Project by Abbas Alnaji in Research in Medical & Engineering Sciences
Complete tetraplegia means shoulder is involved due to cervical spinal cord segment four is damaged. We have to bypass this gap. One method is by picking up the signals of facial muscles where volitionally controlled, propagate them (afferent similarity) to a digital processor to generate a package of orders (efferents) transmitted to the effecter organs (muscles) to achieve preprogrammed task. The whole story is implanted sub-cutanously.
An extensive review over current technology, possibilities and ethical implications in the area of neuronal implants.
Topics include:
- different forms of neuronal implants
- problems with current technology
- future possibilities
Bioelectromagnetism examines electric, electromagnetic, and magnetic phenomena that arise in biological tissues. It has been studied since ancient Egyptians observed electric shocks from stingrays. One early medical application used stingrays to treat headaches and arthritis. Virtually all scientists are aware of bioelectricity in nerves and muscles, but fewer know the importance of biomagnetism - the magnetic fields surrounding living organisms produced by electrical activity. Applications of bioelectromagnetism include transcranial magnetic stimulation of the brain and magnetic stimulation of neural tissue. Adverse effects can include tissue heating from intense electromagnetic fields.
This document provides an overview of medical electronics course material covering biopotential recording and measurement. It discusses the origin of biopotentials from cellular electrical activity and the volume conductor fields that link this activity to external recordings. It covers biopotential electrodes and the electrode-electrolyte interface, including half-cell potentials, polarization, and the Nernst equation. Example biopotentials discussed include ECG, EEG, and EMG. The document also lists topics to be covered in subsequent units, such as biomedical measurement techniques, assist devices, radiological equipment, and recent trends.
Cranial Laser Reflex Technique: Healthcare for GeniusesNicholas Wise
Cranial Laser Reflex Technique is an exciting new development in natural pain relief and functional improvement. This stand-alone method allows a practitioner with any cold laser to be able to reduce someone's musculoskeletal pain with amazing speed. This condensed version of Dr. Nick Wise's recent lecture gives the scientific basis of CLRT.
This document provides an introduction and historical perspective on electromyography (EMG). It discusses how EMG evolved from its earliest roots using electric eels to modern applications using electrodes and electronic devices to detect and analyze electrical signals from muscles. Key developments included establishing relationships between EMG amplitude and force/velocity in the 1940s-1950s, the introduction of wire electrodes in the 1960s, and the development of mathematical models to explain properties of EMG signals in the 1960s-1970s. Modern applications include prosthesis control, motor control studies, and decomposition of EMG signals into individual motor unit activity.
radiation physics is important to know for dental student to be able to utlize xray and to know the benefita and overcome the hazards of radiation. in this lecture history of discovery of xray and properties of xrays and properties of elecromagnetic waves. mechanism of xay production and parts of ddental xray machine morreover the factors affecting image quality is also discussed in details . diagrams and images are included for verification
Microwave radiation guidelines and debate during the last 50 yearsMikko Ahonen
This document discusses guidelines for microwave radiation exposure over the last 50 years. It describes how early guidelines focused on preventing thermal harm from high-level radar exposure based on military research. However, some studies found non-thermal biological effects. Guidelines now focus on SAR (specific absorption rate) measures, but these have limitations as they assume uniform tissue heating and do not consider effects from chronic or simultaneous exposures. New research on non-thermal effects and more accurate modeling of exposure is needed to develop improved safety guidelines.
Electromyography and its uses about signals.pptRGCE
1. Electromyography (EMG) involves recording the electrical activity of muscles. Important historical events include Galvani's discovery that muscles contract in response to electricity in the late 18th century and Duchenne's systematic investigations using electrical stimulation in the 19th century.
2. EMG signals are detected using surface or indwelling electrodes and amplified. Factors like electrode placement, distance between electrodes, and signal filtering influence the recorded signal. Signals are typically sampled above the Nyquist frequency and processed in the time or frequency domain.
3. Common processing techniques in the time domain include rectification, filtering, integration, and root mean square. These aim to extract meaningful information from raw EMG signals and correlate
Warm
Low
density
Cool
High
density
Warm
Platinum
film
Spin
current
a
b
c
Electric field
Electric field
Chemical
potential m
m↓
m↑
Ferromagnet
Magnetic
field (’spin-up’)
Ferromagnet
Metal bar
Cool
Warm Cool
process. In the rest frame of the electron, the
charged impurity rushing towards it consti-
tutes a current filament, so the electron ‘sees’ a
weak magnetic field circling the filament. This
non-uniform magnetic field imparts a force
on the electron along a direction that depends
on its spin orientation3,4. The net result is that
spin-up electrons are pushed to the right of
the impurity whereas spin-down electrons are
pushed to its left.
In effect, each impurity acts like a spin filter
that selectively kicks electrons to one side or
the other, depending on their spin. As shown
in Figure 1c, the excess spin-up population
in the incident beam results in more charge
accumulating on the far face than on the near
face of the platinum film. The voltage differ-
ence between the two faces is observable as
a Hall signal. The asymmetric scattering of
electrons is especially large in materials with
a high atomic number, such as platinum. Fol-
lowing its prediction3,4, the spin Hall effect was
first observed by applying purely optical tech-
niques to semiconductors5,6, and was later
detected electrically in metals7,8.
In a series of tests, Uchida et al.2 convincingly
show that the Hall voltage in the platinum film
arises from the spin voltage. The Hall signal in
the platinum film tracks both the magnitude
and the direction of the magnetization in the
nickel–iron film. Moreover, by moving the
platinum film along the length of the nickel–
iron film, they show that the spin voltage varies
linearly over the 6-mm length of the sample.
In demonstrating that the spin Seebeck effect
can produce a large, calibrated spin-voltage
source that can be ‘tapped’ anywhere along
the length of the ferromagnet, Uchida and
colleagues have added an important tool to the
spintronics toolbox. ■
N. P. Ong is in the Department of Physics,
Princeton University, Princeton, New Jersey
08544, USA.
e-mail: [email protected]
1. Gregg, J. F. in Spin Electronics (eds Ziese, M. & Thornton,
M. J.) 3–31 (Springer, 2001).
2. Uchida, K. et al. Nature 455, 778–781 (2008).
3. D’yakonov, M. I. & Perel, V. I. Phys. Lett. A 35, 459–460
(1971).
4. Hirsch, J. E. Phys. Rev. Lett. 83, 1834–1837 (1999).
5. Kato, Y. K., Myers, R. C., Gossard, A. C. & Awschalom, D. D.
Science 306, 1910–1913 (2004).
6. Wunderlich, J., Kaestner, B., Sinova, J. & Jungwirth, T.
Phys. Rev. Lett. 94, 047204 (2005).
7. Valenzuela, S. O. & Tinkham, M. Nature 442, 176–179
(2006).
8. Kimura, T., Otani, Y., Sato, T., Takahashi, S. & Maekawa, S.
Phys. Rev. Lett. 98, 156601 (2007).
Figure 1 | The spin Seebeck effect. a, In
the ordinary Seebeck effect, a temperature
gradient in a metal bar causes more electrons to
accumulate at the cool end, producing a ti.
The document summarizes research studying changes in motor axon excitability in stroke survivors using a technique called TROND. The study had two aims: 1) compare dominant and non-dominant sides in healthy subjects, and 2) compare paretic and non-paretic sides in stroke survivors. The results found no differences between dominant/non-dominant sides in healthy subjects. While membrane potential did not differ between paretic/non-paretic sides in stroke survivors, excitability differences were found, likely due to changes in ionic conductances. The research contributes to understanding mechanisms behind motor deficits post-stroke.
A case report of posterior reversible encephalopathy syndrome in a patient di...bijnnjournal
Posterior reversible encephalopathy syndrome (PRES), a clinical radiological syndrome, is characterized by the
abrupt development of neurological symptoms such as headaches, convulsions, altered sensorium, and visual
problems. PRES has been linked to a number of risk factors or etiologies, including the use of immunosuppressants
or cytotoxins, hypertensive encephalopathy, eclampsia, preeclampsia, and underlying autoimmune diseases.
A 41-year-old female was admitted with acute necrotizing emphysematous pancreatitis complicated by posterior
reversible encephalopathy syndrome
Balint syndrome: an unusual triad, Balint syndrome: an unusual triadbijnnjournal
The paper investigates a case of sudden loss of vision in a patient with recent history of blurred vision of right eye
diagnosed with Central retinal artery occlusion (CRAO). The point of interest of this case report is that the clinical
features are something different from those of a CRAO and revealed cardinal triad of simultanagnosia, optic ataxia,
and oculomotor apraxia which are conclusive of a rare clinical entity known as Balint syndrome.
More Related Content
Similar to The development of transcranial magnetic stimulation
This document summarizes scientific research on the mechanisms of acupuncture. It discusses that acupuncture stimulates the body's natural healing systems through neurological, biochemical and bioelectrical mechanisms. Extensive clinical research has found acupuncture effective for conditions like arthritis, dysmenorrhea, headache, and angina. Modern research has identified anatomical structures comprising acupuncture meridians and their distinct electrical properties. Studies show acupuncture enhances the body's natural healing responses by activating the nervous system and stimulating the release of chemicals and electric currents.
Effect of Combined Antenna Electromagnetic Power to Humandrboon
This paper investigates the effect of the combined signals from the nearby cellular towers that have toward population health in Thailand. We investigate the frequencies in the operating ranges of GSM 850/ 900/ 1800/ 1900/ and 2100 MHz. Both power and frequency of electromagnetic wave have influence to living cell. In theory, these combined signals strength can fluctuate the energy level of certain minerals that are key components of human internal organs. These minerals, such as K+, Ca++, and Na+, are crucial in maintaining the balance for healthy body. The damage to the living organ from the small amount of heat energy that caused by the vibration of polar dielectric, such as H2O is even less than the damage that is caused by displacement of electron in the these minerals. In theory the charged particle that originated from as such demonstrates property of electric vector (magnitude, phase and direction) which cause the living cell to be prone to oxidization and degenerated; it can deviate from its normality. Hence, this study is crucial to human and all livings.
The document summarizes research on how low electromagnetic fields interact with excitable cells. It discusses how the heart generates the largest electrical and magnetic fields in the body within the extremely low frequency range. It also describes how cardiac muscle cells are interconnected through intercalated discs and gap junctions to propagate electrical signals. Finally, it provides background on bioelectricity, biomagnetism, and how electrical and magnetic fields can induce currents in tissues.
This document describes an experiment to study how yeast cells move when subjected to non-uniform electric fields (dielectrophoresis). Yeast cells were placed in a suspension between two pointed platinum electrode tips and exposed to alternating electric fields of varying frequency. The motion and clustering of cells at the electrode tips, where the electric field was strongest, was observed under a microscope over time. The clustering behavior depended on factors like field strength, frequency, suspension conductivity, and biological characteristics of the yeast cells.
neurophysiological basis of therapeutic electricityRuchika Gupta
Neural control of muscles involves the transmission of nerve action potentials from the brain to muscles. Electrical stimulation of nerves and muscles works by altering the polarization of cell membranes. Cathodal stimulation causes depolarization by making the outside of cells more negative, while anodal stimulation causes hyperpolarization by making the outside more positive. The orientation of cells relative to the anode and cathode determines whether they are activated or deactivated during stimulation.
Digitally Modulated Higher Cervical Tetraplegic by facial Signaling Project |...CrimsonpublishersMedical
Digitally Modulated Higher Cervical Tetraplegic by facial Signaling Project by Abbas Alnaji in Research in Medical & Engineering Sciences
Complete tetraplegia means shoulder is involved due to cervical spinal cord segment four is damaged. We have to bypass this gap. One method is by picking up the signals of facial muscles where volitionally controlled, propagate them (afferent similarity) to a digital processor to generate a package of orders (efferents) transmitted to the effecter organs (muscles) to achieve preprogrammed task. The whole story is implanted sub-cutanously.
An extensive review over current technology, possibilities and ethical implications in the area of neuronal implants.
Topics include:
- different forms of neuronal implants
- problems with current technology
- future possibilities
Bioelectromagnetism examines electric, electromagnetic, and magnetic phenomena that arise in biological tissues. It has been studied since ancient Egyptians observed electric shocks from stingrays. One early medical application used stingrays to treat headaches and arthritis. Virtually all scientists are aware of bioelectricity in nerves and muscles, but fewer know the importance of biomagnetism - the magnetic fields surrounding living organisms produced by electrical activity. Applications of bioelectromagnetism include transcranial magnetic stimulation of the brain and magnetic stimulation of neural tissue. Adverse effects can include tissue heating from intense electromagnetic fields.
This document provides an overview of medical electronics course material covering biopotential recording and measurement. It discusses the origin of biopotentials from cellular electrical activity and the volume conductor fields that link this activity to external recordings. It covers biopotential electrodes and the electrode-electrolyte interface, including half-cell potentials, polarization, and the Nernst equation. Example biopotentials discussed include ECG, EEG, and EMG. The document also lists topics to be covered in subsequent units, such as biomedical measurement techniques, assist devices, radiological equipment, and recent trends.
Cranial Laser Reflex Technique: Healthcare for GeniusesNicholas Wise
Cranial Laser Reflex Technique is an exciting new development in natural pain relief and functional improvement. This stand-alone method allows a practitioner with any cold laser to be able to reduce someone's musculoskeletal pain with amazing speed. This condensed version of Dr. Nick Wise's recent lecture gives the scientific basis of CLRT.
This document provides an introduction and historical perspective on electromyography (EMG). It discusses how EMG evolved from its earliest roots using electric eels to modern applications using electrodes and electronic devices to detect and analyze electrical signals from muscles. Key developments included establishing relationships between EMG amplitude and force/velocity in the 1940s-1950s, the introduction of wire electrodes in the 1960s, and the development of mathematical models to explain properties of EMG signals in the 1960s-1970s. Modern applications include prosthesis control, motor control studies, and decomposition of EMG signals into individual motor unit activity.
radiation physics is important to know for dental student to be able to utlize xray and to know the benefita and overcome the hazards of radiation. in this lecture history of discovery of xray and properties of xrays and properties of elecromagnetic waves. mechanism of xay production and parts of ddental xray machine morreover the factors affecting image quality is also discussed in details . diagrams and images are included for verification
Microwave radiation guidelines and debate during the last 50 yearsMikko Ahonen
This document discusses guidelines for microwave radiation exposure over the last 50 years. It describes how early guidelines focused on preventing thermal harm from high-level radar exposure based on military research. However, some studies found non-thermal biological effects. Guidelines now focus on SAR (specific absorption rate) measures, but these have limitations as they assume uniform tissue heating and do not consider effects from chronic or simultaneous exposures. New research on non-thermal effects and more accurate modeling of exposure is needed to develop improved safety guidelines.
Electromyography and its uses about signals.pptRGCE
1. Electromyography (EMG) involves recording the electrical activity of muscles. Important historical events include Galvani's discovery that muscles contract in response to electricity in the late 18th century and Duchenne's systematic investigations using electrical stimulation in the 19th century.
2. EMG signals are detected using surface or indwelling electrodes and amplified. Factors like electrode placement, distance between electrodes, and signal filtering influence the recorded signal. Signals are typically sampled above the Nyquist frequency and processed in the time or frequency domain.
3. Common processing techniques in the time domain include rectification, filtering, integration, and root mean square. These aim to extract meaningful information from raw EMG signals and correlate
Warm
Low
density
Cool
High
density
Warm
Platinum
film
Spin
current
a
b
c
Electric field
Electric field
Chemical
potential m
m↓
m↑
Ferromagnet
Magnetic
field (’spin-up’)
Ferromagnet
Metal bar
Cool
Warm Cool
process. In the rest frame of the electron, the
charged impurity rushing towards it consti-
tutes a current filament, so the electron ‘sees’ a
weak magnetic field circling the filament. This
non-uniform magnetic field imparts a force
on the electron along a direction that depends
on its spin orientation3,4. The net result is that
spin-up electrons are pushed to the right of
the impurity whereas spin-down electrons are
pushed to its left.
In effect, each impurity acts like a spin filter
that selectively kicks electrons to one side or
the other, depending on their spin. As shown
in Figure 1c, the excess spin-up population
in the incident beam results in more charge
accumulating on the far face than on the near
face of the platinum film. The voltage differ-
ence between the two faces is observable as
a Hall signal. The asymmetric scattering of
electrons is especially large in materials with
a high atomic number, such as platinum. Fol-
lowing its prediction3,4, the spin Hall effect was
first observed by applying purely optical tech-
niques to semiconductors5,6, and was later
detected electrically in metals7,8.
In a series of tests, Uchida et al.2 convincingly
show that the Hall voltage in the platinum film
arises from the spin voltage. The Hall signal in
the platinum film tracks both the magnitude
and the direction of the magnetization in the
nickel–iron film. Moreover, by moving the
platinum film along the length of the nickel–
iron film, they show that the spin voltage varies
linearly over the 6-mm length of the sample.
In demonstrating that the spin Seebeck effect
can produce a large, calibrated spin-voltage
source that can be ‘tapped’ anywhere along
the length of the ferromagnet, Uchida and
colleagues have added an important tool to the
spintronics toolbox. ■
N. P. Ong is in the Department of Physics,
Princeton University, Princeton, New Jersey
08544, USA.
e-mail: [email protected]
1. Gregg, J. F. in Spin Electronics (eds Ziese, M. & Thornton,
M. J.) 3–31 (Springer, 2001).
2. Uchida, K. et al. Nature 455, 778–781 (2008).
3. D’yakonov, M. I. & Perel, V. I. Phys. Lett. A 35, 459–460
(1971).
4. Hirsch, J. E. Phys. Rev. Lett. 83, 1834–1837 (1999).
5. Kato, Y. K., Myers, R. C., Gossard, A. C. & Awschalom, D. D.
Science 306, 1910–1913 (2004).
6. Wunderlich, J., Kaestner, B., Sinova, J. & Jungwirth, T.
Phys. Rev. Lett. 94, 047204 (2005).
7. Valenzuela, S. O. & Tinkham, M. Nature 442, 176–179
(2006).
8. Kimura, T., Otani, Y., Sato, T., Takahashi, S. & Maekawa, S.
Phys. Rev. Lett. 98, 156601 (2007).
Figure 1 | The spin Seebeck effect. a, In
the ordinary Seebeck effect, a temperature
gradient in a metal bar causes more electrons to
accumulate at the cool end, producing a ti.
The document summarizes research studying changes in motor axon excitability in stroke survivors using a technique called TROND. The study had two aims: 1) compare dominant and non-dominant sides in healthy subjects, and 2) compare paretic and non-paretic sides in stroke survivors. The results found no differences between dominant/non-dominant sides in healthy subjects. While membrane potential did not differ between paretic/non-paretic sides in stroke survivors, excitability differences were found, likely due to changes in ionic conductances. The research contributes to understanding mechanisms behind motor deficits post-stroke.
Similar to The development of transcranial magnetic stimulation (20)
A case report of posterior reversible encephalopathy syndrome in a patient di...bijnnjournal
Posterior reversible encephalopathy syndrome (PRES), a clinical radiological syndrome, is characterized by the
abrupt development of neurological symptoms such as headaches, convulsions, altered sensorium, and visual
problems. PRES has been linked to a number of risk factors or etiologies, including the use of immunosuppressants
or cytotoxins, hypertensive encephalopathy, eclampsia, preeclampsia, and underlying autoimmune diseases.
A 41-year-old female was admitted with acute necrotizing emphysematous pancreatitis complicated by posterior
reversible encephalopathy syndrome
Balint syndrome: an unusual triad, Balint syndrome: an unusual triadbijnnjournal
The paper investigates a case of sudden loss of vision in a patient with recent history of blurred vision of right eye
diagnosed with Central retinal artery occlusion (CRAO). The point of interest of this case report is that the clinical
features are something different from those of a CRAO and revealed cardinal triad of simultanagnosia, optic ataxia,
and oculomotor apraxia which are conclusive of a rare clinical entity known as Balint syndrome.
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Leigh syndrome is a severe neurological disorder that impairs mobility and respiration, among other bodily
functions. Progressive brain deterioration is what makes it distinctive. This case report describes a 10-monthold female child who displayed symptoms such as vibratory movements in the right upper and left lower limbs,
failure to thrive, decreased activity, and vomiting after consuming supplemental feeds. Multiple clinical signs of
Leigh syndrome, including missed developmental milestones and mild acute malnutrition, were identified during
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Endovascular complications: Antiplatelet management for flow diversionbijnnjournal
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The development of transcranial magnetic stimulation
1. BOHR International Journal of Neurology and Neuroscience
2023, Vol. 1, No. 1, pp. 9–21
DOI: 10.54646/bijnn.2023.02
www.bohrpub.com
The development of transcranial magnetic stimulation
Bradley J. Roth*
Department of Physics, Oakland University, Rochester, MI, United States
*Correspondence:
Bradley J. Roth,
roth@oakland.edu
Received: 24 January 2023; Accepted: 16 February 2023; Published: 28 February 2023
This review describes the development of transcranial magnetic stimulation in 1985 and the research related to
this technique over the following 10 years. It not only focuses on work done at the National Institutes of Health
but provides a survey of other related research as well. Key topics are the calculation of the electric field produced
during magnetic stimulation, the interaction of this electric field with a long nerve axon, coil design, the time course
of the magnetic stimulation pulse, and the safety of magnetic stimulation.
Keywords: transcranial magnetic stimulation, electromagnetic induction, nerve, brain, coil
Introduction
Transcranial stimulation is a technique to excite the brain
using electromagnetic induction: a changing magnetic field
induces an electric field that activates the neurons. The main
advantage of magnetic stimulation over electrical stimulation
is that it is non-invasive and painless. Magnetic stimulation
has a long history (1). This review focuses on developments
that occurred in the 1980s and 1990s, when magnetic
stimulation was introduced as a research and clinical tool.
Although I survey the entire body of research, the emphasis is
on work done at the National Institutes of Health (NIH). The
goal of this review is to introduce the history and principles of
magnetic stimulation to young investigators and researchers
not familiar with the topic.
Effects of coil design on delivery of
focal magnetic stimulation
I joined the Biomedical Engineering and Instrumentation
Program at the NIH in the fall of 1988. The NIH intramural
program is located on a large campus in Bethesda, Maryland,
just outside of Washington, DC Most of the NIH researchers
at that time were focused on biochemistry and genetics,
but there were so many scientists at the NIH campus that,
nevertheless, many were interested in neurophysiology. The
goal of the Biomedical Engineering and Instrumentation
Program, then led by Murray Eden, was to have its physicists,
engineers, and mathematicians collaborate with biologists
and medical doctors working in the disease institutes.
I arrived soon after receiving my PhD in physics from
Vanderbilt University, where I had measured the magnetic
field produced by nerves and muscle.
One of my first tasks at NIH was to meet with two
medical doctors in the National Institute of Neurological
Disorders and Stroke—Mark Hallett and Leo Cohen—who
had recently begun using magnetic stimulation. Hallett
obtained his medical degree from Harvard and was chief of
the Human Motor Control Section, housed in NIH’s famous
clinical center. He is a leading figure in neurophysiology,
specifically in magnetic stimulation research, and is often
asked to publish tutorials about magnetic stimulation in
leading journals (2, 3). Hallett once told me that he began
college as a physics major but switched to a pre-med program
after a year or 2. Cohen earned his MD from the University
of Buenos Aires in Argentina. In the late 1980s, he worked
in Hallett’s section, but eventually became the head of his
own Human Cortical Physiology Section at NIH. Together
Hallett and Cohen were doing ground-breaking research in
magnetic stimulation but lacked the technical expertise in
physics required to do things like calculate the electric fields
produced by different coils.
At that time, magnetic stimulation was only a few years
old. It was invented by Tony Barker, an English clinical
engineer at the Royal Hallamshire Hospital in Sheffield,
9
2. 10 Roth
who obtained his PhD from the University of Sheffield.
His landmark invention would eventually earn him awards,
including the International Brain Stimulation Award in 2017.
Working with his student Mike Polson and collaborator Ian
Freeston, Barker developed a method to stimulate peripheral
nerves in the arm using a time-varying magnetic field (4).
Subsequently, Barker, Freeston, and another student, Reza
Jalinous, built a more powerful device to stimulate the
brain. In a recent interview with neurophysiologist John
Rothwell.1 Barker described how he travelled to the Institute
of Neurology at Queen Square in London to demonstrate his
stimulator to the prominent neurophysiologist Pat Merton.
Merton had developed an electrical method to stimulate
the brain, but it was painful because in order to produce
a sufficient electric field in the brain to excite neurons, a
much larger electric field was created in the scalp (5). In
magnetic stimulation, on the other hand, the magnetic field
passed through the skull and induced an electric field in
the brain that was similar in magnitude to that produced
in the scalp, so it was virtually painless. Barker’s visit
caused a stir among neurophysiologists at Queen Square and
triggered an avalanche of research on magnetic stimulation.
Following the meeting, Barker published a two-page paper
in the leading British medical journal The Lancet. This
publication marks the birth of modern transcranial magnetic
stimulation. It has been cited over 5,000 times in the scientific
literature (6).
Over the next few years, Barker and his team continued
to develop magnetic stimulation (7–10). A group at Queen
Square that included Christian Hess, Kerry Mills, and Nick
Murray found that magnetic stimulation of the brain could
elicit contractions of small muscles in the hand, such as the
abductor digiti minimi, and they could measure conduction
times for propagation in the central and peripheral nervous
systems (11–13). Another group at Queen Square, including
John Rothwell and Brian Day and led by the eminent
neurophysiologist C. David Marsden, explored if electric and
magnetic stimulation activated different neuronal elements
in the brain (14, 15). Although these studies all made
use of a circular coil, Shoogo Ueno and his coworkers,
working at Kyushu University in Fukuoka, Japan, found that
two side-by-side circular coils, forming a figure-8 shape,
resulted in a stronger, more localized stimulus (16, 17).
The figure-8 coil soon became the most widely used coil
design for magnetic stimulation. The field of magnetic
stimulation through 1987 was summarized in the book
Magnetic Stimulation in Clinical Neurophysiology, edited by
Sudhansu Chokroverty.
Hallett and Cohen obtained a magnetic stimulator at
NIH in the late 1980s. They described magnetic stimulation
and its potential uses in the Journal of the American
Medical Association (18), where they highlighted how
1 www.youtube.com/watch?v=1DI3EC2pQ44&t=645s
assessment of central conduction times using magnetic
stimulation could be useful for diagnosing diseases,
such as multiple sclerosis, and also how the method
could be suitable for monitoring the integrity of the
spinal cord during surgery. They emphasized that
although methods existed to measure the conduction
time in the brain for sensory fibers, stimulation of
the brain was needed to measure conduction times in
central motor fibers.
Not entirely realizing the explosion of research I was lucky
enough to be wading into, I started collaborating with Hallett
and Cohen to calculate the electric fields produced during
magnetic stimulation (the details of those calculations are
described in the next section). Our first work together was
a technical paper comparing the electric and magnetic fields
produced by a variety of coils with different shapes (19).
The electric field under a round coil was largest under the
coil perimeter and was zero below its center (Figure 1). The
stimulator produced a magnetic field of 1–2 T by passing a
current of several kiloamps through the coil in a pulse lasting
for approximately one-tenth of the millisecond. The resulting
peak electric field 1 cm below the coil was about 400 V/m,
which was more than sufficient for neural excitation. The
field was even stronger and more localized under a figure-8
coil (Figure 2).
The electric field induced during
magnetic stimulation
In August 1989, I attended the International Motor Evoked
Potential Symposium in Chicago, Illinois, where I met many
of the leaders in magnetic stimulation research. Papers
associated with talks at that meeting were published in the
journal Electroencephalography and Clinical Neurophysiology
(Supplement 43, 1991). In a paper with Cohen and Hallett,
FIGURE 1 | The magnitude of the electric field (red) in a plane 1 cm
below a circular coil. The coil (purple) had a diameter of 5 cm, 14
turns, and carried a current changing at a rate of 150 kA/ms. Adapted
from Figure 5C of Cohen et al. (19).
3. 10.54646/bijnn.2023.02 11
FIGURE 2 | The magnitude of the electric field (red) in a plane 1 cm
below a figure-8 coil. The coil (purple) had 15 turns and carried a
current changing at a rate of 150 kA/ms. Adapted from Figure 5F of
Cohen et al. (19).
I described the mathematical method I used to calculate the
electric field produced by a coil (20).
I approximated the coil as a polygon. The advantage of a
polygon is that I could derive an analytical solution for the
electric field produced by a straight wire and then I could add
the contributions of all the line segments to obtain the electric
field of the entire coil. The equation for the electric field was
as follows:
E(r, t) = −
µoN
4π
dI(t)
dt
Z
dl
0
|r − r
0
|
, (1)
where µo was a constant (4π 10−7 T m/A), N was the number
of turns, dI/dt was the rate of change of the coil current, r was
the position where the electric field was calculated, and r0 was
the location of the segment of coil dl0. The details of how to
evaluate this integral for a straight segment of coil were given
in the appendix of Roth et al. (20). The final result was given
as follows:
E(r, t) = −
µoN
4π
dI(t)
dt
δ
δ
(
sinh−1
"
δ
2R + cosφ
sinφ
#
− sinh−1
"
− δ
2R + cosφ
sinφ
#)
, (2)
where sinh−1 was the inverse hyperbolic sine function, δ was
a vector equal to the difference between the two end points
of the line segment, R was the vector from the midpoint of
the line segment to r, φ was the angle between R and δ, and
R and δ were the lengths of R and δ. The inverse hyperbolic
sine function can be written in terms of the natural logarithm,
so an alternative expression for the electric field is given as
follows:
E(r, t) = −
µ0N
4π
dI(t)
dt
δ
δ
×ln
δ
2R + cosφ +
q
δ
2R
2
+ δ
R cosφ + 1
− δ
2R + cosφ +
q
δ
2R
2
− δ
R cosφ + 1
. (3)
The only part of the integral that varies with time
is the coil current, so the expression for the electric
field separates into the product of dI(t)/dt and a time-
independent expression that depends on the coil geometry.
The integral in Equation (1) is dimensionless (dl0 has units
of length, and so does r – r0). This implies that the electric
field one coil radius below a 10-cm circular coil is the
same as the electric field one coil radius below a 1-cm
circular coil. The length scale (or, in other words, the unit
for length) is irrelevant. The logarithm function changes
notoriously slowly; if the argument inside the bracket in
Equation (3) is 1000, its natural logarithm is less than
7. Therefore, in terms of an order of magnitude, the
electric field produced by the coil is 0.1 N dI(t), where the
electric field has units of volts per meter (V/m) and the
rate of change of the current has units of kiloamps per
millisecond (kA/ms).
Although these expressions were useful, they did not tell
the entire story. They gave the electric field caused directly by
electromagnetic induction. However, an electric field could
also be produced by charge accumulating at the tissue surface.
For example, suppose you held a magnetic coil perpendicular
to the surface of the body.
The electric field due to induction would be directed in
circular loops concentric with the coil (Figure 3A). This
electric field would cause current to flow in the tissue.
However, that current could not flow into the surrounding
air, an insulator, so charge would accumulate at the tissue
surface (shown by the green plus and minus signs) until
the perpendicular component of the electric field produced
by the charge (Figure 3B) was equal and opposite to the
perpendicular component of the electric field produced
by induction. This effect happened not only at the air–
tissue interface but also at any boundary between regions
of different electrical conductivity. You could determine
the electric field that charge produced by solving Laplace’s
equation for the voltage (20, 21).
For example, suppose you viewed the circular coil of
Figure 3 from above (Figure 4). The total electric field (from
both induction and charge) is restricted to planes parallel to
the tissue surface. It is strongest directly below the coil and
spreads out in loops on both sides of the coil. Moreover, the
peak electric field is weaker than if no tissue had been present.
The electric field from charge partially cancels the inductive
electric field, making stimulation more difficult.
4. 12 Roth
FIGURE 3 | (A,B) A schematic drawing of the electric field (red)
produced by electromagnetic induction (top) and surface charge
(bottom). The coil (purple) was oriented perpendicular to the tissue
surface. Adapted from Figure 1 of Roth et al. (20).
My initial interest was in magnetic stimulation of
peripheral nerves, despite such stimulation being not as
suitable for routine nerve conduction studies as it was for
brain studies (22). So, my first calculation that included
the effect of the tissue boundary was of the electric field
induced in a cylindrical arm (21). Figure 5 shows the
distribution of the electric field in the arm when a coil
is held near it. The field is largest at the top of the arm
under the edge of the coil, but it is also large and in the
opposite direction on the right surface of the arm below the
center of the coil.
I was not the only researcher calculating electric fields
produced during magnetic stimulation. Paul Tofts, a
physicist at Queen Square, performed similar calculations,
including dividing the electric field into two parts, one
caused by induction and the other by charge, although
his calculations were only for circular coils as opposed
to my computations for any coil geometry using my
line segment approximation (23, 24). He also carried out
experiments to measure the electric field using a bipolar
probe in a saline bath below the coil. Following his
research into magnetic stimulation, Tofts became known for
his work developing dynamic contrast-enhanced magnetic
resonance imaging. Dominique Durand and his collaborators
in the Department of Biomedical Engineering at Case
Western Reserve University further examined the effect of
FIGURE 4 | The electric field (red lines) produced by a circular coil
held perpendicular to a tissue having a flat surface. The coil (purple),
seen edge on from above, had a diameter of 5 cm, 10 turns, and
carried a current changing at a rate of 100 kA/ms. The nearest edge
of the coil was 0.5 cm above the tissue surface, and the electric field
was calculated 1 cm below the surface. Adapted from Figure 2 of
Roth et al. (20).
FIGURE 5 | A contour map of the axial component (into the paper
in the end view) of the electric field in a cylindrical arm when a 5 cm
diameter, 10 turn coil (purple) carrying a current increasing at a rate
of 100 kA/ms was placed 1 cm over the arm edge. The electric field
values (red) are given in V/m. Adapted from Figure 7 in Roth et al. (21).
charge accumulation on the tissue surface (25); Ferdinando
Grandori and Paolo Ravazzani, at the Polytechnic University
of Milan in Italy, examined coils with different sizes
and orientations (26); Kent Davey and his collaborators
performed similar calculations at the Georgia Institute of
Technology (27); and J. Patrick Reilly of the Johns Hopkins
Applied Physics Laboratory calculated electric fields in the
body produced by a changing magnetic field, although
primarily in the context of neural stimulation caused by
magnetic resonance imaging (MRI) (28, 29). The field was
becoming quite crowded.
5. 10.54646/bijnn.2023.02 13
FIGURE 6 | A contour map of the magnitude of the electric field
(red) 0.3 cm below the surface of the brain, produced by magnetic
stimulation with a figure-8 coil (purple) and by electric stimulation
using closely spaced electrodes on the scalp (green). The head was
represented using a three-sphere model (brain, skull, and scalp).
During magnetic stimulation, the figure-8 coil had 15 turns, was
1 cm above the top of the head, and carried a current changing at a
rate of 25 kA/ms. During electric stimulation, the electrodes passed
a current of 566 mA. The electric field strength was given in V/m.
Adapted from Figure 1 of Saypol et al. (31).
A theoretical calculation of the
electric field induced in the cortex
during magnetic stimulation
Hallett and Cohen were most interested in the electric
field induced during transcranial magnetic stimulation,
so my next task was to use a three-sphere model to
calculate the electric field in the brain (30). I had
help from an undergraduate engineering student from
Brown University, Joshua Saypol, who worked at NIH
during his summer breaks. Saypol and I represented
the head as three concentric spherical layers: the scalp,
skull, and brain. We were able to calculate the electric
field just below the brain surface using the method
described in the last section. Saypol then compared
the electric field induced during transcranial magnetic
stimulation to that produced by electrical stimulation using
electrodes on the scalp (31, 32). He found that transcranial
magnetic stimulation using a figure-8 coil created a
more localized stimulus than did electrical stimulation
with two closely spaced scalp electrodes (Figure 6). The
main reason for the superior focality during magnetic
stimulation was that the high-resistance skull not only
reduced the fraction of the current reaching the brain
during electric stimulation, but also spread out the spatial
distribution of that current within the brain. One often-
cited disadvantage of magnetic stimulation is the lack of
spatial resolution, and that is true when compared to
electrical stimulation of the exposed cortex, but compared
to using scalp electrodes, the spatial resolution of magnetic
stimulation is impressive.
Again, other researchers were also analyzing brain
stimulation. Harry Eaton, an engineer at the Johns Hopkins
Applied Physics Lab, derived a detailed analytical model
of transcranial magnetic stimulation that even included
the capacitive properties of the tissue, a factor I had
ignored (33). Leon Heller and David van Hulsteyn from
Los Alamos National Laboratory analyzed brain stimulation
and showed that the radial electric field in the brain
vanished (34), a point independently made by David Cohen
and B. Neil Cuffin from the Massachusetts Institute of
Technology (35). Saypol and I had found that the radial
component of the electric field in the brain was very
small, but now we realized that we were just looking at
the numerical error in our solution to Laplace’s equation,
and a more accurate calculation would give zero radial
field (31). This result was quite different than for electrical
stimulation using scalp electrodes, where the electric field
was primarily radial. Heller and van Hulsteyn also proved
that the electric field deep in the brain can never be
larger than the electric field at its surface, regardless of the
coil design (assuming a homogeneous tissue). No clever
coil shape can create “hot spots” of strong electric field
deep in the brain.
Nowadays the electric field in the brain can be calculated
using more powerful finite element methods. For instance,
Pedro Miranda, a physicist from the University of Lisbon,
and his colleagues calculated the electric field produced
during transcranial magnetic stimulation (36). Their
calculation included heterogeneity and anisotropy, which
can significantly affect the electric field distribution.
Tim Wagner of MIT and his coworkers performed
a finite element calculation that included a realistic
shape for the brain and found that modifications to the
cortical geometry could perturb the predicted site of
excitation (37).
The research at NIH was assisted by an outstanding
group of young scientists who worked with Hallett and
Cohen. For example, the Brazilian neurologist Joaquim
Brasil-Neto examined how the orientation of the electric
field influenced the stimulation threshold (38). I was a
co-author on this paper because I contributed a few
electric field calculations, and it is now my most highly
cited publication. Peter Fuhr analyzed how the latency of
motor-evoked potentials depended on the position of the
stimulating coil relative to the head (39). The NIH group
used magnetic stimulation to create topographic maps of the
brain in patients with amputations, spinal cord injuries, and
mirror movement disorders (40). Much of this research was
described in an article published in a special issue of the
Journal of Clinical Neurophysiology dedicated to magnetic
stimulation (41).
6. 14 Roth
A model of the stimulation of a
nerve fiber by electromagnetic
induction
Determining the electric field distribution produced by a coil
was important, but equally important was analyzing how that
electric field coupled to a nerve. Frank Rattay had previously
derived an “activating function” for electrical stimulation of
a long peripheral nerve (42). Polarization of an axon occurs
where the second derivative of the voltage along the axon
is largest. A similar activating function exists for magnetic
stimulation. However, you cannot describe an electric field
caused by electromagnetic induction in terms of a voltage.
Instead, you need to express the activating function in terms
of the electric field itself. I derived such an activating function
for magnetic stimulation in collaboration with Peter Basser.
Basser obtained his PhD in engineering from Harvard
and joined the Biomedical Engineering and Instrumentation
Program just a year or 2 before I did. Together, we
determined that polarization occurs along the axon where the
gradient of the electric field is largest (21). If you are reading
that paper, be aware that we published two errata (43, 44). In
addition to his work on magnetic stimulation (45, 46), Basser
is famous for developing MRI diffusion tensor imaging and
was awarded a gold medal from the International Society of
Magnetic Resonance in Medicine.
Our analysis was based on a rederivation of the nerve
cable equation, including a term containing the electric field
produced by the coil,
where λ and τ were the axon length and time constants,
respectively, V was the transmembrane potential, x was
the position along the axon, and Ex was the component
of the stimulating electric field parallel to the axon during
magnetic stimulation. The term on the right-hand side of
the equation was called the activating function, following
Rattay’s nomenclature. It acted as the source term for
the transmembrane potential. Depolarization and excitation
should occur where dEx/dx is negative in sign and large
in magnitude. In retrospect, this result seems obvious
given Rattay’s analogous activating function for electrical
stimulation, but at the time, it was quite a surprise.
As an example, we considered a peripheral nerve being
stimulated by magnetic stimulation (Figure 7). The nerve
(light blue) was long and straight and passed 1 cm below
the edge of a circular coil (purple). Along the nerve, the
electric field pointed in the negative x direction and was
largest just below the coil. However, this was not where the
nerve would be depolarized (meaning its transmembrane
potential was raised toward the threshold for excitation).
Instead, the nerve would be depolarized 2 or 3 cm away,
where the gradient of the electric field was largest. It
would also be hyperpolarized (its transmembrane potential
was lowered below rest, opposing excitation) 2 or 3 cm
along the nerve in the other direction. If you changed
FIGURE 7 | A contour plot of dEx /dx (green), 1 cm below the plane
of a circular coil, where x was the direction parallel to the nerve (light
blue) and Ex was the component of the electric field along the nerve.
The coil (purple) had 30 turns, a diameter of 5 cm, and carried a
current changing at a rate of 1 kA/ms. Adapted from Figure 3 of Roth
and Basser (21).
FIGURE 8 | Motor fiber compound action potential for two polarities
of magnetic stimulation, recorded at the distal end of the human
median nerve during stimulation with a circular coil. Adapted from
Figure 6A in Nilsson et al. (53).
the polarity of the stimulus, the location of depolarization
and hyperpolarization would switch, resulting in a testable
prediction: Measure the arrival time of the action potential
at the far end of the nerve for one polarity of the stimulus
and then for the other (easily done by flipping the coil over).
There should be a latency difference between the two arrival
times because in one case the nerve must propagate about 4
or 5 cm farther than in the other.
Basser and I took the calculation further. We implemented
the Hodgkin and Huxley model describing the ion channels
in the axon membrane, calculated where and when
stimulation occurred, and predicted all the propagation
dynamics (47). We even modified the model to include a
myelinated axon in a cylindrical arm, so we could make more
accurate predictions (48).
Again, other researchers were developing similar models.
Durand, with his student Sri Nagarajan, analyzed where
excitation occurred along a nerve fiber (49, 50). They found
results similar to ours, but also found that when the nerve
is not long, excitation can occur at its end. This mechanism
operates where the electric field itself is large, not where its
7. 10.54646/bijnn.2023.02 15
gradient is large. Maria Stuchly and her team in Canada made
additional contributions (51, 52).
Determining the site of stimulation
during magnetic stimulation of a
peripheral nerve
I was anxious to test the prediction of where excitation occurs
along a peripheral nerve during magnetic stimulation. The
ideal experiment would be to dissect a nerve, place it in a
dish filled with saline, and then stimulate it. However, Hallett
and Cohen were focused mainly on clinical applications, so
we tested the prediction in humans (53). The experiment was
performed by Marcela Panizza, an Italian medical doctor, and
her husband Jan Nilsson, a biomedical engineer originally
from Denmark but working with Panizza in Italy. Panizza
and Nilsson would often visit NIH to collaborate with
Hallett and Cohen. In the experiment, the median nerve
was stimulated at the forearm and the motor response was
recorded using electrodes attached to the thumb. Figure 8
shows a latency shift in the motor response of about 0.65 ms
obtained upon switching the polarity of the stimulus by
FIGURE 9 | Contour plots of the electric field (Ey, red) and its
spatial derivative (dEy /dy, blue) induced by a figure-eight coil (purple)
placed under a tank filled with saline and measured using a bipolar
recording electrode. The y direction is downward in the figure, parallel
to the direction of the nerve (see Figure 10). Adapted from Figure 2
of Maccabee et al. (54).
FIGURE 10 | Recordings from an electrode (black dot) at the distal
end of a bullfrog sciatic nerve (green) that was immersed in a trough
filled with saline (blue) and stimulated with a figure-8 coil (purple). The
nerve emerged from the saline to rest on the recording electrode in
air. The compound nerve action potentials were elicited by a stimulus
of one polarity (orange), then the other (red). Adapted from Figure 3
of Maccabee et al. (54).
flipping the coil over. The propagation velocity was about 60
m/s, implying a shift in the position of excitation of nearly
4 cm, close to that predicted by our calculations. Nilsson
and Panizza also used electrical stimulation to create a map
of how propagation time related to position along the arm
and then used this calibration curve to show that magnetic
stimulation did not occur where the electric field was largest,
but instead where its spatial derivative was largest.
Although this experiment confirmed our prediction, there
were nevertheless concerns because of the heterogeneous
nature of the bones and muscles in the human arm. At
about the same time Nilsson and Panizza were doing
their experiment at NIH, Paul Maccabee was performing
an even better experiment at the New York Down state
Medical Center in Brooklyn. Maccabee obtained his MD
from Boston University and collaborated in Brooklyn with
the internationally acclaimed neuroscientist Vahe Ammasian
(55–59). This research culminated in their 1,993 article in
the Journal of Physiology, in which they examined magnetic
stimulation of a peripheral nerve lying in a saline bath (54).
First, they measured the electric field Ey (they assumed the
nerve would lie above the coil along the y-axis) and its
derivative along the nerve produced by a figure-8 coil located
under the bath (Figure 9). They found that the electric field
was maximum directly under the center of the coil, but the
magnitude of the gradient dEy/dy was maximum a couple
centimeters either side of the center.
Next they placed a bullfrog sciatic nerve in the dish and
recorded the electrical response from one end (Figure 10).
They found a 0.9 ms delay between the recorded action
potentials when the polarity of a magnetic stimulus was
reversed (the yellow and red traces on the right). Given a
propagation speed of about 40 m/s, the shift in excitation
position was about 3.6 cm, consistent with what Basser and
I would predict.
So far, their study was similar to what we performed at
NIH in a human, but then they did an experiment that
we could not do. To determine how a heterogeneity would
impact their results, they placed two insulating cylinders on
either side of the nerve (Figure 11). These cylinders modified
the electric field, moving the negative and positive peaks
of the activating function closer together. They observed a
corresponding reduction in the latency shift. This experiment
provided insight into what happens when a human nerve
passes between two bones, or some similar heterogeneity.
Finally, they changed the experiment by bending the nerve
and found that a bend caused a low threshold “hot spot,” and
that excitation at that spot occurred where the electric field,
not its gradient, was large. This result was consistent with
Nagarajan and Durand’s analysis of excitation of truncated
nerves (49).
In my opinion, Maccabee’s (54) article is the most
impressive publication in the magnetic stimulation literature.
Only Barker’s original demonstration of transcranial
magnetic stimulation can compete with it (6).
8. 16 Roth
Just when it seemed the prediction was established
that dEx/dx determined the location of excitation, Jarmo
Ruohonen, working with coworkers in Italy, including
Panizza and Nilsson, challenged this conclusion (60). They
presented data indicating that the transverse component
of the electric field, rather than the component parallel to
the axon length, could cause excitation. According to the
activating function idea, if a nerve passed directly below
the center of a circular coil, no excitation should occur
because the gradient of the electric field, and indeed the
electric field parallel to the direction of the nerve, was
zero. However, Ruohonen and his collaborators found that
sometimes excitation did occur in this configuration. The
result was difficult to explain, because a transverse field
ought to depolarize one side of an axon and hyperpolarize
the other, so their effects cancel out. Moreover, because
the axon radius is so small (typically tens of microns), the
threshold for excitation by a transverse field should be very
high. Viet Schnabel and Johannes Struijk, working at Aalborg
University in Denmark, examined this issue. They found
that transverse stimulation may occur because the axons
in a nerve undulate (61). The model Basser and I derived
assumed that the axon was straight, although we did note that
if the axon followed a sinuous path the activating function
would have to be evaluated along it (47). Schnabel and Struijk
concluded that even a small amount of undulation (say,
20 µm) could trigger excitation by a transverse field. It is
an important reminder that we must always be aware of the
assumptions underlying a mathematical model.
In vitro evaluation of a four-leaf coil
design for magnetic stimulation of
peripheral nerve
One frustrating feature of the activating function approach
is that excitation does not occur directly under the center
of a figure-8 coil, where the electric field is largest, but off
to one side, where the gradient peaks (Figure 9). Medical
doctors do not want to guess how far from the coil center
excitation occurs; they would prefer a coil for which “x”
marks the spot. It occurred to me that such a coil could
be designed using two adjacent figure-8 coils. I called this
the four-leaf coil (Figure 12). John Cadwell from Cadwell
Laboratories (Kennewick, Washington, DC, USA) built such
a coil for me. Having seen the excellent results that Maccabee
was obtaining using his nerve-in-a-dish setup, I sent the
coil to him so he could test it. The resulting paper (62)
showed that for one polarity of the stimulus the magnitude
of the gradient of the electric field was largest directly under
the coil center so the axons there were depolarized (“x”
really did mark the spot of excitation). In addition, if the
polarity of the stimulus was reversed, the magnitude of the
gradient remained large under the coil center, but it now
FIGURE 11 | Magnetic stimulation of a sheep phrenic nerve
immersed in a homogeneous (left) and inhomogeneous (right)
volume conductor. The figure-8 coil (purple) was positioned under the
nerve (green). The yellow circles indicate the position of the insulating
cylinders. The electric field Ex (red) and its gradient dEx/dx (blue)
were measured along the nerve trajectory. The compound nerve
action potentials at the recording electrode were measured for a
magnetic stimulus of one polarity (orange) and then the other (green).
Adapted from Figure 5 of Maccabee et al. (54).
tended to hyperpolarize rather than depolarize the axons.
Maccabee and I hoped that such hyperpolarization could
be used to block action potential propagation, acting like
an anesthetic. The Brooklyn experiments verified all the
predictions of the activating function model for the four-
leaf coil. Unfortunately, Maccabee never observed any action
potential block. Perhaps, the hyperpolarization required for
block was greater than the coil could produce.
The four-leaf coil is not widely used in transcranial
magnetic stimulation. It is based on the assumption that
you are stimulating a long, straight peripheral nerve, so
dEx/dx is the relevant quantity to determine excitation. In
the brain, where bending, truncating axons are common,
the electric field itself is probably the relevant quantity,
not its gradient, so a figure-8 coil is superior to a four-
leaf coil. Researchers who use the dEx/dx concept for brain
stimulation are making a mistake.
Coil design has been an important part of magnetic
stimulation research (Figure 13). Yiftach Roth (no relation)
proposed the “H-coil,” which was designed to excite deep
brain structures (63, 64). With Shokrollah Momen and
Robert Turner, I used an inverse problem technique to
predict a new design for a figure-8 coil in which the various
turns of the coil were all tightly packed under the coil
center, but splayed out in a variety of sized loops on its
9. 10.54646/bijnn.2023.02 17
periphery (65). Chunye Ren and his collaborators at the
University of Miami designed a coil shaped like a slinky
(66). Karl Kraus and his collaborators developed a “cap coil”
that was optimized for spinal cord monitoring (67). Eugen
Lontis and his coworkers in Denmark designed a “cone coil”
with improved focality (68). Ruohonen and his coworkers
proposed a multichannel system consisting of an array of
many small coils (69). The current could be independently
varied in each coil to produce almost any electric field
distribution the user desired. Coil design continues to be an
active area of study to this day (70).
David Cohen attempted to make a very small magnetic
stimulation coil in order to improve the spatial resolution of
the stimulus (35). He found that as the coil became smaller, he
had to use more and more current until the magnetic forces
between different parts of the coil winding tore the coil apart.
Even if he had been successful, the spatial resolution was
limited as much by the distance from the coil to the brain,
set by the thickness of the scalp and skull, as by the radius of
the coil itself. Lee et al. (71) have claimed they can perform
magnetic stimulation using an implanted microcoil having
one turn with a diameter of about 100 µm and carrying a
current of about 50 mA. They calculated the electric field
produced by such a coil, but their results were far larger
than what I would predict using Equation (2). I have not
been able to reproduce their calculations, and they may in
fact be observing capacitive coupling rather than magnetic
stimulation (for more, see).2
Relevance of stimulus duration for
activation of motor and sensory
fibers
So far, we have considered the spatial distribution of the
electric field, but we have not analyzed how it changes
with time. A typical magnetic stimulator produces a brief
stimulus pulse, about one-tenth of a millisecond in duration,
by discharging a capacitor through the coil. A simplified
stimulator circuit is shown in Figure 14 (72). Initially, the
switch is to the left and the capacitor C is charged by
the power supply. When ready to stimulate, the switch is
thrown to the right and the charge stored in the capacitor is
discharged through the coil, represented by in the circuit by
its resistance R and inductance L.
When the switch is thrown, the current I in the coil cannot
turn on instantaneously because of the coil inductance.
Instead, it rises to a maximum and then falls. In a circuit
containing a capacitor and inductor, the current will typically
not decay to zero but instead will overshoot zero, reversing
direction. Such oscillations will continue, but the coil
resistance will cause their amplitude to ultimately decay
2 hobbieroth.blogspot.com/2016/12/implantable-microcoils-for.html
FIGURE 12 | A four-leaf coil (purple) used to stimulate a peripheral
nerve (blue). Adapted from Figure 1 of Roth et al. (62).
FIGURE 13 | Different coil designs. Clockwise from top left: A slinky
coil, a coil based on an inverse calculation, a cap coil, and a cone
coil.
FIGURE 14 | A simplified circuit diagram for a magnetic stimulator,
containing a power supply (blue), a switch (orange), a capacitor
(green), and a coil represented by its resistance (red) and inductance
(purple).
(Figure 15, upper left). The electric field induced in the
brain varies as the rate of change of the coil current, dI/dt.
The rate of change turns on abruptly and then oscillates
out of phase with the coil current (Figure 15, upper right).
Some stimulators include a diode in the circuit (a diode can
only pass current in one direction), suppressing oscillations
(Figure 15, lower left). However, even in this case, dI/dt is
not “monophasic” (entirely one polarity). The rate of change
will be positive as the coil current rises to its peak and then
negative as it decays. This rate of change is analogous to the
current through an electrode during electrical stimulation.
However, it always changes from positive to negative and
10. 18 Roth
FIGURE 15 | The coil current (left) and its rate of change (right)
through a coil during magnetic stimulation, for a circuit without a
diode (top) and with a diode (bottom).
FIGURE 16 | A log–log plot of the strength–duration curve for
electric (blue) and magnetic (red) stimulation. The electric curve was
determined using a square stimulus pulse, and the magnetic curve
was determined using a triangular stimulus pulse. The strength is in
terms of multiples of the rheobase, and the duration is in terms of
multiples of the axon time constant.
is biphasic for a circuit with a diode (Figure 15, lower
right). A truly monophasic stimulus pulse for magnetic
stimulation is impossible.
Stimulators without a diode, such as those manufactured
by Cadwell Laboratories and used at NIH in the 1990s,
could produce a powerful stimulus. They were often useful
for clinical studies, but sometimes the oscillating stimulus
could make it a confusing research tool. Stimulators with
a diode, such as those manufactured by Dantec Electronics
(Skovlunde, Denmark) and also used at NIH, provided a
biphasic stimulus, but the first phase was brief and strong
whereas the second phase was long and weak. The first phase
acted as the main stimulus, being somewhat analogous to a
monophasic electric stimulus.
Panizza and Nilsson performed experiments at NIH
examining both electric and magnetic stimulation of
peripheral motor and sensory nerves (73). Shorter duration
stimuli selectively stimulate motor fibers, while longer
duration stimuli selectively stimulate sensory fibers. The
FIGURE 17 | The temperature increase of a silver EEG electrode
attached to the forearm, as a function of time. In each case the
electrode received 40 magnetic stimulation pulses, but they were
delivered at different frequencies. After the train of stimuli ended, the
electrode cooled with a time constant of about 45 s. Adapted from
Figure 3A of Roth et al. (78).
magnetic stimulation pulse acts like a brief stimulus, so the
threshold for motor fibers is lower than for sensory fibers.
To better compare magnetic and electric stimuli, I
modeled the electric stimulus as a square pulse and the
magnetic stimulus as triangular: an instantaneous upstroke
followed by a linear decay (ignoring the weaker second
phase). I found that the strength–duration curves for these
two cases were different (Figure 16). The rheobase (the
threshold for a long stimulus) was the same in both cases, but
the chronaxie (the threshold duration for a strength of twice
rheobase) was more than three times longer for magnetic
than electric stimulation.
The heating of metal electrodes
during rapid-rate magnetic
stimulation: a possible safety
hazard
Transcranial magnetic stimulation is a powerful research
and clinical tool, but is it safe? Eric Wassermann—a
medical doctor who trained with Hallett and was editor
of the Oxford Handbook of Transcranial Stimulation—
wrote a review of safety issues based on an international
workshop held in June 1996 (74). This review was updated
by Simone Rossi and his collaborators a decade later
(75). Concerns about safety focus on rapid rate magnetic
stimulation, when trains of stimuli are produced at rates as
high as 60 stimuli per second. Seizures are one potential
safety hazard but are rare. Magnetic stimulation produces
a magnetic field of a few tesla, which can exert forces
on magnetic objects. The magnetic stimulator could in
theory interfere with implanted medical devices. Magnetic
11. 10.54646/bijnn.2023.02 19
forces between turns in a coil can produce surprisingly
loud, brief sounds. S. Allen Counter and his collaborators
have found evidence of acoustic trauma arising from
transcranial magnetic stimulation and recommend using ear
plugs (76).
One of the most serious safety hazards was discovered
by Alvaro Pascual-Leone, a Spanish MD/PhD who trained
at NIH in the 1990s. Pascual-Leone and his colleagues
wanted to record the electroencephalogram (EEG) during
and immediately following rapid rate transcranial magnetic
stimulation, so they stimulated with silver EEG recording
electrodes placed over the scalp. One patient suffered a burn
under an electrode (77). To examine if this was caused
by Joule heating from the induced eddy currents in the
electrode, Pascual-Leone and I measured the temperature
of different electrodes with different sizes and made from
different metals (44). During stimulation, the temperature
rose and then returned to its original value in about
a minute or 2 after stimulation ended (Figure 17). We
were able to determine what total number of stimuli
and what rate of stimulation were safe, and which were
unsafe. Interestingly, we could reduce the increase in
temperature dramatically by cutting a slot in the EEG
electrode, which did not affect its ability to record the
EEG but did reduce the eddy currents induced in the
silver significantly. Pascual-Leone went on to become a
professor of neurology at Harvard Medical School and
received the Ramón y Cajal Award in Neuroscience. In 2002,
he was the lead editor on the Handbook of Transcranial
Magnetic Stimulation.
Conclusion
I summarized my work on magnetic stimulation in a
review article in the CRC Critical Reviews of Biomedical
Engineering (79) and then left the NIH and magnetic
stimulation research in 1995. However, the field exploded
as the 21st century began. Mark George, working at
NIH, discovered that daily rapid rate transcranial magnetic
stimulation affects mood and now the most common
application of magnetic stimulation is in psychiatry (80).
Brain stimulation has been approved by the Food and
Drug Administration and applications are multiplying.
Transcranial magnetic stimulation remains a vibrant and
exciting field of research (81).
Conflict of interest
The author declares that the research was conducted in the
absence of any commercial or financial relationships that
could be construed as a potential conflict of interest.
Author contributions
The author wrote this review article alone and is, therefore,
entirely accountable for its content.
Acknowledgments
This research would not have been possible without the
contributions of many excellent collaborators, including MH,
LC, PB, JS, and many others.
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