5. Shapes of Lesions
īŽ The shape of a lesion frequently gives clues to
the etiology of the skin lesion.
īŽ Shapes include lesions that are: round,
polygonal, polycyclic, annular, iris, serpiginous,
umbilicated,and target.
īŽ Margination is also important â are the lesions
well or ill defined
īŽ Arrangement â are the lesions grouped or
disseminated
6. Distribution of Lesions
īŽ A significant number of skin diseases are
limited to specific regions of the body
īŽ Are the lesions isolated, localized,
regional, or generalized
īŽ Are the lesions symmetrical; limited to
exposed areas, sites of pressure, or
intertriginous areas
7.
8. Eczema - Common Definitions
īŽ Any itching rash
īŽ Any red itching rash
īŽ Any red itching rash that has scales or is
dry
īŽ The itch that rashes
īŽ Any rash that cannot otherwise be
identified
9. Eczema-Dermatological
Definition
īŽ An acute, subacute but usually chronic
pruritic inflammation of the epidermis and
the dermis, often occurring in association
with a personal family history of hay fever,
asthma, allergic rhinitis or atopic
dermatitis. 1
īŽ 1 Color Atlas and Synopsis of Clinical Dermatology
10. Characteristics of Acute Eczema
īŽ Well demarcated plaques of erythema
and edema on which are superimposed
and closely spaced small vesicles filled
with clear fluid with punctate erosions and
crusting
īŽ Distribution may be isolated and localized
or general
11. Acute Eczema
(Note the erythema, vesicles and
swelling)
īŽ Term dyshidrotic is a misnomer as sweat
glands are not involved
īŽ Also known as pompholyx
12.
13. Characteristics of Subacute
Eczema
īŽ Plaques of mild erythema with small dry
scales and or superficial desquamation,
sometimes associated with small red,
pointed or round papules
īŽ Distribution may be isolated and localized
or general
15. Characteristics of Chronic
Eczema
īŽ Plaques of lichenification with deepening
of the skin lines with satellite, small, firm
flat or round top papules, excoriations and
pigmentations or mild erythema
Distribution â isolated and localized or
generalized
22. Atopic/IgE Eczema
(endogenous or exogenous?)
Characteristics:
īŽ 60% have onset in the first year of life
īŽ Influenced by genetics and environmental
factors
īŽ More common in males that females
īŽ Ethnicity may be a factor âless common in
Asians; more common in Westerners and higher
socioeconomic families
īŽ Theory is - manifestation of well nourished
immune system rarely challenged by infection
īŽ Rare to have adult onset
īŽ 2/3 of patients have family history of
asthma, hay fever or allergic rhinitis
23. īŽ Characteristics:
īŽ May persist months to years
īŽ All patients have dry skin
īŽ Exacerbations caused by allergens, stress,
hormones, climate, skin dehydration
īŽ Physical characteristic may include all phases
Distinctive Characteristics:
īŽ Lesions are usually bilateral
īŽ Located frequently in skin folds/creases and
flexor surfaces
Atopic/IgE Eczema cont.
25. Atopic/IgE Eczema cont.
Triggers:
Irritants
īŽ Dry skin; bathing without moisturizing
īŽ Harsh/perfumed soaps, detergents
īŽ Disinfectants
īŽ Contact with wool, occupational chemicals/fumes
Allergens
īŽ Dust mites
īŽ Pet dander (cat more allergenic than dog)
īŽ Pollens, seasonal and molds
īŽ Foods- strawberries, carrots
26. Atopic/IgE Eczema cont.
Triggers (contâd):
Infections
Bacterial
Viral
1. Cold and other URI viruses
2. GI viruses
Fungal
Environmental
Extremes in temperature and/or humidity
Perspiration
Stress
30. Allergic (Contact)Eczema
(exogenous or endogenous?)
Characteristic:
īŽ Delayed, cell mediated hypersensitivity
īŽ Strong sensitizer results in reaction soon after
exposure
īŽ Weak sensitizer my take months or years to
develop reaction
īŽ Age does not influence capacity for sensitization
but more common in adults
īŽ Black skin is less susceptible
īŽ Important cause of disability in industry
īŽ Non seasonal
31. Allergic (Contact) Eczema cont.
Characteristics:
īŽ usually clears quite rapidly on withdrawal of
offending agent
īŽ may appear as erythematous papules, vesicles
or bullous
īŽ more common where epidermis is thinner
Distinctive Characteristics:
īŽ Initial lesions usually limited to contact area
īŽ not bilateral
īŽ lesions with sharp borders or angles are
pathognomonic
32. Causes of Allergic/Contact
Eczema
īŽ Metals- nickel, platinum (10% of women)
īŽ Detergents
īŽ Plants and fibers
īŽ Chemicals and dyes
īŽ Polyethylene glycol and polysorbate 60
īŽ Topical antibiotics and medications
īŽ Animal keratin
42. Toxic / Irritant Eczema
(occurring in non allergic skin)
īŽ Characteristics:
īŽ Accounts for 75% of exogenous eczema
īŽ Age, race and sex are insignificant
īŽ Results from repeated exposure to toxic or
subtoxic agents
īŽ Severity of skin symptoms vary with the
individual and the type of irritant and the length
of contact
īŽ Includes sx of itching, stinging and burning
īŽ Usually associated with chronic disturbance of
the barrier function of the skin
43. Toxic/Irritant Eczema cont.
Common causes:
īŽ Repeated exposure to alkaline detergents
īŽ Repeated exposure to organic solvents
īŽ Corrosive agents
īŽ Industrial chemicals
īŽ Chronic self perpetuating habits that
irritate the skin
44. Toxic/Irritant Eczema cont.
Treatment:
īŽ Remove the cause
īŽ Application of emollients
īŽ Use of soap substitutes
īŽ Barrier creams
īŽ Borrowâs or potassium permanganate
soaks twice daily
Biopsy/testing- usually not necessary
47. Chronic Toxic/Irritant Eczema
īŽ Note:papulosquamous dermatosis with
hyperkeratosis, maceration, fissuring and
erosions
īŽ Eruptions tend to
be sore rather than
itching
48. Acute, subacute, or chronic?
Swelling? Erythema? Desquamation?
Lichenification?
49. Comparison of Classifications of
the 3 common types of eczema
ACUTE Atopic
IgE
Toxic/
Irritant
Allergic
Contact
Erythema X X X
Papules X NA X
Vesicles X X X
Erosions X X X
Crusts X X X
Scales X NA X
Sharp/ confined NA X X
Spreading peripherally Flexor surfaces,
neck, eye lids, d
foot
X NA
Onset rapid Before age
12
X Usually as
adult
Onset slow NA NA X
Concentration L/H NA H L
Incidence Other signs Anyone Sensitized
50. Comparison of Classifications
Chronic Atopic
IgE
Toxic/Irritant Allergic/Contact
scaling X X X
fissues X X X
crusts NA X X
papules NA X X
excoriation X NA X
lichenification X NA X
Periorbital
pigmentation
X NA NA
Infraorbital folds in
the eyelids
X NA NA
Foillicular papules X more common
in the black pop.
NA NA
51. Pompholyx
(from Greek word meaning
blister)
īŽ Characteristics:
īŽ Intense itching and burning proceed lesions
īŽ Blisters and vesicles on hands/ feet
īŽ Becomes highly exudative
īŽ Dries up in about 2 wks leaving painful fissuring
īŽ Acute symptom of a chronic problem
īŽ Usually no cause but can be due to trichophytin
and associated with fungal infection of the feet
52. Pomhpolyx cont.
īŽ Treatment:
īŽ Avoidance of soap
īŽ Emollients
īŽ Soaks ( burrows or potassium permanganate)
īŽ Potent or very potent topical steroids with or with
occlusion
īŽ Antibiotics for infection
īŽ Systemic steroids
īŽ Coal tar extracts
īŽ Biopsy/testing- usually not necessary
54. Nummular Eczema
īŽ Characteristics:
īŽ usually -personal or family history of allergy,
especially asthma, hay fever, and childhood eczema
īŽ Distinctive Characteristics - Coin-shaped
papulovesicular patches that develop in to scaling
and crusting lesions; lesions may be as large as 4-
5cm in diameter with distinct margins, initial
eruptions on arms and legs; intense itching; tends to
be chronic
55. Nummular Eczema cont.
īŽ Characteristics:
īŽ Most severe during winter; may be aggravated by
systematic administration of iodine or bromine;
secondary bacterial infections are common
īŽ Treatment: skin hydration, topical corticosteroids,
intralesional injection, coal tar ointments, UVB
treatment, treat secondary infection
56. Nummular Eczema cont.
īŽ Confused with â contact dermatitis/eczema,
atopic eczema, psoriasis, impetigo, tinea
corporis
īŽ Biopsy/testing â not usually necessary
59. Seborrehea
īŽ Characteristics: Positive family history is common
īŽ Seen in all age groups equally
īŽ May occur on presternal area and mid upper back
īŽ Stress may increase symptoms
īŽ Pityrosporum ovale may be causative factor
īŽ Distinctive Characteristics:
īŽ Red greasy scaling rash consists of patches and plaques
with indistinct margins and an underlying red glazed look
to the skin
īŽ Most commonly located in the hairy areas, nasolabial
folds, retroauriclar folds
īŽ Excoriations from scratching are rare
60. Seborrhea cont.
Treatment:
Scalp â
īŽ try OTC preps first (antidandruff, tar or ketoconazole
shampoo)
īŽ Steroid lotions for very short term use
īŽ 10% Liquor Carbonis Detergens HS and shampoo in AM
with Dawn Detergent
Skin -
īŽ try OTCâs first
īŽ corticosteroids (mild to moderate potency) and/or
ketoconazole topically
61. Seborrhea cont.
Eye lashes-
īŽ Warm compresses and gentle debridment
with Q tip
īŽ Sulfacetamide ophthalmic ointment applied topically
** Areas that become exudative may be treated with
potassium permanganate or burrowâs soaks
Confused with â atopic dermatitis, eczema, psoriasis,
discoid lupus, tinea
Biopsy/testing â usually none
66. Asteatotic Eczema
(Xerotic Eczema, âWinter Itchâ)
Characteristics:
īŽ Seen mainly in elderly
īŽ Worse in the winter
īŽ Precipitated by excessive washing
Treatment:
īŽ Avoid excessive washing and use of soap
īŽ Emollients
īŽ Increase humidity in the environment
īŽ Topical steroids for a short periods of time
67. Localized Neurodermatitis
Cont.
īŽ Treatment:
īŽ Stop the scratching
īŽ Occlusive steroid dressings esp. at night
īŽ Lubrication
īŽ Doxepin ointment and/or po 10-20mg
īŽ Hydroxyzine at night
īŽ Intralesional steroid injection
īŽ Stress management and/or medication
īŽ Treatment is longterm and may be unsatisfactory
īŽ Confused with â atopic eczema, psorasis, tinea,
seborrhea
īŽ Biopsy / testing â none usually necessary
68. Localized Neurodermatitis
(known as Lichen Chronicus Simplex)
īŽ Characterisitcs:
īŽ Origin often small patch of dermatitis or insect bite
starting the itch âscratch- itch cycle
īŽ Condition unrelated to allergies or family history
īŽ More common in women
īŽ Nonseasonal
īŽ aggravated by stress
īŽ worse at night
īŽ may be secondary to atopic eczema, contact dermatitis,
lichen planus, psoriasis, or insect bite
69. Localized Neurodermatitis
(known as Lichen Chronicus Simplex) CONT.
Distinctive Characteristics:
īŽ Lesions lichenified or excoriated
īŽ usually limited to a single patch at hairline of
nape of neck or on wrists, ankles, ears, or anal
area
īŽ Not bilateral
īŽ Llichenification of dark skin develops a âfollicular
patternâ
75. Education
īŽ Chronicity of eczema
īŽ Association of other conditions: AR,
asthma
īŽ Vast number of sensitizing chemicals used
currently in our soaps, shampoos,
detergents, foods, etc.
īŽ Likelihood of finding a trigger low
īŽ Detailed sensitizers/triggers (see Pocket
Guide to Medications used in Dermatology
by Scheman and Severson)
76. Patient Resources
īŽ The Eczema Survival Guide â 30 page guide by
the NEASE
īŽ http://www.medlineplus.com â the single best
general patient medical resource on the internet
â sponsored by NIH
īŽ http://www.eczema.org - National Eczema
Society
īŽ http://www.nationaleczema.org â National
Eczema Assoc. for Science and Education
īŽ http://dermatlas.med.jhmi.edu/derm/ - online
dermatology atlas from Johns Hopkins Univ.
77. Prevention Checklist
īž Moisturize daily
īž Wear cotton, avoid wool and tight clothes
īž Take lukewarm showers, using mild soap or
nonsoap cleansers
īž Pat dry â do not rub
īž Apply moisturizer within 3 min. to âlock inâ
moisture
īž Avoid extremes of heat/humidity and
perspiration
īž Learn triggers and how to avoid them
īž Keep fingernails short
īž Remove carpets and pets from the home
78. Soaps and Cleansers
īŽ Any product that removes skin oils (sebum), dirt, other
undesirable substances
īŽ Range from very moisturizing to neutral to very drying
īŽ âIf it is dry, wet it; and if it is wet, dry itâ â derm mantra
īŽ Normal skin pH is 5.6-5.8; most soaps are basic and
therefore can be irritating
īŽ Rinsing may be an issue if irritating
īŽ Choose the appropriate cleanser to match your patientâs
skin type (most eczema patients will need hydration of
the skin and neutral or acidic pH)
īŽ Again, see Pocket Guide to Medications used in
Dermatology for detailed ingredients of skin products
79. Soap Free Cleansers
īŽ Cetaphil
īŽ Aquanil
īŽ Aveeno Daily Mositurizer
īŽ Eucerin Gentle Hydrating Cleanser
īŽ Lobana Body Shampoo
īŽ Moisturel
īŽ pHisoderm
Indications:
For use in those eczema patients who may be sensitive
to one or more of the various potential sensitizers in
soaps and shampoos.
To cleanse, reduce irritation (if sensitive to soaps), and
reduce dryness (thereby increase absorption of other
topicals).
80. Emollients/Moisturizers
īŽ Aquaphor
īŽ Balmex Daily
īŽ AmLactin
īŽ Cutemol
īŽ DML Forte
īŽ Eucerin Original
īŽ Hydrisinol
īŽ Lanolor
īŽ Indication: To soften and soothe rough, dry skin
and increase absorbability of topical medications
īŽ Directions: Apply as necessary or as
prescribed; generally after showering/bathing
and pat drying; apply liberally to affected areas
īŽ Neutrogena Norwegian
Formula
īŽ Lac-Hydrin
īŽ Aveeno
īŽ Pen-Kera
īŽ Curel
īŽ Lubriderm Advanced Therapy
īŽ Minerin
81. Astringents
īŽ Astringents â reduce secretions (by causing
contraction of tissues) and are antibacterial
īŽ Best used in eczema where vesicular or draining
lesions are present
īŽ Acetic Acid 5% (white vinegar) â especially
useful in Pseudomonas infections
īŽ Burowâs Solution (Domeboro and others)
īŽ Potassium Permanganate
82. Burowâs Solution
(aluminum acetate)
Indication:
īŽ Used as an astringent wet to dry dressing for relief of
inflammatory conditions of the skin such as insect bites,
poison ivy, allergy, eczema, and athleteâs foot.
Directions: One tablet or one pack per pint of water =
1:40 solution
Actions:
īŽ Collagenase enzyme activity may be inhibited by
aluminum acetate solution because of the metal ion and
low pH.
83. Burowâs Solution
As a compress or wet dressing: Saturate a
clean, soft, white cloth in the solution. Gently
squeeze and apply loosely to affected area. May
cover with dry dressing. Saturate the cloth in
solution every 15 to 30 minutes and apply to
affected area. Repeat as often as necessary
As a soak: Soak affected area in solution for 15
to 30 minutes. Discard solution after each use.
Repeat 3 times a day
84. Burowâs Solution
Precautions:
īŽ Discontinue use if intolerance, irritation, or
extension of inflammatory condition being
treated occurs. If symptoms persist >7 days,
discontinue use and consult physician
īŽ Do not use plastic or any other impervious
material to prevent evaporation
īŽ Avoid contact with the eyes
88. Properties of the Ideal Drug
(prescription or otc)
īŽ (Acronym IDEA)
īŽ Inexpensive
īŽ Dosage â once daily or bid or less
īŽ Effective
īŽ Adverse effects absent
90. Basic Rules of Dermal Absorption
īŽ The larger the surface area the formulation is
applied to, the greater the absorption
īŽ Formulations or dressings that increase the
hydration of the skin generally improve
absorption
īŽ The greater the amount of rubbing in of the
formulation, the greater the absorption
īŽ The more active inflammation or open vesicles
or ulcers present, the greater the absorption
īŽ The longer the formulation remains in contact
with the skin, the greater will be the absorption
92. Topical Vehicles
Creams:
īŽ Less greasy and most
acceptable to patient
īŽ Applies more easily
īŽ Penetrates skin well
īŽ Works well in intertriginous
and hairy areas
īŽ Can be drying
īŽ Have a cooling effect
īŽ Easy to wash off
Lotions: more water content and
less viscous than creams
Ointments:
īŽ Petrolatum based
īŽ Alleviates dryness by
prevention of evaporation
īŽ Removes scales
īŽ Enables medication to
penetrates skin well
īŽ Water repellant
īŽ Remains on the skin
īŽ Occlusive and protective
īŽ Soothing and lubricating
93. Prescription Topical Steroids
Low and Medium Potency
Do consider use in:
īŽ Allergic/Contact
Dermatitis
īŽ Seborrheic Dermatitis
īŽ Intertrigo of axillary, crural
or inframammary regions
īŽ Atopic Eczema
īŽ Neurodermatitis
īŽ Otic eczema
Do not use:
īŽ Large body areas
because of expense,
difficulty with application,
and question of internal
absorption
94. Prescription Topical Steroids
High Potency and Fluorinated
Do consider use:
īŽ With or without
occlusive dressing in
palmar or plantar
atopic dermatitis
īŽ Localized
neurodermatitis
Do not use:
īŽ Face
īŽ Intertriginous areas
** prolonged use in any
area may cause
thinning of the skin,
telangiectasia, striae
96. Elidel
Elidel (pimecrolimus) 1% cream
Indications:
īŽ Short term and repeated courses for mild to moderate eczema in
nonimmunocompromised patients greater that 2 years of age in
whom the use of alternative conventional treatment is inadvisable or
those with are none responsive to conventional treatment.
īŽ Can be used anywhere on the skin
Precautions:
Do not use in treatment of infected atopic dermatitis, including
eczema herpeticum
Patients who develop lymphadenopathy should have a complete
evaluation to R/O lymphoma
Avoid sun light exposure as sun exposure and use of pimecrolimus
shortens time of skin lesion to skin tumor formation in animals
Do not use occlusive dressings
97. Elidel (contâd)
Adverse Effects (often resolve after a few days of therapy):
Warmth or burning where applied
Headache
Cold-like symptoms (st, cough, rn)
Fever
Viral skin infection
Dosage:
Apply BID
Discontinue when symptoms resolved
Further evaluation needed if symptoms persist > 6 weeks
MOA:
Calcineurin inhibitor
Cost:
30 grams: $63; 60 grams $117
98. Protopic
Protopic (tacrolimus) adults 0.03% & 0.1% ointment
Indications:
Protopic ointment 0.1% for adults only
Protopic ointment 0.03% for children age 2 and older
Short term and repeated courses of moderate to severe eczema in
whom the use of alternative conventional treatment is inadvisable or
those who are not responsive to conventional treatment
Can be used anywhere on the skin
Precautions:
Do not use in treatment of infected atopic dermatitis, including
eczema herpeticum
Patients who develop lymphadenopathy should have a complete
evaluation to R/O lymphoma
īŽ Avoid sunlight, tanning salons, phototherapy (PUVA), as sunlight
shortens time of skin lesion to skin tumor formation in animals
Do not use occlusive dressings
99. Protopic (contâd)
Adverse reactions ( often resolve after few days of application):
Skin stinging and burning (dependent on degree of eczema)
Increased skin infections
Dosage:
Apply BID
Discontinue 1 week after symptoms resolved
Further evaluation needed if symptoms persist > 6 weeks
MOA:
Calcineurin inhibitor
Cost:
30 grams: $62; 60 grams $130
100. Potential problem with both TIMâs
(Elidel and Protopic)
īŽ Feb. 15th 2005: the Pediatric Advisory Committee of the FDA met
and recommended that a âblack box warningâ be added to both
Elidel and Protopic due to âpotential cancer riskâ
īŽ This is due to animal studies where animals swallowed large
amounts of both drugs over a long period of time, achieved
significant blood levels of the drugs, and developed lymphomas.
īŽ March 10, 2005: The FDA issued a Public Health Advisory warning
the public about potential carcinogenic safety issues involving both
TIMâs.
īŽ The American Academy of Dermatology, the Natâl. Eczema Assn. for
Science and Education (NEASE), and the Inflammatory Skin
Disease Institute (ISDI) all have issued statements declaring the
FDA action premature and all feel that the drugs are safe when used
appropriately
īŽ There are already websites dedicated to class action litigation
against both manufacturers
īŽ Bottom Line: I would not adivse using in any pediatric patients, or in
any patient that can be controlled with less expensive and
efficacious therapy.
101. Nontraditional Agents
Problem: these are not deemed safe or effective by the
FDA
Herbal remedies
1. Licorice as topical gel
2. Guava leaves (as tea)
3. Chinese herbal teas
4. St. Johnâs wort (as lotion or tea)
īŽ Probiotics â thought to help relieve inflammation
īŽ Homeopathic â arsenicum alba and calcara carbonica
īŽ Hypnosis
īŽ Acupuncture
īŽ Gamma linoleic acid oils
1. Evening primrose oil
2. Borage oil
102. PO Prescription Drug Therapy
īŽ Antipruritics
1. Hydroxyzine 10-25mg q6h prn itching
2. Doxepin 10-25mg q12-24h prn itching (off label)
also can be compounded as a cream)
īŽ Oral Steroids
1. May give in tapering short courses for selected
episodes of acute and/or severe eczema
2. Effective, inexpensive, qd dosing, few side effects
in most people with short term use
īŽ Cyclosporine â reserve for specialty use
īŽ Methotrexate â reserve for specialty use
103. Coal Tar Preparations
īŽ Tegrin cream and lotion
īŽ Medotar ointment
īŽ PsoriGel gel
īŽ Polytar and Tegrin soaps
īŽ Tegrin, T/Gel, and other shampoos
Indication: to relieve and control itching, and
flaking skin associated with psoriasis and
seborrhea as well as eczema
Directions: Depending on product 1-4 times daily
104. Coal Tar Preparations
(contâd)
Contraindications:
īŽ Hypersensitivity
Precautions:
īŽ Do not use on broken skin, genital or rectal area
except on the advise of your health care
provider.
īŽ Photosensitivity x 24hr after application
īŽ May stain light colored hair
Warning:
īŽ High concentrations of some chemicals in coal
tar may cause cancer. Concentrations of 0.5% to
5% appear to be safe.
105. PUVA Therapy
Indications: Psoriasis, eczema, pruritic rashes of
other causes
Consists of PO psoralen (photosensitizing agent)
followed by UVA phototherapy
Must avoid sunlight for 24h after po psoralen
Sessions are 3d/wk, may be from 12-30 sessions,
increasing in duration
Side effects are redness, burning, occasional
nausea
Litigation very high in some states
106. Summary of Treatment
1. Conservative Therapy
a) Education (chronicity, prevention, and trigger id)
b) Use of astringents and emollients/moisturizers
c) OTC products (hydrocortisone, Benadryl, Calamine, etc.)
2. Low to mid potency steroid creams
3. High potency steroid creams
4. Immunomodulators - Elidel and Protopic creams
5. Nontraditional agents
6. PO therapy: antiprurutics, steroids, cyclosporine,
methotrexate
7. Coal Tar
8. PUVA therapy (phototherapy)