This document discusses the development of regional innovation ecosystems to create jobs. It defines key terms like assets, regions, and organizations. Regions are typically defined as within 25 miles of a hub city. Assets include tangible resources like capital and human capital, as well as intangible factors like culture. Organizations that can support innovation ecosystems are described, like venture development organizations and enabling organizations. The goal is to learn from regions that have successfully developed innovation ecosystems and create models to help other regions.