Technology transfer

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Technology transfer should be evaluated holistically to maximize value. It needs clear definition and design from a comprehensive perspective to fully realize benefits. The document discusses technical collaboration between companies over many pages without providing additional context or details.

Technology

Technology transfer should be assessed,
defined, designed, and managed from
a comprehensive value perspective to capture
the full benefits of the transfer..

page 16
TechnicalCollaborationbetweenCompanies

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Syngulon’s technology expands the capacity for selection of microorganisms. The ability to select individual microbes with a behavior of interest is essential, whether for simple cloning at the bench, or for industry-scale production. Synthetic biology uses the concept of “bioengineering” to improve or modify existing genetic systems to create microbes with desired behaviors, and Syngulon uses this approach to develop its selection technologies. This selection technology is based on bacteriocins, ribosomally-produced peptides naturally made by most bacteria to kill competitive microbial species. These bacteriocins can have a limited or wide target range against other microbial species. This technology offers advantageous over antibiotic selection for several reasons: it avoids the use of antibiotics in the first place, helping to reduce the spread of antibiotic resistant microbes. The technology also increases product yield; as bacteriocins are generally smaller peptides, they do not impose a heavy metabolic burden on the producing cell. They can have a wide target specificity, helping to avoid genetic drift. Finally, our system is 100% plasmid-based (e.g. without chromosomal mutations), making it applicable for use in any E. coli strains.

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Technology transfer

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