Target selection lead discovery medicinal drug discovery process style design 5 powerpoint ppt slides.

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The document outlines the multi-step drug discovery process, including identifying genetic and cellular targets, synthesizing compounds through combinatorial chemistry and high-throughput screening, developing structure-activity relationships through in silico and in vitro studies, evaluating drug affinity and selectivity in cellular disease models, testing lead candidates in animal models of disease states, and conducting clinical trials and therapeutics in humans.

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The document outlines the key stages of the drug discovery process, including identifying genetic and cellular targets, synthesizing and isolating compounds through combinatorial chemistry and high-throughput screening, developing structure-activity relationships through in silico and in vitro studies, evaluating drug affinity and selectivity in cellular and disease models, testing lead candidates in animal models of disease states, and conducting clinical trials and therapeutics in humans.

Target selection lead discovery medicinal drug discovery process design 5 pow...

SlideTeam.net

The document outlines the multi-step drug discovery process, including cellular and genetic target identification, compound synthesis and isolation, library development, drug affinity and selectivity testing, animal disease modeling, and clinical trials. Key steps involve genomics, proteomics, high-throughput screening, medicinal chemistry, in vitro and in vivo studies to identify lead candidates and refine drug properties before progressing to clinical testing.

Drug discovery process style 5 powerpoint presentation slides db ppt templates

SlideTeam.net

The document outlines the key stages in the drug discovery process, including target selection, lead discovery, drug development, preclinical testing, and clinical trials. Genetic and cellular targets are identified through genomics and proteomics. Combinatorial chemistry and high-throughput screening are used to develop compound libraries and identify potential drug candidates. Lead compounds are refined through medicinal chemistry and testing in cellular and animal disease models. Top candidates then progress to clinical trials in humans to test for safety and efficacy.

Traditional drug discovery process design 6 powerpoint ppt slides.

SlideTeam.net

The document describes two approaches to drug discovery: the traditional approach and the SWITCH drug re-profiling approach. The traditional approach involves lengthy timelines of 0.5-6 years across target identification, validation, lead identification, candidate optimization, pre-clinical trials, and clinical trials. The SWITCH approach aims to shorten timelines by mining existing drug data to identify new therapeutic uses for existing drugs and performing a clinical proof of concept trial within 0.5-1 year on a re-profiled drug.

Drug discovery process style 6 powerpoint presentation templates

SlideTeam.net

The document describes two approaches to drug discovery: traditional drug discovery and a SWITCH drug re-profiling approach. The traditional approach involves multiple sequential steps over 6-10 years, including target identification, validation, lead identification, candidate optimization, pre-clinical testing, and clinical trials. The SWITCH approach uses data mining to identify existing drugs that could be re-purposed for new indications, potentially shortening the process to just 0.5-1 years for target identification and proof-of-concept clinical trials on re-profiled drugs.

Drug discovery process style 5 powerpoint presentation templates

SlideTeam.net

The document describes the key stages in the drug discovery process, including cellular and genetic target identification, compound synthesis and isolation, high-throughput screening, lead optimization, preclinical testing in animal models and in vitro/in vivo studies, and clinical trials in humans. The flow diagram shows the iterative process moving from early research to identify biological targets through compound development and testing, culminating in clinical evaluation and potential approval of new therapeutics.

How to make create genomic research target molecules drug discovery strategy ...

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How to make create genomic research target molecules drug discovery strategy ...

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The document outlines the key steps in the drug discovery process: 1. Identification of target molecules through genomic research and functional analysis of genes and enzymes. 2. Discovery of seed lead compounds through high-throughput screening and combinatorial chemistry. 3. Scrutiny of drug candidates including estimation of drug efficacy and safety evaluation. 4. Manufacturing development and clinical studies prior to new drug application and launch.

The document describes the Institute for Cell Dynamics and Biotechnology, which conducts research in systems biology using a multidisciplinary approach. The key goals of the Institute are to conduct frontier research in cell function and dynamics using systems biology models, and to apply this research to important scientific and societal problems. It supports over 70 young researchers and postdocs and has an extensive international collaborations network. The research focuses on areas like metabolic networks, protein engineering, and metabolomics.

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Drug discovery process style 3 powerpoint presentation templates

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The document summarizes the key steps in the drug discovery process. It involves: 1) Identifying a biological target molecule through genomic research and functional analysis of genes. 2) Discovering seed lead compounds through high-throughput screening and combinatorial chemistry. 3) Scrutinizing drug candidates through estimation of efficacy, safety evaluation, pharmacokinetics studies, and manufacturing development. 4) Conducting clinical studies and applying for a new drug approval.

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Biovays is a biomarker solutions provider that offers specialized services to support drug development from target discovery through FDA approval. Their services include biomarker selection and assay development, pharmacodynamics testing, toxicity analysis, and various in vitro and ex vivo assays. By providing biomarker analysis and expertise, Biovays aims to streamline drug development, reduce costs, and improve success rates.

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Metin Bilgin is an experienced molecular and cellular biologist with over 12 years of postgraduate research experience. He co-developed the first proteome chip and assay protocols for protein array technology. His research has focused on studying cell cycle regulation, cytochrome P450 metabolism, and nuclear hormone receptor regulated drug metabolism through interactive proteomics, protein expression, and recombinant protein purification techniques. He holds a Ph.D. in Molecular and Cellular Biology from Szeged University and has worked in academic research positions in Turkey, Hungary, the UK, and the US.

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Metin Bilgin is an experienced molecular and cellular biologist with over 12 years of postgraduate research experience. He co-developed the first proteome chip and assays for protein array technology. His research has focused on studying cell cycle regulation, cytochrome P450 metabolism, and nuclear hormone receptor-regulated drug metabolism. He is skilled in interactive proteomics, protein expression, purification of multi-protein complexes, and developing high-throughput molecular assays. Currently he works as a postdoctoral research associate at the University of Illinois studying regulation of cytochrome P450 activity by nuclear hormone receptor CAR.

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This document provides an overview of the course Pharm 202 on Computer Aided Drug Design. It discusses the principles of drug discovery including modern target identification, lead identification, and data-driven approaches. The drug discovery process is outlined involving natural products, synthetic chemicals, and biologicals as starting points. Computer aided drug design has evolved from early visualization to modern automation and high-throughput approaches leveraging genomics, structural bioinformatics, and databases. The perspectives of targets, computers, and drugs in discovery are presented.

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Metin Bilgin is a molecular and cellular biologist with over 12 years of postgraduate research experience. He has expertise in proteomics, protein expression, and characterization. Some of his accomplishments include co-developing the first proteome chip and establishing HTP assay protocols for protein array technology. He has studied various topics like cell cycle regulation, cytochrome P450 metabolism, and nuclear hormone receptor regulated drug metabolism. Currently, he is a postdoctoral research associate studying regulation of cytochrome P450 activity by nuclear hormone receptor CAR. He aims to work for a leading life sciences research company focused on discovery and translational medicine.

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Target selection lead discovery medicinal drug discovery process style design 5 powerpoint ppt slides.

1. Drug Discovery Process - Style 5 Cellular & Synthesis & Library Drug Affinity Animal Models Clinical Trials Genetic Targets Isolation Development & Selectivity of Disease States & Therapeutics Combinatorial Structure Activity Cellular Behavioural Genomics Disease Models Studies Chemistry Studies Assay In Silico Mechanism Functional Proteomics Development Screening of Action Imaging Bioinformatics High-throughput Chemical Lead Candidate Ex Vivo Screening Synthesis Refinement Studies Target Lead Medicinal In Vitro In Vivo Selection Discovery Chemistry Studies Studies www.slideteam.net Your logo

2. Drug Discovery Process - Style 5 Cellular & Synthesis & Library Drug Affinity Animal Models Clinical Trials Genetic Targets Isolation Development & Selectivity of Disease States & Therapeutics Combinatorial Structure Activity Cellular Behavioural Genomics Disease Models Studies Chemistry Studies Assay In Silico Mechanism Functional Proteomics Development Screening of Action Imaging Bioinformatics High-throughput Chemical Lead Candidate Ex Vivo Screening Synthesis Refinement Studies Target Lead Medicinal In Vitro In Vivo Selection Discovery Chemistry Studies Studies Text Here Text Here Text Here Text Here Text Here Text Here • Your Text • Your Text • Your Text • Your Text • Your Text • Your Text Goes here Goes here Goes here Goes here Goes here Goes here • Download • Download • Download • Download • Download • Download this this this this this this awesome awesome awesome awesome awesome awesome diagram diagram diagram diagram diagram diagram www.slideteam.net Your logo

3. Drug Discovery Process - Style 5 Cellular & Synthesis & Library Drug Affinity Animal Models Clinical Trials Genetic Targets Isolation Development & Selectivity of Disease States & Therapeutics Combinatorial Structure Activity Cellular Behavioural Genomics Disease Models Studies Chemistry Studies Assay In Silico Mechanism Functional Proteomics Development Screening of Action Imaging Bioinformatics High-throughput Chemical Lead Candidate Ex Vivo Screening Synthesis Refinement Studies Target Lead Medicinal In Vitro In Vivo Selection Discovery Chemistry Studies Studies Text Here Text Here Text Here Text Here Text Here Text Here • Your Text • Your Text • Your Text • Your Text • Your Text • Your Text Goes here Goes here Goes here Goes here Goes here Goes here • Download • Download • Download • Download • Download • Download this this this this this this awesome awesome awesome awesome awesome awesome diagram diagram diagram diagram diagram diagram www.slideteam.net Your logo

4. Drug Discovery Process - Style 5 Cellular & Synthesis & Library Drug Affinity Animal Models Clinical Trials Genetic Targets Isolation Development & Selectivity of Disease States & Therapeutics Combinatorial Structure Activity Cellular Behavioural Genomics Disease Models Studies Chemistry Studies Assay In Silico Mechanism Functional Proteomics Development Screening of Action Imaging Bioinformatics High-throughput Chemical Lead Candidate Ex Vivo Screening Synthesis Refinement Studies Target Lead Medicinal In Vitro In Vivo Selection Discovery Chemistry Studies Studies Text Here Text Here Text Here Text Here Text Here Text Here • Your Text • Your Text • Your Text • Your Text • Your Text • Your Text Goes here Goes here Goes here Goes here Goes here Goes here • Download • Download • Download • Download • Download • Download this this this this this this awesome awesome awesome awesome awesome awesome diagram diagram diagram diagram diagram diagram www.slideteam.net Your logo

5. Drug Discovery Process - Style 5 Cellular & Synthesis & Library Drug Affinity Animal Models Clinical Trials Genetic Targets Isolation Development & Selectivity of Disease States & Therapeutics Combinatorial Structure Activity Cellular Behavioural Genomics Disease Models Studies Chemistry Studies Assay In Silico Mechanism Functional Proteomics Development Screening of Action Imaging Bioinformatics High-throughput Chemical Lead Candidate Ex Vivo Screening Synthesis Refinement Studies Target Lead Medicinal In Vitro In Vivo Selection Discovery Chemistry Studies Studies Text Here Text Here Text Here Text Here Text Here Text Here • Your Text • Your Text • Your Text • Your Text • Your Text • Your Text Goes here Goes here Goes here Goes here Goes here Goes here • Download • Download • Download • Download • Download • Download this this this this this this awesome awesome awesome awesome awesome awesome diagram diagram diagram diagram diagram diagram www.slideteam.net Your logo

6. Drug Discovery Process - Style 5 Cellular & Synthesis & Library Drug Affinity Animal Models Clinical Trials Genetic Targets Isolation Development & Selectivity of Disease States & Therapeutics Combinatorial Structure Activity Cellular Behavioural Genomics Disease Models Studies Chemistry Studies Assay In Silico Mechanism Functional Proteomics Development Screening of Action Imaging Bioinformatics High-throughput Chemical Lead Candidate Ex Vivo Screening Synthesis Refinement Studies Target Lead Medicinal In Vitro In Vivo Selection Discovery Chemistry Studies Studies Text Here Text Here Text Here Text Here Text Here Text Here • Your Text • Your Text • Your Text • Your Text • Your Text • Your Text Goes here Goes here Goes here Goes here Goes here Goes here • Download • Download • Download • Download • Download • Download this this this this this this awesome awesome awesome awesome awesome awesome diagram diagram diagram diagram diagram diagram www.slideteam.net Your logo

7. Drug Discovery Process - Style 5 Cellular & Synthesis & Library Drug Affinity Animal Models Clinical Trials Genetic Targets Isolation Development & Selectivity of Disease States & Therapeutics Combinatorial Structure Activity Cellular Behavioural Genomics Disease Models Studies Chemistry Studies Assay In Silico Mechanism Functional Proteomics Development Screening of Action Imaging Bioinformatics High-throughput Chemical Lead Candidate Ex Vivo Screening Synthesis Refinement Studies Target Lead Medicinal In Vitro In Vivo Selection Discovery Chemistry Studies Studies Text Here Text Here Text Here Text Here Text Here Text Here • Your Text • Your Text • Your Text • Your Text • Your Text • Your Text Goes here Goes here Goes here Goes here Goes here Goes here • Download • Download • Download • Download • Download • Download this this this this this this awesome awesome awesome awesome awesome awesome diagram diagram diagram diagram diagram diagram www.slideteam.net Your logo

8. Drug Discovery Process - Style 5 Cellular & Synthesis & Library Drug Affinity Animal Models Clinical Trials Genetic Targets Isolation Development & Selectivity of Disease States & Therapeutics Combinatorial Structure Activity Cellular Behavioural Genomics Disease Models Studies Chemistry Studies Assay In Silico Mechanism Functional Proteomics Development Screening of Action Imaging Bioinformatics High-throughput Chemical Lead Candidate Ex Vivo Screening Synthesis Refinement Studies Target Lead Medicinal In Vitro In Vivo Selection Discovery Chemistry Studies Studies Text Here Text Here Text Here Text Here Text Here Text Here • Your Text • Your Text • Your Text • Your Text • Your Text • Your Text Goes here Goes here Goes here Goes here Goes here Goes here • Download • Download • Download • Download • Download • Download this this this this this this awesome awesome awesome awesome awesome awesome diagram diagram diagram diagram diagram diagram www.slideteam.net Your logo

9. All images are 100% editable in Powerpoint “Change color, size and orientation of any icon to your liking” www.slideteam.net

10. Ungrouping the object 2 1 3 1. Right click the object. 2. Choose Group and then Ungroup. 3. Click beside the object and drag the arrow over it. www.slideteam.net

11. Edit Color 2 3 1 1. Select the shape to change the color and Right click the object( click any object which you want to change color) 2. Choose Format Shape in the dialog box. 3. Choose “Fill” in the Format Shape box then “Solid” or “Gradient” depending on the appearance of the object. Change colour as shown in the picture. www.slideteam.net

Target selection lead discovery medicinal drug discovery process style design 5 powerpoint ppt slides.

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