The study aimed to examine respiratory diseases in newborns, especially respiratory distress syndrome (RDS), and the relationship between gestational age, birth weight and RDS. It analyzed 30 newborns admitted to the neonatal intensive care unit and department from January to February 2008. The findings were that RDS predominantly affects preterm infants under 32 weeks gestation. Treatment for RDS included surfactant therapy, CPAP, ventilation and antibiotics. Combinations and durations of antibiotics depended on diagnosis and severity, with most NICU patients receiving two or more antibiotics.

5. Percentage of Term and Preterm newborn Total 30 patients: Boys 20(67%) & Girls 10(30%) 5

6. Body weight of patients

7. Pathologic events in RDS Rosario N. Santos--Chua, et al , UpToDate , 2009.

8. Investigation of Respiratory Distress Syndrome in newborn

11. 11

13. Surfactant therapy Alveofact, Curosurf, Infasurg, Survanta Curosurf Dosage: Intratracheal: Initial: 2.5 mL/kg/dose (200 mg/kg/dose); may repeat 1.25 mL/kg/dose (100 mg/kg/dose); at 12-hour intervals for up to 2 additional doses; maximum total dose: 5 mL/kg. Curosurf It produces rapid improvements in lung oxygenation and compliance that may require immediate reductions in ventilator settings and FiO2.

14. Surfactant versus placebo treatment from Liechty EA; et al, July 1991.

15. Differences between the percentage of following cases in Newborn’s Department and NICU

16. Antibiotic usage for newborn’s 3 diseases in following department *3 diseases are Aspiration pneumonia, Respiratory distress syndrome & Congenital pneumonia. Pt.no= Patient’s number Pt.no Pt.no Pt.no Antibiotics in NICU (N=21) Antibiotics in Newborn Department (N=9) Antibiotics in Newborn department after treated from NICU (N=21) Netilmicin ( Нетилмицин ) 13 Cefotaxime (Клафоран) 8 Ceftriaxone 10 Ceftriaxone ( Роцефин ) 13 Fluconazole 2 Ciprofloxacin 8 Ciprofloxacin ( Ципробай ) 10 Amikacin 1 Fluconazole 7 Vancomycin ( Ванкомицин ) 6 Netilmicin 4 Fluconazole ( Дифлюкан ) 6 Vancomycin 2 Metronidazole (Метрогил) 5 Metronidazole 2 Ceftazidime (Фортум) 4 Ceftazidime 1 Rifampicin (Рифампицин) 3 Imipenem (Имипенем) 1 Amikacin (Амикацин) 3 Imipenem+Cilastatin (Тиенам) 1 Linezolide (Линизолед) 1

17. Differences between antibiotics combination in Newborn Department, Newborn Department after treated from NICU and NICU

18. Combine antibiotic treatment according to following diseases

19. CPAP and Mechanical Ventilation

20. Duration of stay in Neonatal Intensive Care Unit and Newborn’s department NICU Newborn’s department duration 20