Tablet Granulation by dr. umesh kumar sharma (2)

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This document discusses granulation, which is the process of agglomerating powder particles into larger, multiparticle entities called granules. Granulation improves the flow properties of powders allowing for easier handling in manufacturing processes and improves the uniformity of the final dosage form. There are different granulation techniques including dry granulation which uses roller compaction or slugging, and wet granulation which uses liquid binders or granulating solvents to form granules. The document describes the various steps and considerations in wet and dry granulation processes.

Education

GRANULATION
Dr. UMESH KUMAR SHARMA,
DEPARTMENT OF PHARMACEUTICS,
MAR DIOSCORUS COLLEGE OF PHARMACY,
THIRUVANANTHAPURAM, KERALABy- Dr. Umesh Kumar Sharma

Granulation : Definition & Concept
By- Dr. Umesh Kumar Sharma

Why we prepare granules when we have powders….. ?
By- Dr. Umesh Kumar Sharma

Direct Compression :
By- Dr. Umesh Kumar Sharma

Limitation
Low dose API, poor content uniformity.
High dose API - which is not easily compress, usually
restricted to about 30 %, tablet will be costly and
difficult to swallow.
Direct compression diluent may interact with the API.
Because of the dry nature of direct compression,
static charge develops which effect the uniform
distribution of API in dosage form.
By- Dr. Umesh Kumar Sharma

Dry Granulation :
By- Dr. Umesh Kumar Sharma

Steps Involved in Dry Granulation :
By- Dr. Umesh Kumar Sharma

How we do it ? ……
Two method are used:
By- Dr. Umesh Kumar Sharma

Equipment’s Used:
By- Dr. Umesh Kumar Sharma

Roller Compacter: Chilsonator
By- Dr. Umesh Kumar Sharma

Wet Granulation:
By- Dr. Umesh Kumar Sharma

Solvents in Wet Granulation :
By- Dr. Umesh Kumar Sharma

Characteristics of a Granulating Agent:
By- Dr. Umesh Kumar Sharma

The most used granulating solvents
By- Dr. Umesh Kumar Sharma

Granulating Solvents cont..
By- Dr. Umesh Kumar Sharma

STAGES OF WET GRANULATION:
By- Dr. Umesh Kumar Sharma

Stepwise wet granulation process:
1
2
3
4
5
By- Dr. Umesh Kumar Sharma

Milling Techniques:
By- Dr. Umesh Kumar Sharma

Characterisation of Granules
By- Dr. Umesh Kumar Sharma

Mass- volume Relationships;
By- Dr. Umesh Kumar Sharma

Characterisation of Granules Cont …….
By- Dr. Umesh Kumar Sharma

FLOW PROPERTIES
By- Dr. Umesh Kumar Sharma

ANGLE OF REPOSE
By- Dr. Umesh Kumar Sharma

Tablet Granulation by dr. umesh kumar sharma (2)

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Tablet Granulation by dr. umesh kumar sharma (2)

1. GRANULATION Dr. UMESH KUMAR SHARMA, DEPARTMENT OF PHARMACEUTICS, MAR DIOSCORUS COLLEGE OF PHARMACY, THIRUVANANTHAPURAM, KERALABy- Dr. Umesh Kumar Sharma

2. CONTENTS: By- Dr. Umesh Kumar Sharma

3. Granulation : Definition & Concept By- Dr. Umesh Kumar Sharma

4. Why we prepare granules when we have powders….. ? By- Dr. Umesh Kumar Sharma

5. Mechanism : By- Dr. Umesh Kumar Sharma

6. Granulation Techniques :

7. Granulation Method:

8. Direct Compression : By- Dr. Umesh Kumar Sharma

9. Direct compression : By- Dr. Umesh Kumar Sharma

10. Limitation Low dose API, poor content uniformity. High dose API - which is not easily compress, usually restricted to about 30 %, tablet will be costly and difficult to swallow. Direct compression diluent may interact with the API. Because of the dry nature of direct compression, static charge develops which effect the uniform distribution of API in dosage form. By- Dr. Umesh Kumar Sharma

11. Dry Granulation : By- Dr. Umesh Kumar Sharma

12. Steps Involved in Dry Granulation : By- Dr. Umesh Kumar Sharma

13. How we do it ? …… Two method are used: By- Dr. Umesh Kumar Sharma

14. Equipment’s Used: By- Dr. Umesh Kumar Sharma

15. Roller Compacter: Chilsonator By- Dr. Umesh Kumar Sharma

16. Slugging : By- Dr. Umesh Kumar Sharma

17.

18. Roller Compacter: Chilsonator By- Dr. Umesh Kumar Sharma

19. Wet Granulation: By- Dr. Umesh Kumar Sharma

20. Wet Granulation : By- Dr. Umesh Kumar Sharma

21. Solvents in Wet Granulation : By- Dr. Umesh Kumar Sharma

22. Characteristics of a Granulating Agent: By- Dr. Umesh Kumar Sharma