The document provides an agenda for a system design and simulation workshop taking place on October 21, 2010. The workshop consists of three sessions with various speakers presenting on topics related to system design, simulation, and engineering. Presentations will cover subjects such as design frameworks, early simulation and specification validation, model-based systems engineering, model-driven approaches, distributed network engineering, model-based space systems, live-virtual-constructive simulation, graphical system design, multidisciplinary analysis, and system design methodology and tools. The day will also include a visit to an exhibition area from workshop sponsors.