The document discusses the biomedical applications of aloe vera gel, highlighting its structure, preparation methods, chemical composition, and medicinal properties. It outlines various uses of aloe vera, including its anti-inflammatory, wound healing, and skin protection benefits, supported by research findings. Additionally, it emphasizes the plant's therapeutic qualities and its approval as a dietary supplement by regulatory bodies.

1. Aloe vera Gel and its Biomedical
Applications
DEPARTMENT OF CHEMISTRY
ODISHA UNIVERSITY OF TECHNOLOGY AND
RESEARCH
BHUBANESWER
NAME-SUBHASMITA BEHERA
REGISTRATION NO-23220030
M. Sc. CHEMISTRY
1

2. • Introduction
• Structure of aloe leaf
• Preparation of aloe vera gel
• Preparation of aloe vera gel-polymer composites
• Chemical compositions and properties
• Medicinal utilities of Aloe vera
• Conclusion
• References
• Acknowledgement
2
CONTEN
TS

3. INTRODUCTION
• Scientific name of Aloe vera is Aloe barbadensis miller.
• The name aloe vera is derived from the Arabic word
“alloeh” meaning “shining bitter substance”,
while “vera” in Latin means “true’.
• Aloe vera contains over 75 biologically active and
naturally-occurring compounds,
including polysaccharides, vitamins,
enzymes, amino acids, and
minerals.
3
M. Chelu et al. Gels, 9, 2023, 539

4. Structure of Aloe leaf
The structure of the Aloe leaf is
configured in the form of three layers:
• The inner layer consists of
a transparent gel containing 99%
water and 1% solid matter that
compresses over 75 different
compounds.
• The middle layer is a bitter latex in
the form of yellow juice rich in
glycosides and anthraquinones.
• The outer layer is a thick cortex
4
M. Chelu et al. Gels, 9, 2023, 539

5. Preparation of
aloe vera gel
5
P. Jithendra et al. ACS Appl. Mater. Interfaces 2013, 5, 7291–7298

6. 6
Preparation of aloe vera gel-polymer composites
P. Jithendra et al. ACS Appl. Mater. Interfaces 2013, 5, 7291–7298
Synthesis, optical imaging of three composite hydrogels with
different concentrations of Aloe vera (5%, 10%, and 20% w/v),
and evaluation of their properties

7. SCANNING ELECTRON MICROSCOPY
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Aloe vera gel examined with SEM (x1000): (a)
younger aloe vera gel, (b) older aloe vera gel, (c) aloe
gel extracted with hexane and (d) aloe gel extracted
with mixture of hexane and ethanol.
• Two types of solvent were
used which were hexane and
ethanol.
• In order to identify the
different extracted bioactive
compound, both hexane and
ethanol were combined in
specific ratio.
Yuharmon, N. A. S., et al. IOP Conf. Ser., 1, 2018, . 1123.

8. CHEMICAL COMPOSITION AND PROPERTIES OF ALOE VERA
Chemical Group Constituents Properties and activity
Amino Acids Provides 20 of the 22 required
amino acids and 7 of the 8 essential
ones.
Basic building blocks of
proteins in the body and
muscle tissues
Hormones Auxins and gibberellins Wound healing and anti-
inflammatory
Salicylic Acid Aspirin like compounds Analgesic
Minerals Calcium,copper, iron, potassium,
sodium and zinc etc.
Essential for good health
Vitamins A, B, C, E, choline, B12, folic acid Antioxidant
(A,C,E),neutralizes free
radical
M. Chelu et al. Gels, 9, 2023, 539
8

9. THE MEDICINAL UTILITIES OF ALOE
VERA
Anti-diabetic
Anti bacterial
Wound
healing
Anti-
inflammatory
Skin
protection
Anti
septic
Anti
cancer
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10. 10
P. Jithendra et al. ACS Appl. Mater. Interfaces 2013, 5, 7291–7298
Aloe Vera Gels in Wound
Schematic illustration
vera-based hydrogel
potential use as
of
Aloe and
the a
wound
dressing: (a) and (b) wet; Images
of a wound during the healing
process using Aloe vera
hydrogel:
(c) Schematic illustration of Aloe
vera-based hydrogel and the
potential use
dressing
as a
wound
Aloe
vera
hydrogel(initial time) (d) after 5
min; (e) the wound was healed
after 20 days;

11. 11
M. Tummalapalli et al. Int. J. Biol. Macromol. 2016, 82, 104 – 113
Pectin-gelatin hydrogels loaded with aloe vera showed good wound healing and
antiinflammation properties

12. 12
PVA + Aloe vera gel membranes
1%
Aloe
0.5%
Aloe
0%
Aloe
2%
Aloe
E. Kenawy et al. J Polym Environ . 2023, 32, 2140 – 2157
study demonstrated
The
that, PVA/Aloe
membranes
remarkable
healing and
Vera
have
wound
skin
regeneration properties.
PVA AND AVG are the
compatible materials
that can be used to
creat membranes with a
variety concentrations

13. Aloe Vera in Cosmetic Formulations
• Mucopolysaccharides help in binding moisture into the skin.
• The amino acids also soften hardened skin cells and
zinc acts as an astringent to tighten pores.
• The Aloe gel gives cooling effect and also acts as
a moisturizing agent.
• The gel contains an emollient polysaccharide, glucomannan.
It is a good moisturizer.
• It also has role in gerontology and rejuvenation of
aging skin.
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S. Dal’Belo, et al, Skin Res Technol. 2006; 12: 241–246

14. 14
Aloe Vera as Food Supplement
✓ Food and beverage market is a promising arena of Aloe vera.
✓ Food and Drug Administration (FDA) has approved the oral
consumption of Aloe juice as a “dietary supplement” in the United
States.
✓ In the European Commission Annex I of Regulation No. 1831/2003,
Aloe is included among “flavoring compounds” in feeding
industries.
✓ Aloe vera gel prolongs the shelf life of table grapes when coated.
✓ Moreover, Aloe gel inhibits microbial counts of the stored items.
S. Javed, et al, Studies Nat. Prod. Chem. 2014; 41: 261–
285

15. 15
Conclusion
✓ Having therapeutic, rejuvenating and health enhancing properties, Aloe
vera gel is widely used in food, healthcare and medicinal industries.
✓ The plant exhibits many pharmacological activities such antioxidant,
antimicrobial, immune boosting, antitumor, wound healing, and
antidiabetic.
✓ Many traditional uses are also reported such as burn injury, eczema,
cosmetics, inflammation, and fever, which continue to be studied, and
further research still has to be done.
✓ The US Food and Drug Administration has already approved the
developmental study of A. vera in the treatment of cancer and AIDS.

16. REFERENCES
1. El-Meligy MA, Valachová K, Juránek I, Tamer TM, Šoltés L (2022) Preparation and
physicochemical characterization of gelatin-aldehyde derivatives. Molecules 27(20):7003
2. Lim ZX, Cheong KY (2015) Effects of drying temperature and ethanol concentration on bipolar
switching characteristics of natural Aloe vera-based memory devices. Phys Chem Chem Phys
17(40):26833–26853
3. Bonilla J, Fortunati ELENA, Atarés L, Chiralt A, Kenny JM (2014) Physical, structural and
antimicrobial properties of poly vinyl alcohol–chitosan biodegradable membranes. Food
Hydrocoll 35:463–470
4. Eldin MM, Hashem AI, Omer AM, Tamer TM (2015) Wound dressing membranes based on
chitosan: Preparation, characterization and biomedical evaluation. Int J Adv Res 3(8):908–922
5. Kamoun EA, Chen X, Mohy Eldin MS, Kenawy ES (2015) Crosslinked poly (vinyl alcohol)
hydrogels for wound dressing applications. Arab J Chem 8:1–14
6. Reynolds T, Dweck AC (1999) Aloe vera leaf gel: a review update. J Ethnopharmacol 68:3–37
7. Choi S-W, Son B-W, Son Y-S, Park Y-I, Lee S-K, Chung M-H (2001) The wound healing effect
of a glycoprotein fraction isolated from Aloe vera. Br J Dermatol 145:535–545
8. Kenawy, ER., El-Meligy, M.A., Ghaly, Z.S. et al. Novel Physically-Crosslinked Caffeine and
Vitamin C-Loaded PVA/Aloe Vera Hydrogel Membranes for Topical Wound Healing: Syn1t6hesis,
Characterization and In-Vivo Wound Healing Tests. J Polym Environ 32, 2140–2157 (2024).

17. ACKNOWLEDGEME
NT
I would like to convey my special thanks of gratitude to the
Honourable Dean Sir, Honourable HOS sir, and respected
teachers for providing this opportunity to present this
seminar on the topic “ALOE VERA AND ITS BIOMEDICAL
APPLICATION” which also helped me to gain more
knowledge and many new things about this topic.
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THANK YOU