Carl Bazan, MD, possesses diverse experience in research and director roles within the drug development industry. Dr. Carl Bazan has been involved in studies examining the latest research concerning the potential causes of cancer.
Air pollution has been linked to cancer development. Fine particulate matter and toxic gases in polluted air can cause DNA damage and mutations in cells. Long-term exposure to air pollution has been shown to increase risks of lung cancer and other cancers according to numerous epidemiological studies.
Air pollution has been linked to increased cancer risks. Long-term exposure to pollutants like particulate matter can cause cellular damage and increase oxidative stress, both of which are associated with cancer development. More research is still needed, but the evidence so far suggests that reducing air pollution could help lower population cancer rates over time.
This document discusses a Canadian study that found a link between consuming a diet high in refined carbohydrates and sugars and an increased risk of ovarian cancer. The study observed 49,000 women over 16 years and found that those who developed ovarian cancer had higher Glycemic Load values, which measures sugar consumption and portion sizes, than those who did not develop cancer. Specifically, the study suggested that higher Glycemic Load values were associated with over a 70% increased risk of ovarian cancer.
This document discusses the Mediterranean diet and its potential to reduce risk of colorectal cancer. It summarizes research finding that following a Mediterranean diet, which emphasizes plant-based foods, unsaturated fats, and spices instead of salt, can effectively reduce colorectal cancer risk. Individual components like antioxidants, fiber, and unsaturated fats in the Mediterranean diet have synergistic effects in reducing cancer risk. Modifications at the individual, environmental, and policy levels could promote the Mediterranean diet and potentially save lives.
Colorectal cancer (CRC) incidence varies globally, with higher rates in industrialized areas. CRC risk factors include genetic predisposition, inflammatory bowel disease, height, obesity, diet, lifestyle factors, and medication use. Diets high in vegetables and physical activity likely decrease CRC risk, while alcohol, red meat and processed meat probably or possibly increase risk. Factors such as fiber, folate, aspirin, and NSAIDs may also influence CRC risk, but evidence is currently insufficient. Overall, lifestyle and dietary modifications could help lower CRC incidence.
This document discusses the relationship between diet and cancer incidence based on various studies. It notes that early estimates suggested 35% of cancer deaths in the US could be prevented by dietary changes. Dietary factors like fat intake and consumption of fruits and vegetables have been examined in many epidemiological studies but results have been mixed, with some associations found but none described as conclusively proven. The complexity of diet makes definitively linking individual foods to cancer risk difficult.
This document discusses a case-control study examining the relationship between sugar intake and pancreatic cancer risk in Lebanese adults aged 50-80 years. It provides background on pancreatic cancer statistics globally and in Lebanon. Previous studies have found associations between high glycemic load/index diets and pancreatic cancer risk, particularly for inactive/overweight individuals. Prospective cohort studies have also linked greater consumption of sugar-sweetened foods and beverages to higher pancreatic cancer risk. The proposed case-control study will examine pancreatic cancer patients' diets to determine if sugar intake is associated with disease development.
Air pollution has been linked to cancer development. Fine particulate matter and toxic gases in polluted air can cause DNA damage and mutations in cells. Long-term exposure to air pollution has been shown to increase risks of lung cancer and other cancers according to numerous epidemiological studies.
Air pollution has been linked to increased cancer risks. Long-term exposure to pollutants like particulate matter can cause cellular damage and increase oxidative stress, both of which are associated with cancer development. More research is still needed, but the evidence so far suggests that reducing air pollution could help lower population cancer rates over time.
This document discusses a Canadian study that found a link between consuming a diet high in refined carbohydrates and sugars and an increased risk of ovarian cancer. The study observed 49,000 women over 16 years and found that those who developed ovarian cancer had higher Glycemic Load values, which measures sugar consumption and portion sizes, than those who did not develop cancer. Specifically, the study suggested that higher Glycemic Load values were associated with over a 70% increased risk of ovarian cancer.
This document discusses the Mediterranean diet and its potential to reduce risk of colorectal cancer. It summarizes research finding that following a Mediterranean diet, which emphasizes plant-based foods, unsaturated fats, and spices instead of salt, can effectively reduce colorectal cancer risk. Individual components like antioxidants, fiber, and unsaturated fats in the Mediterranean diet have synergistic effects in reducing cancer risk. Modifications at the individual, environmental, and policy levels could promote the Mediterranean diet and potentially save lives.
Colorectal cancer (CRC) incidence varies globally, with higher rates in industrialized areas. CRC risk factors include genetic predisposition, inflammatory bowel disease, height, obesity, diet, lifestyle factors, and medication use. Diets high in vegetables and physical activity likely decrease CRC risk, while alcohol, red meat and processed meat probably or possibly increase risk. Factors such as fiber, folate, aspirin, and NSAIDs may also influence CRC risk, but evidence is currently insufficient. Overall, lifestyle and dietary modifications could help lower CRC incidence.
This document discusses the relationship between diet and cancer incidence based on various studies. It notes that early estimates suggested 35% of cancer deaths in the US could be prevented by dietary changes. Dietary factors like fat intake and consumption of fruits and vegetables have been examined in many epidemiological studies but results have been mixed, with some associations found but none described as conclusively proven. The complexity of diet makes definitively linking individual foods to cancer risk difficult.
This document discusses a case-control study examining the relationship between sugar intake and pancreatic cancer risk in Lebanese adults aged 50-80 years. It provides background on pancreatic cancer statistics globally and in Lebanon. Previous studies have found associations between high glycemic load/index diets and pancreatic cancer risk, particularly for inactive/overweight individuals. Prospective cohort studies have also linked greater consumption of sugar-sweetened foods and beverages to higher pancreatic cancer risk. The proposed case-control study will examine pancreatic cancer patients' diets to determine if sugar intake is associated with disease development.
This document summarizes several studies on the relationship between alcohol consumption and colorectal cancer risk. The studies found that low to moderate wine consumption, especially of red wine, may lower cancer risk, while high alcohol intake, particularly of beer and spirits, is associated with increased risk. Beer consumption was found to have the strongest relationship to distal colon and rectal cancers. Up to 30g of alcohol per day is considered safe, and polyphenols in red wine may help protect against colon cancer.
Integrative medicine - The link between red meat and cancerraynoronha
The media has recently reported the warnings from scientist regarding red meat consumption. This presentation uncovers the findings and provides guidelines for healthcare professionals and the public.
The incidence of lung cancer is the third highest in the United States, and it is the leading cause of cancer-related mortality globally. Rates of lung cancer and deaths from the disease have been falling in the United States over the last two decades, while five-year survival rates have been rising.
This document provides information on cancer prevention and screening strategies. It discusses overall prevention approaches, strategies for specific cancers like breast and lung, and where to find screening guidelines. Key websites for cancer prevention and statistics are listed. The document discusses estimating cancer risk based on lifestyle factors like diet, exercise and smoking. It provides cancer statistics in the US and probabilities of developing different cancers. Screening is recommended only when proven beneficial and cost-effective. Healthy lifestyle choices can significantly reduce cancer and other disease risks.
Cancer is characterized by uncontrolled cell growth. There are over 100 types of cancer including breast, skin, colon, prostate, lymphoma, lung, cervical, and oral cancer. Globally in 2012, 8.2 million people died from cancer. Common causes of cancer include tobacco use, alcohol consumption, unhealthy diet, pollution, certain infections, and genetic factors. Signs and symptoms vary depending on the cancer type but may include lumps, unexplained weight loss, changes in bowel or bladder habits, and persistent coughing or difficulty swallowing. Diet and lifestyle factors can both increase and decrease cancer risk.
This document discusses steps that can be taken to prevent breast cancer, including maintaining a healthy diet and lifestyle. It notes that while some risk factors cannot be changed, lifestyle factors like being overweight, lack of exercise, smoking, alcohol consumption and an unhealthy diet can potentially trigger or promote breast cancer. Two studies discussed found that a diet rich in fruits and vegetables and low in starchy carbohydrates may help prevent and reduce recurrence of breast cancer. The document also suggests that consuming high-fat foods during puberty may increase the risk of developing more aggressive breast cancer at a younger age. Maintaining a healthy diet and lifestyle is emphasized as an important way to prevent breast cancer.
The well being of breast cancer patient: can nutrition help?Nilly Shams
The document discusses the potential links between diet, lifestyle, and breast cancer risk and prognosis. It notes that malnutrition is common in cancer patients, occurring in 31-87% depending on cancer stage and type. Several studies found links between excess body weight, dietary patterns high in carbohydrates and animal fats, and lack of exercise with increased breast cancer risk. One-third of breast cancer cases may be preventable through a diet high in fruits/vegetables, olive oil and low in alcohol, as well as increased physical activity. Certain nutrients like vitamin E, B-carotene, and soy have been associated with reduced breast cancer risk in some studies.
Increased vitamin d intake may protect against early onset colorectal cancerDoriaFang
More vitamin D intake (mainly from dietary sources) may help prevent young-onset colorectal cancer or precancerous colon polyps. Therefore, intake of more vitamin D is expected to be a prevention strategy for colorectal cancer for adults under 50.
Diabetes and cancer are linked in several ways. They share common risk factors such as age, obesity, diet, and physical activity. Patients with diabetes have higher risks of developing liver, pancreatic, uterine and other cancers. Those with diabetes and cancer also tend to have poorer outcomes, with shorter remission times and survival rates. High blood sugar levels and insulin imbalances related to diabetes can promote cancer cell growth and metastasis. Ongoing research is exploring whether antidiabetic drugs like metformin may help treat some cancers as well.
Literary Research on Cancer Life Style Disorder and its Managementijtsrd
The primary goal of palliative cancer care is typically to relieve suffering and improve quality of life. Most approaches to diet in this setting have focused only on eating as many calories as possible to avoid cachexia. However, as the concept of palliative care has evolved to include all aspects of cancer survivorship and not just end of life care, there is an increasing need to thoughtfully consider diet and nutrition approaches that can impact not only quality of life but overall health outcomes and perhaps even positively affect cancer recurrence and progression. In this regard, there has been a recent emphasis in the literature on nutrition and cancer as an important factor in both quality of life and in the pathophysiology of cancer. Hence, the primary purpose of this paper is to review the current data on diet and nutrition as it pertains to a wide range of cancer patients in the palliative care setting. Dr. Mahan Choudhary | Dr. Prerna Tiwari | Dr. Kamal Dwivedi "Literary Research on Cancer - Life Style Disorder and its Management" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6 , October 2022, URL: https://www.ijtsrd.com/papers/ijtsrd52018.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/52018/literary-research-on-cancer--life-style-disorder-and-its-management/dr-mahan-choudhary
Three key points from the document:
1. Research has found that people who drink 3-4 cups of coffee per day have a 25% lower risk of developing type 2 diabetes compared to those who drink less than 2 cups per day. Clinical trials also found lower early glucose and insulin responses after consuming chemicals found in coffee.
2. Several theories exist for how coffee could improve blood sugar regulation, such as increasing energy expenditure and metabolism or chemicals affecting glucose balance and insulin sensitivity.
3. Moderate coffee consumption is also linked to a lower risk of heart disease and cardiovascular problems, and some studies associate it with living longer. More research is still needed but coffee does not appear as unhealthy as previously thought.
This document discusses the rising rates of cancer and suggests increasing antioxidant intake through fruits and vegetables as a potential solution. It notes statistics from the WHO and NIH showing cancer rates have increased significantly between 1975 and 2014. While billions have been spent on cancer research and treatment, rates continue rising. It then promotes Monavie acai juice products as having the highest antioxidant levels and guarantees to raise antioxidant levels in the body to help reduce cancer risks.
This study compared alcohol consumption between mothers with and without a family history of breast cancer. Data on alcohol intake was collected through questionnaires in the LEGACY Girls Study. Mothers with a family history of breast cancer reported higher average alcohol consumption (12.3 drinks/month) than mothers without a family history (10.1 drinks/month). This refuted the hypothesis that mothers with a family history would drink less due to alcohol's association with breast cancer risk. The results suggest mothers at higher breast cancer risk may not be sufficiently lowering other modifiable risk factors like alcohol intake. Future research should examine if family history influences other risk factors and the impact of specific alcohol types on breast cancer gene mutations.
This document summarizes findings from the Continuous Update Project (CUP) on diet, weight, physical activity and cancer risk. The CUP analyzes global research on cancer prevention and survival. The summary identifies several factors that increase cancer risk, such as being overweight, eating processed meat, drinking alcohol, and smoking. It also identifies factors that decrease cancer risk, such as eating vegetables, fruits, whole grains, and engaging in physical activity. The CUP findings are used to update the World Cancer Research Fund's Cancer Prevention Recommendations.
Feature story from the Garvan Institute of Medical Research's April 2014 issue of Breakthrough newsletter. More at https://www.garvan.org.au/news-events/newsletters
Obesity is now clearly established as a major risk factor for endometrial cancer.
In medium income country like ours , Obesity prevention and lifestyle initiatives should become the responsibility of public health services. Stepwise programmes with realistic time-related goals are required, starting with modification of lifestyle, progressing to pharmacotherapy and ultimately obesity surgery.
The real challenge now is to triage those women at a higher risk and offer them prophylactic measures as COCPs ,DMPA, oral progesterone or Mirena coil.
Standard treatment for endometrial cancer is surgery.
Obesity is associated with numerous disorders which put the patient at increase risk of peri-operative complications that require more detailed pre-operative assessment and more intensive post-operative care.
Thus treatment for endometrial cancer needs to be reassessed in the complex and increasingly common situation of the obese, older women with this disease.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
More Related Content
Similar to Studies Link Added Sugar to Higher Cancer Risks
This document summarizes several studies on the relationship between alcohol consumption and colorectal cancer risk. The studies found that low to moderate wine consumption, especially of red wine, may lower cancer risk, while high alcohol intake, particularly of beer and spirits, is associated with increased risk. Beer consumption was found to have the strongest relationship to distal colon and rectal cancers. Up to 30g of alcohol per day is considered safe, and polyphenols in red wine may help protect against colon cancer.
Integrative medicine - The link between red meat and cancerraynoronha
The media has recently reported the warnings from scientist regarding red meat consumption. This presentation uncovers the findings and provides guidelines for healthcare professionals and the public.
The incidence of lung cancer is the third highest in the United States, and it is the leading cause of cancer-related mortality globally. Rates of lung cancer and deaths from the disease have been falling in the United States over the last two decades, while five-year survival rates have been rising.
This document provides information on cancer prevention and screening strategies. It discusses overall prevention approaches, strategies for specific cancers like breast and lung, and where to find screening guidelines. Key websites for cancer prevention and statistics are listed. The document discusses estimating cancer risk based on lifestyle factors like diet, exercise and smoking. It provides cancer statistics in the US and probabilities of developing different cancers. Screening is recommended only when proven beneficial and cost-effective. Healthy lifestyle choices can significantly reduce cancer and other disease risks.
Cancer is characterized by uncontrolled cell growth. There are over 100 types of cancer including breast, skin, colon, prostate, lymphoma, lung, cervical, and oral cancer. Globally in 2012, 8.2 million people died from cancer. Common causes of cancer include tobacco use, alcohol consumption, unhealthy diet, pollution, certain infections, and genetic factors. Signs and symptoms vary depending on the cancer type but may include lumps, unexplained weight loss, changes in bowel or bladder habits, and persistent coughing or difficulty swallowing. Diet and lifestyle factors can both increase and decrease cancer risk.
This document discusses steps that can be taken to prevent breast cancer, including maintaining a healthy diet and lifestyle. It notes that while some risk factors cannot be changed, lifestyle factors like being overweight, lack of exercise, smoking, alcohol consumption and an unhealthy diet can potentially trigger or promote breast cancer. Two studies discussed found that a diet rich in fruits and vegetables and low in starchy carbohydrates may help prevent and reduce recurrence of breast cancer. The document also suggests that consuming high-fat foods during puberty may increase the risk of developing more aggressive breast cancer at a younger age. Maintaining a healthy diet and lifestyle is emphasized as an important way to prevent breast cancer.
The well being of breast cancer patient: can nutrition help?Nilly Shams
The document discusses the potential links between diet, lifestyle, and breast cancer risk and prognosis. It notes that malnutrition is common in cancer patients, occurring in 31-87% depending on cancer stage and type. Several studies found links between excess body weight, dietary patterns high in carbohydrates and animal fats, and lack of exercise with increased breast cancer risk. One-third of breast cancer cases may be preventable through a diet high in fruits/vegetables, olive oil and low in alcohol, as well as increased physical activity. Certain nutrients like vitamin E, B-carotene, and soy have been associated with reduced breast cancer risk in some studies.
Increased vitamin d intake may protect against early onset colorectal cancerDoriaFang
More vitamin D intake (mainly from dietary sources) may help prevent young-onset colorectal cancer or precancerous colon polyps. Therefore, intake of more vitamin D is expected to be a prevention strategy for colorectal cancer for adults under 50.
Diabetes and cancer are linked in several ways. They share common risk factors such as age, obesity, diet, and physical activity. Patients with diabetes have higher risks of developing liver, pancreatic, uterine and other cancers. Those with diabetes and cancer also tend to have poorer outcomes, with shorter remission times and survival rates. High blood sugar levels and insulin imbalances related to diabetes can promote cancer cell growth and metastasis. Ongoing research is exploring whether antidiabetic drugs like metformin may help treat some cancers as well.
Literary Research on Cancer Life Style Disorder and its Managementijtsrd
The primary goal of palliative cancer care is typically to relieve suffering and improve quality of life. Most approaches to diet in this setting have focused only on eating as many calories as possible to avoid cachexia. However, as the concept of palliative care has evolved to include all aspects of cancer survivorship and not just end of life care, there is an increasing need to thoughtfully consider diet and nutrition approaches that can impact not only quality of life but overall health outcomes and perhaps even positively affect cancer recurrence and progression. In this regard, there has been a recent emphasis in the literature on nutrition and cancer as an important factor in both quality of life and in the pathophysiology of cancer. Hence, the primary purpose of this paper is to review the current data on diet and nutrition as it pertains to a wide range of cancer patients in the palliative care setting. Dr. Mahan Choudhary | Dr. Prerna Tiwari | Dr. Kamal Dwivedi "Literary Research on Cancer - Life Style Disorder and its Management" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6 , October 2022, URL: https://www.ijtsrd.com/papers/ijtsrd52018.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/52018/literary-research-on-cancer--life-style-disorder-and-its-management/dr-mahan-choudhary
Three key points from the document:
1. Research has found that people who drink 3-4 cups of coffee per day have a 25% lower risk of developing type 2 diabetes compared to those who drink less than 2 cups per day. Clinical trials also found lower early glucose and insulin responses after consuming chemicals found in coffee.
2. Several theories exist for how coffee could improve blood sugar regulation, such as increasing energy expenditure and metabolism or chemicals affecting glucose balance and insulin sensitivity.
3. Moderate coffee consumption is also linked to a lower risk of heart disease and cardiovascular problems, and some studies associate it with living longer. More research is still needed but coffee does not appear as unhealthy as previously thought.
This document discusses the rising rates of cancer and suggests increasing antioxidant intake through fruits and vegetables as a potential solution. It notes statistics from the WHO and NIH showing cancer rates have increased significantly between 1975 and 2014. While billions have been spent on cancer research and treatment, rates continue rising. It then promotes Monavie acai juice products as having the highest antioxidant levels and guarantees to raise antioxidant levels in the body to help reduce cancer risks.
This study compared alcohol consumption between mothers with and without a family history of breast cancer. Data on alcohol intake was collected through questionnaires in the LEGACY Girls Study. Mothers with a family history of breast cancer reported higher average alcohol consumption (12.3 drinks/month) than mothers without a family history (10.1 drinks/month). This refuted the hypothesis that mothers with a family history would drink less due to alcohol's association with breast cancer risk. The results suggest mothers at higher breast cancer risk may not be sufficiently lowering other modifiable risk factors like alcohol intake. Future research should examine if family history influences other risk factors and the impact of specific alcohol types on breast cancer gene mutations.
This document summarizes findings from the Continuous Update Project (CUP) on diet, weight, physical activity and cancer risk. The CUP analyzes global research on cancer prevention and survival. The summary identifies several factors that increase cancer risk, such as being overweight, eating processed meat, drinking alcohol, and smoking. It also identifies factors that decrease cancer risk, such as eating vegetables, fruits, whole grains, and engaging in physical activity. The CUP findings are used to update the World Cancer Research Fund's Cancer Prevention Recommendations.
Feature story from the Garvan Institute of Medical Research's April 2014 issue of Breakthrough newsletter. More at https://www.garvan.org.au/news-events/newsletters
Obesity is now clearly established as a major risk factor for endometrial cancer.
In medium income country like ours , Obesity prevention and lifestyle initiatives should become the responsibility of public health services. Stepwise programmes with realistic time-related goals are required, starting with modification of lifestyle, progressing to pharmacotherapy and ultimately obesity surgery.
The real challenge now is to triage those women at a higher risk and offer them prophylactic measures as COCPs ,DMPA, oral progesterone or Mirena coil.
Standard treatment for endometrial cancer is surgery.
Obesity is associated with numerous disorders which put the patient at increase risk of peri-operative complications that require more detailed pre-operative assessment and more intensive post-operative care.
Thus treatment for endometrial cancer needs to be reassessed in the complex and increasingly common situation of the obese, older women with this disease.
Similar to Studies Link Added Sugar to Higher Cancer Risks (20)
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
2. INTRODUCTION
Carl Bazan, MD, possesses diverse experience in
research and director roles within the drug development
industry. Dr. Carl Bazan has been involved in studies
examining the latest research concerning the potential
causes of cancer.
In recent years, several studies have found strong
correlations between high sugar consumption and the
risks of certain cancers. A 2017 study published in the
journal European Surgery reported an increased risk of
esophageal cancer in patients with chronic acid reflux
and high sugar intake.
3. CANCER
More recently, a survey of more than 100,000 adults
revealed a relationship between consuming sugary
beverages, including natural fruit juices, and cancer.
The results were published in the British Medical Journal.
Nutrition experts suggest that sugar may heighten
cancer risks by raising blood glucose and insulin levels.
There is also some evidence that sugar contributes to
cell damage, which can lead to cancer. Individuals with a
predisposition to certain cancers should reduce their
intake of sugar by avoiding sweetened beverages and
consuming more vegetables than fruit.