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Huateng Pharma https://en.huatengsci.com
Increased Vitamin D Intake May Protect
Against Early-onset Colorectal Cancer
Although the overall incidence of colorectal cancer has been declining these years, the
number of cases among young people is increasing. By 2030, nearly 11% of colon cancer
and 23% of rectal cancer will occur in American adults under the age of 50. Because a
significant proportion of patients with early-onset colorectal cancer do not have a family
history of colorectal cancer or a known genetic syndrome, changes in lifestyle factors and
diet patterns are considered to be the reasons for the increased incidence of early-onset
colorectal cancer.
The Nurses' Health Study (NHS) II is a prospective cohort study of nurses between 25
and 42 years old started in 1989. A questionnaire survey of these women on
demographics, diet and lifestyle factors, as well as medical and other health-related
information is conducted every two years. Recent studies in this cohort have confirmed a
significant association between sedentary & obesity and an increased risk of early-onset
colorectal cancer, indicating that at least some well-known traditional colorectal cancer
risk factors may also lead to early colorectal cancer.
Huateng Pharma https://en.huatengsci.com
In the past few decades, people's intake of fish, mushrooms, eggs and milk which are rich
in vitamin D has decreased a lot. More and more evidence suggests that there is an
association between vitamin D and the risk of death from colorectal cancer. However,
whether total vitamin D intake is associated with the risk of young-onset colorectal cancer
is unclear.
Recently, the research team of Harvard University's Chen Zengxi School of Public Health
published a research paper titled: Total Vitamin D Intake and Risks of Early-Onset
Colorectal Cancer and Precursors in the top academic journal Gastroenterology in the
field of gastroenterology.
This work prospectively studied the relationship between the total vitamin D intake of
94,205 young women registered in the NHS II and the risk of early-onset colorectal cancer
and pre-disease, and found that more vitamin D intake (mainly from dietary sources)
may help prevent young-onset colorectal cancer or precancerous colon polyps.
Therefore, intake of more vitamin D is expected to be a prevention strategy for
colorectal cancer for adults under 50.
The research team found 111 cases of young-onset colorectal cancer and 3317 cases of
colorectal polyps from 94,205 women who were followed up from 1991 to 2015.
The median vitamin D intake is 372IU/day. Among women under the age of 50, those with
a higher intake of vitamin D have a lower body mass index, and are less likely to smoke,
drink, watch TV, eat red meat and processed meat. They consume more dietary fiber,
total folic acid and total calcium, use more aspirin and multivitamins, and are more likely to
be physically active and have a healthy diet.
Huateng Pharma https://en.huatengsci.com
The increase in total vitamin D intake is associated with a decrease in the risk of
early-onset colorectal cancer. Compared with women who consume less than 300 IU of
vitamin D per day, the risk ratio was 0.51 for women who consumed between 300 and 450
IU of vitamin D daily, and 0.49 for women who consumed more than 450 IU.
Huateng Pharma https://en.huatengsci.com
The research team also evaluated the difference between dietary vitamin D and
supplemental vitamin D intake. The two sources of vitamin D intake are negatively
correlated with early-onset colorectal cancer, but the correlation between dietary vitamin
D (mainly from dairy products) is significant and stronger, which is higher than the
correlation with vitamin D supplementation. This finding may be due to accidental or
unknown factors that are not yet unknown.
The higher the total vitamin D intake, the lower the risk of early onset of
conventional adenomas. Compared with women who consume less than 300 IU of total
vitamin D per day, women who consume 600 IU per day have a lower risk of developing
conventional adenomas.
Interestingly, the researchers did not find a significant association between total vitamin D
intake and the risk of colorectal cancer diagnosed after the age of 50. The results of the
study cannot explain this inconsistency, and it is necessary to conduct further studies on
larger samples to determine whether vitamin D is actually more protective against
younger-onset colorectal cancer.
In general, higher total vitamin D intake is associated with a lower risk of younger-onset
colorectal cancer and pre-disease (adenoma or polyps). The research further supports the
idea that vitamin D may be important for the health of young people and the
prevention of colorectal cancer.
Huateng Pharma is a leading supplier of innovative chemistry products and services
throughout the pharmaceutical R&D and commercial production. We are committed to
providing pharmaceutical APIs and intermediates, Boronic Acids/Esters, PEG
Huateng Pharma https://en.huatengsci.com
Derivatives, Vitamin D Derivatives and so on. We have over 200 dedicated chemists
and a 34000m2 GMP standard manufacturing base equipped with state-of-the art facilities
that can meet the requirement of worldwide clients.
Reference:
Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors

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Increased vitamin d intake may protect against early onset colorectal cancer

  • 1. Huateng Pharma https://en.huatengsci.com Increased Vitamin D Intake May Protect Against Early-onset Colorectal Cancer Although the overall incidence of colorectal cancer has been declining these years, the number of cases among young people is increasing. By 2030, nearly 11% of colon cancer and 23% of rectal cancer will occur in American adults under the age of 50. Because a significant proportion of patients with early-onset colorectal cancer do not have a family history of colorectal cancer or a known genetic syndrome, changes in lifestyle factors and diet patterns are considered to be the reasons for the increased incidence of early-onset colorectal cancer. The Nurses' Health Study (NHS) II is a prospective cohort study of nurses between 25 and 42 years old started in 1989. A questionnaire survey of these women on demographics, diet and lifestyle factors, as well as medical and other health-related information is conducted every two years. Recent studies in this cohort have confirmed a significant association between sedentary & obesity and an increased risk of early-onset colorectal cancer, indicating that at least some well-known traditional colorectal cancer risk factors may also lead to early colorectal cancer.
  • 2. Huateng Pharma https://en.huatengsci.com In the past few decades, people's intake of fish, mushrooms, eggs and milk which are rich in vitamin D has decreased a lot. More and more evidence suggests that there is an association between vitamin D and the risk of death from colorectal cancer. However, whether total vitamin D intake is associated with the risk of young-onset colorectal cancer is unclear. Recently, the research team of Harvard University's Chen Zengxi School of Public Health published a research paper titled: Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors in the top academic journal Gastroenterology in the field of gastroenterology. This work prospectively studied the relationship between the total vitamin D intake of 94,205 young women registered in the NHS II and the risk of early-onset colorectal cancer and pre-disease, and found that more vitamin D intake (mainly from dietary sources) may help prevent young-onset colorectal cancer or precancerous colon polyps. Therefore, intake of more vitamin D is expected to be a prevention strategy for colorectal cancer for adults under 50. The research team found 111 cases of young-onset colorectal cancer and 3317 cases of colorectal polyps from 94,205 women who were followed up from 1991 to 2015. The median vitamin D intake is 372IU/day. Among women under the age of 50, those with a higher intake of vitamin D have a lower body mass index, and are less likely to smoke, drink, watch TV, eat red meat and processed meat. They consume more dietary fiber, total folic acid and total calcium, use more aspirin and multivitamins, and are more likely to be physically active and have a healthy diet.
  • 3. Huateng Pharma https://en.huatengsci.com The increase in total vitamin D intake is associated with a decrease in the risk of early-onset colorectal cancer. Compared with women who consume less than 300 IU of vitamin D per day, the risk ratio was 0.51 for women who consumed between 300 and 450 IU of vitamin D daily, and 0.49 for women who consumed more than 450 IU.
  • 4. Huateng Pharma https://en.huatengsci.com The research team also evaluated the difference between dietary vitamin D and supplemental vitamin D intake. The two sources of vitamin D intake are negatively correlated with early-onset colorectal cancer, but the correlation between dietary vitamin D (mainly from dairy products) is significant and stronger, which is higher than the correlation with vitamin D supplementation. This finding may be due to accidental or unknown factors that are not yet unknown. The higher the total vitamin D intake, the lower the risk of early onset of conventional adenomas. Compared with women who consume less than 300 IU of total vitamin D per day, women who consume 600 IU per day have a lower risk of developing conventional adenomas. Interestingly, the researchers did not find a significant association between total vitamin D intake and the risk of colorectal cancer diagnosed after the age of 50. The results of the study cannot explain this inconsistency, and it is necessary to conduct further studies on larger samples to determine whether vitamin D is actually more protective against younger-onset colorectal cancer. In general, higher total vitamin D intake is associated with a lower risk of younger-onset colorectal cancer and pre-disease (adenoma or polyps). The research further supports the idea that vitamin D may be important for the health of young people and the prevention of colorectal cancer. Huateng Pharma is a leading supplier of innovative chemistry products and services throughout the pharmaceutical R&D and commercial production. We are committed to providing pharmaceutical APIs and intermediates, Boronic Acids/Esters, PEG
  • 5. Huateng Pharma https://en.huatengsci.com Derivatives, Vitamin D Derivatives and so on. We have over 200 dedicated chemists and a 34000m2 GMP standard manufacturing base equipped with state-of-the art facilities that can meet the requirement of worldwide clients. Reference: Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors