This document provides guidelines for the management of severe sepsis and septic shock from the Surviving Sepsis Campaign. Key recommendations include: early quantitative resuscitation of septic patients within 6 hours; blood cultures before antibiotics; source control within 12 hours; broad-spectrum antibiotics within 1 hour for septic shock and severe sepsis; tight glycemic control targeting glucose ≤180 mg/dL; and norepinephrine as the first-choice vasopressor. Specific pediatric recommendations include respiratory support for distress/hypoxemia and consideration of less invasive ventilation where possible.
This document provides guidelines for the management of severe sepsis and septic shock last updated in 2008. A consensus committee of 68 international experts from 30 organizations used the GRADE methodology to develop recommendations based on a review of the literature. Key recommendations include early quantitative resuscitation, blood cultures before antibiotics, source control within 12 hours, broad-spectrum antibiotics within 1 hour for septic shock, targeting a mean arterial pressure of 65 mmHg with norepinephrine, and low tidal volume ventilation for acute respiratory distress syndrome. The guidelines are intended to improve outcomes for patients with severe sepsis and septic shock worldwide.
This document summarizes guidelines from the Surviving Sepsis Campaign for the management of severe sepsis and septic shock. It provides an update to previous guidelines published in 2004. The guidelines were created by an international panel of experts using the GRADE system to assess evidence quality and determine recommendation strength. Key recommendations include early goal-directed resuscitation, appropriate antibiotic therapy, source control, fluid resuscitation, vasopressor use, steroid therapy, lung-protective ventilation, glycemic control, renal replacement therapy, thrombosis prophylaxis, and stress ulcer prophylaxis. The guidelines are intended to improve outcomes for patients with severe sepsis or septic shock.
This study examined disseminated intravascular coagulation (DIC) scores on day 1 and day 3 in sepsis patients and their association with mortality. The incidence of overt DIC was 27.9% on day 1 and 30.1% on day 3. While day 1 and 3 DIC scores were not associated with mortality, the change in DIC score between days was significantly associated with mortality. Patients with pneumonia had lower DIC on day 1 but higher mortality than other sepsis patients. Day 3 DIC scores predicted mortality more accurately than day 1 scores, especially for non-pneumonia sepsis patients.
The document describes the development and validation of a new prognostic model called the Lille model to identify patients with severe alcoholic hepatitis who are unlikely to survive when treated with corticosteroids. The model was developed based on data from 320 patients and validated in 118 additional patients. It combines six reproducible variables measured at baseline and at day 7 of treatment - age, renal insufficiency, albumin, prothrombin time, bilirubin, and the change in bilirubin at day 7. The Lille model had an area under the receiver operating characteristic curve of 0.89 for predicting 6-month mortality, outperforming other existing models. It identified a cutoff of 0.45 that distinguished patients with low
Glisodin, a vegetal sod with gliadin, as preventative agent vs atherosclerosi...Esther K
SUMMARY: Prevention of cardiovascular disease should target high-risk subjects based on genetic/familial factors, blood chemistry, blood pressure, body mass index (BMI), and a history of/or current cigarette smoking. We selected active adults (n=76) aged 30-60 and investigated these risk factors, in order to recommend preventive measures.
Another interesting variable is the preclinical status or atheroma of the arterial (carotid) wall or lumen. We also investigated the presence of oxidative stress in, and the anti-oxidant status of these subjects.
We studied the anti-oxidative efficacy of superoxide dismutase (SOD) and variations of malondialdehyde (MDA).
Supplementation with GliSODin®, a vegetal SOD associated with gliadin, was effective in controlling the thickness of the carotid artery intima and media layers as measured by ultrasonography-B.
We could demonstrate the preventive efficacy of GliSODin at a preclinical stage in subjects with risk factors of cardiovascular disease.
This document provides guidelines for managing dialysis and kidney transplant patients who are infected with COVID-19. It finds that these patients are at high risk for severe illness due to common comorbidities. Based on initial experience in Brescia, Italy, the disease progression can be severe, especially in transplant patients. The document establishes 7 categories of infected patients and outlines treatment plans depending on their symptoms and test results. It aims to help nephrology teams safely treat these high-risk patients during the COVID-19 pandemic.
This study evaluated the effects of early prone positioning on outcomes in patients with severe acute respiratory distress syndrome (ARDS). 466 patients with severe ARDS were randomly assigned to undergo at least 16 hours of prone positioning sessions or to remain in the supine position. The primary outcome was 28-day mortality. The results showed significantly lower 28-day mortality in the prone group (16.0%) compared to the supine group (32.8%). Unadjusted 90-day mortality was also significantly lower in the prone group. Complication rates were similar between the groups except cardiac arrests, which were higher in the supine group. The study concluded that in patients with severe ARDS, early application of prolonged prone positioning sessions significantly decreased
Renin - Angiotensin - Aldosterone System Inhibitors in Patients with Covid-19Valentina Corona
This document summarizes the current understanding of how medications that inhibit the renin-angiotensin-aldosterone system (RAAS), such as ACE inhibitors and angiotensin receptor blockers (ARBs), may impact COVID-19. It notes that while animal studies have found mixed results on how these drugs affect ACE2 levels, human studies provide little evidence they increase ACE2. It also raises the possibility that ACE2 may be beneficial rather than harmful for lung injury in COVID-19. The document concludes more research is needed to understand the complex interactions between SARS-CoV-2 and the RAAS system in humans before making recommendations about RAAS inhibitor use in COVID-19 patients.
This document provides guidelines for the management of severe sepsis and septic shock last updated in 2008. A consensus committee of 68 international experts from 30 organizations used the GRADE methodology to develop recommendations based on a review of the literature. Key recommendations include early quantitative resuscitation, blood cultures before antibiotics, source control within 12 hours, broad-spectrum antibiotics within 1 hour for septic shock, targeting a mean arterial pressure of 65 mmHg with norepinephrine, and low tidal volume ventilation for acute respiratory distress syndrome. The guidelines are intended to improve outcomes for patients with severe sepsis and septic shock worldwide.
This document summarizes guidelines from the Surviving Sepsis Campaign for the management of severe sepsis and septic shock. It provides an update to previous guidelines published in 2004. The guidelines were created by an international panel of experts using the GRADE system to assess evidence quality and determine recommendation strength. Key recommendations include early goal-directed resuscitation, appropriate antibiotic therapy, source control, fluid resuscitation, vasopressor use, steroid therapy, lung-protective ventilation, glycemic control, renal replacement therapy, thrombosis prophylaxis, and stress ulcer prophylaxis. The guidelines are intended to improve outcomes for patients with severe sepsis or septic shock.
This study examined disseminated intravascular coagulation (DIC) scores on day 1 and day 3 in sepsis patients and their association with mortality. The incidence of overt DIC was 27.9% on day 1 and 30.1% on day 3. While day 1 and 3 DIC scores were not associated with mortality, the change in DIC score between days was significantly associated with mortality. Patients with pneumonia had lower DIC on day 1 but higher mortality than other sepsis patients. Day 3 DIC scores predicted mortality more accurately than day 1 scores, especially for non-pneumonia sepsis patients.
The document describes the development and validation of a new prognostic model called the Lille model to identify patients with severe alcoholic hepatitis who are unlikely to survive when treated with corticosteroids. The model was developed based on data from 320 patients and validated in 118 additional patients. It combines six reproducible variables measured at baseline and at day 7 of treatment - age, renal insufficiency, albumin, prothrombin time, bilirubin, and the change in bilirubin at day 7. The Lille model had an area under the receiver operating characteristic curve of 0.89 for predicting 6-month mortality, outperforming other existing models. It identified a cutoff of 0.45 that distinguished patients with low
Glisodin, a vegetal sod with gliadin, as preventative agent vs atherosclerosi...Esther K
SUMMARY: Prevention of cardiovascular disease should target high-risk subjects based on genetic/familial factors, blood chemistry, blood pressure, body mass index (BMI), and a history of/or current cigarette smoking. We selected active adults (n=76) aged 30-60 and investigated these risk factors, in order to recommend preventive measures.
Another interesting variable is the preclinical status or atheroma of the arterial (carotid) wall or lumen. We also investigated the presence of oxidative stress in, and the anti-oxidant status of these subjects.
We studied the anti-oxidative efficacy of superoxide dismutase (SOD) and variations of malondialdehyde (MDA).
Supplementation with GliSODin®, a vegetal SOD associated with gliadin, was effective in controlling the thickness of the carotid artery intima and media layers as measured by ultrasonography-B.
We could demonstrate the preventive efficacy of GliSODin at a preclinical stage in subjects with risk factors of cardiovascular disease.
This document provides guidelines for managing dialysis and kidney transplant patients who are infected with COVID-19. It finds that these patients are at high risk for severe illness due to common comorbidities. Based on initial experience in Brescia, Italy, the disease progression can be severe, especially in transplant patients. The document establishes 7 categories of infected patients and outlines treatment plans depending on their symptoms and test results. It aims to help nephrology teams safely treat these high-risk patients during the COVID-19 pandemic.
This study evaluated the effects of early prone positioning on outcomes in patients with severe acute respiratory distress syndrome (ARDS). 466 patients with severe ARDS were randomly assigned to undergo at least 16 hours of prone positioning sessions or to remain in the supine position. The primary outcome was 28-day mortality. The results showed significantly lower 28-day mortality in the prone group (16.0%) compared to the supine group (32.8%). Unadjusted 90-day mortality was also significantly lower in the prone group. Complication rates were similar between the groups except cardiac arrests, which were higher in the supine group. The study concluded that in patients with severe ARDS, early application of prolonged prone positioning sessions significantly decreased
Renin - Angiotensin - Aldosterone System Inhibitors in Patients with Covid-19Valentina Corona
This document summarizes the current understanding of how medications that inhibit the renin-angiotensin-aldosterone system (RAAS), such as ACE inhibitors and angiotensin receptor blockers (ARBs), may impact COVID-19. It notes that while animal studies have found mixed results on how these drugs affect ACE2 levels, human studies provide little evidence they increase ACE2. It also raises the possibility that ACE2 may be beneficial rather than harmful for lung injury in COVID-19. The document concludes more research is needed to understand the complex interactions between SARS-CoV-2 and the RAAS system in humans before making recommendations about RAAS inhibitor use in COVID-19 patients.
Renin angiotensin system inhibitors improve the clinical outcomes of covid 19...gisa_legal
This study evaluated the effects of renin-angiotensin system (RAS) inhibitors on COVID-19 patients with hypertension. The study found that:
1) Patients receiving ACE inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) had lower rates of severe disease and lower levels of the inflammatory marker IL-6 compared to those receiving other hypertension drugs.
2) ACEI/ARB therapy was associated with higher CD3 and CD8 T cell counts and lower peak viral loads.
3) The results suggest that continuing or prioritizing ACEIs/ARBs for hypertension treatment may improve clinical outcomes for COVID-19 patients with hypertension by reducing inflammation and modulating
This document appears to be a curriculum vitae or resume for Tawfik El-Said. It includes personal information like his name, date of birth, contact information, and qualifications. It details his educational background including degrees obtained and areas of study. It also lists international research participation, courses and conferences attended both within Egypt and abroad, and lectures given on topics like hypertension, obesity, and smoking hazards.
This study evaluated the impact of a pharmacist-led stress ulcer prophylaxis management program on inappropriate stress ulcer prophylaxis use among hospitalized patients. The study found that the program was associated with a significant reduction in inappropriate stress ulcer prophylaxis days in both ICU and general ward patients. Specifically, inappropriate days decreased by 58.3% in ICU patients and 83.5% in general ward patients. The rates of patients inappropriately continued on stress ulcer prophylaxis upon hospital discharge also significantly decreased. The program resulted in estimated annual cost savings of over $200,000. No differences in clinical outcomes like bleeding or pneumonia were observed before or after the program.
The T2 magnetic resonance (T2MR) assay demonstrated high sensitivity and specificity for rapid diagnosis of candidemia directly from whole blood. In a multicenter clinical trial of 1801 patients, T2MR had an overall sensitivity of 91.1% and specificity of 99.4% for detecting five Candida species, with results available in an average of 4.4 hours. Subgroup analysis showed sensitivities ranging from 88.1-94.2% for individual species and specificities of 98.9-99.9%. The assay has the potential to improve outcomes for candidemia by enabling earlier targeted antifungal treatment.
Presentation of Dr. Lluis Blanch at 10th Pulmonary Medicine Update Course, Cairo, Egypt. Pulmonary Medicine Update Course is organized by Scribe : www.scribeofegypt.com
This document outlines the topics, schedule, faculty, and learning outcomes for the Adult Health Nursing I course at Southwest Tennessee Community College for the Spring 2012 semester. The course covers several units: Unit I on genitourinary and blood topics from January 12th-26th; Unit II on respiratory topics from January 31st-February 14th; and Unit III on cardiovascular topics from February 16th-23rd. The schedule includes class meetings, exams, and exam reviews. Learning outcomes cover assessing, diagnosing, treating, educating patients, and administering medications for conditions in each body system.
This study examined the association between hydroxychloroquine use and intubation or death in 1376 patients hospitalized with COVID-19 at Columbia University Irving Medical Center in New York City. The primary outcome was a composite of intubation or death. 811 patients (58.9%) received hydroxychloroquine. There was no significant association between hydroxychloroquine use and intubation or death in the primary analysis or sensitivity analyses. Randomized controlled trials are still needed to determine if hydroxychloroquine is effective for treating COVID-19.
Vai trò của thuốc kháng virus trong đại dịch Covid 19EfenPhamNgoc
Tocilizumab provided benefit in reducing mortality and improving other outcomes in hospitalized COVID-19 patients in early studies. However, subsequent larger studies found no clear benefit, especially when given later in disease course. The drug may be most effective very early in severe cases, when hyperinflammation is predominant over viral replication. Overall, the efficacy of tocilizumab in COVID-19 remains unclear based on current evidence.
Role of Budesonide in Corona Virus Disease: Systematic Review DrHeena tiwari
Inhaled budesonide has been shown to significantly reduce the likelihood of Covid-19 patients requiring urgent or emergency care or hospitalization when given early to patients with mild symptoms. A systematic review of studies found inhaled budesonide reduced the risk of these adverse outcomes by 91% in one study. It also reduced the median time to recovery by 3 days in another study of patients with risk factors who were not hospitalized. The studies support the potential for inhaled budesonide to control the excessive inflammatory response to Covid-19 and prevent disease progression when administered early in mild cases.
Adherence to treatment and quality of life during hepatitis C therapy:a prosp...Michel Rotily
Adherence to treatment and quality of life during hepatitis C therapy:a prospective, real-life, observational study by Patrick Marcellin, Michel Chousterman, Thierry Fontanges, Denis Ouzan, Michel Rotily, Marina Varastet,Jean-Philippe Lang, Pascal Melin and Patrice Cacoub, for the CheObs Study Group published in Liver Int 2011
This study investigated whether monitoring levels of immature neutrophils (myelocytes, metamyelocytes, and band cells) could help differentiate patients with sepsis from those with non-infectious systemic inflammatory response syndrome (SIRS). Blood samples from 136 critically ill patients and 20 healthy controls were analyzed. Patients were retrospectively classified as having definite sepsis, possible sepsis, or non-infectious SIRS. Higher levels of band cells were seen in patients with definite sepsis compared to other groups, with a sensitivity of 84% and specificity of 71% for detecting sepsis. Patients who died within a week had higher levels of myelocytes and metamyelocytes than those who died later, indicating immature neutrophils may have
The document discusses kidney involvement in COVID-19 patients. It notes that acute kidney injury (AKI) occurs in 3-9% of early COVID-19 patients, rising to 19-50% of ICU patients. AKI is associated with higher mortality, between 35-90% among those with COVID-19. Pathological findings include collapsing glomerulopathy and acute tubular injury. Viral particles have been found in podocytes and tubular cells on postmortem and kidney biopsy studies.
This study analyzed data from a multicenter observational study to investigate the incidence of nephrotoxicity and associated risk factors in intensive care unit patients receiving vancomycin for the treatment of hospital-acquired, ventilator-associated, or healthcare-associated pneumonia. The study found that nephrotoxicity occurred in 15.4% of vancomycin-treated patients. Initial vancomycin trough levels ≥15 mg/L, concomitant aminoglycoside use, and longer duration of vancomycin therapy were independently associated with an increased risk of nephrotoxicity. The incidence of nephrotoxicity rose with higher initial vancomycin trough levels. This highlights
This document provides an overview of clinical trials in Turkey. It discusses the history and evolution of regulations governing clinical trials from the 1920s to present day. Key events include the first regulations in 1928, formation of ethics committees in 1993, and adoption of ICH-GCP guidelines in 1995. The infrastructure for clinical trials in Turkey has grown significantly in recent decades with over 100 ethics committees and several phase I centers. Inspections by regulatory authorities like the FDA and EMA have increased transparency. Current regulations aim to protect participants and uphold ethical standards in research.
Cryptic Disseminated Tuberculosis: a Secondary Analysis of Previous Hospital-...fahmi khan
The main purpose of this study was to describe the demographic and clinical features of cryptic disseminated TB; it was also aimed to shed light on diagnostic test, procedure results, organ involvement, and outcomes of cryptic disseminated TB in patients with confirmed disseminated TB.
Research Center on Information and Communication Technologies (CITIC) is a technology center of the Universidade da Coruña (Spain), in order to promote the advancement and excellence in research, development and innovation on Information and Communications Technology (ICT) and promote the transfer of knowledge and results to society.
CITIC is a meeting point between the university and the company that combines R&D departments of companies in the ICT sector with researchers from the university. Current working in different R&D projects more than 250 researchers from public and private sectors, providing a mixed environment that enables university-industry collaboration and knowledge transfer.
The units of CITIC are formed by two intelligent buildings (3.200m2) that are configurable for R&D activities of our researchers, companies and employees.
Technology Areas
[◄] Information Retrieval
[◄] Application integration / Information integration
[◄] Artificial Intelligence and Applications
[◄] Mathematics: Statistics and Operation Research. Applied mathematics
[◄] Digital Home and Networked Media
[◄] Systems Usability and Testing Methods
[◄] Digital Image Processing
[◄] Wireless Communications Systems
[◄] Web Information Systems (WIS)
[◄] Geographic Information System (GIS)
[◄] Distributed Systems and Service Oriented Architecture (SOA)
[◄] High performance computing (HPC)
This document contains a custom hotkey configuration for Warcraft 3 DotA Allstars 6.74. It assigns hotkeys for common actions like move, attack, and stop. It also assigns hotkeys for hero abilities and creep/neutral abilities. Finally, it includes hotkeys for courier abilities like changing courier type and delivering items. The hotkeys are designed to work with an external tool that provides additional hotkey functions.
This teaching unity provides an introduction to healthy diet by discussing energy requirements, nutrients, and diet tips. It then explores the Mediterranean diet and organic foods. Specifically, it covers the characteristics of a balanced diet, compares organic versus conventional foods, and examines the health benefits of the Mediterranean diet and organic cultivation. The goal is to help participants understand how to organize a nutritious diet and evaluate different food options.
Renin angiotensin system inhibitors improve the clinical outcomes of covid 19...gisa_legal
This study evaluated the effects of renin-angiotensin system (RAS) inhibitors on COVID-19 patients with hypertension. The study found that:
1) Patients receiving ACE inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) had lower rates of severe disease and lower levels of the inflammatory marker IL-6 compared to those receiving other hypertension drugs.
2) ACEI/ARB therapy was associated with higher CD3 and CD8 T cell counts and lower peak viral loads.
3) The results suggest that continuing or prioritizing ACEIs/ARBs for hypertension treatment may improve clinical outcomes for COVID-19 patients with hypertension by reducing inflammation and modulating
This document appears to be a curriculum vitae or resume for Tawfik El-Said. It includes personal information like his name, date of birth, contact information, and qualifications. It details his educational background including degrees obtained and areas of study. It also lists international research participation, courses and conferences attended both within Egypt and abroad, and lectures given on topics like hypertension, obesity, and smoking hazards.
This study evaluated the impact of a pharmacist-led stress ulcer prophylaxis management program on inappropriate stress ulcer prophylaxis use among hospitalized patients. The study found that the program was associated with a significant reduction in inappropriate stress ulcer prophylaxis days in both ICU and general ward patients. Specifically, inappropriate days decreased by 58.3% in ICU patients and 83.5% in general ward patients. The rates of patients inappropriately continued on stress ulcer prophylaxis upon hospital discharge also significantly decreased. The program resulted in estimated annual cost savings of over $200,000. No differences in clinical outcomes like bleeding or pneumonia were observed before or after the program.
The T2 magnetic resonance (T2MR) assay demonstrated high sensitivity and specificity for rapid diagnosis of candidemia directly from whole blood. In a multicenter clinical trial of 1801 patients, T2MR had an overall sensitivity of 91.1% and specificity of 99.4% for detecting five Candida species, with results available in an average of 4.4 hours. Subgroup analysis showed sensitivities ranging from 88.1-94.2% for individual species and specificities of 98.9-99.9%. The assay has the potential to improve outcomes for candidemia by enabling earlier targeted antifungal treatment.
Presentation of Dr. Lluis Blanch at 10th Pulmonary Medicine Update Course, Cairo, Egypt. Pulmonary Medicine Update Course is organized by Scribe : www.scribeofegypt.com
This document outlines the topics, schedule, faculty, and learning outcomes for the Adult Health Nursing I course at Southwest Tennessee Community College for the Spring 2012 semester. The course covers several units: Unit I on genitourinary and blood topics from January 12th-26th; Unit II on respiratory topics from January 31st-February 14th; and Unit III on cardiovascular topics from February 16th-23rd. The schedule includes class meetings, exams, and exam reviews. Learning outcomes cover assessing, diagnosing, treating, educating patients, and administering medications for conditions in each body system.
This study examined the association between hydroxychloroquine use and intubation or death in 1376 patients hospitalized with COVID-19 at Columbia University Irving Medical Center in New York City. The primary outcome was a composite of intubation or death. 811 patients (58.9%) received hydroxychloroquine. There was no significant association between hydroxychloroquine use and intubation or death in the primary analysis or sensitivity analyses. Randomized controlled trials are still needed to determine if hydroxychloroquine is effective for treating COVID-19.
Vai trò của thuốc kháng virus trong đại dịch Covid 19EfenPhamNgoc
Tocilizumab provided benefit in reducing mortality and improving other outcomes in hospitalized COVID-19 patients in early studies. However, subsequent larger studies found no clear benefit, especially when given later in disease course. The drug may be most effective very early in severe cases, when hyperinflammation is predominant over viral replication. Overall, the efficacy of tocilizumab in COVID-19 remains unclear based on current evidence.
Role of Budesonide in Corona Virus Disease: Systematic Review DrHeena tiwari
Inhaled budesonide has been shown to significantly reduce the likelihood of Covid-19 patients requiring urgent or emergency care or hospitalization when given early to patients with mild symptoms. A systematic review of studies found inhaled budesonide reduced the risk of these adverse outcomes by 91% in one study. It also reduced the median time to recovery by 3 days in another study of patients with risk factors who were not hospitalized. The studies support the potential for inhaled budesonide to control the excessive inflammatory response to Covid-19 and prevent disease progression when administered early in mild cases.
Adherence to treatment and quality of life during hepatitis C therapy:a prosp...Michel Rotily
Adherence to treatment and quality of life during hepatitis C therapy:a prospective, real-life, observational study by Patrick Marcellin, Michel Chousterman, Thierry Fontanges, Denis Ouzan, Michel Rotily, Marina Varastet,Jean-Philippe Lang, Pascal Melin and Patrice Cacoub, for the CheObs Study Group published in Liver Int 2011
This study investigated whether monitoring levels of immature neutrophils (myelocytes, metamyelocytes, and band cells) could help differentiate patients with sepsis from those with non-infectious systemic inflammatory response syndrome (SIRS). Blood samples from 136 critically ill patients and 20 healthy controls were analyzed. Patients were retrospectively classified as having definite sepsis, possible sepsis, or non-infectious SIRS. Higher levels of band cells were seen in patients with definite sepsis compared to other groups, with a sensitivity of 84% and specificity of 71% for detecting sepsis. Patients who died within a week had higher levels of myelocytes and metamyelocytes than those who died later, indicating immature neutrophils may have
The document discusses kidney involvement in COVID-19 patients. It notes that acute kidney injury (AKI) occurs in 3-9% of early COVID-19 patients, rising to 19-50% of ICU patients. AKI is associated with higher mortality, between 35-90% among those with COVID-19. Pathological findings include collapsing glomerulopathy and acute tubular injury. Viral particles have been found in podocytes and tubular cells on postmortem and kidney biopsy studies.
This study analyzed data from a multicenter observational study to investigate the incidence of nephrotoxicity and associated risk factors in intensive care unit patients receiving vancomycin for the treatment of hospital-acquired, ventilator-associated, or healthcare-associated pneumonia. The study found that nephrotoxicity occurred in 15.4% of vancomycin-treated patients. Initial vancomycin trough levels ≥15 mg/L, concomitant aminoglycoside use, and longer duration of vancomycin therapy were independently associated with an increased risk of nephrotoxicity. The incidence of nephrotoxicity rose with higher initial vancomycin trough levels. This highlights
This document provides an overview of clinical trials in Turkey. It discusses the history and evolution of regulations governing clinical trials from the 1920s to present day. Key events include the first regulations in 1928, formation of ethics committees in 1993, and adoption of ICH-GCP guidelines in 1995. The infrastructure for clinical trials in Turkey has grown significantly in recent decades with over 100 ethics committees and several phase I centers. Inspections by regulatory authorities like the FDA and EMA have increased transparency. Current regulations aim to protect participants and uphold ethical standards in research.
Cryptic Disseminated Tuberculosis: a Secondary Analysis of Previous Hospital-...fahmi khan
The main purpose of this study was to describe the demographic and clinical features of cryptic disseminated TB; it was also aimed to shed light on diagnostic test, procedure results, organ involvement, and outcomes of cryptic disseminated TB in patients with confirmed disseminated TB.
Research Center on Information and Communication Technologies (CITIC) is a technology center of the Universidade da Coruña (Spain), in order to promote the advancement and excellence in research, development and innovation on Information and Communications Technology (ICT) and promote the transfer of knowledge and results to society.
CITIC is a meeting point between the university and the company that combines R&D departments of companies in the ICT sector with researchers from the university. Current working in different R&D projects more than 250 researchers from public and private sectors, providing a mixed environment that enables university-industry collaboration and knowledge transfer.
The units of CITIC are formed by two intelligent buildings (3.200m2) that are configurable for R&D activities of our researchers, companies and employees.
Technology Areas
[◄] Information Retrieval
[◄] Application integration / Information integration
[◄] Artificial Intelligence and Applications
[◄] Mathematics: Statistics and Operation Research. Applied mathematics
[◄] Digital Home and Networked Media
[◄] Systems Usability and Testing Methods
[◄] Digital Image Processing
[◄] Wireless Communications Systems
[◄] Web Information Systems (WIS)
[◄] Geographic Information System (GIS)
[◄] Distributed Systems and Service Oriented Architecture (SOA)
[◄] High performance computing (HPC)
This document contains a custom hotkey configuration for Warcraft 3 DotA Allstars 6.74. It assigns hotkeys for common actions like move, attack, and stop. It also assigns hotkeys for hero abilities and creep/neutral abilities. Finally, it includes hotkeys for courier abilities like changing courier type and delivering items. The hotkeys are designed to work with an external tool that provides additional hotkey functions.
This teaching unity provides an introduction to healthy diet by discussing energy requirements, nutrients, and diet tips. It then explores the Mediterranean diet and organic foods. Specifically, it covers the characteristics of a balanced diet, compares organic versus conventional foods, and examines the health benefits of the Mediterranean diet and organic cultivation. The goal is to help participants understand how to organize a nutritious diet and evaluate different food options.
CITIC is a research center on ICT of the University of A Coruña (Spain). CITIC is a meeting point between the university and the company that combines R&D departments of companies in the ICT sector with researchers from the university. Currently, more than 250 researchers are working in different R&D projects.
The areas through which is developed the R & D activity of the CITIC are:
Wireless Communications Systems
Artificial Intelligence and Applications
Application integration / Information integration
Systems Usability and Testing Methods
Digital Home and Networked Media
Mathematics: Statistics and Operation Research. Applied mathematics
High Performance Computing (HPC)
Advanced Visualization
Distributed Systems and Service Oriented Architecture (SOA)
Geographic Information System (GIS)
Digital Image Processing
Web Information Systems (WIS)
Information Retrieval
CITIC Technology Centre bets on European projects.So far in 2013, the technology center CITIC has made five requests to European calls for financing R & D in ICT in a clear belief that internationalization will be one of the key stages in the growth and consolidation the center.
1) Wireless Communications Systems
Telecommunication systems with particular emphasis on wireless data transmission technologies, applications and services
2) Artificial Intelligence and Applications
Development intelligent systems for monitoring and supervising
3) Advanced Visualization
Development of technologies: real-time visualization, virtual reality, 360º video, interactive installations, interface design and so on
4) Application integration / Information integration
Development of techniques and algorithms to solve problems in data integration and distributed applications
5) Systems Usability and Testing Methods
Development of new methodologies, tools, techniques for usability of systems
6) Distributed Systems and Service Oriented Architecture (SOA)
Analysis, development, test and evaluation of systems performance. Devices distributed software systems in a logical or physical computers on a network
7) Digital Home and Networked Media
Applications for Interactive Digital TV Systems
8) Geographic Information System (GIS)
Technology Development based on GIS
9) Digital Image Processing
Ophthalmic image processing. Optical imaging.Biometrics. People identification. Civil engineering developments.
10) Web Information Systems (WIS)
Development of Web information systems for digital libraries, eGovernment, eCommerce, ….
11) Information Retrieval
Research and development of techniques and algorithms to the characteristics of business information
12) Mathematics: Statistics and Operation Research. Applied mathematics
Statistical applications. Nonparametric inference. Dependent data. Survival analysis.
Mathematical models in engineering and applied sciences. Partial Differential Equations (PDE´s). Numerical methods: analysis and programming. Numerical simulation of processes
13) High Performance Computing (HPC)
This document provides a summary of R. Rakesh Kumar's academic and professional background. It details his educational qualifications including a Ph.D from the Indian Institute of Science. It also outlines his professional experience as an Assistant Professor and past research roles. Finally, it lists his publications, research interests, and teaching experience.
This document presents a mathematical model of voltage-controlled oscillators with the Colpitts and Clapp topology. It derives more precise equations for calculating oscillation frequency and small-signal negative resistance by taking into account field-effect transistor parasitic capacitances. The model shows that the input impedance of the circuits can be represented by a negative resistance that is required for oscillation. Simulations verify that the derived equations provide a more accurate modeling, design, and implementation of Colpitts and Clapp voltage-controlled oscillators.
This document provides an update to the 2008 Surviving Sepsis Campaign Guidelines for the management of severe sepsis and septic shock. It was created by an international committee of 68 experts from 30 organizations using the GRADE methodology. The guidelines contain recommendations in three categories: those directly targeting severe sepsis, those targeting general critical care, and pediatric considerations. Key recommendations include early resuscitation, infection source control, appropriate antibiotic therapy, and protocolized management of fluids, vasopressors, glycemic control and other aspects of care. The guidelines are intended to improve outcomes for patients with severe sepsis and septic shock worldwide.
This document summarizes the guidelines from an international expert panel on the management of severe sepsis and septic shock. It was updated from 2008 guidelines. A 68-member expert panel representing 30 organizations developed the guidelines through a consensus process including subgroup meetings and teleconferences. Key recommendations include early quantitative resuscitation, blood cultures before antibiotics, source control within 12 hours, vasopressors like norepinephrine as first choice, low tidal volume ventilation for ARDS, DVT prophylaxis, and addressing goals of care within 72 hours of admission. The guidelines are meant to improve outcomes for critically ill septic patients.
This document summarizes the guidelines from an international expert panel on the management of severe sepsis and septic shock. It was updated from 2008 guidelines. A 68-member expert panel representing 30 organizations developed the guidelines through a consensus process including subgroup meetings and teleconferences. Key recommendations include early quantitative resuscitation, blood cultures before antibiotics, source control within 12 hours, vasopressors like norepinephrine as first choice, low tidal volume ventilation for ARDS, DVT prophylaxis, and addressing goals of care within 72 hours of admission. The guidelines were developed independently without industry funding using the GRADE system to assess evidence quality and strength of recommendations.
This document provides an update to the 2004 Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock using an evidence-based methodology. Key recommendations include early goal-directed resuscitation, administration of broad-spectrum antibiotics within 1 hour of diagnosis, stress-dose steroids for septic shock, low tidal volume ventilation for acute lung injury/ARDS, and glycemic control targeting blood glucose under 150 mg/dL. Recommendations were made by an international panel of experts based on the available evidence and are intended to improve outcomes for patients with severe sepsis.
Who 2019-n cov-corticosteroids-2020.1-engCIkumparan
This document provides recommendations from the WHO on the use of corticosteroids for the treatment of COVID-19. It recommends the use of systemic corticosteroids for patients with severe or critical COVID-19 based on moderate certainty evidence showing benefits. It conditionally recommends against the use of corticosteroids for non-severe COVID-19 based on low certainty evidence. The document was developed in collaboration with experts and reviews evidence on corticosteroid use from multiple clinical trials. It provides the background, methods, evidence and practical considerations regarding the recommendations.
Prognosis of pulmonary arterial hypertensiongisa_legal
1) The expected survival of patients with pulmonary arterial hypertension (PAH) varies based on the underlying cause, with idiopathic PAH having a median survival of 2.8 years based on historical studies.
2) Medical therapies like epoprostenol have improved survival rates, with studies showing 1, 2, and 3 year survival rates with epoprostenol between 63-87%, compared to 27-52% historically.
3) The prognosis is worse for PAH associated with scleroderma or collagen vascular diseases, with median survival around 1-2 years, while PAH associated with congenital heart disease has a better prognosis, with reported 3 year survival of 77%.
Guidelines for the management of hospital-adquired pneumonia ERJ 2017.pdfDenisBacinschi2
This document provides guidelines from the European Respiratory Society (ERS) and other groups for the management of hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP). It summarizes recent studies on the epidemiology, diagnosis, treatment and prevention of HAP/VAP. An international panel of experts was convened to develop evidence-based recommendations using the GRADE methodology. The resulting guidelines address the diagnosis, treatment and prevention of HAP/VAP to improve patient outcomes and reduce healthcare costs.
This document discusses using convalescent plasma therapy to treat critically ill COVID-19 patients. It provides background on using convalescent plasma to treat emerging infectious diseases. Limited data from China suggests convalescent plasma therapy provided clinical benefits for COVID-19 patients, including reduced viral loads and improved survival. However, there are challenges in recruiting eligible donors and ensuring the plasma contains sufficient neutralizing antibodies against SARS-CoV-2.
The document provides guidelines for the management of hypertension from the 2020 International Society of Hypertension. It begins by defining its scope and purpose in providing worldwide guidelines tailored for both low and high resource settings. It then discusses definitions of hypertension, recommendations for blood pressure measurement, diagnostic evaluations, treatment approaches, and specific circumstances. The guidelines are intended to standardize hypertension care globally and address the needs of all clinical settings.
By providing a short pocket guide describing the best possible practices in the treatment and management of transfusion-dependent thalassaemia (TDT), TIF seeks to support physicians worldwide in making good clinical decisions that can benefit individual patients with the disorder and enable them to advocate for more and better resources for thalassaemia care at the level of national health authorities.
The 4th edition of the original full-length Guidelines, published in June 2022, includes a full review of the evidence supporting almost each recommendation for physicians to know all the facts that form the basis of their clinical decisions in the form of a long textbook, difficult to use on a daily basis.
The ProCESS trial found no significant difference in mortality between patients receiving protocol-based early goal-directed therapy (EGDT), protocol-based standard therapy, or usual care for early septic shock. While the EGDT group received fluid resuscitation more consistently, there were no differences in outcomes like mortality, organ failure, or length of stay. This prompted review by the Surviving Sepsis Campaign. They concluded that early diagnosis and treatment remain important. ProCESS did not assess patients with severe sepsis without shock. It also showed improved usual care since 2001, with mortality dropping from 46.5% to 18%, so key bundles should still be followed.
2018 ASH guidelines for management of venous thromboembolism prophylaxis fo...Vinh Pham Nguyen
1. The guidelines provide 19 recommendations for preventing venous thromboembolism (VTE) in hospitalized and non-hospitalized medical patients and long-distance travelers.
2. Strong recommendations include providing pharmacological VTE prophylaxis to acutely or critically ill hospitalized patients at low bleeding risk, and using mechanical prophylaxis for those at high bleeding risk.
3. Conditional recommendations suggest not routinely using VTE prophylaxis for long-term care patients, outpatients with minor risk factors, or low-risk long-distance travelers. Prophylaxis may be considered for high-risk groups such as recent surgery or cancer patients.
2020 International Society of Hypertension Global Hypertension Practice Guide...Angela Fonseca Latino
This document provides an overview and summary of the 2020 International Society of Hypertension (ISH) Global Hypertension Practice Guidelines. It begins with an introduction stating the purpose and motivation for developing worldwide guidelines. It describes the guideline development process, including the composition of the guidelines committee. The document then provides definitions of hypertension based on blood pressure readings and classifications of blood pressure levels. It outlines recommendations for diagnosing hypertension through office blood pressure measurements and details proper measurement techniques. The summary highlights the key goals and approaches of the 2020 ISH Global Hypertension Practice Guidelines.
This document provides guidelines for the management of critically ill adults with COVID-19 in the intensive care unit. It was created by an international panel of 36 experts across multiple disciplines. The panel reviewed available evidence and issued 54 recommendations on topics including infection control, laboratory testing, hemodynamic support, ventilatory support, and COVID-19 therapy. When direct evidence was limited, the panel considered evidence from other coronaviruses, influenza, and conditions like acute respiratory distress syndrome to inform their recommendations. The guidelines are meant to help clinicians caring for critically ill COVID-19 patients, and will be updated as new evidence emerges.
This document discusses the history and evidence surrounding intravenous (IV) fluid administration in critically ill patients. It notes that while IV fluids were traditionally seen as beneficial, recent evidence shows that excessive fluid administration can cause harm by leading to fluid overload and accumulation. The document reviews several clinical trials that demonstrate associations between fluid overload, positive fluid balance, and increased mortality. It argues that IV fluids should be prescribed carefully and tailored to individual patient needs, with the goal of achieving zero cumulative fluid balance to avoid potential complications of overzealous fluid therapy.
This document provides guidelines for the management of hypertension from the International Society of Hypertension (ISH). It aims to provide evidence-based recommendations that are practical for both low and high resource settings.
The guidelines were developed by extracting evidence from recently published guidelines and tailoring them to be concise and easy to use globally. They define hypertension as a blood pressure over 140/90 mmHg based on office measurements. The guidelines recommend lifestyle modifications and pharmacological treatment for confirmed hypertension. They also provide guidance on diagnostic tests, risk factors, target organ damage, comorbidities and special circumstances like pregnancy. The goal is to reduce the global burden of raised blood pressure through practical standards of care.
Newest 2020 ISH global hypertension practice guidelinesChanRyan4
This document provides an introduction and table of contents for guidelines on the management of hypertension. It aims to provide evidence-based recommendations tailored for both high and low resource settings. The guidelines were developed by extracting content from recently published extensively reviewed guidelines. It recognizes that optimal care may not always be possible, so essential standards of care are provided that recognize limitations in clinical evidence and resources. The motivation for developing these guidelines is the large global burden of raised blood pressure, with awareness, treatment and control rates especially low in low- and middle-income countries.
This document provides guidelines for the management of hypertension from the International Society of Hypertension (ISH). It aims to extract evidence-based recommendations from major guidelines and tailor them for both high and low resource settings. Section 1 introduces the context and purpose of the guidelines, which is to reduce the global burden of raised blood pressure. It notes that while over 1 billion people have hypertension, rates of awareness, treatment and control remain low, especially in low- and middle-income countries. The guidelines thus seek to provide practical, globally-applicable recommendations to improve hypertension management worldwide.
2. Special Article
before antibiotic therapy (1C); imaging studies performed unless contraindicated (1B); a conservative fluid strategy for
promptly to confirm a potential source of infection (UG); admin- patients with established ARDS who do not have evidence of
istration of broad-spectrum antimicrobials therapy within 1 hr of tissue hypoperfusion (1C); protocols for weaning and seda-
recognition of septic shock (1B) and severe sepsis without sep- tion (1A); minimizing use of either intermittent bolus sedation
tic shock (1C) as the goal of therapy; reassessment of antimi- or continuous infusion sedation targeting specific titration
crobial therapy daily for de-escalation, when appropriate (1B); endpoints (1B); avoidance of neuromuscular blockers if pos-
infection source control with attention to the balance of risks and sible in the septic patient without ARDS (1C); a short course
benefits of the chosen method within 12 hrs of diagnosis (1C); of neuromuscular blocker (no longer than 48 hrs) for patients
initial fluid resuscitation with crystalloid (1B) and consideration with early ARDS and a Pao2/Fio2 150 mm Hg (2C); a proto-
of the addition of albumin in patients who continue to require colized approach to blood glucose management commencing
substantial amounts of crystalloid to maintain adequate mean insulin dosing when two consecutive blood glucose levels are
arterial pressure (2C) and the avoidance of hetastarch formula- 180 mg/dL, targeting an upper blood glucose ≤ 180 mg/dL
tions (1C); initial fluid challenge in patients with sepsis-induced (1A); equivalency of continuous veno-venous hemofiltration or
tissue hypoperfusion and suspicion of hypovolemia to achieve a intermittent hemodialysis (2B); prophylaxis for deep vein throm-
minimum of 30 mL/kg of crystalloids (more rapid administration bosis (1B); use of stress ulcer prophylaxis to prevent upper
and greater amounts of fluid may be needed in some patients) gastrointestinal bleeding in patients with bleeding risk factors
(1C); fluid challenge technique continued as long as hemody- (1B); oral or enteral (if necessary) feedings, as tolerated, rather
namic improvement, as based on either dynamic or static vari- than either complete fasting or provision of only intravenous
ables (UG); norepinephrine as the first-choice vasopressor to glucose within the first 48 hrs after a diagnosis of severe sep-
maintain mean arterial pressure ≥ 65 mm Hg (1B); epinephrine sis/septic shock (2C); and addressing goals of care, including
when an additional agent is needed to maintain adequate blood treatment plans and end-of-life planning (as appropriate) (1B),
pressure (2B); vasopressin (0.03 U/min) can be added to nor- as early as feasible, but within 72 hrs of intensive care unit
epinephrine to either raise mean arterial pressure to target or admission (2C). Recommendations specific to pediatric severe
to decrease norepinephrine dose but should not be used as sepsis include: therapy with face mask oxygen, high flow nasal
the initial vasopressor (UG); dopamine is not recommended cannula oxygen, or nasopharyngeal continuous PEEP in the
except in highly selected circumstances (2C); dobutamine presence of respiratory distress and hypoxemia (2C), use of
infusion administered or added to vasopressor in the presence physical examination therapeutic endpoints such as capillary
of a) myocardial dysfunction as suggested by elevated cardiac refill (2C); for septic shock associated with hypovolemia, the
filling pressures and low cardiac output, or b) ongoing signs use of crystalloids or albumin to deliver a bolus of 20 mL/kg
of hypoperfusion despite achieving adequate intravascular vol- of crystalloids (or albumin equivalent) over 5 to 10 mins (2C);
ume and adequate mean arterial pressure (1C); avoiding use more common use of inotropes and vasodilators for low cardiac
of intravenous hydrocortisone in adult septic shock patients if output septic shock associated with elevated systemic vascular
adequate fluid resuscitation and vasopressor therapy are able resistance (2C); and use of hydrocortisone only in children with
to restore hemodynamic stability (2C); hemoglobin target of suspected or proven “absolute”‘ adrenal insufficiency (2C).
7–9 g/dL in the absence of tissue hypoperfusion, ischemic Conclusions: Strong agreement existed among a large cohort
coronary artery disease, or acute hemorrhage (1B); low tidal of international experts regarding many level 1 recommenda-
volume (1A) and limitation of inspiratory plateau pressure (1B) tions for the best care of patients with severe sepsis. Although
for acute respiratory distress syndrome (ARDS); application of a significant number of aspects of care have relatively weak
at least a minimal amount of positive end-expiratory pressure support, evidence-based recommendations regarding the
(PEEP) in ARDS (1B); higher rather than lower level of PEEP acute management of sepsis and septic shock are the founda-
for patients with sepsis-induced moderate or severe ARDS tion of improved outcomes for this important group of critically
(2C); recruitment maneuvers in sepsis patients with severe ill patients. (Crit Care Med 2013; 41:580–637)
refractory hypoxemia due to ARDS (2C); prone positioning in Key Words: evidence-based medicine; Grading of Recommendations
sepsis-induced ARDS patients with a Pao2/Fio2 ratio of ≤ 100 Assessment, Development and Evaluation criteria; guidelines;
mm Hg in facilities that have experience with such practices infection; sepsis; sepsis bundles; sepsis syndrome; septic shock;
(2C); head-of-bed elevation in mechanically ventilated patients severe sepsis; Surviving Sepsis Campaign
Sponsoring organizations: American Association of Critical-Care America, Indian Society of Critical Care Medicine, International Pan
Nurses, American College of Chest Physicians, American College Arabian Critical Care Medicine Society, Japanese Association for Acute
of Emergency Physicians, American Thoracic Society, Asia Pacific Medicine, Japanese Society of Intensive Care Medicine, Pediatric Acute
Association of Critical Care Medicine, Australian and New Zealand Lung Injury and Sepsis Investigators, Society for Academic Emergency
Intensive Care Society, Brazilian Society of Critical Care, Canadian
Medicine, Society of Critical Care Medicine, Society of Hospital
Critical Care Society, Chinese Society of Critical Care Medicine,
Medicine, Surgical Infection Society, World Federation of Critical
Chinese Society of Critical Care Medicine−China Medical Association,
Emirates Intensive Care Society, European Respiratory Society, Care Nurses, World Federation of Pediatric Intensive and Critical Care
European Society of Clinical Microbiology and Infectious Diseases, Societies; World Federation of Societies of Intensive and Critical Care
European Society of Intensive Care Medicine, European Society of Medicine. Participation and endorsement: The German Sepsis Society
Pediatric and Neonatal Intensive Care, Infectious Diseases Society of and the Latin American Sepsis Institute.
Critical Care Medicine www.ccmjournal.org 581
3. Dellinger et al
Dr. Dellinger consulted for Biotest (immunoglobulin concentrate available in Dr. Douglas received grants paid to his institution from Eli Lilly (PROWESS
Europe for potential use in sepsis) and AstraZeneca (anti-TNF compound Shock site), Eisai (study site), National Institutes of Health (ARDS Network),
unsuccessful in recently completed sepsis clinical trial); his institution received Accelr8 (VAP diagnostics), CCCTG (Oscillate Study), and Hospira (Dexme-
consulting income from IKARIA for new product development (IKARIA has detomidine in Alcohol Withdrawal RCT). His institution received an honorar-
inhaled nitric oxide available for off-label use in ARDS) and grant support from ium from the Society of Critical Care Medicine (Paragon ICU Improvement);
Spectral Diagnostics Inc (current endotoxin removal clinical trial), Ferring (vaso- he consulted for Eli Lilly (PROWESS Shock SC and Sepsis Genomics
pressin analog clinical trial-ongoing); as well as serving on speakers bureau for Study) in accordance with institutional policy; he received payment for pro-
Eisai (anti-endotoxin compound that failed to show benefit in clinical trial). viding expert testimony (Smith Moore Leatherwood LLP); travel/accommo-
dations reimbursed by Eli Lilly and Company (PROWESS Shock Steering
Dr. Levy received grant support from Eisai (Ocean State Clinical Coordi-
Committee) and the Society of Critical Care Medicine (Hospital Quality Alli-
nating Center to fund clinical trial [$500K]), he received honoraria from Eli
ance, Washington DC, four times per year 2009−2011); he received hono-
Lilly (lectures in India $8,000), and he has been involved with the Surviving
raria from Covidien (non-CME lecture 2010, US$500) and the University
Sepsis Campaign guideline from its beginning.
of Minnesota Center for Excellence in Critical Care CME program (2009,
Dr. Rhodes consulted for Eli Lilly with monetary compensation paid to him- 2010); he has a pending patent for a bed backrest elevation monitor.
self as well as his institution (Steering Committee for the PROWESS Shock
Dr. Jaeschke has disclosed that he has no potential conflicts of interest.
trial) and LiDCO; travel/accommodation reimbursement was received from
Eli Lilly and LiDCO; he received income for participation in review activities Dr. Osborn consulted for Sui Generis Health ($200). Her institution
such as data monitoring boards, statistical analysis from Orion, and for Eli receives grant support from the National Institutes of Health Research,
Lilly; he is an author on manuscripts describing early goal-directed therapy, Health Technology Assessment Programme-United Kingdom (trial doc-
and believes in the concept of minimally invasive hemodynamic monitoring. tor for sepsis-related RCT). Salary paid through the NIHR government
funded (nonindustry) grant. Grant awarded to chief investigator from
Dr. Annane participated on the Fresenius Kabi International Advisory Board ICNARC. She is a trial clinician for ProMISe.
(honorarium 2000€). His nonfinancial disclosures include being the princi-
pal investigator of a completed investigator-led multicenter randomized con- Dr. Nunnally received a stipend for a chapter on diabetes mellitus; he is an
trolled trial assessing the early guided benefit to risk of NIRS tissue oxygen author of editorials contesting classic tight glucose control.
saturation; he was the principal investigator of an investigator-led randomized Dr. Townsend is an advocate for healthcare quality improvement.
controlled trial of epinephrine vs norepinephrine (CATS study)–Lancet 2007; Dr. Reinhart consulted for EISAI (Steering Committee member−less then
he also is the principle investigator of an ongoing investigator-led multina- US $10,000); BRAHMS Diagnostics (less than US $10,000); and SIRS-
tional randomized controlled trial of crystalloids vs colloids (Crystal Study). Lab Jena (founding member, less than US $10,000). He received hono-
Dr. Gerlach has disclosed that he has no potential conflicts of interest; raria for lectures including service on the speakers’ bureau from Biosyn
he is an author of a review on the use of activated protein C in surgical Germany (less than €10,000) and Braun Melsungen (less than €10,000).
patients (published in the New England Journal of Medicine, 2009). He received royalties from Edwards Life Sciences for sales of central
venous oxygen catheters (~$100,000).
Dr. Opal consulted for Genzyme Transgenics (consultant on trans-
genic antithrombin $1,000), Pfizer (consultant on TLR4 inhibitor project Dr. Kleinpell received monetary compensation for providing expert testimony
$3,000), British Therapeutics (consultant on polyclonal antibody project (four depositions and one trial in the past year). Her institution receives
$1,000), and Biotest A (consultant on immunoglobul project $2,000). grants from the Agency for Healthcare Research and Quality and the Prince
His institution received grant support from Novartis (Clinical Coordinat- Foundation (4-year R01 grant, PI and 3-year foundation grant, Co-l). She
ing Center to assist in patient enrollment in a phase III trial with the use received honoraria from the Cleveland Clinic and the American Association
of Tissue Factor Pathway Inhibitor [TFPI] in severe community acquired of Critical Care Nurses for keynote speeches at conferences; she received
pneumonia [SCAP] $30,000 for 2 years), Eisai ($30,000 for 3 years), royalties from McGraw Hill (co-editor of critical care review book); travel/
Astra Zeneca ($30,000 for 1 year), Aggenix ($30,000 for 1 year), Inimex accommodations reimbursed from the American Academy of Nurse Prac-
($10,000), Eisai ($10,000), Atoxbio ($10,000), Wyeth ($20,000), Sirtris titioners, Society of Critical Care Medicine, and American Association of
(preclinical research $50,000), and Cellular Bioengineering Inc. ($500). Critical Care Nurses (one night hotel coverage at national conference).
He received honoraria from Novartis (clinical evaluation committee TFPI Dr. Angus consulted for Eli Lilly (member of the Data Safety Monitoring
study for SCAP $20,000) and Eisai ($25,000). He received travel/accom- Board, Multicenter trial of a PC for septic shock), Eisai Inc (Anti-TLR4
modations reimbursed from Sangart (data and safety monitoring $2,000), therapy for severe sepsis), and Idaho Technology (sepsis biomarkers); he
Spectral Diagnostics (data and safety monitoring $2,000), Takeda (data received grant support (investigator, long-term follow-up of phase III trial
and safety monitoring $2,000) and Canadian trials group ROS II oseltami- of an anti-TLR4 agent in severe sepsis), a consulting income (anti-TRL4
vir study (data and safety monitoring board (no money). He is also on the therapy for severe sepsis), and travel/accommodation expense reimburse-
Data Safety Monitoring Board for Tetraphase (received US $600 in 2012). ment from Eisai, Inc; he is the primary investigator for an ongoing National
Institutes of Health-funded study comparing early resuscitation strategies
Dr. Sevransky received grant support to his institution from Sirius Genom- for sepsis-induced tissue hypoperfusion.
ics Inc; he consulted for Idaho Technology ($1,500); he is the co-principal
investigator of a multicenter study evaluating the association between Dr. Deutschman has nonfinancial involvement as a coauthor of the Society
intensive care unit organizational and structural factors, including proto- of Critical Care Medicine’s Glycemic Control guidelines.
cols and in-patient mortality. He maintains that protocols serve as useful Dr. Machado reports unrestricted grant support paid to her institution for
reminders to busy clinicians to consider certain therapies in patients with Surviving Sepsis Campaign implementation in Brazil (Eli Lilly do Brasil);
sepsis or other life-threatening illness. she is the primary investigator for an ongoing study involving vasopressin.
Dr. Sprung received grants paid to his institution from Artisan Pharma Dr. Rubenfeld received grant support from nonprofit agencies or foundations
($25,000–$50,000), Eisai, Corp ($1,000–$5,000 ACCESS), Ferring including National Institutes of Health ($10 million), Robert Wood Johnson
Pharmaceuticals A/S ($5,000–$10,000), Hutchinson Technology Incorpo- Foundation ($500,000), and CIHR ($200,000). His institution received grants
rated ($1,000–$5,000), Novartis Corp (less than $1,000). His institution from for-profit companies including Advanced Lifeline System ($150,000),
receives grant support for patients enrolled in clinical studies from Eisai Cor- Siemens ($50,000), Bayer ($10,000), Byk Gulden ($15,000), AstraZen-
poration (PI. Patients enrolled in the ACCESS study $50,000–$100,000), eca ($10,000), Faron Pharmaceuticals ($5,000), and Cerus Corporation
Takeda (PI. Study terminated before patients enrolled). He received grants ($11,000). He received honoraria, consulting fees, editorship, royalties, and
paid to his institution and consulting income from Artisan Pharma/Asahi Data and Safety Monitoring Board membership fees paid to him from Bayer
Kasei Pharma America Corp ($25,000–$50,000). He consulted for Eli ($500), DHD ($1,000), Eli Lilly ($5,000), Oxford University Press ($10,000),
Lilly (Sabbatical Consulting fee $10,000–$25,000) and received honoraria Hospira ($15,000), Cerner ($5,000), Pfizer ($1,000), KCI ($7,500), Ameri-
from Eli Lilly (lecture $1,000–$5,000). He is a member of the Australia and can Association for Respiratory Care ($10,000), American Thoracic Society
New Zealand Intensive Care Society Clinical Trials Group for the NICE- ($7,500), BioMed Central ($1,000), National Institutes of Health ($1,500),
SUGAR Study (no money received); he is a council member of the Inter- and the Alberta Heritage Foundation for Medical Research ($250). He has
national Sepsis Forum (as of Oct. 2010); he has held long time research database access or other intellectual (non financial) support from Cerner.
interests in steroids in sepsis, PI of Corticus study, end-of-life decision mak- Dr. Webb consulted for AstraZeneca (anti-infectives $1,000−$5,000) and
ing and PI of Ethicus, Ethicatt, and Welpicus studies. Jansen-Cilag (anti-infectives $1,000-$5,000). He received grant support
582 www.ccmjournal.org February 2013 • Volume 41 • Number 2
4. Special Article
from a NHMRC project grant (ARISE RECT of EGDT); NHMRC proj- Eli Lilly and Company (development of educational presentations including
ect grant and Fresinius-unrestricted grant (CHEST RCT of voluven vs. service on speaker’ bureaus (intensive care school hosted in department);
saline); RCT of steroid vs. placebo for septic shock); NHMRC project travel/accommodations were reimbursed from bioMerieux (GeneXpert Focus
grant (BLISS study of bacteria detection by PRC in septic shock) Intensive Group, France) and LiDCO (Winter Anaesthetic and Critical Care Review
Care Foundation-ANZ (BLING pilot RCT of beta-lactam administration Conference), Surviving Sepsis Campaign (Publications Meeting, New York;
by infusion); Hospira (SPICE programme of sedation delirium research); Care Bundles Conference, Manchester), SSC Publication Committee Meet-
NHMRC Centres for Research Excellent Grant (critical illness microbi- ing and SSC Executive Committee Meeting, Nashville; SSC Meeting, Man-
ology observational studies); Hospira-unrestricted grant (DAHlia RCT of chester), Novartis (Advisory Board Meeting, Zurich), Institute of Biomedical
dexmedetomidine for agitated delirium). Travel/accommodations reim- Engineering (Hospital of the Future Grand Challenge Kick-Off Meeting,
bursed by Jansen-Cilag ($5,000–$10,000) and AstraZeneca ($1,000- Hospital of the Future Grand Challenge Interviews EPSRC Headquarters,
$5,000); he has a patent for a meningococcal vaccine. He is chair of the Swindon, Philips (Kick-Off Meeting, Boeblingen, Germany; MET Conference,
ANZICS Clinical Trials Group and is an investigator in trials of EGDT, PCR Cohenhagen), Covidien (Adult Monitoring Advisory Board Meeting, Frank-
for determining bacterial load and a steroid in the septic shock trial. furt), Eisai (ACCESS Investigators Meeting, Barcelona). His nonfinancial dis-
closures include authorship of the position statement on fluid resuscitation
Dr. Beale received compensation for his participation as board member for
from the ESICM task force on colloids (yet to be finalized).
Eisai, Inc, Applied Physiology, bioMérieux, Covidien, SIRS-Lab, and Novartis;
consulting income was paid to his institution from PriceSpective Ltd, Easton Dr. Vincent reports consulting income paid to his institution from Astellas,
Associates (soluble guanylate cyclase activator in acute respiratory distress AstraZeneca, Curacyte, Eli Lilly, Eisai, Ferring, GlaxoSmithKline, Merck, and
syndrome/acute lung injury adjunct therapy to supportive care and ventila- Pfizer. His institution received honoraria on his behalf from Astellas, Astra-
tion strategies), Eisai (eritoran), and Phillips (Respironics); he provided expert Zeneca, Curacyte, Eli Lilly, Eisai, Ferring, Merck, and Pfizer. His institution
testimony for Eli Lilly and Company (paid to his institution); honoraria received received grant support from Astellas, Curacyte, Eli Lilly, Eisai, Ferring, and
(paid to his institution) from Applied Physiology (Applied Physiology PL SAB, Pfizer. His institution received payment for educational presentations from
Applied Physiology SAB, Brussels, Satellite Symposium at the ISICEM, Astellas, AstraZeneca, Curacyte, Eli Lilly, Eisai, Ferring, Merck, and Pfizer.
Brussels), bioMérieux (GeneXpert Focus Group, France), SIRS-Lab (SIRS- Dr. Moreno consulted for bioMerieux (expert meeting). He is a coauthor of
LAB SAB Forum, Brussels and SIRS-LAB SAB, Lisbon), Eli Lilly (CHMP a paper on corticosteroids in patients with septic shock. He is the author
Hearing), Eisai (eritoran through leader touch plan in Brussels), Eli Lilly of several manuscripts defining sepsis and stratification of the patient with
(Lunchtime Symposium, Vienna), Covidien (adult monitoring advisory board sepsis. He is also the author of several manuscripts contesting the utility
meeting, Frankfurt), Covidien (Global Advisory Board CNIBP Boulder USA), of sepsis bundles.
S METHODOLOGY
epsis is a systemic, deleterious host response to infection
leading to severe sepsis (acute organ dysfunction second-
ary to documented or suspected infection) and septic Definitions
shock (severe sepsis plus hypotension not reversed with fluid Sepsis is defined as the presence (probable or documented) of
resuscitation). Severe sepsis and septic shock are major health- infection together with systemic manifestations of infection.
care problems, affecting millions of people around the world Severe sepsis is defined as sepsis plus sepsis-induced organ
each year, killing one in four (and often more), and increasing dysfunction or tissue hypoperfusion (Tables 1 and 2) (6).
in incidence (1–5). Similar to polytrauma, acute myocardial Throughout this manuscript and the performance improve-
infarction, or stroke, the speed and appropriateness of therapy ment bundles, which are included, a distinction is made
administered in the initial hours after severe sepsis develops between definitions and therapeutic targets or thresholds. Sep-
are likely to influence outcome. sis-induced hypotension is defined as a systolic blood pressure
The recommendations in this document are intended to (SBP) 90 mm Hg or mean arterial pressure (MAP) 70 mm
provide guidance for the clinician caring for a patient with Hg or a SBP decrease 40 mm Hg or less than two standard
severe sepsis or septic shock. Recommendations from these deviations below normal for age in the absence of other causes
guidelines cannot replace the clinician’s decision-making capa- of hypotension. An example of a therapeutic target or typical
bility when he or she is presented with a patient’s unique set of threshold for the reversal of hypotension is seen in the sepsis
clinical variables. Most of these recommendations are appro- bundles for the use of vasopressors. In the bundles, the MAP
priate for the severe sepsis patient in the ICU and non-ICU set- threshold is ≥ 65 mm Hg. The use of definition vs. threshold will
tings. In fact, the committee believes that the greatest outcome be evident throughout this article. Septic shock is defined as
improvement can be made through education and process sepsis-induced hypotension persisting despite adequate fluid
change for those caring for severe sepsis patients in the non- resuscitation. Sepsis-induced tissue hypoperfusion is defined
ICU setting and across the spectrum of acute care. Resource as infection-induced hypotension, elevated lactate, or oliguria.
limitations in some institutions and countries may prevent
physicians from accomplishing particular recommendations. History of the Guidelines
Thus, these recommendations are intended to be best practice These clinical practice guidelines are a revision of the 2008
(the committee considers this a goal for clinical practice) and SSC guidelines for the management of severe sepsis and septic
not created to represent standard of care. The Surviving Sepsis shock (7). The initial SSC guidelines were published in 2004
Campaign (SSC) Guidelines Committee hopes that over time, (8) and incorporated the evidence available through the end
particularly through education programs and formal audit of 2003. The 2008 publication analyzed evidence available
and feedback performance improvement initiatives, the guide- through the end of 2007. The most current iteration is based
lines will influence bedside healthcare practitioner behavior on updated literature search incorporated into the evolving
that will reduce the burden of sepsis worldwide. manuscript through fall 2012.
Critical Care Medicine www.ccmjournal.org 583
5. Dellinger et al
Selection and Organization of Committee Members Grading of Recommendations
The selection of committee members was based on inter- We advised the authors to follow the principles of the Grading
est and expertise in specific aspects of sepsis. Co-chairs and of Recommendations Assessment, Development and Evalua-
executive committee members were appointed by the Society tion (GRADE) system to guide assessment of quality of evi-
of Critical Care Medicine and European Society of Intensive dence from high (A) to very low (D) and to determine the
Care Medicine governing bodies. Each sponsoring organiza- strength of recommendations (Tables 3 and 4). (9–11). The
tion appointed a representative who had sepsis expertise. Addi- SSC Steering Committee and individual authors collaborated
tional committee members were appointed by the co-chairs with GRADE representatives to apply the system during the
and executive committee to create continuity with the previous SSC guidelines revision process. The members of the GRADE
committees’ membership as well as to address content needs group were directly involved, either in person or via e-mail, in
for the development process. Four clinicians with experience all discussions and deliberations among the guidelines com-
in the GRADE process application (referred to in this docu- mittee members as to grading decisions.
ment as GRADE group or Evidence-Based Medicine [EBM] The GRADE system is based on a sequential assessment of
group) took part in the guidelines development. the quality of evidence, followed by assessment of the balance
The guidelines development process began with appoint- between the benefits and risks, burden, and cost, leading to
ment of group heads and assignment of committee members development and grading of a management recommendation.
to groups according to their specific expertise. Each group was Keeping the rating of quality of evidence and strength of
responsible for drafting the initial update to the 2008 edition recommendation explicitly separate constitutes a crucial and
in their assigned area (with major additional elements of infor- defining feature of the GRADE approach. This system classifies
mation incorporated into the evolving manuscript through quality of evidence as high (grade A), moderate (grade B), low
year-end 2011 and early 2012). (grade C), or very low (grade D). Randomized trials begin
With input from the EBM group, an initial group meet- as high-quality evidence but may be downgraded due to
ing was held to establish procedures for literature review and limitations in implementation, inconsistency, or imprecision of
development of tables for evidence analysis. Committees and the results, indirectness of the evidence, and possible reporting
their subgroups continued work via phone and the Internet. bias (Table 3). Examples of indirectness of the evidence
Several subsequent meetings of subgroups and key indi- include population studied, interventions used, outcomes
viduals occurred at major international meetings (nominal measured, and how these relate to the question of interest.
groups), with work continuing via teleconferences and elec- Well-done observational (nonrandomized) studies begin as
tronic-based discussions among subgroups and members low-quality evidence, but the quality level may be upgraded on
of the entire committee. Ultimately, a meeting of all group the basis of a large magnitude of effect. An example of this is
heads, executive committee members, and other key commit- the quality of evidence for early administration of antibiotics.
tee members was held to finalize the draft document for sub- References to supplemental digital content appendices of
mission to reviewers. GRADEpro Summary of Evidence Tables appear throughout
this document.
Search Techniques The GRADE system classifies recommendations as strong
A separate literature search was performed for each clearly (grade 1) or weak (grade 2). The factors influencing this deter-
defined question. The committee chairs worked with subgroup mination are presented in Table 4. The assignment of strong
heads to identify pertinent search terms that were to include, or weak is considered of greater clinical importance than a
at a minimum, sepsis, severe sepsis, septic shock, and sepsis syn- difference in letter level of quality of evidence. The commit-
drome crossed against the subgroup’s general topic area, as well tee assessed whether the desirable effects of adherence would
as appropriate key words of the specific question posed. All outweigh the undesirable effects, and the strength of a rec-
questions used in the previous guidelines publications were ommendation reflects the group’s degree of confidence in
searched, as were pertinent new questions generated by gen- that assessment. Thus, a strong recommendation in favor of
eral topic-related searches or recent trials. The authors were an intervention reflects the panel’s opinion that the desirable
specifically asked to look for existing meta-analyses related to effects of adherence to a recommendation (beneficial health
their question and search a minimum of one general database outcomes; lesser burden on staff and patients; and cost sav-
(ie, MEDLINE, EMBASE) and the Cochrane Library (both ings) will clearly outweigh the undesirable effects (harm to
The Cochrane Database of Systematic Reviews [CDSR] and health; more burden on staff and patients; and greater costs).
Database of Abstracts of Reviews of Effectiveness [DARE]). The potential drawbacks of making strong recommenda-
Other databases were optional (ACP Journal Club, Evidence- tions in the presence of low-quality evidence were taken into
Based Medicine Journal, Cochrane Registry of Controlled account. A weak recommendation in favor of an intervention
Clinical Trials, International Standard Randomized Controlled indicates the judgment that the desirable effects of adherence
Trial Registry [http://www.controlled-trials.com/isrctn/] or to a recommendation probably will outweigh the undesirable
metaRegister of Controlled Trials [http://www.controlled- effects, but the panel is not confident about these tradeoffs—
trials.com/mrct/]. Where appropriate, available evidence was either because some of the evidence is low quality (and thus
summarized in the form of evidence tables. uncertainty remains regarding the benefits and risks) or the
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6. Special Article
Table 1. Diagnostic Criteria for Sepsis
Infection, documented or suspected, and some of the following:
General variables
Fever ( 38.3°C)
Hypothermia (core temperature 36°C)
Heart rate 90/min–1 or more than two sd above the normal value for age
Tachypnea
Altered mental status
Significant edema or positive fluid balance ( 20 mL/kg over 24 hr)
Hyperglycemia (plasma glucose 140 mg/dL or 7.7 mmol/L) in the absence of diabetes
Inflammatory variables
Leukocytosis (WBC count 12,000 µL–1)
Leukopenia (WBC count 4000 µL–1)
Normal WBC count with greater than 10% immature forms
Plasma C-reactive protein more than two sd above the normal value
Plasma procalcitonin more than two sd above the normal value
Hemodynamic variables
Arterial hypotension (SBP 90 mm Hg, MAP 70 mm Hg, or an SBP decrease 40 mm Hg in adults or less than two sd
below normal for age)
Organ dysfunction variables
Arterial hypoxemia (Pao2/Fio2 300)
Acute oliguria (urine output 0.5 mL/kg/hr for at least 2 hrs despite adequate fluid resuscitation)
Creatinine increase 0.5 mg/dL or 44.2 µmol/L
Coagulation abnormalities (INR 1.5 or aPTT 60 s)
Ileus (absent bowel sounds)
Thrombocytopenia (platelet count 100,000 µL–1)
Hyperbilirubinemia (plasma total bilirubin 4 mg/dL or 70 µmol/L)
Tissue perfusion variables
Hyperlactatemia ( 1 mmol/L)
Decreased capillary refill or mottling
WBC = white blood cell; SBP = systolic blood pressure; MAP = mean arterial pressure; INR = international normalized ratio; aPTT = activated partial thromboplastin
time.
Diagnostic criteria for sepsis in the pediatric population are signs and symptoms of inflammation plus infection with hyper- or hypothermia (rectal temperature
38.5° or 35°C), tachycardia (may be absent in hypothermic patients), and at least one of the following indications of altered organ function: altered mental
status, hypoxemia, increased serum lactate level, or bounding pulses.
Adapted from Levy MM, Fink MP, Marshall JC, et al: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31:
1250–1256.
benefits and downsides are closely balanced. A strong recom- The implications of calling a recommendation strong
mendation is worded as “we recommend” and a weak recom- are that most well-informed patients would accept that
mendation as “we suggest.” intervention and that most clinicians should use it in most
Throughout the document are a number of statements situations. Circumstances may exist in which a strong rec-
that either follow graded recommendations or are listed as ommendation cannot or should not be followed for an
stand-alone numbered statements followed by “ungraded” individual because of that patient’s preferences or clinical
in parentheses (UG). In the opinion of the committee, characteristics that make the recommendation less applica-
these recommendations were not conducive for the GRADE ble. A strong recommendation does not automatically imply
process. standard of care. For example, the strong recommendation
Critical Care Medicine www.ccmjournal.org 585
7. Dellinger et al
Table 2. Severe Sepsis
Severe sepsis definition = sepsis-induced tissue hypoperfusion or organ dysfunction (any of the
following thought to be due to the infection)
Sepsis-induced hypotension
Lactate above upper limits laboratory normal
Urine output 0.5 mL/kg/hr for more than 2 hrs despite adequate fluid resuscitation
Acute lung injury with Pao2/Fio2 250 in the absence of pneumonia as infection source
Acute lung injury with Pao2/Fio2 200 in the presence of pneumonia as infection source
Creatinine 2.0 mg/dL (176.8 µmol/L)
Bilirubin 2 mg/dL (34.2 µmol/L)
Platelet count 100,000 µL
Coagulopathy (international normalized ratio 1.5)
Adapted from Levy MM, Fink MP, Marshall JC, et al: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31:
1250–1256.
for administering antibiotics within 1 hr of the diagnosis were available for advice throughout the process. Subgroups
of severe sepsis, as well as the recommendation for achiev- agreed electronically on draft proposals that were then
ing a central venous pressure (CVP) of 8 mm Hg and a cen- presented for general discussion among subgroup heads, the
tral venous oxygen saturation (Scvo2) of 70% in the first 6 SSC Steering Committee (two co-chairs, two co-vice chairs,
hrs of resuscitation of sepsis-induced tissue hypoperfusion, and an at-large committee member), and several selected key
although deemed desirable, are not yet standards of care as committee members who met in July 2011 in Chicago. The
verified by practice data. results of that discussion were incorporated into the next
Significant education of committee members on the version of recommendations and again discussed with the
GRADE approach built on the process conducted during 2008 whole group using electronic mail. Draft recommendations
efforts. Several members of the committee were trained in were distributed to the entire committee and finalized during
the use of GRADEpro software, allowing more formal use of an additional nominal group meeting in Berlin in October
the GRADE system (12). Rules were distributed concerning 2011. Deliberations and decisions were then recirculated to the
assessing the body of evidence, and GRADE representatives entire committee for approval. At the discretion of the chairs
Table 3. Determination of the Quality of Evidence
Underlying methodology
A (high) RCTs
B (moderate) Downgraded RCTs or upgraded observational studies
C (low) Well-done observational studies with control RCTs
D (very low) Downgraded controlled studies or expert opinion based on other evidence
Factors that may decrease the strength of evidence
1. Poor quality of planning and implementation of available RCTs, suggesting high likelihood of bias
2. Inconsistency of results, including problems with subgroup analyses
3. Indirectness of evidence (differing population, intervention, control, outcomes, comparison)
4. Imprecision of results
5. High likelihood of reporting bias
Main factors that may increase the strength of evidence
1. Large magnitude of effect (direct evidence, relative risk 2 with no plausible confounders)
2. Very large magnitude of effect with relative risk 5 and no threats to validity (by two levels)
3. Dose-response gradient
RCT = randomized controlled trial.
586 www.ccmjournal.org February 2013 • Volume 41 • Number 2
8. Special Article
Table 4. Factors Determining Strong vs. Weak Recommendation
What Should be Considered Recommended Process
High or moderate evidence The higher the quality of evidence, the more likely a strong recommendation.
(Is there high or moderate quality
evidence?)
Certainty about the balance of benefits vs. The larger the difference between the desirable and undesirable consequences and
harms and burdens (Is there certainty?) the certainty around that difference, the more likely a strong recommendation. The
smaller the net benefit and the lower the certainty for that benefit, the more likely a
weak recommendation.
Certainty in or similar values The more certainty or similarity in values and preferences, the more likely a strong
(Is there certainty or similarity?) recommendation.
Resource implications The lower the cost of an intervention compared to the alternative and other costs related to
(Are resources worth expected benefits?) the decision–ie, fewer resources consumed–the more likely a strong recommendation.
and following discussion, competing proposals for wording they had the least COI. They were required to work within
of recommendations or assigning strength of evidence were their group with full disclosure when a topic for which they
resolved by formal voting within subgroups and at nominal had relevant COI was discussed, and they were not allowed
group meetings. The manuscript was edited for style and form to serve as group head. At the time of final approval of the
by the writing committee with final approval by subgroup document, an update of the COI statement was required. No
heads and then by the entire committee. To satisfy peer review additional COI issues were reported that required further
during the final stages of manuscript approval for publication, adjudication.
several recommendations were edited with approval of the SSC
executive committee group head for that recommendation and MANAGEMENT OF SEVERE SEPSIS
the EBM lead.
Initial Resuscitation and Infection Issues (Table 5)
Conflict of Interest Policy A. Initial Resuscitation
Since the inception of the SSC guidelines in 2004, no members 1. We recommend the protocolized, quantitative resuscitation of
of the committee represented industry; there was no industry patients with sepsis- induced tissue hypoperfusion (defined in
input into guidelines development; and no industry represen- this document as hypotension persisting after initial fluid chal-
tatives were present at any of the meetings. Industry awareness lenge or blood lactate concentration ≥ 4 mmol/L). This proto-
or comment on the recommendations was not allowed. No col should be initiated as soon as hypoperfusion is recognized
member of the guidelines committee received honoraria for and should not be delayed pending ICU admission. During the
any role in the 2004, 2008, or 2012 guidelines process. first 6 hrs of resuscitation, the goals of initial resuscitation of
A detailed description of the disclosure process and all sepsis-induced hypoperfusion should include all of the follow-
author disclosures appear in Supplemental Digital Content 1 ing as a part of a treatment protocol (grade 1C):
in the supplemental materials to this document. Appendix B a) CVP 8–12 mm Hg
shows a flowchart of the COI disclosure process. Committee b) MAP ≥ 65 mm Hg
members who were judged to have either financial or nonfi- c) Urine output ≥ 0.5 mL·kg·hr
nancial/academic competing interests were recused during the d) uperior vena cava oxygenation saturation (Scvo2) or
S
closed discussion session and voting session on that topic. Full mixed venous oxygen saturation (Svo2) 70% or 65%,
disclosure and transparency of all committee members’ poten- respectively.
tial conflicts were sought. 2. We suggest targeting resuscitation to normalize lactate in
On initial review, 68 financial conflict of interest (COI)
patients with elevated lactate levels as a marker of tissue
disclosures and 54 nonfinancial disclosures were submitted
hypoperfusion (grade 2C).
by committee members. Declared COI disclosures from 19
members were determined by the COI subcommittee to be Rationale. In a randomized, controlled, single-center study,
not relevant to the guidelines content process. Nine who early quantitative resuscitation improved survival for emer-
were determined to have COI (financial and nonfinancial) gency department patients presenting with septic shock (13).
were adjudicated by group reassignment and requirement Resuscitation targeting the physiologic goals expressed in rec-
to adhere to SSC COI policy regarding discussion or voting ommendation 1 (above) for the initial 6-hr period was associ-
at any committee meetings where content germane to their ated with a 15.9% absolute reduction in 28-day mortality rate.
COI was discussed. Nine were judged as having conflicts This strategy, termed early goal-directed therapy, was evalu-
that could not be resolved solely by reassignment. One of ated in a multicenter trial of 314 patients with severe sepsis in
these individuals was asked to step down from the commit- eight Chinese centers (14). This trial reported a 17.7% absolute
tee. The other eight were assigned to the groups in which reduction in 28-day mortality (survival rates, 75.2% vs. 57.5%,
Critical Care Medicine www.ccmjournal.org 587
9. Dellinger et al
p = 0.001). A large number of other observational studies using generally can be relied upon as supporting positive response to
similar forms of early quantitative resuscitation in comparable fluid loading. Either intermittent or continuous measurements
patient populations have shown significant mortality reduction of oxygen saturation were judged to be acceptable. During
compared to the institutions’ historical controls (Supplemental the first 6 hrs of resuscitation, if Scvo2 less than 70% or Svo2
Digital Content 2, http://links.lww.com/CCM/A615). Phase III equivalent of less than 65% persists with what is judged to be
of the SSC activities, the international performance improve- adequate intravascular volume repletion in the presence of
ment program, showed that the mortality of septic patients persisting tissue hypoperfusion, then dobutamine infusion (to a
presenting with both hypotension and lactate ≥ 4 mmol/L was maximum of 20 μg/kg/min) or transfusion of packed red blood
46.1%, similar to the 46.6% mortality found in the first trial cited cells to achieve a hematocrit of greater than or equal to 30% in
above (15). As part of performance improvement programs, attempts to achieve the Scvo2 or Svo2 goal are options. The strong
some hospitals have lowered the lactate threshold for triggering recommendation for achieving a CVP of 8 mm Hg and an Scvo2
quantitative resuscitation in the patient with severe sepsis, but of 70% in the first 6 hrs of resuscitation of sepsis-induced tissue
these thresholds have not been subjected to randomized trials. hypoperfusion, although deemed desirable, are not yet the
The consensus panel judged use of CVP and Svo2 targets standard of care as verified by practice data. The publication
to be recommended physiologic targets for resuscitation. of the initial results of the international SSC performance
Although there are limitations to CVP as a marker of improvement program demonstrated that adherence to CVP
intravascular volume status and response to fluids, a low CVP and Scvo2 targets for initial resuscitation was low (15).
Table 5. Recommendations: Initial Resuscitation and Infection Issues
A. Initial Resuscitation
1. rotocolized, quantitative resuscitation of patients with sepsis- induced tissue hypoperfusion (defined in this document as hypotension
P
persisting after initial fluid challenge or blood lactate concentration ≥ 4 mmol/L). Goals during the first 6 hrs of resuscitation:
a) Central venous pressure 8–12 mm Hg
b) Mean arterial pressure (MAP) ≥ 65 mm Hg
c) Urine output ≥ 0.5 mL/kg/hr
d) Central venous (superior vena cava) or mixed venous oxygen saturation 70% or 65%, respectively (grade 1C).
2. In patients with elevated lactate levels targeting resuscitation to normalize lactate (grade 2C).
B. Screening for Sepsis and Performance Improvement
1. outine screening of potentially infected seriously ill patients for severe sepsis to allow earlier implementation of therapy (grade 1C).
R
2. Hospital–based performance improvement efforts in severe sepsis (UG).
C. Diagnosis
1. ultures as clinically appropriate before antimicrobial therapy if no significant delay ( 45 mins) in the start of antimicrobial(s) (grade
C
1C). At least 2 sets of blood cultures (both aerobic and anaerobic bottles) be obtained before antimicrobial therapy with at least 1 drawn
percutaneously and 1 drawn through each vascular access device, unless the device was recently (48 hrs) inserted (grade 1C).
2. se of the 1,3 beta-D-glucan assay (grade 2B), mannan and anti-mannan antibody assays (2C), if available and invasive
U
candidiasis is in differential diagnosis of cause of infection.
3. Imaging studies performed promptly to confirm a potential source of infection (UG).
D. Antimicrobial Therapy
1. dministration of effective intravenous antimicrobials within the first hour of recognition of septic shock (grade 1B) and severe
A
sepsis without septic shock (grade 1C) as the goal of therapy.
2a. nitial empiric anti-infective therapy of one or more drugs that have activity against all likely pathogens (bacterial and/or fungal or
I
viral) and that penetrate in adequate concentrations into tissues presumed to be the source of sepsis (grade 1B).
2b. Antimicrobial regimen should be reassessed daily for potential deescalation (grade 1B).
3. se of low procalcitonin levels or similar biomarkers to assist the clinician in the discontinuation of empiric antibiotics in patients
U
who initially appeared septic, but have no subsequent evidence of infection (grade 2C).
4a. Combination empirical therapy for neutropenic patients with severe sepsis (grade 2B) and for patients with difficult-to-treat, multidrug-
resistant bacterial pathogens such as Acinetobacter and Pseudomonas spp. (grade 2B). For patients with severe infections
associated with respiratory failure and septic shock, combination therapy with an extended spectrum beta-lactam and either an
aminoglycoside or a fluoroquinolone is for P. aeruginosa bacteremia (grade 2B). A combination of beta-lactam and macrolide for
patients with septic shock from bacteremic Streptococcus pneumoniae infections (grade 2B).
(Continued)
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10. Special Article
Table 5. (Continued) Recommendations: Initial Resuscitation and Infection Issues
4b. mpiric combination therapy should not be administered for more than 3–5 days. De-escalation to the most appropriate single
E
therapy should be performed as soon as the susceptibility profile is known (grade 2B).
5. Duration of therapy typically 7–10 days; longer courses may be appropriate in patients who have a slow clinical response,
undrainable foci of infection, bacteremia with S. aureus; some fungal and viral infections or immunologic deficiencies, including
neutropenia (grade 2C).
6. Antiviral therapy initiated as early as possible in patients with severe sepsis or septic shock of viral origin (grade 2C).
7. Antimicrobial agents should not be used in patients with severe inflammatory states determined to be of noninfectious cause
(UG).
E. Source Control
1. A specific anatomical diagnosis of infection requiring consideration for emergent source control be sought and diagnosed or
excluded as rapidly as possible, and intervention be undertaken for source control within the first 12 hr after the diagnosis is
made, if feasible (grade 1C).
2. When infected peripancreatic necrosis is identified as a potential source of infection, definitive intervention is best delayed until
adequate demarcation of viable and nonviable tissues has occurred (grade 2B).
3. When source control in a severely septic patient is required, the effective intervention associated with the least physiologic insult
should be used (eg, percutaneous rather than surgical drainage of an abscess) (UG).
4. f intravascular access devices are a possible source of severe sepsis or septic shock, they should be removed promptly after
I
other vascular access has been established (UG).
F. Infection Prevention
1a. elective oral decontamination and selective digestive decontamination should be introduced and investigated as a method to
S
reduce the incidence of ventilator-associated pneumonia; This infection control measure can then be instituted in health care
settings and regions where this methodology is found to be effective (grade 2B).
1b. ral chlorhexidine gluconate be used as a form of oropharyngeal decontamination to reduce the risk of ventilator-associated
O
pneumonia in ICU patients with severe sepsis (grade 2B).
In mechanically ventilated patients or those with known fluid responsiveness during resuscitation, including flow and
preexisting decreased ventricular compliance, a higher target possibly volumetric indices and microcirculatory changes,
CVP of 12 to 15 mm Hg should be achieved to account for may have advantages (29–32). Available technologies allow
the impediment in filling (16). Similar consideration may be measurement of flow at the bedside (33, 34); however, the effi-
warranted in circumstances of increased abdominal pressure cacy of these monitoring techniques to influence clinical out-
(17). Elevated CVP may also be seen with preexisting clini- comes from early sepsis resuscitation remains incomplete and
cally significant pulmonary artery hypertension, making use requires further study before endorsement.
of this variable untenable for judging intravascular volume The global prevalence of severe sepsis patients initially pre-
status. Although the cause of tachycardia in septic patients senting with either hypotension with lactate ≥ 4 mmol//L, hypo-
may be multifactorial, a decrease in elevated pulse rate with tension alone, or lactate ≥ 4 mmol/L alone, is reported as 16.6%,
fluid resuscitation is often a useful marker of improving intra- 49.5%, and 5.4%, respectively (15). The mortality rate is high in
vascular filling. Published observational studies have dem- septic patients with both hypotension and lactate ≥ 4 mmol/L
onstrated an association between good clinical outcome in (46.1%) (15), and is also increased in severely septic patients
septic shock and MAP ≥ 65 mm Hg as well as Scvo2 ≥ 70% with hypotension alone (36.7%) and lactate ≥ 4 mmol/L alone
(measured in the superior vena cava, either intermittently or (30%) (15). If Scvo2 is not available, lactate normalization may
continuously [18]). Many studies support the value of early be a feasible option in the patient with severe sepsis-induced
protocolized resuscitation in severe sepsis and sepsis-induced tissue hypoperfusion. Scvo2 and lactate normalization may also
tissue hypoperfusion (19–24). Studies of patients with shock be used as a combined endpoint when both are available. Two
indicate that Svo2 runs 5% to 7% lower than Scvo2 (25). While multicenter randomized trials evaluated a resuscitation strat-
the committee recognized the controversy surrounding egy that included lactate reduction as a single target or a tar-
resuscitation targets, an early quantitative resuscitation pro- get combined with Scvo2 normalization (35, 36). The first trial
tocol using CVP and venous blood gases can be readily estab- reported that early quantitative resuscitation based on lactate
lished in both emergency department and ICU settings (26). clearance (decrease by at least 10%) was noninferior to early
Recognized limitations to static ventricular filling pressure quantitative resuscitation based on achieving Scvo2 of 70% or
estimates exist as surrogates for fluid resuscitation (27, 28), but more (35). The intention-to-treat group contained 300, but the
measurement of CVP is currently the most readily obtainable number of patients actually requiring either Scvo2 normalization
target for fluid resuscitation. Targeting dynamic measures of or lactate clearance was small (n = 30). The second trial included
Critical Care Medicine www.ccmjournal.org 589
11. Dellinger et al
348 patients with lactate levels ≥ 3 mmol/L (36). The strategy in 32,000 patient charts gathered from 239 hospitals in 17 countries
this trial was based on a greater than or equal to 20% decrease through September 2011 as part of phase III of the campaign
in lactate levels per 2 hrs of the first 8 hrs in addition to Scvo2 informed the revision of the bundles in conjunction with the
target achievement, and was associated with a 9.6% absolute 2012 guidelines. As a result, for the 2012 version, the management
reduction in mortality (p = 0.067; adjusted hazard ratio, 0.61; bundle was dropped and the resuscitation bundle was broken into
95% CI, 0.43−0.87; p = 0.006). two parts and modified as shown in Figure 1. For performance
B. Screening for Sepsis and Performance improvement quality indicators, resuscitation target thresholds
Improvement are not considered. However, recommended targets from the
guidelines are included with the bundles for reference purposes.
1. We recommend routine screening of potentially infected
seriously ill patients for severe sepsis to increase the early C. Diagnosis
identification of sepsis and allow implementation of early 1. We recommend obtaining appropriate cultures before anti-
sepsis therapy (grade 1C). microbial therapy is initiated if such cultures do not cause sig-
Rationale. The early identification of sepsis and imple- nificant delay ( 45 minutes) in the start of antimicrobial(s)
mentation of early evidence-based therapies have been doc- administration (grade 1C). To optimize identification of caus-
umented to improve outcomes and decrease sepsis-related ative organisms, we recommend obtaining at least two sets of
mortality (15). Reducing the time to diagnosis of severe sepsis blood cultures (both aerobic and anaerobic bottles) before
is thought to be a critical component of reducing mortality antimicrobial therapy, with at least one drawn percutaneously
from sepsis-related multiple organ dysfunction (35). Lack of and one drawn through each vascular access device, unless
early recognition is a major obstacle to sepsis bundle initiation. the device was recently ( 48 hours) inserted. These blood
Sepsis screening tools have been developed to monitor ICU cultures can be drawn at the same time if they are obtained
patients (37–41), and their implementation has been associ- from different sites. Cultures of other sites (preferably quan-
ated with decreased sepsis-related mortality (15). titative where appropriate), such as urine, cerebrospinal fluid,
wounds, respiratory secretions, or other body fluids that may
2. Performance improvement efforts in severe sepsis should be
be the source of infection, should also be obtained before
used to improve patient outcomes (UG).
antimicrobial therapy if doing so does not cause significant
Rationale. Performance improvement efforts in sepsis have delay in antibiotic administration (grade 1C).
been associated with improved patient outcomes (19, 42–46).
Improvement in care through increasing compliance with sep- Rationale. Although sampling should not delay timely
sis quality indicators is the goal of a severe sepsis performance administration of antimicrobial agents in patients with severe
improvement program (47). Sepsis management requires a mul- sepsis (eg, lumbar puncture in suspected meningitis), obtain-
tidisciplinary team (physicians, nurses, pharmacy, respiratory, ing appropriate cultures before administration of antimicrobials
dieticians, and administration) and multispecialty collaboration is essential to confirm infection and the responsible pathogens,
(medicine, surgery, and emergency medicine) to maximize the and to allow de-escalation of antimicrobial therapy after receipt
chance for success. Evaluation of process change requires consis- of the susceptibility profile. Samples can be refrigerated or fro-
tent education, protocol development and implementation, data zen if processing cannot be performed immediately. Because
collection, measurement of indicators, and feedback to facilitate rapid sterilization of blood cultures can occur within a few
the continuous performance improvement. Ongoing educational hours after the first antimicrobial dose, obtaining those cultures
sessions provide feedback on indicator compliance and can help before therapy is essential if the causative organism is to be iden-
identify areas for additional improvement efforts. In addition to tified. Two or more blood cultures are recommended (51). In
traditional continuing medical education efforts to introduce patients with indwelling catheters (for more than 48 hrs), at least
guidelines into clinical practice, knowledge translation efforts one blood culture should be drawn through each lumen of each
have recently been introduced as a means to promote the use of vascular access device (if feasible, especially for vascular devices
high-quality evidence in changing behavior (48). Protocol imple- with signs of inflammation, catheter dysfunction, or indicators
mentation associated with education and performance feedback of thrombus formation). Obtaining blood cultures peripherally
has been shown to change clinician behavior and is associated and through a vascular access device is an important strategy. If
with improved outcomes and cost-effectiveness in severe sepsis the same organism is recovered from both cultures, the likeli-
(19, 23, 24, 49). In partnership with the Institute for Healthcare hood that the organism is causing the severe sepsis is enhanced.
Improvement, phase III of the Surviving Sepsis Campaign targeted In addition, if equivalent volumes of blood drawn for cul-
the implementation of a core set (“bundle”) of recommendations ture and the vascular access device is positive much earlier than
in hospital environments where change in behavior and clinical the peripheral blood culture (ie, more than 2 hrs earlier), the
impact were measured (50). The SSC guidelines and bundles can data support the concept that the vascular access device is the
be used as the basis of a sepsis performance improvement program. source of the infection (36, 51, 52). Quantitative cultures of
Application of the SSC sepsis bundles led to sustained, catheter and peripheral blood may also be useful for determin-
continuous quality improvement in sepsis care and was associated ing whether the catheter is the source of infection. The volume
with reduced mortality (15). Analysis of the data from nearly of blood drawn with the culture tube should be ≥ 10 mL (53).
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12. Special Article
Rationale. The diagnosis of
SURVIVING SEPSIS CAMPAIGN BUNDLES
systemic fungal infection (usu-
TO BE COMPLETED WITHIN 3 HOURS: ally candidiasis) in the critically
1) Measure lactate level ill patient can be challenging,
2) Obtain blood cultures prior to administration of antibiotics
3) Administer broad spectrum antibiotics and rapid diagnostic methodolo-
4) Administer 30 mL/kg crystalloid for hypotension or lactate 4mmol/L gies, such as antigen and antibody
detection assays, can be helpful in
TO BE COMPLETED WITHIN 6 HOURS:
5) Apply vasopressors (for hypotension that does not respond to initial fluid resuscitation) detecting candidiasis in the ICU
to maintain a mean arterial pressure (MAP) ≥ 65 mm Hg patient. These suggested tests have
6) In the event of persistent arterial hypotension despite volume resuscitation (septic
shown positive results significantly
shock) or initial lactate 4 mmol/L (36 mg/dL):
- Measure central venous pressure (CVP)* earlier than standard culture meth-
- Measure central venous oxygen saturation (ScvO2)* ods (62–67), but false-positive
7) Remeasure lactate if initial lactate was elevated*
reactions can occur with coloni-
*Targets for quantitative resuscitation included in the guidelines are CVP of ≥8 mm Hg, zation alone, and their diagnostic
ScvO2 of 70%, and normalization of lactate. utility in managing fungal infec-
tion in the ICU needs additional
Figure 1. Surviving Sepsis Campaign Care Bundles.
study (65).
Quantitative (or semiquantitative) cultures of respiratory tract 3. We recommend that imaging studies be performed
secretions are often recommended for the diagnosis of venti- promptly in attempts to confirm a potential source of infec-
lator-associated pneumonia (54), but their diagnostic value tion. Potential sources of infection should be sampled as
remains unclear (55). they are identified and in consideration of patient risk for
The Gram stain can be useful, in particular for respiratory transport and invasive procedures (eg, careful coordination
tract specimens, to determine if inflammatory cells are pres- and aggressive monitoring if the decision is made to trans-
ent (greater than five polymorphonuclear leukocytes/high- port for a CT-guided needle aspiration). Bedside studies,
powered field and less than ten squamous cells/low-powered such as ultrasound, may avoid patient transport (UG).
field) and if culture results will be informative of lower respi-
Rationale. Diagnostic studies may identify a source of
ratory pathogens. Rapid influenza antigen testing during peri-
infection that requires removal of a foreign body or drainage to
ods of increased influenza activity in the community is also
maximize the likelihood of a satisfactory response to therapy.
recommended. A focused history can provide vital informa-
Even in the most organized and well-staffed healthcare facili-
tion about potential risk factors for infection and likely patho-
ties, however, transport of patients can be dangerous, as can
gens at specific tissue sites. The potential role of biomarkers
be placing patients in outside-unit imaging devices that are
for diagnosis of infection in patients presenting with severe
difficult to access and monitor. Balancing risk and benefit is
sepsis remains undefined. The utility of procalcitonin levels or
therefore mandatory in those settings.
other biomarkers (such as C-reactive protein) to discriminate
the acute inflammatory pattern of sepsis from other causes of D. Antimicrobial Therapy
generalized inflammation (eg, postoperative, other forms of 1. The administration of effective intravenous antimicrobials
shock) has not been demonstrated. No recommendation can within the first hour of recognition of septic shock (grade
be given for the use of these markers to distinguish between 1B) and severe sepsis without septic shock (grade 1C)
severe infection and other acute inflammatory states (56–58). should be the goal of therapy. Remark: Although the weight
In the near future, rapid, non-culture-based diagnostic meth- of the evidence supports prompt administration of antibi-
ods (polymerase chain reaction, mass spectroscopy, microar- otics following the recognition of severe sepsis and septic
rays) might be helpful for a quicker identification of pathogens shock, the feasibility with which clinicians may achieve this
and major antimicrobial resistance determinants (59). These ideal state has not been scientifically evaluated.
methodologies could be particularly useful for difficult-to-cul-
ture pathogens or in clinical situations where empiric antimi- Rationale. Establishing vascular access and initiating
crobial agents have been administered before culture samples aggressive fluid resuscitation are the first priorities when
were been obtained. Clinical experience remains limited, and managing patients with severe sepsis or septic shock. Prompt
more clinical studies are needed before recommending these infusion of antimicrobial agents should also be a priority and
non-culture molecular methods as a replacement for standard may require additional vascular access ports (68, 69). In the
presence of septic shock, each hour delay in achieving admin-
blood culture methods (60, 61).
istration of effective antibiotics is associated with a measurable
2. We suggest the use of the 1,3 β-d-glucan assay (grade 2B), increase in mortality in a number of studies (15, 68, 70–72).
mannan and anti-mannan antibody assays (grade 2C) Overall, the preponderance of data support giving antibiot-
when invasive candidiasis is in the differential diagnosis of ics as soon as possible in patients with severe sepsis with or
infection. without septic shock (15, 68, 70–77). The administration of
Critical Care Medicine www.ccmjournal.org 591
13. Dellinger et al
antimicrobial agents with a spectrum of activity likely to treat of amphotericin B) should be tailored to the local pattern of
the responsible pathogen(s) effectively within 1 hr of the diag- the most prevalent Candida species and any recent exposure
nosis of severe sepsis and septic shock. Practical considerations, to antifungal drugs (78). Recent Infectious Diseases Society
for example challenges with clinicians’ early identification of of America (IDSA) guidelines recommend either fluconazole
patients or operational complexities in the drug delivery chain, or an echinocandin. Empiric use of an echinocandin is pre-
represent unstudied variables that may impact achieving this ferred in most patients with severe illness, especially in those
goal. Future trials should endeavor to provide an evidence base patients who have recently been treated with antifungal agents,
in this regard. This should be the target goal when managing or if Candida glabrata infection is suspected from earlier cul-
patients with septic shock, whether they are located within the ture data. Knowledge of local resistance patterns to antifungal
hospital ward, the emergency department, or the ICU. The agents should guide drug selection until fungal susceptibility
strong recommendation for administering antibiotics within 1 test results, if available, are performed. Risk factors for candi-
hr of the diagnosis of severe sepsis and septic shock, although demia, such as immunosuppressed or neutropenic state, prior
judged to be desirable, is not yet the standard of care as verified intense antibiotic therapy, or colonization in multiple sites,
by published practice data (15). should also be considered when choosing initial therapy.
If antimicrobial agents cannot be mixed and delivered promptly Because patients with severe sepsis or septic shock have little
from the pharmacy, establishing a supply of premixed antibiotics margin for error in the choice of therapy, the initial selection
for such urgent situations is an appropriate strategy for ensuring of antimicrobial therapy should be broad enough to cover all
prompt administration. Many antibiotics will not remain stable if likely pathogens. Antibiotic choices should be guided by local
premixed in a solution. This risk must be taken into consideration prevalence patterns of bacterial pathogens and susceptibility
in institutions that rely on premixed solutions for rapid availabil- data. Ample evidence exists that failure to initiate appropriate
ity of antibiotics. In choosing the antimicrobial regimen, clinicians therapy (ie, therapy with activity against the pathogen that is
should be aware that some antimicrobial agents have the advan- subsequently identified as the causative agent) correlates with
tage of bolus administration, while others require a lengthy infu- increased morbidity and mortality in patients with severe sep-
sion. Thus, if vascular access is limited and many different agents sis or septic shock (68, 71, 79, 80). Recent exposure to anti-
must be infused, bolus drugs may offer an advantage. microbials (within last 3 months) should be considered in
the choice of an empiric antibacterial regimen. Patients with
2a. We recommend that initial empiric anti-infective therapy
severe sepsis or septic shock warrant broad-spectrum therapy
include one or more drugs that have activity against all
until the causative organism and its antimicrobial susceptibili-
likely pathogens (bacterial and/or fungal or viral) and that
ties are defined. Although a global restriction of antibiotics is
penetrate in adequate concentrations into the tissues pre-
an important strategy to reduce the development of antimi-
sumed to be the source of sepsis (grade 1B).
crobial resistance and to reduce cost, it is not an appropri-
Rationale. The choice of empirical antimicrobial therapy ate strategy in the initial therapy for this patient population.
depends on complex issues related to the patient’s history, However, as soon as the causative pathogen has been identi-
including drug intolerances, recent receipt of antibiotics (previ- fied, de-escalation should be performed by selecting the most
ous 3 months), underlying disease, the clinical syndrome, and appropriate antimicrobial agent that covers the pathogen
susceptibility patterns of pathogens in the community and hos- and is safe and cost-effective. Collaboration with antimicro-
pital, and that previously have been documented to colonize bial stewardship programs, where they exist, is encouraged to
or infect the patient. The most common pathogens that cause ensure appropriate choices and rapid availability of effective
septic shock in hospitalized patients are Gram-positive bac- antimicrobials for treating septic patients. All patients should
teria, followed by Gram-negative and mixed bacterial micro- receive a full loading dose of each agent. Patients with sepsis
organisms. Candidiasis, toxic shock syndromes, and an array often have abnormal and vacillating renal or hepatic function,
of uncommon pathogens should be considered in selected or may have abnormally high volumes of distribution due to
patients. An especially wide range of potential pathogens exists aggressive fluid resuscitation, requiring dose adjustment. Drug
for neutropenic patients. Recently used anti-nfective agents
i serum concentration monitoring can be useful in an ICU set-
should generally be avoided. When choosing empirical therapy, ting for those drugs that can be measured promptly. Significant
clinicians should be cognizant of the virulence and growing expertise is required to ensure that serum concentrations max-
prevalence of oxacillin (methicillin)-esistant Staphylococcus
r imize efficacy and minimize toxicity (81, 82).
aureus, and resistance to broad-spectrum beta-lactams and car-
2b. The antimicrobial regimen should be reassessed daily for
bapenem among Gram-negative bacilli in some communities
potential de-escalation to prevent the development of resis-
and healthcare settings. Within regions in which the prevalence
tance, to reduce toxicity, and to reduce costs (grade 1B).
of such drug-resistant organisms is significant, empiric therapy
adequate to cover these pathogens is warranted. Rationale. Once the causative pathogen has been identified,
Clinicians should also consider whether candidemia is a the most appropriate antimicrobial agent that covers the pathogen
likely pathogen when choosing initial therapy. When deemed and is safe and cost-effective should be selected. On occasion,
warranted, the selection of empirical antifungal therapy (eg, an continued use of specific combinations of antimicrobials
echinocandin, triazoles such as fluconazole, or a formulation might be indicated even after susceptibility testing is available
592 www.ccmjournal.org February 2013 • Volume 41 • Number 2