This document discusses three projects - SOFIA, SMARCOS, and CHIRON - that aim to drive innovation in smart spaces through interoperability. The SOFIA project provides principles, platforms, and design kits to enable cross-domain application interoperability. The SMARCOS project applies SOFIA's technology for attentive personal systems and complex systems control. The CHIRON project uses a middleware from SOFIA to support healthcare with an integrated framework for person-centric health management over the full care cycle.