The document discusses two hospitals, Mayo Clinic and Cincinnati Children's Hospital, that have experience using patent-pending pharmacogenomic technologies. Both hospitals have genotyped over 5,000 and 7,000 patients, respectively, and use the genetic insights routinely in clinical care. The document also discusses AssureRx Health, a privately-held company with investments from several venture capital firms, and its GeneSightRx test which provides a pharmacogenomic analysis and treatment support for antidepressant and antipsychotic medications. Clinical trials show GeneSightRx improves antidepressant response rates compared to treatment as usual.
WASHINGTON, D.C.—Use of certain doses of atopaxar in acute coronary syndrome patients can reduce rates of bleeding, cardiovascular events and better achieve platelet inhibition, according to the results of the LANCELOT-ACS trial presented Sept. 23 as a late-breaking clinical trial during the 2010 Transcatheter Cardiovascular Therapeutics (TCT) annual meeting.
www.cardiovascularbusiness.com/topics/coronary-intervention-surgery/tct-lancelot-acs-says-certain-doses-atopaxar-can-reduce-bleeding-cv-events
Axel Grothey, M.D., Professor of Oncology; Consultant, Medical Oncology, Mayo Clinic
New Perspectives in GI Malignancies
Presented at New Frontiers in the Management of Solid and Liquid Tumors hosted by the John Theurer Cancer Center at Hackensack University Medical Center. jtcancercenter.org/CME
WASHINGTON, D.C.—Use of certain doses of atopaxar in acute coronary syndrome patients can reduce rates of bleeding, cardiovascular events and better achieve platelet inhibition, according to the results of the LANCELOT-ACS trial presented Sept. 23 as a late-breaking clinical trial during the 2010 Transcatheter Cardiovascular Therapeutics (TCT) annual meeting.
www.cardiovascularbusiness.com/topics/coronary-intervention-surgery/tct-lancelot-acs-says-certain-doses-atopaxar-can-reduce-bleeding-cv-events
Axel Grothey, M.D., Professor of Oncology; Consultant, Medical Oncology, Mayo Clinic
New Perspectives in GI Malignancies
Presented at New Frontiers in the Management of Solid and Liquid Tumors hosted by the John Theurer Cancer Center at Hackensack University Medical Center. jtcancercenter.org/CME
Susan O'Brien, M.D., Professor, Dept. of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center: Newest Strategies in the Treatment of CML/CLL presented at New Frontiers in the Management of Solid and Liquid Tumors hosted by the John Theurer Cancer Center at Hackensack University Medical Center.
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Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. The term pharmacogenetics is often used interchangeably with the term pharmacogenomics which also investigates the role of acquired and inherited genetic differences in relation to drug response and drug behavior through a systematic examination of genes, gene products, and inter- and intra-individual variation in gene expression and function.
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Impedance and EFP recordings of iCell Cardiomyocytes2 on the CardioExcyte 96Ali Obergrussberger
Impedance and EFP recordings of ICell Cardiomyocytes2 on the CardioExcyte 96. iCell Cardiomyocytes2 from Cellular Dynamics International were monitored on the CardioExcyte 96 in impedance and EFP modes over several days. After 4 days the impedance and EFP signals had stabilised and pharmacology experiments were performed. The effect of isoproterenol and E4031 on the impedance and EFP signals is shown in this Application Note. Impedance and EFP measurements are receiving increasing interest for safety testing of potential drug candidates and the use of human induced pluripotent stem cell-derived cardiomyocytes is ideally suited to these measurements. For more information about the CardioExcyte 96 visit our website: http://www.nanion.de/products/cardioexcyte-96.html.
Escitalopram Tablets 5mg/10mg/20mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Escitalopram Dosage & Rx Info | Escitalopram Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Escitalopram-Drug Information –Taj Pharma, Escitalopram dose Taj pharmaceuticals Escitalopram interactions, Taj Pharmaceutical Escitalopram contraindications, Escitalopram price, Escitalopram Taj Pharma Escitalopram SmPC-Taj Pharma Stay connected to all updated on Escitalopram Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Susan O'Brien, M.D., Professor, Dept. of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center: Newest Strategies in the Treatment of CML/CLL presented at New Frontiers in the Management of Solid and Liquid Tumors hosted by the John Theurer Cancer Center at Hackensack University Medical Center.
Erlotinib 100 mg, 150mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
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Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. The term pharmacogenetics is often used interchangeably with the term pharmacogenomics which also investigates the role of acquired and inherited genetic differences in relation to drug response and drug behavior through a systematic examination of genes, gene products, and inter- and intra-individual variation in gene expression and function.
Erlotinib Tablet USP 25mg/100mg/150mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Erlotinib Dosage & Rx Info | Erlotinib Uses, Side Effects Erlotinib: Indications, Side Effects, Warnings, Erlotinib -Drug Information –Taj Pharma, Erlotinib dose Taj pharmaceuticals Erlotinib interactions, Taj Pharmaceutical Erlotinib contraindications, Erlotinib price, Erlotinib Taj Pharma Erlotinib SmPC-Taj Pharma Stay connected to all updated on Erlotinib Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Impedance and EFP recordings of iCell Cardiomyocytes2 on the CardioExcyte 96Ali Obergrussberger
Impedance and EFP recordings of ICell Cardiomyocytes2 on the CardioExcyte 96. iCell Cardiomyocytes2 from Cellular Dynamics International were monitored on the CardioExcyte 96 in impedance and EFP modes over several days. After 4 days the impedance and EFP signals had stabilised and pharmacology experiments were performed. The effect of isoproterenol and E4031 on the impedance and EFP signals is shown in this Application Note. Impedance and EFP measurements are receiving increasing interest for safety testing of potential drug candidates and the use of human induced pluripotent stem cell-derived cardiomyocytes is ideally suited to these measurements. For more information about the CardioExcyte 96 visit our website: http://www.nanion.de/products/cardioexcyte-96.html.
Escitalopram Tablets 5mg/10mg/20mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Escitalopram Dosage & Rx Info | Escitalopram Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Escitalopram-Drug Information –Taj Pharma, Escitalopram dose Taj pharmaceuticals Escitalopram interactions, Taj Pharmaceutical Escitalopram contraindications, Escitalopram price, Escitalopram Taj Pharma Escitalopram SmPC-Taj Pharma Stay connected to all updated on Escitalopram Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
1992-93 Oil on Canvass 48"x48"
The Resevoir behind the College Grounds.
Winslow, Me.
When the ice thaws and reflections start to appear - its finally Spring!
Many websites rely on search instead of good information architecture, but many times search isn't well designed. This presentation reviews how to look at site search analytics, metadata and taxonomy, and user testing to improve the internal search
www.3-14.com
pi is the strategic partner of choice to some of the world’s leading life science companies. We offer our clients unique expertise and strategic consultancy of the highest quality.
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And better able to redefine accepted best practice.
To accept no other standard than excellence.
2016 - IGNITE - Being an introvert and at a conference, not as hellish as you...devopsdaysaustin
Ignite presentation by JJ Asghar
I'd like to give some advice on how to deal with conferences as an introvert.
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Side Effects Management for the Ovarian Cancer Communitybkling
Dr. William Tew of Memorial Sloan Kettering Cancer Center discusses how to manage side effects of targeted therapies for ovarian cancer. Dr. Tew also discusses the severity of your side effects, communicating them to your doctor, and the latest information on symptom-tracking tools.
Personalized medicine involves the prescription of specific therapeutics best suited for an individual based on their genetic or proteomic profile. This talk discusses current approaches in drug discovery/development, the role of genetics in drug metabolism, and lawful/ethical issues surrounding the deployment of new health technology. I highlight some bioinformatic roles in the drug discovery process, and discuss the use of semantic web technologies for data integration and knowledge discovery..
Overview of intravenous anti-epileptic drugs, including benzodiazepine(BZD), phenytoin, valproate, levetiracetam, phenobarbital, lacosamide and general anesthetics.
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pharmacogenomics is a new drug discovry approach. It is the study of how genes affect a person's response to drugs, combining pharmacology and genomics
Most current highly active antiretroviral therapy (HAART) regimens for HIV-positive patients contain two nucleoside reverse transcriptase inhibitors (NRTIs) with either a Protease inhibitor (PIs) or a non-nucleoside reverse transcriptase inhibitors (NNRTI). Notwithstanding the regulatory guidelines recommending therapeutic drug monitoring (TDM) for these drugs, therapeutic failure is a very serious concern implying drug induced toxicity and more importantly viral rebound and viral resistance.
Single dose, steady state and dose ranging studies have all more or less demonstrated that there is a positive correlation between plasma concentrations and therapeutic effects of anti-retrovirals (ARVs). However, one of the main challenges still seems to be the target concentrations for these drugs and their relevant inhibitory quotient. In this talk, we are going to examine these issues along with bioanalytical challenges, drug-effect and drug –toxicity relationships and finally drug-drug interactions within different HAART regimes.
4. Lifetime prevalence of psychiatric illnesses
Eating Disorders 1-3%
PTSD 3.5%
ADHD 4.1 %
Mood Disorders 9.5%
Anxiety Disorders 15%
Cancer (All) 3.7%
Coronary Heart Disease 5.6%
Diabetes 8%
0 5 10 1 20
5
Percentage of US Population
Two-fold greater aggregate prevalence of psychiatric illness vs
cancer, cardiovascular, or metabolic disorders (NIMH, 2009; Am. Cancer
Society 2006; Am. Diabetes Assn, 2008; Am. Heart Assn, 2006, Lindner Center of
Hope, Cincinnati, OH).
5. CYP450 Metabolizer Phenotypes
ULTRA-RAPID: Increased expression of a metabolizing
enzyme, and will metabolize a drug at a rapid rate.
EXTENSIVE: Wild type or “normal” phenotype,
in some cases.
INTERMEDIATE: An individual who possesses one semi-
functional or non-functional allele
POOR: An individual with decreased or no expression
of a metabolizing enzyme, and metabolize a drug very
slowly or not at all.
7. Using the GeneSightRx® treatment-support
solution for medication selection
e-Test ordered
Web-based patient report
Proprietary
Algorithm
PGx Sample
Clinical Laboratory Improvement
Amendments (CLIA) compliant
College of American Pathologists
(CAP) accredited
Certified by the New York
Department of Health
8. GeneSightRx® Psychotropic Test
Genotype Phenotype Interpretive Drug Medication
Sorting Binning
CYP2D6 Metabolizer Status Use as
Directed
CYP2C19 Metabolizer Status
CYP2C9 Metabolizer Status Effect of
Composite
Use with
Phenotype on
CYP1A2 Metabolizer Status Caution
Each Drug
SLC6A4 Transporter Activity
Use with Caution and
5HTR2A Receptor Activity More Frequent
Monitoring
1. The patient’s genotype is determined for each gene in the panel
2. A phenotype is predicted for each genotype
3. A composite phenotype for each drug is created based on all 6
phenotypes
4. The 19 most commonly prescribed antidepressants and 13
antipsychotics are positioned in a green, yellow, or red “bin”.
10. Meta-analysis: GeneSightRx
improves 8 week antidepressant response
A meta-analysis of 3 independent, prospective, controlled studies of GeneSightRx-
managed patients shows a 28% reduction in the rate of failure among patients who
had previously failed pharmacotherapy for MDD.
11. Cost benefits of improving therapeutic response
with GeneSightRx®
Direct medical costs and productivity costs
Fail to
Annual MDD costs per patient Respond
respond
Annual direct medical costs per patient $12,155 $5,755
Pharmacy - Depression drug costs $1,246 $429
Inpatient $2,600 $1,283
Outpatient Physician $6,053 $1,913
Other $2,256 $2,130
Employer productivity costs $4,973 $1,015
Productivity $504 $278
Absenteeism $4,469 $737
Annual medical & productivity cost/pt $17,128 $6,770
Comparisons of TAU and GeneSightRx TAU GSRx
Failure to respond rate 79% 51%
Response rate 21% 47%
12. Conclusions
Prospective, randomized double-blind clinical trials show that
GeneSightRx® improves antidepressant efficacy compared to
patients who receive treatment as usual (TAU).
Efficacy improvement is greatest for patients on multiple
medications (likely to be treatment-resistant), and those
identified by the test to be taking problematic, red-binned
drugs (data not shown).
GeneSightRx® is a rapid and effective pharmacogenomic
decision support tool, and can be used for cohort stratification
prior to clinical trials.
18. Trends in NGS and Drug Development
1. Precompetitive data sharing using collaborative informatics:
• tranSMART
• TransCelerate BioPharma
2. Nanopore-based, single molecule sequencing.
1. Improved understanding of human variation of all types–
“it isn't just the SNPs anymore.”
AssureRx Health, Inc. CONFIDENTIAL 18
19. Applications in Drug Discovery
“The ideal nucleic acid sequencing technology for drug discovery
and development should:
• Sequence natural DNA/RNA fragments of various sizes fully with
minimal (or no) errors
• Haplotype phasing on a chromosome scale;
• Generate no sequence-dependent or other biases;
• Require minimum quantities of input material, ideally single cells;
• Have high/complete efficiency in all of the sequencing steps;
• Detect modified nucleotides (such as methylated cytosines)
directly;
• Operate in laboratories and low-resource settings without special
external environment requirements such as temperature and
humidity control.” – Mike Braxenthaler, Roche and Pistoia Alliance
AssureRx Health, Inc. CONFIDENTIAL 19
20. The Biggest Problem we can’t solve
Potential for Drug-Drug Interactions!
Number of Patients Aged 18-24 / VA Med. Ctr.
Average number of prescription drugs per day
3,125 5,860 6,001 12, 392
average average average average
number of number of number of number of
drugs each drugs each drugs each drugs each
day =19 day = 15 day = 12 day = 7
AssureRx Health, Inc. CONFIDENTIAL 20
Editor's Notes
Prevalence of mental illness (NIMH 2009):Eating disorders 1-3% of population (includes three basic types: anorexia nervosa, bulimia nervosa and binge-eating disorder). 90% female. While it’s not a highly prevalent disorder, it is deadly. Over a decade, the mortality rate for people with anorexia is 5.6% which is about 12 times higher than the annual death rate due to all causes of death among females age 15-24. PTSD: 3.5% or 7.7 M AmericansADHD: one of most common disorders in children and adolescents also affect 4.1% adults in a given yearMood Disorders include all forms of depression and bipolar disorder 9.5% or 20.9 million adults in a given year have a mood disorderAnxiety Disorders: include panic disorder, general anxiety disorder, OCD,phobias 33 million peopleFor comparisonAll forms of Cancer 3.7% or 11 millionDiabetes 8% or 23.5 million Statistics from the American Heart Association Estimates for the year 2006 gave the breakdown for that year as follows - In 2006, among those who had heart disease, approximately 73.6 million suffered from high blood pressure, 16.8 million had coronary artery disease (i.e. had experienced an acute heart attack or had active angina or chest pain), 6.5 million had dealt with a stroke, and 5.7 million had experienced heart failure. American Cancer FoundationAmerican Diabetes AssociationAmerican Heart Association
Prevalence of mental illness (NIMH 2009):Eating disorders 1-3% of population (includes three basic types: anorexia nervosa, bulimia nervosa and binge-eating disorder). 90% female. While it’s not a highly prevalent disorder, it is deadly. Over a decade, the mortality rate for people with anorexia is 5.6% which is about 12 times higher than the annual death rate due to all causes of death among females age 15-24. PTSD: 3.5% or 7.7 M AmericansADHD: one of most common disorders in children and adolescents also affect 4.1% adults in a given yearMood Disorders include all forms of depression and bipolar disorder 9.5% or 20.9 million adults in a given year have a mood disorderAnxiety Disorders: include panic disorder, general anxiety disorder, OCD,phobias 33 million peopleFor comparisonAll forms of Cancer 3.7% or 11 millionDiabetes 8% or 23.5 million Statistics from the American Heart Association Estimates for the year 2006 gave the breakdown for that year as follows - In 2006, among those who had heart disease, approximately 73.6 million suffered from high blood pressure, 16.8 million had coronary artery disease (i.e. had experienced an acute heart attack or had active angina or chest pain), 6.5 million had dealt with a stroke, and 5.7 million had experienced heart failure. American Cancer FoundationAmerican Diabetes AssociationAmerican Heart Association