Sesquiterpenes are terpenes that contain 15 carbon atoms. They contain hydrogen and carbon, making them organic compounds. Sesquiterpenes contain 3 isoprene units. Major sesquiterpenes are found in Psidium species. Terpenes and terpenoids can be extracted using traditional methods like maceration and hydrodistillation or modern methods like solvent extraction and supercritical CO2 extraction. Some potential benefits of terpenes and terpenoids found in essential oils include anti-cancer, anti-oxidant, anti-inflammatory, and anti-microbial properties. Some examples discussed are hinokitol, carvacrol, limonene, and myrcene.

1. By,
Navanidhan.M
I M.Sc,Biotechnology
Kongunadu Arts and Science College,
Coimbatore, Tamilnadu

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WHAT ARE SESQUITERPENES? (C15H18O3 )
 They are Terpenes. (C15H24)
 Contain Hydrogen and Carbon which makes them Organic
compound.
 They are C15 terpenoids, contains 3 isoprene units.
2D - Structure Model
Artemisin (C15H18O4 )

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Major sesquiterpenes found
in Psidium species.

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5. EXTRACTION TRADITIONAL
MODERN
MARCERATION
HYDRODISTILATION
PLE
SOLVENT
SOXHLET
SUPER
CRITICAL
CO2
UAE
SFE
MWHD

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SCHEME OF GENERAL WORKFLOW FOLLOWED IN TERPENES AND
TERPENOIDS ANALYSIS ON FOUR IMPORTANT STEPS.

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The methods for extraction, separation, isolation, purification, and determination of the
structural compounds of terpenes and terpenoids.

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The potential benefits of terpenes and terpenoids found in
EOs.

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HINOKITOL
PHARMACEUTICALS COSMETIC
Anti-Cancer
-Inhibits A549 cells.
Plants, Soaps Etce.,
-quenches free radicals
Anti-Oxidant -
 From the woods of Cupracea.
 Widely used in cosmetics, clinic
products and other areas.

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CARVACROL
 Isolated from Origanum vulgare

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LIMONENE
 Isolated from Citrus.
 Anti-Microbial,Anti-Oxidant etc.,
 Has greater effects with Gentamycin Antibiotics.
 Inhibition of Gram (+ve) S.aureus and Gram (-ve) E.coli
and several Resistant bacteria’s

14. MYRCENE
 Inhibit the Over production of Pro-Inflammatory Cytokines.
 Upregulation of Endogenous AO’s and GSH.
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 Found in South African Adenandra villosa.
 Anti-Inflammatory,Anti-Microbial, Anti-
Catabolic.
 Also usewd to traet Diabetes, Diarrhoea,
Dysentry and Hypertension.

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ANTI-INFLAMMATORY

16. CITRONELOL
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 Component from Geranium.
 Used as a component of many
fragrances and food flavourings
for its floral-citrus notes.
 Anti-Allergic.
Inhibits the Degranulation of Mast cells and the IgE induced TNF-
α production.

17. REFERENCES
• Fan M, Yuan S, Li L, Zheng J, Zhao D, Wang C, Wang H, Liu X,
Liu J. Application of Terpenoid Compounds in Food and
Pharmaceutical Products. Fermentation. 2023; 9(2):119.
• Abdallah, Ingy & Quax, Wim. (2017). A Glimpse into the
Biosynthesis of Terpenoids. KnE Life Sciences. 2017. 81-98.
10.18502/kls.v3i5.981.
• Wojtunik-Kulesza, Karolina & Kasprzak, Kamila & Oniszczuk,
Tomasz & Oniszczuk, Anna. (2019). Natural Monoterpenes: Much
More than Only a Scent. Chemistry & Biodiversity. 16.
10.1002/cbdv.201900434.
• Moujir L, Callies O, Sousa PMC, Sharopov F, Seca AML.
Applications of Sesquiterpene Lactones: A Review of Some
Potential Success Cases. Applied Sciences. 2020; 10(9):3001
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