Seminario Biología Molecular
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A venous thrombosis occurs when a blood clot forms in a vein, typically in the legs, thighs, or pelvis. These clots can block blood flow and cause swelling, pain, or break off and travel to the lungs, leading to a pulmonary embolism. The objective of this experimental method is to investigate how the protein composition of blood clots, veins, and immune cells is influenced by exposure to IL-6 or an inhibitor of protein transport. The experiments found that IL-6 plays a crucial role in the resolution of blood clots by promoting the differentiation of monocytes into macrophages that can phagocytose dead cells and debris to facilitate clot dissolution.
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Seminario Biología Molecular
- 1. LISSETH KARINA MARÍN RÍOS 3RD SEMESTER UNIVERSIDAD PONTIFICIA BOLIVARIANA 2024
- 2. A venous thrombosis is a serious condition that occurs when a blood clot forms in a vein, typically in the legs, thighs, or pelvis. These clots can block blood flow and cause swelling, pain, and even break off and travel to the lungs, leading to a life-threatening condition called pulmonary embolism. VENOUS THROMBUS INTRODUCTION
- 3. Function: Acts as both a pro-inflammatory cytokine and an anti- inflammatory myokine (produced by muscle cells) Production: Primarily produced by immune cells like macrophages and T cells, but also by other cell types like endothelial cells and fibroblasts Effects: Stimulates the production of acute phase proteins in the liver during inflammation Plays a role in fever and the acute phase response Regulates various metabolic processes IL-6 INTRODUCTION
- 4. Analyzing experimental resolution of venous thrombus is driven by IL-6- mediated monocyte actions. GENERAL OBJECTIVE
- 5. The objective of this experimental method is to investigate how the protein composition of blood clots (thrombi), the inferior vena cava (IVC), and specific immune cells (BMDMs and RAW264.7) is influenced by exposure to IL-6 (an inflammatory molecule) or Brefeldin A (an inhibitor of protein transport). The objective of this method is to analyze the structure, cellular composition, and components of blood clots (thrombus) formed in the lower back (retroperitoneal area) of mice. METHODS WESTERN BLOTS HISTOLOGY
- 6. The objective of this experimental method is to measure and analyze the levels of specific RNA molecules within cells METHODS FLOW CITOMETRY PCR The objective of this experimental method is to isolate and analyze specific types of immune cells from mice to investigate how they are involved in the process of blood clot formation or resolution
- 7. Following sham surgery or stasis thrombosis, vein wall lysate protein levels Gel blots cropped from different parts of the gel are presented, with white line separation. Protein levels of intrathrombus. Representative photomicrographs at 40 × of WT (left, arrows mark recanalization channels) and IL-6−/− RESULTS
- 8. Quantification of protein levels relative to total protein loading is shown in the upper panels. Protein levels of MMP9 and Urokinase were assayed in the BMDMs
- 9. DISCUSSION From this series of experiments, we have characterized the role of IL-6 in two models of VT which replicate clinical venous thrombosis; namely, partial and complete blood stasis. We found that IL6 gene deletion did not affect thrombus formation, contrary to data suggesting that anti- IL-6 inhibition can impair thrombogenesis . Zhang, Y. (2020) . Deatrick,K.B. (2011) IL-6 has been shown to play a role in thrombogenesis and resolution17,54, but not as a key mediator of fibrinolysis . Stouthard,J.M. (1996) AUTHOR What did they say? AGREE OR DESAGRREE
- 10. Conclusions Interleukin-6 (IL-6) plays a crucial role in the resolution of venous thrombi: The article demonstrates that IL-6 is produced by macrophages at the thrombus site. IL-6 promotes the differentiation of monocytes to macrophages with a pro-resolving phenotype. These pro-resolving macrophages phagocytize (ingest) dead cells and debris, which facilitates dissolution of the thrombus. Implications for the development of new therapies: Strategies that modulate IL-6 signaling or that increase the activity of pro-resolving macrophages could be useful in promoting thrombus dissolution and preventing thrombotic complications.
- 11. * TVP: Trombosis venosa profunda EP: Embolisis Pulmonar Referencias: Mayo Clinic Trombosis venosa profunda (TVP) [Internet]. 2022. Disponible en: https://www.mayoclinic.org/es/diseases-conditions/deep-vein-thrombosis/symptoms-causes/syc-20352557 National Heart, Lung, and Blood Institute. Venous thromboembolism [Internet]. Disponible en: https://www.nhlbi.nih.gov/health/venous-thromboembolism