SEMINAR ON DRUG DESIGN-1.pptx
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This document summarizes key concepts related to drug design. It begins by defining what drugs are and how they are classified based on pharmacological effects, drug action, chemical structure, and molecular targets. It then defines drug design as the logical effort to rationally design drugs to minimize trial and error. The main types of drug design discussed are ligand-based and structure-based drug design. The concepts of prodrugs and soft drugs are introduced, where prodrugs are inactive derivatives that are metabolized into the active drug and soft drugs are designed to reduce side effects by minimizing systemic toxicity. Examples are provided for each major topic.
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SEMINAR ON DRUG DESIGN-1.pptx
- 1. SESSION: 2022-23 TOPIC : DRUG DESIGN Presented by : Pooja Vinod Mohod M.Sc II (SEM - IV) Department of Chemistry
- 2. CONTENT What is mean by drugs? Classification of drugs. What is mean by drug design? Types of drug design Concept of prodrug Concept of soft drug Reference
- 3. WHAT IS MEAN BY DRUGS? Drug Active chemical portion Medicine Diagnosis ,prevention ,treatment, cure of a disease
- 4. CLASSIFICATION OF DRUGS • On the basis of pharmacological • On the basis of drug action • On the basis of chemical structure • On the basis of molecular target
- 5. ON THE BASIS OF PHARMACOLOGICAL EFFECT • ANTIBIOTICS • ANTI HIV • ANTI CANCER • ANTI MALARIA EXAMPLE: ON THE BASIS OF DRUG ACTION HIV REVERSE TRANSCRIP TASE HIV PROTEASE HIV INTEGRASE HIV DRUG
- 6. ON THE BASIS OF CHEMICAL STRUCTURE EXAMPLE: STEROIDS ON THE BASIS OF MOLECULAR TARGET DRUG TARGET THE MACROMOLECULES INSIDE THE BODY TO GENERATE BIOLOGICAL RESPONSE
- 7. WHAT IS MEAN BY DRUG DESIGN? It is the logical effort to design a drug as much a rational basis as possible thus reducing to the minimum trial and error
- 8. TYPES OF DRUG DESIGN LIGAND BASED DRUG DESIGN : It is the knowledge of other molecules that bind to the biological target of interest. STRUCTURE BASED DRUG DESIGN : Identificationof drug target Determination of target structure Identification of binding site Computation drug design methods Evaluation of potential lead candidate
- 9. CONCEPT OF PRODRUG PRODRUG Applied Appropriate derivative Undergoes Vivo hydrolysis To parents drug EXAMPLE:- TESTOSTERONE PROPIONATE
- 10. CONCEPT OF SOFT DRUG THE PURPOSE OF THIS DRUG IS TO REDUCE SIDE EFFECT BY MINIMIZING THE SYSTEMIC TOXICITY OF THE DRUG. IT IS OPPOSITE TO PRODRUG. EXAMPLES: CICLESONIDE
- 11. PREVIOUS YEAR QUESTIONS (Q) What is mean by prodrug? (Q) What is mean by softdrug (Q) Explain drug design with suitable example?
- 12. 1) Medicinal Chemistry by Ashutosh Kar 2) An introduction to drug design by S.N.Pandeya and J.R.Dimmock REFERENCE