Diabetes is increasing worldwide and can negatively impact male fertility. This study examined semen quality in 32 adolescent diabetics compared to controls. Key findings:
- Semen volume, motility, and morphology were significantly lower in diabetics.
- Seminal fructose and glucose levels were significantly higher in diabetics.
- Poor metabolic control and neuropathy were associated with worse semen quality.
- Retinopathy did not correlate with semen quality.
The study suggests diabetes deteriorates semen quality in adolescents, with high blood sugar and nerve damage playing important roles.
Physiology of Male Infertility | Seeds of InnocenceSOI Delhi
Male Infertility is a inability that causes pregnancy in a female fertile. Male infertility is commonly due to Low sperm Count. Soi provides best male infertility treatment in delhi, ghaziabad - India. Call us : 9810350512
visit : www.seedsofinnocence.com
Semen Analysis being one of the basic test and gold standard for male infertility evaluation. Guidelines by World Health Organization published in 2010 remain the most discussed and currently worldwide accepted in interpretation of semen examination.
Physiology of Male Infertility | Seeds of InnocenceSOI Delhi
Male Infertility is a inability that causes pregnancy in a female fertile. Male infertility is commonly due to Low sperm Count. Soi provides best male infertility treatment in delhi, ghaziabad - India. Call us : 9810350512
visit : www.seedsofinnocence.com
Semen Analysis being one of the basic test and gold standard for male infertility evaluation. Guidelines by World Health Organization published in 2010 remain the most discussed and currently worldwide accepted in interpretation of semen examination.
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Newer Modalities for Semen Testing | Male Infertility | Seeds Of InnocenceSOI Delhi
Male Infertility is a inability that causes pregnancy in a female fertile. Male infertility is commonly due to Low sperm Count. Soi provides best male infertility treatment in delhi, ghaziabad - India. For more information call us 9810350512
In this presentation we talk about the current management of male infertility in Delhi India.
Dr Vijayant Gupta is male infertility expert in new Delhi India
We talk about
1. Non obstructive azoospermia
2. Obstructive azoospermia
3. Oligospermia
http://drvijayantgovinda.com/male-infertility-treatment-in-delhi-male-infertility-specialist/
http://drvijayantgovinda.com/male-infertility-treatment-in-delhi-male-infertility-specialist/azoospermia-treatment-in-delhi-nil-sperm-count/
Treatment of Male infertility:-Emphasis on enhnacing Sperm count: New Natural...VISHAL CHANDRA
Oligospermia is a Medical problem commonly known as 'MALE INFERTILITY' and is signified by deficit in Sperm count due to which the female partner shows inability to conceive.
A new Herbal Medicine has been clinically researched & developed for treatment of OLIGOSPERMIA.
The clinical trial has been indexed by World Health Organization ( WHO) Clinical registry platform.
The research & development has been done by an Indian pharmaceutical MNC- TULIP LAB PVT. LTD.
The company has modern research center and Internationally accredited Manufacturing facility and has Pharmaceutical Products & Clinically researched Herbal Medicines/supplements.
For OUT LICENSING /CONTRACT MANUFACTURING, connect with :
Mr. VISHAL CHANDRA (GENERAL MANAGER-INTERNATIONAL BUSINESS):
* e-mail: vishalvns04@yahoo.co.in
* Skype: vishalukraine
Role of LH supplementation in reproductive medicine - Aspire 2013Sankalp Singh
To add or not to add LH is a highly contentious issue.Here,i would be discussing role of LH supplementation in IVF cycle as per present day evidence.
Also,will be scrutinising the available studies for their reliability or lack of it.
The cause for infertility could be in the male or the female or both or neither-as in ‘Unexplained Infertility.’
Male infertility is usually caused by problems that affect either sperm production or sperm transport.
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Newer Modalities for Semen Testing | Male Infertility | Seeds Of InnocenceSOI Delhi
Male Infertility is a inability that causes pregnancy in a female fertile. Male infertility is commonly due to Low sperm Count. Soi provides best male infertility treatment in delhi, ghaziabad - India. For more information call us 9810350512
In this presentation we talk about the current management of male infertility in Delhi India.
Dr Vijayant Gupta is male infertility expert in new Delhi India
We talk about
1. Non obstructive azoospermia
2. Obstructive azoospermia
3. Oligospermia
http://drvijayantgovinda.com/male-infertility-treatment-in-delhi-male-infertility-specialist/
http://drvijayantgovinda.com/male-infertility-treatment-in-delhi-male-infertility-specialist/azoospermia-treatment-in-delhi-nil-sperm-count/
Treatment of Male infertility:-Emphasis on enhnacing Sperm count: New Natural...VISHAL CHANDRA
Oligospermia is a Medical problem commonly known as 'MALE INFERTILITY' and is signified by deficit in Sperm count due to which the female partner shows inability to conceive.
A new Herbal Medicine has been clinically researched & developed for treatment of OLIGOSPERMIA.
The clinical trial has been indexed by World Health Organization ( WHO) Clinical registry platform.
The research & development has been done by an Indian pharmaceutical MNC- TULIP LAB PVT. LTD.
The company has modern research center and Internationally accredited Manufacturing facility and has Pharmaceutical Products & Clinically researched Herbal Medicines/supplements.
For OUT LICENSING /CONTRACT MANUFACTURING, connect with :
Mr. VISHAL CHANDRA (GENERAL MANAGER-INTERNATIONAL BUSINESS):
* e-mail: vishalvns04@yahoo.co.in
* Skype: vishalukraine
Role of LH supplementation in reproductive medicine - Aspire 2013Sankalp Singh
To add or not to add LH is a highly contentious issue.Here,i would be discussing role of LH supplementation in IVF cycle as per present day evidence.
Also,will be scrutinising the available studies for their reliability or lack of it.
The cause for infertility could be in the male or the female or both or neither-as in ‘Unexplained Infertility.’
Male infertility is usually caused by problems that affect either sperm production or sperm transport.
Normal fertile couples of reproductive age have a conception rate of 20% to 25% per month, with more than 90% conceiving within 1 year.
Male factor infertility is involved in approximately 50% of infertile couples.
In 30% of the cases, an abnormality is discovered solely in the man.
As many as 2% of all men will exhibit suboptimal sperm parameters.
Study of Trace Elements Selenium, Copper, Zinc and Manganese Level in Polycys...AnuragSingh1049
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, trace elements play an important role in PCOS, selenium performs various biological functions such as defense against oxidative stress, immune function and thyroid function, polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, trace Elements have important role in PCOS, selenium is involved in many biological functions, such as, protection against oxidative stress, immune function and thyroid function, Copper, zinc and manganese are essential micronutrients that have been integrated into various proteins and metalloenzymes and are active in the metabolic process of cells and in oxidative stress pathways that can lead to oxidative stress.
One hundred and twenty-four of patients' women with poly cystic ovarian syndrome (PCOS) patients and 56 normal ovulatory women participated in the study. Seleniumand serum Copper, zinc and manganese were measured by using flame atomic absorption spectrometry (FAAS).
Detection of Polycystic Ovary Syndrome and Its Treatment with Pergularia Daem...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
semen analysis of diabetics and non diabetics in forensic perspective
1. A Review On
“ Examination of Semen in diabetics and non
diabetics in forensic perspective"
By
ELIPE ARJUN
Msc Forensic science
4th semester
GURU GHASIDAS VISHWAVIDYALAYA BILASPUR,
CHHATTISGARH
2. We All Know Semen Is The Most Available Biological Fluid In
Rape Cases, Forensic Scientists Often Collect Semen For Sperm
Which Contain DNA Which Help In Finding The Suspect . The
Project Work Is About Whether There Is Any Difference Between
Diabetic And Non Diabetic Semen Composition. If We Found
Whether There Is A Difference, We Can Find The Definite One,
Among Suspects In Case Of Gang Rape. The Work Also Deals
With The Examination Of Sugar Content . According To The
Latest NCRB Report, 2019 Saw Over 4 Lakh Reported Cases Of
Crimes Committed Against Women, Up From 3.78 Lakh In 2018
And 3.59 Lakh Cases In 2017. NCRB Reported 32,033 Rape Cases
Which Translates To A Shocking 88 Rape Cases A Day.
And This Is Just 10% Of All Crimes Against Women. One In Six
People With Diabetes In The World Is From India. The Numbers
Place The Country Among The Top 10 Countries For People With
Diabetes, Coming In At Number Two With An Estimated 77
Million Diabetics.
ABSTRACT
3. INTRODUCTION
Human semen is a protein-rich body fluid produced by the
male reproductive organs. It is a complex cell suspension in a
fluid containing an array of heterogeneous substances
produced by different male reproductive glands like the testis,
prostate, seminal vesicles, epididymis, Cowper’s gland
(bulbourethral) and glands of Littre (periurethral glands).
Their main function is to act as a buffered, nutrient-rich
medium which transports the sperm through the male
reproductive tract into the female reproductive tract.Sperms
are produced in testes and they mature at epididymis
maturation took place around 3 months then it joins the
ductus deferens, which transport mature sperm from the
epididymis to ejaculatory duct from there it will follow into
prostatic urethras. The process of generating spermatozoa is
called spermatogenesis.
4. Normal semen is a greyish, opalescent fluid with a density between 1.043 and
1.102 g/ml. The colour may appear whitish due to the presence of a high
number of sperm or leukocytes. If red blood cells are present (hemospermia),
the colour may appear reddish brown (WHO 2010).Semen is slightly alkaline
which helps in neutralizing the acidic environment of vagina. The pH measured
can vary from 7.2 to 7.8 depending on the time elapsed since ejaculation.
Increase in pH of whole semen over time is attributed to fructolysis and
production of lactic acid. A typical semen sample contain the combined
accessory glands.
PHYSICAL PROPERTIES
6. FRUCTOLYSIS
Due to the high motility of sperm, their energy requirement is very high. The major energy
source for sperm in the semen is fructose which is produced by the seminal vesicle. Typical
concentration of fructose in human semen is 200 mg/dl. To maintain a high adenosine
triphosphate/adenosine diphosphate (ATP/ADP) ratio, the sperm utilize anaerobic glycolysis of
fructose termed as fructolysis. The process of fructolysis has been described below
SeminalVesicles. Each fructose molecule yields 2 lactate − ions and 2 hydrogen ions (H+). A
positive correlation exists between the degree of sperm motility and the rate of fructolysis in
human semen (Peterson and Freund 1976). However,immobilization by spermicidal agent (lipid
peroxidase) leads to irreversibleloss of fructolytic ability of the sperm (Mann et al. 1980).
7. SPERMATOZOA
A human spermatozoa has three morphologically distinct structures: thehead,middle
piece,and the tail (Fig 1.1.2 Richard C. Li) the head contain anucleus with densely packed
chromosomes. At the tip of the head of thesperm there is a cap-like structure called
acrosomal cap which containscertain enzymes for fertilization and this is also used for
penetration into the egg. The head is attached to the middle piece through a short neck
where mitochondria are present which provide energy for the moving tail.The tail is
responsible for the motility of sperm. In contrast to other cell types a maturespermatozoa
lacks various intracellular organelles like endoplasmicreticulum,golgi
apparatus,peroxisomes and lysosomes.In a normal male 60% of spermatozoa have normal
morphology.
8. Prostate-specific
Antigen
Prostate-specific antigen (PSA) is a major
protein present in seminal fluid at
concentrations of 0.5–2.0 mg/mL. PSA is
produced in the prostate epitheliumand
secreted into the semen. PSA can also be
found in the paraurethral glands,perianal
glands, apocrine sweat glands, and
mammary glands. Thus smallquantities
can be detected in urine, fecal material,
sweat, and milk. PSA caalsobe be found at
much lower levels in the bloodstream. An
elevated plasma PSA is present in prostate
cancer patients, and it is widely used as a
screening test for this disease
ACID PHOSPHATASE
Acid phosphatase (AP) consists of a
group of phosphatases with
optimalactivity in an acidic pH
environment. The greatest forensic
importance of AP is that the prostate-
derived AP contributes most of the AP
activity present insemen. AP levels in
semen are not affected by vasectomies.
AP isoenzymes are also found in other
tissues.
9. Human seminal vesicle–specific antigen (SVSA) includes two major types,
semenogelin I (Sg I) and semenogelin II (Sg II), and constitutes the major seminal
vesicle–secreted protein in semen. On ejaculation, SVSA forms coagulum that is
liquefied after a few minutes due to the degradation of SVSA by PSA. In humans,
both Sg I and Sg II are present in a number of tissues of the male reproductive
system, including the seminal vesicles, ductus eferens, prostate, and epididymis.
They are also present in several other tissues such as skeletal muscle, kidney,
colon, and trachea. They have also been found in the sera of lung cancer patients.
The use of Sg as a marker for semen identification instead of PSA presents certain
advantages. The concentration of Sg in seminal fluid is much higher than that of
PSA, and this is beneficial for the sensitivity of detection. Sg is present in seminal
fluid and absent in urine, milk, and sweat, where PSA can be found. Although Sg
compounds are present in skeletal muscle, kidney, and colon, this is not a great
concern because these tissue samples are not routinely collected for semen
detection in sexual assault cases
Seminal Vesicle–Specific
Antigen
10. Acid Phosphatase
Techniques
Colorimetric assays can be used for
the presumptive identification of
semen.The AP contained in semen
can hydrolyze a variety of phosphate
esters. It catalyzes the removal of
the phosphate group from a
substrate .Subsequently, aninsoluble
colored precipitate at sites of acid
phosphatase activity is formed witha
stabilized diazonium salt (usually in
the form of zinc double salts).
Analytical Techniques for Identifying Semen:
Presumptive
Assay
ALS( ALTERNATE LIGHT
SOURCES) are most commonly
utilized for thevisual examination
of semen stains. Excitation
wavelengths between 450 and495
nm can be used, allowing for the
visualization of fluorescence with
orangegoggles. However, this
approach is not specific for
semen. Other bodily fluid stains,
such as saliva and urine stains,
can also fluoresce with less
intensity.
11. Microscopic Examination of Spermatozoa: The most
common
staining technique is the Christmas tree stain red component called nuclear
fast red and green component PIC (picroindigocarmine)(stains the neck and
tail portions of the sperm. The acro-somal cap and thenucleus stain pink-red,
and the sperm tails and the midpiece stain blue-green.Epithelial cells, if
present in the sample, appear blue-green andrednuclei nuclei. Additionally,
fluorescent detection utilizing SPERM HYLITER Fluorescent Staining Kit can
facilitate the identification of spermatozoa.
Confirmatory Assays
Identification of Prostate-Specific
Antigen
Over the years, a number of methods have been
utilized to detect PSA:immunodiffusion,
immunoelectrophoresis, enzyme-linked
immunosorbentasass (ELISA), and immunochro-
matographic assays. ELISA and
immunochromatographic assays have been found
to be the most sensitive methods
12. The incidence of diabetes mellitus (DM) is increasing throughout the world. It has been
estimated that by the year 2025, more than 300 million people will be The rising rate of
diabetes in younger men might have significant negative effects. India has been declared
as the 'Diabetes Capital' of the world in a recent reportby IDF (International Diabetes
Federation). It has also stated that India's 9%population is expected to be diabetic by
2030.Exploitable semen for analysis can be detected up to 31 hours in the mouth, 44 hours
in the anus, 110 hours in the rectum 10 daysin the vagina, 19 days in the cecerv. Males
with juvenile diabetes frequently show a lag in sexual development which is manifested in
a delayed appearance of pubic and axillary hair, slow incrimination in testicular size, and
late voice change In adult diabetics, a decrease in libido and potentia is a frequent
complaint.Calcification of the vas deferens occurs 6 times as frequent in diabetics as in
normal individuals.
REVIEW OF LITERATURE
13. In the literature I found only the paper by BARTIK et al. on semen analysis (volume,
sperm density, morphology and velocity) inadolescent diabetic patients. They designed
the study in an attempt to clarify whether spermiogram parameters and seminal
biochemistry components inadolescent patients with type I diabetes mellitus (insulin-
dependent) difromthose those of nondiabetic adolescent subjects; whether angiopathy
(retinopathy),neuropathy and metabolic control influence semen quality, and whether
there isany correlation between some diabetes clinical characteristics and semen
quality.
Materials and methods:
A Study conducted by national institute of endocrinology
cuba they havestudied studied 32 adolescent patients with
type I diabetes mellitus (insulin-dependent) and a control
group of 4 normal adolescent subjects in the sameage range.
Termination of adolescence was defined according to
Dorland's Medical Dictionary as the cessation of somatic
growth. Patient's mean age was 18.6 years (range 17 to 22
years), mean age at onset of diabetes mellitus was11.6 years
(range 2 to 21 years), mean duration of the disease was 6.6
years(range 0.5 to 15 years), and mean age at first
ejaculation was 14.5 years (range 13 to16years)
14. In 28 patients and 23 control subjects
estimations of blood testosterone levels
were done by radioimmunoassay using
reagents and standards provided by the
Matched Reagent Programme
HRP/WHO. The aim of the study were
explained to patients and controls, and
consent was obtained before starting the
procedures.Correlations between some
clinical parameters (age at onset and
duration of diabetes mellitus, time since
first ejaculation) and semen parameters
(volume,density, motility, morphology',
viability, velocity, fructose, glucose)
were assessed.
Two semen analyses, at least two weeks apart, after 3 to 7 days sexual abstinence
was performed. In each sample, obtained by masturbation in the Hospital, They
determined ejaculated volume (ml), sperm density (10S/ml), motility (%), normal
morphology (%), viability (%), and velocity (µ/sec),according to standardized
methods. When the semen volume was large enough, estimations of fructose ,
glucose and citric acid were performed.
15.
16.
17. Spermiogram parameters were lower in diabetics with unsatisfactory
metabolic control. No significant differences were found in seminal fructose
and plasma testosterone levels between these two subgroups.Seminal
glucose was higher in diabetics with unsatisfactory metabolic control
18. Studies on spermiogram and seminal biochemistry in patients with diabetesmellitus are scanty and contradictory data
have been reported. The paperby BaRTIE et al.: was particularly concerned with some semen studies in 25 juvenile
diabetics. In agreement with these authors they found lower average values in spermiogram parameters in the group
of adolescent diabetics when compared to those of nondiabetic adolescents. No negative influence on semenquality
was demonstrated for duration of diabetes, age at onset or time since first ejaculation. MANN and ROTTENBERG
reported high values of seminal fructose were found to be associated with diabetes in rabbits. This probably applied
also to other species, including man.Their study proves that fructose content in semen is increased in human
adolescent diabetic patients. With regard to seminal glucose their resultsdemonstrate its presence in low
concentration in nondiabetic but considerably increased semen glucose was found in diabetics.
DISCUSSION
19. They have studied the semen quality and plasma testosterone levels (T)
in 32 adolescent patients with insulin-dependent diabetes mellitus and
in anaged-matched control group. &'men volume, motility and
morphology weresignificantly lower in diabetics whereas seminal
fructose and glucose were significantlhigher. No difference was
observed in plasma testosterone levels.BARTAK and VISNAK reported
In this study, based on 32 adolescent diabetic patients, They were not
able to demonstrate any correlation between fructose and/or glucose
levels in semen, glycemia and glycosuria, suggestingthat other factors
may influence seminal fructose and glucose concentration to a greater
extent.In conclusion, a deterioration of the quality of human semen
occurs in adolescent diabetic patients. Neuropathy and poor metabolic
control seem to be important ffactos of this deterioration. The presence
of retinopathy does not correlate.
SUMMARY
20. REFERENCES
Basics of human Andrology; a text book geredigeerd Anand kumar mona Sharma.
1.World Health Organization. 2002). Diabetes: The cost of diabetes (Fact sheet 236).
2. Baccetti B, La Marca A, Piomboni P et al. Insulin-dependent diabetes in men is
associated with hypothalamo-pituitary derangement and with impairment in semen
quality. Hum Reprod 2002; 17: 2673–2677.
3. Ballester J, Munoz MC, Dominguez J, Rigan T, Guinovart JJ, Rodriguez-Gil JE. Insulin-
dependent diabetes affects testicular function by FSH and LH-linked mechanism. J Androl
2004; 25: 706–719.
4. World Health Organization. WHO Laboratory Manual for the Examination of Human
Semen and Sperm – Cervical Interaction, 4th edn. Cambridge: Cambridge University
Press, 1999.
5. Bhattacharya SM. Association of various sperm parameters with unexplained
repeated early pregnancy loss: which is important? Int Urol Nephrol 2008; 40: 391–395.
6. Cameron DF, Rountree J, Schultz RE, Repetta D, Murray FT. Sustained hyperglycemia
results in testicular dysfunction and reduced fertility potential in BBWOR diabetic rats.
Am J Physiol 1990; 259: E881–E889.
21. 7. Bhattacharya SM. Hypo osmotic swelling test and unexplained repeat early pregnancy
loss. J Obstet Gynecol Res 2010;36: 119–122.
8. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of
semen during the last 50 years. BMJ 1992; 305: 609–613.
9. Agarwal A, Said TM. Role of sperm chromatin abnormalities and DNA damage in male
infertility. Hum Reprod Update 2003; 9: 331–345.
10. Henkel R, Haji Mohammad M, Stalf T et al. Influence of deoxribonucleic acid damage
on fertilization and pregnancy.Fertil Steril 2004; 81: 965–972.
11. Agbaje IM, Rogers DA, McVicar CM et al. Insulin dependent