The document contains the resume of Dr. E.Selvarajan which details his educational qualifications including a Ph.D in Biotechnology, professional experience as an Assistant Professor at NIT Calicut, areas of research interest in bio nanotechnology and bioprocess technology, list of publications, and skills in areas such as chromatography, fermentation, and molecular techniques.
POTENTIAL OF CURCUMIN IN PYRAMID CELL NECROSIS OF MICE (MUS MUSCULUS) DUE TO ...IAEME Publication
Mercury pollution in the aquatic environment can cause intoxication of marine
organisms and the formation of free radicals in the human body if consumed. Curcumin
is a natural ingredient that contains extracellular antioxidants to overcome the
formation of free radicals in the body. The purpose of the study was to determine the
effect of administering curcumin to the number of pyramid cells that were necrotic in
mice (Mus musculus) exposed to methylmercury. This experiment used a completely
randomized design with 4 groups of mice, i.e. 0.5 ml distilled water, 0.056 mg/kg
methylmercury, 0.0056 mg/kg methylmercury + 150 mg/kg curcumin and 0.0056 mg/kg
methylmercury + 300 mg/kg curcumin. Examination of total pyramid cell necrosis was
observed with a 400x magnification light microscope. In this study, there was a
decrease in the number of pyramid cell necrosis in mice. The decrease in the number
of necrotic cells was directly proportional to the increase in dose given. The treatment
results as positive controls showed the highest value with the number of pyramid cells
experiencing necrosis of 23.28. The highest decreases in the number of each treatment
were 10.32 in 150 mg/kgBW curcumin and 5.80 in 300 mg/kgBW curcumin. Curcumin
can reduce the number of pyramid cells that experience necrosis due to exposure to
methylmercury.
The HortFlora Research Spectrum (HRS), is an international-peer reviewed, open access journal that serves as a forum for the exchange and dissemination of R & D advances and innovations in all facets of Horticultural Science (Pomology, Olericulture, Floriculture, Post Harvest Technology, Plant Biotechnology, and Medicinal & Aromatic Plants etc.) and its allied branches on an international level.
HRS is officially published quarterly (March, June, September and December) every year, in English (print & online version), under the keen auspices of Biosciences & Agriculture Advancement Society (BAAS), Meerut (India).
Aims & Scope
The main objective of the journal ‘HortFlora Research Spectrum’ is to serve as a platform to promote, publish and disseminate the R & D innovations and advances in all aspects of Horticultural Sciences and allied branches of botanical sciences & technology, and to facilitate closer interaction among the academicians, researchers and entrepreneurs at global scale.
The journal HortFlora Research Spectrum (HRS), having International impact (ICV: 27.39; GIF: 0.364; IBI Factor: 2.8), publishes high quality peer reviewed/refereed original research papers, review articles and research notes on all aspects of Horticultural plants’ research including agronomic management, plant nutrition, biotechnology, crop improvement, plant protection, plant physiology, cell & molecular biology, medicinal & aromatic plants, food & nutrition science, agroforestry, environmental science, plant medicinal properties, ethno-phytomedicine, technology dissemination etc.
Profile of PhD Students in the research laboratory of Prof. Satya P. Singh
Satya P. Singh, Ph.D.
UGC-BSR Faculty Fellow (Professor Emeritus)
UGC-CAS Department of Biosciences
Saurashtra University
RAJKOT-360 005 Gujarat, INDIA
POTENTIAL OF CURCUMIN IN PYRAMID CELL NECROSIS OF MICE (MUS MUSCULUS) DUE TO ...IAEME Publication
Mercury pollution in the aquatic environment can cause intoxication of marine
organisms and the formation of free radicals in the human body if consumed. Curcumin
is a natural ingredient that contains extracellular antioxidants to overcome the
formation of free radicals in the body. The purpose of the study was to determine the
effect of administering curcumin to the number of pyramid cells that were necrotic in
mice (Mus musculus) exposed to methylmercury. This experiment used a completely
randomized design with 4 groups of mice, i.e. 0.5 ml distilled water, 0.056 mg/kg
methylmercury, 0.0056 mg/kg methylmercury + 150 mg/kg curcumin and 0.0056 mg/kg
methylmercury + 300 mg/kg curcumin. Examination of total pyramid cell necrosis was
observed with a 400x magnification light microscope. In this study, there was a
decrease in the number of pyramid cell necrosis in mice. The decrease in the number
of necrotic cells was directly proportional to the increase in dose given. The treatment
results as positive controls showed the highest value with the number of pyramid cells
experiencing necrosis of 23.28. The highest decreases in the number of each treatment
were 10.32 in 150 mg/kgBW curcumin and 5.80 in 300 mg/kgBW curcumin. Curcumin
can reduce the number of pyramid cells that experience necrosis due to exposure to
methylmercury.
The HortFlora Research Spectrum (HRS), is an international-peer reviewed, open access journal that serves as a forum for the exchange and dissemination of R & D advances and innovations in all facets of Horticultural Science (Pomology, Olericulture, Floriculture, Post Harvest Technology, Plant Biotechnology, and Medicinal & Aromatic Plants etc.) and its allied branches on an international level.
HRS is officially published quarterly (March, June, September and December) every year, in English (print & online version), under the keen auspices of Biosciences & Agriculture Advancement Society (BAAS), Meerut (India).
Aims & Scope
The main objective of the journal ‘HortFlora Research Spectrum’ is to serve as a platform to promote, publish and disseminate the R & D innovations and advances in all aspects of Horticultural Sciences and allied branches of botanical sciences & technology, and to facilitate closer interaction among the academicians, researchers and entrepreneurs at global scale.
The journal HortFlora Research Spectrum (HRS), having International impact (ICV: 27.39; GIF: 0.364; IBI Factor: 2.8), publishes high quality peer reviewed/refereed original research papers, review articles and research notes on all aspects of Horticultural plants’ research including agronomic management, plant nutrition, biotechnology, crop improvement, plant protection, plant physiology, cell & molecular biology, medicinal & aromatic plants, food & nutrition science, agroforestry, environmental science, plant medicinal properties, ethno-phytomedicine, technology dissemination etc.
Profile of PhD Students in the research laboratory of Prof. Satya P. Singh
Satya P. Singh, Ph.D.
UGC-BSR Faculty Fellow (Professor Emeritus)
UGC-CAS Department of Biosciences
Saurashtra University
RAJKOT-360 005 Gujarat, INDIA
Microbiologist with proficient experience in teaching (2.5 yrs) as well as research (2.5 yrs) and eager to utilize best of my knowledge and experience as team-leader or member.
1. Dr. E.Selvarajan, M.Tech, Ph.D
MISTE
Communication
Address
#86, Thanthai periyar st,
St.Joseph nagar, Kondur,
Cuddalore - 607 006,
Tamil Nadu.
Permanent Address
#86, Thanthai periyar st,
St.Joseph nagar, Kondur,
Cuddalore - 607 006,
Tamil Nadu.
e-mail : selrajan@gmail.com
Mobile : +91 9843430425
D.O.B : 24.11.1985
Objective:
A self motivated, enthusiastic individual looking for an opportunity in an Academic sector and in
thirst to apply my academic skills in a practical work environment to prove myself in the field I am
affianced with.
Professional Experience (5 years)
1. Organization : NIT Calicut
Designation : Assistant Professor [Adhoc] (Aug’15 to till date)
2. Organization : DBT (Indo-Russia joint project)
Designation : Senior Research Fellow (Jan’15 to Jun”15)
3. Organization : Indian Council of Medical Research
Designation : Senior Research Fellow (Sep’13 to Dec’14)
3. Organization : Vellore Institute of Technology University
Designation : Research Associate (Mar’11 to Aug’ 13)
4. Organization : Sree Sastha Institute of Engineering &Technology(Anna Univ)
Designation : Assistant Professor (June’10 to Dec’10)
5. Organization : Bangalore Biotech Labs Pvt. Ltd. (BIOZEEN)
Designation : Trainee (BCIL- BITP) November’09 to April’10
Educational Qualification
Doctor of Philosophy in Biotechnology – Vellore Institute of Technology University, Tamil Nadu
(April 2015).
Master of Technology in Industrial Bio-Technology - SASTRA University, Tamil Nadu with
CGPA of 9.11/10 and placed in First class with distinction (May 2009).
Bachelor of Technology in Industrial Bio-Technology - Arunai Engineering College, Anna
University,Chennai with 78% and placed in First class (April 2007).
Higher Secondary Education – St. Joseph’s Higher Secondary School, Cuddalore with 82.83 %
(March 2003).
SSLC – St. Joseph’s Higher Secondary School, Cuddalore with 92.2 % (April 2001).
2. Area of Interest
Bio Nanotechnology
Bioprocess Technology
Technical Skills
AKTA PRIME PLUS, AKTA PILOT, AKTA PROCESS, HPLC (SHIMADZU).
Column Packing and Protein purification by Chromatographic techniques (IEC, GFC, HIC, AC).
Tangential Flow Filtration (Millipore, Sartorius) and its optimization.
Microbial Fermentor (5L, 40 L) and scale up, Fermentation growth kinetics.
IEF and SDS Electrophoresis (BIO-RAD).
Integrity testing of liquid and gas filters, Sterilization and cleaning in place (FSIP, ESIP) with valve
matrix and P & ID’s, validation.
Cryopreservation, monolayer culture and microcarriers, Karyotyping, MTT Assay, Suspension
culture and scale-up.
Aspen tech V7.1 (Aspen Plus and Aspen HYSYS)
MATLAB (Basics)
FTIR
Book Publications
Book: V.Mohanasrinivasan, C.Subathra devi, V.Suganthi, E.Selvarajan (2012).”Nisin based
Lantibiotic Engineering”. Lambert Academic publishing, Germany. ISBN: 978-3-659-25473-4.
Book: Selvarajan Ethiraj, V.Mohanasrinivasan, V.Suganthi (2011).”Purification of growth
factor expressed as a fusion protein in E.coli”. Lambert Academic publishing,
Germany.ISBN:978-3-8443-8167-2.
Paper Publications (Total Impact Factor = 9.64; citations 45; h-index 3, i10-index 2)
Santhisudha Sarva, Jayaprakash Soora Harinath, Siva Prasad Sthanikam, E. Selvarajan,
V.Mohanasrinivasan, Suresh Reddy Cirandur, “Synthesis, antibacterial and anti-inflammatory
activity of bis(indolyl)methanes” doi:10.1016/j.cclet.2015.08.012 [Impact factor 1.587].
E. Selvarajan, V.Mohanasrinivasan, C.Subathra Devi, George Priya Doss. “Immobilization of β-
galactosidase from Lactobacillus plantarum HF571129 on ZnO nanoparticles:
Characterization and lactose hydrolysis” Bioprocess and Biosystem Engineering , DOI
10.1007/s00449-015-1407-6 [Impact factor 1.998].
E. Selvarajan, V.Mohanasrinivasan. “Kinetic studies on exploring lactose hydrolysis potential
of β galactosidase extracted from Lactobacillus plantarum HF571129”. Journal of Food
Science and Technology , DOI 10.1007/s13197-015-1729-z [Impact factor - 2.203].
Geetha rani Y, Arulval R, E.Selvarajan. “Studies on kinetic parameters and biochemical
characteristics of polyphenol oxidase purified from jackfruit (artocarpus heterophyllus)
waste”. International Journal of Pharmacy and Pharmaceutical Sciences 6(9), 2014.
V. Mohanasrinivasan, Damini Diksha , V.Suganthi, E.Selvarajan, C.Subathra Devi. “Process
optimization for enhanced production of α-amylase by submerged (SmF) and solid state
fermentation (SSF) using Bacillus pumilus VITMDS2”. Research Journal of Pharmaceutical,
Biological and Chemical Sciences 5(2), 2014.
3. V.Mohanasrinivasan*, Taniya ghosal, Thaslim J B, Hurmat Jahan Zeba, E. Selvarajan, V.Suganthi,
C.Subathra Devi. “Production and cross linking studies of Dextran from Leuconostoc
mesenteroides MTCC10508 for biopolymer preparation”. Research Journal of Pharmacy and
Technology 7(1), 8-11, 2014.
V.Mohanasrinivasan*, V.Suganthi, E. Selvarajan, C.Subathra Devi. “Bioremediation of
endosulfan contaminated soil”. Research Journal of Chemistry and Environment 17(11), 93-101,
2013.[IF-0.636]
E. Selvarajan, V.Mohanasrinivasan.”Biosynthesis and characterization of ZnO nanoparticles
using Lactobacillus plantarum VITES07” Materials Letters 112 (2013) 180-182.[IF-2.489]
Damini D, Sukriti P, E. Selvarajan, V.Suganthi and V.Mohanasrinivasan*. “Removal of Heavy
Metals from Leather Industry Effluent Using Saccharomyces sp In a Packed Bed Reactor”
Research Journal of Engineering and Technology, 4(2) 2013.
V. Mohanasrinivasan*, Mudit Mishra, Jeny Singh Paliwal, Suneet Kr. Singh, E.Selvarajan,
V.Suganthi, C.Subathra devi. “Studies on heavy metal removal efficiency and antibacterial
activity of chitosan prepared from shrimp shell waste”. 3Biotech (2014) 4:167–175
Mohanasrinivasan V.*, SriramKalyan P, Ipsita Nandi, Subathradevi C, Selvarajan E, Suganthi V and
Jemimah Naine S.” Fermentative production of extracellular pigment from Streptomyces
coelicolor MSIS1””.. RReesseeaarrcchh JJoouurrnnaall ooff BBiiootteecchhnnoollooggyy,, 88((44)) 22001133..[[IIFF--00..229944]]
V.Mohanasrinivasan*, C.Subathra Devi, Ritusree Biswas, Falguni Paul, Mohor Mitra, E.Selvarajan,
V.Suganthi.”Enhanced production of nattokinase from UV mutated Bacillus sp.” Bangladesh
Journal of Pharmacology 8(2) 2013.[1.052]
V. Mohanasrinivasan*, C.Subathra devi, Akata Saha, Madhumanti Mondal, Sudeshna dhar,
V.Suganthi, E.Selvarajan. “Screening for Staphylokinase producing Staphylococcus sp from
bovine milk sample”. IJPPS, 5(2) 2013.
Damini D, Jayasmita D, Sukriti P, Selvarajan E, Suganthi V, Mohanasrinivasan V*. “Fermentative
production of ergosterol using Saccharomyces cerevisiae” Journal of Applied Sciences
Research 9(2) 2013.
C.Subathra Devi, V. Mohanashrinivasan, B.Vaishnavi, E.Selvarajan, S.Jemima
Naine.”Optimization studies for enhanced production of streptokinase by Streptococcus
equisimilis UVM6” Journal of Pure & Applied Microbiology 7(3) 2013.[0.05]
Mudit Mishra, Jeny Singh Paliwal, Suneet Kumar Singh, E Selvarajan, V. Mohanashrinivasan*. ”
Biological synthesis of zinc oxide nanoparticles using Lactobacillus sporogens and its
inhibitory activity against a food borne pathogen Staphylococcus aureus”. Journal of Pure &
Applied Microbiology 7(2) 2013.[0.05]
M.Ramya and E.Selvarajan*.” Purification of human recombinant granulocyte colony
stimulating factor from Escherichia coli”. African Journal of Biotechnology 2012, 11(50), 11104-
11109.[0.56]
V.Suganthi, E.Selvarajan, V.Mohanasrinivasan*, C.Subathra Devi.”Lantibiotic nisin: Natural
preservative from Lactococcus lactis”. International Research Journal of Pharmacy 2012, 3(1),
13-19.
4. M.Ramya, E.Selvarajan, V.Suganthi, V.Mohanasrinivasan*, Com f.Subathra Devi. ”Determination
of human T-cell leukemia virus-1 among pregnant women”. Elixir Virus Research 2012, 42,
6345-6348.
Paper/Poster presentations
Presented a paper entitled “Immobilization of intracellular β-galactosidase from Lactobacillus
plantarum VITES07 on ZnO nanoparticles” in the National Conference on A Prospective Approach
in Herbal Medicine and Microbiology at Sivaraj Siddha Medical College, (Nov’ 2014).
Presented a poster entitled “Immobilization of β-Galactosidase on ZnO NPs and its application
on Lactose hydrolysis for lactose intolerance people” in the 3
rd
Edition of VIT Bio Summit at VIT
University, (Aug 2014).
Presented a paper entitled “Screening for β galactosidase producing lactic acid bacteria from
fermented food products” in the National Conference on Recent trends and future prospects of
microbiology and biotechnology at SJJT University, (Mar 2014).
Presented a poster entitled “Studies on combined effect of prepared ZnO nanoparticles and leaf
extracts of Mangifera indica against wound infection causing bacteria” in the National
Conference on Challenges in Biomaterials Research at VIT University, (Dec 2013).
Presented a poster entitled “Biosynthesis and characterization of ZnO nanoparticles using
Lactobacillus plantarum VITES07” in the National Symposium on Nano-Biotechnology at Indian
Institute of Technology, Mandi (Dec 2013).
Presented a poster entitled “Optimization studies of protease production using Aspergillus
niger” in the National Symposium on New Horizons in Biotechnology and Bionanomedicine at Periyar
University, Salem (Sep 2012).
Presented a poster entitled “Effect of nanoparticles encapsulated nisin on enhancement of
storage &stability of packaged foods” in the International Symposium on Recent Trends in
Processing & Safety of Specialty and Operational Foods at DFRL, Mysore (Nov 2011).
Presented a poster entitled “Lactose free milk production” in the National Conference on Career
and Research trends in Food Processing at IICPT, Thanjavur (Jun 2011).
Presented a paper entitled “Lactose free milk production” in the 2
nd
International Conference on
Science, Engineering and Technology at VIT University (Apr 2011).
Sequence deposited at NCBI
Enterococcus mundtii MVS1 (16S rRNA partial) JX123479
Lactobacillus plantarum VITES04 (16S rRNA partial) KC538945
Lactobacillus plantarum VITES07 (16S rRNA partial) HF571129
Leuconostoc mesenteroides VITMS1 (16S rRNA partial) KC539103
Leuconostoc mesenteroides VITMS4 (16S rRNA partial) HF586418
Pseudomonas aeruginosa TMSS (16S rRNA partial) JX112658
Pseudomonas aeruginosa CMSS (16S rRNA partial) JX112657
Pediococcus pentosaceus VITMS7 (16S rRNA partial) KC692718
Bacillus pumilus VITMDS02 (16S rRNA partial) KC991039
5. Training Programme / Workshop/ International Conference
Participated in the two days workshop on “Pedagogical Aspects of Engineering Education” at NIT
Calicut (Aug 2015).
Participated in the two days workshop on “Transmission Electron Microscopy” at IIT Mandi (Dec
2013).
Participated in the Faculty development programme on “MATLAB“at VIT University (Aug 2013).
Participated in the Faculty development workshop on “Chemical Process Modeling and Simulation
“at AMRITA University, Coimbatore (Jun 2013).
Participated in the lecture workshop on “Microbes, Minerals and Environment” at VIT University,
Vellore (Jan 2013).
Participated in the Faculty development programme on “An introduction to Statistical Analysis
System” at VIT University (Nov 2012).
Participated in the workshop on “How to write research paper” at VIT University, Vellore (Sep 2012).
Participated in the National Workshop on “Microbial Enzyme Technology” at Pondicherry
University, Puducherry (June 2012).
Participated in the Faculty development programme on “Functional Nanomaterials-Synthesis and
Characterization” at SASTRA University (Dec 2011).
Attended the Training programme on “Recent Research Developments in Biotechnology” at VIT
University (Oct 2011).
Participated in the Lecture workshop entitled “Products from Natural Resources: Prospecting and
Utilization” at VIT University (July 2001).
Participated in the Faculty development programme on “Biostatistics and Mathematics for
Biologist” at VIT University (July 2011).
Participated in the National Workshop on “HACCP and Food Safety in Food Industries” at IICPT,
Thanjavur (June 2011).
Attended an awareness workshop on “Intellectual Property Rights” at VIT University (March 2011).
Participated in the International Symposium on “Environmental exposures to Mutagens and
Carcinogens on Human Health” at VIT University (Feb 2011).
Attended a “National Level Orientation Program for Designing Doctoral Research” at AMET
University, Chennai (Feb 2011).
Attended the Training programme on “Animal Handling and Immuno Techniques” at the Centre for
Advanced Studies in Botany, University of Madras, Chennai (Aug 2006).
Undergone Job Training in “IMMUNOTECHNOLOGY” at Sangene Institute of Bioscience, Bangalore
(Jun 2006).
Attended a Short-term course on “Electrophoresis Techniques” at The Electrophoresis Institute,
Yercaud (Feb 2006).
Undergone In-plant training on “Bioreactor” at Shasun chemicals & drugs, Cuddalore (Jun 2005).
Undergone Industrial Training Programme on “Bio Informatics Databases and Tools” at Sai’s
Biosciences Research Institute Pvt. Ltd., Chennai (Jun 2005).
Undergone Training Programme on “Wet lab Training for Bioinformatics” conducted by National
Institute of Ocean Technology, Chennai (May 2005).
6. Attended International conference on “Environment Ecology & Pollution” at Arunai Engineering
College, Thiruvannamalai (Jan 2005).
Professional Membership
Indian Society for Technical Education-ISTE (Life Time)
Member of European Society for Nano Medicine-ESNAM
International Association of Computer Science and Information Technology-IACSIT
International Society for Environmental and Information Science-ISEIS
Asia-Pacific Chemical, Biological & Environmental Engineering Society-APCBEES
International Society for Applied Life Sciences (ISALS)
Journal Reviewer/Editorial Board Member
Indian Journal of Biotechnology
American Journal of Bioscience
African Journal of Biotechnology
Journal of Biotechnological Sciences
Innovare Journal of Engineering and Technology
American Journal of PharmaTech Research
Journal of Critical Reviews
European Journal of Biotechnology and Bioscience
Journal of Natural Sciences
International Journal of Pharmacy and Phamaceutical Sciences
Achievements
Nominated for “Who’s Who in the World 2016” 33rd
Edition, Published from
Marquis Who’s who in America, since 1899.
Research scholar award from VIT University for the year 2012 and 2013
References
1. Dr.V.Mohanasrinivasan, 2. Dr.C.Subathra Devi,
Assistant Professor (Sr), Assistant Professor (Sr),
Environmental Biotechnology Division, Industrial Biotechnology Division,
VIT University. VIT University.
v.mohan@vit.ac.in csubathradevi@vit.ac.in
9486802902 9486420509.
I hereby declare that the details furnished above are true to the best of my knowledge and belief.
Sincerely yours,
(E.SELVARAJAN)