The study examines the prevalence of self-medication among undergraduate medical students at Alexandria Faculty of Medicine, finding that 52.7% of students engage in self-medication, with a notable increase in this behavior as education progresses. It highlights a lack of significant gender differences in self-medication practices but suggests that acquiring medical knowledge influences students' attitudes towards it. The authors recommend enhancing medical curricula to address the risks associated with self-medication and call for broader studies across multiple centers for more generalized results.